CA2797356C - Improved cell culture medium - Google Patents
Improved cell culture medium Download PDFInfo
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- CA2797356C CA2797356C CA2797356A CA2797356A CA2797356C CA 2797356 C CA2797356 C CA 2797356C CA 2797356 A CA2797356 A CA 2797356A CA 2797356 A CA2797356 A CA 2797356A CA 2797356 C CA2797356 C CA 2797356C
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
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CA2911256A1 (en) | 2008-10-20 | 2010-12-09 | Robert K. Hickman | Isolation and purification of antibodies using protein a affinity chromatography |
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US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
WO2013059406A1 (en) | 2011-10-18 | 2013-04-25 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with metal ions |
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US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
US20130281355A1 (en) | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
EP2869817A4 (en) | 2012-07-09 | 2016-04-06 | Coherus Biosciences Inc | STABLE AQUEOUS FORMULATIONS OF ETANERCEPT |
KR20150043523A (ko) | 2012-09-02 | 2015-04-22 | 애브비 인코포레이티드 | 단백질 불균일성의 제어 방법 |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
BR112015005161A2 (pt) | 2012-09-11 | 2017-07-04 | Coherus Biosciences Inc | etanercepte corretamente dobrado em alta pureza e excelente rendimento |
SG11201507230PA (en) | 2013-03-12 | 2015-10-29 | Abbvie Inc | Human antibodies that bind human tnf-alpha and methods of preparing the same |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
WO2014158231A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | Low acidic species compositions and methods for producing and using the same |
WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
BR112016002622B1 (pt) | 2013-08-20 | 2023-04-11 | Lek Pharmaceuticals D.D | Meio de cultura celular e uso de selênio |
US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
KR102510238B1 (ko) * | 2013-10-11 | 2023-03-16 | 리제너론 파마슈티칼스 인코포레이티드 | 대사적으로 최적화된 세포 배양 |
US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
WO2015073884A2 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
JP6749838B2 (ja) * | 2014-01-30 | 2020-09-02 | コヒラス・バイオサイエンシズ・インコーポレイテッド | かん流培地 |
LT3137595T (lt) | 2014-04-29 | 2019-06-25 | Novartis Ag | Naujos stuburinių ląstelės ir dominančio polipeptido rekombinantinės raiškos būdai |
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WO2017106783A1 (en) * | 2015-12-17 | 2017-06-22 | Life Technologies Corporation | Pellets used in cell culture and methods of making thereof |
IL261999B2 (en) * | 2016-04-05 | 2023-04-01 | Pfizer | Cell culture process |
US11702628B2 (en) | 2017-03-31 | 2023-07-18 | Boehringer Ingelheim International Gmbh | Perfusion medium for culturing mammalian cells and reducing cell bleed in a perfusion cell culture |
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US9428727B2 (en) | 2016-08-30 |
AU2011246503B2 (en) | 2013-09-26 |
JP7034991B2 (ja) | 2022-03-14 |
ES2533074T3 (es) | 2015-04-07 |
RU2018101201A3 (e) | 2021-05-27 |
USRE48864E1 (en) | 2021-12-28 |
RU2012150346A (ru) | 2014-06-10 |
EP2563904B1 (en) | 2015-01-21 |
IL222452B (en) | 2019-03-31 |
PT2563904E (pt) | 2015-05-12 |
WO2011134920A1 (en) | 2011-11-03 |
IL222452A0 (en) | 2012-12-31 |
US20130122543A1 (en) | 2013-05-16 |
CN102858952B (zh) | 2015-10-14 |
RU2644651C2 (ru) | 2018-02-13 |
CN102858952A (zh) | 2013-01-02 |
AU2011246503A1 (en) | 2012-11-22 |
JP2019216728A (ja) | 2019-12-26 |
CA2797356A1 (en) | 2011-11-03 |
BR112012027282B1 (pt) | 2020-09-29 |
JP2013524825A (ja) | 2013-06-20 |
EP2563904A1 (en) | 2013-03-06 |
KR20130058699A (ko) | 2013-06-04 |
MX2012012526A (es) | 2012-11-23 |
SG185038A1 (en) | 2012-11-29 |
JP6603628B2 (ja) | 2019-11-06 |
JP6347949B2 (ja) | 2018-06-27 |
BR112012027282A2 (pt) | 2015-09-22 |
DK2563904T3 (en) | 2015-04-07 |
KR101828623B1 (ko) | 2018-02-12 |
RU2018101201A (ru) | 2019-02-21 |
JP2017012180A (ja) | 2017-01-19 |
PL2563904T3 (pl) | 2015-06-30 |
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