ES2523851T3 - Compuestos de quinolinona como agonistas de los receptores 5-HT4 - Google Patents

Compuestos de quinolinona como agonistas de los receptores 5-HT4 Download PDF

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Publication number
ES2523851T3
ES2523851T3 ES06736578.3T ES06736578T ES2523851T3 ES 2523851 T3 ES2523851 T3 ES 2523851T3 ES 06736578 T ES06736578 T ES 06736578T ES 2523851 T3 ES2523851 T3 ES 2523851T3
Authority
ES
Spain
Prior art keywords
compound
isopropyl
dihydroquinoline
oct
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06736578.3T
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English (en)
Spanish (es)
Inventor
Adam Goldblum
Seok-Ki Choi
Paul R. Fatheree
Roland Gendron
Lan Jiang
Daniel Long
Daniel Marquess
Derek S. Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Theravance Biopharma R&D IP LLC
Original Assignee
Theravance Biopharma R&D IP LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application granted granted Critical
Publication of ES2523851T3 publication Critical patent/ES2523851T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES06736578.3T 2005-03-02 2006-03-01 Compuestos de quinolinona como agonistas de los receptores 5-HT4 Active ES2523851T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65800705P 2005-03-02 2005-03-02
US658007P 2005-03-02
PCT/US2006/007284 WO2006094063A1 (en) 2005-03-02 2006-03-01 Quinolinone compounds as 5-ht4 receptor agonists

Publications (1)

Publication Number Publication Date
ES2523851T3 true ES2523851T3 (es) 2014-12-02

Family

ID=36588769

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06736578.3T Active ES2523851T3 (es) 2005-03-02 2006-03-01 Compuestos de quinolinona como agonistas de los receptores 5-HT4

Country Status (16)

Country Link
US (2) US7446114B2 (enExample)
EP (1) EP1871772B1 (enExample)
JP (1) JP5042043B2 (enExample)
KR (1) KR20070107807A (enExample)
CN (1) CN101163701A (enExample)
AU (1) AU2006218603A1 (enExample)
BR (1) BRPI0608392A2 (enExample)
CA (1) CA2599404A1 (enExample)
EA (1) EA013567B1 (enExample)
ES (1) ES2523851T3 (enExample)
IL (1) IL185407A0 (enExample)
MX (1) MX2007010769A (enExample)
NO (1) NO20074884L (enExample)
NZ (1) NZ560828A (enExample)
WO (1) WO2006094063A1 (enExample)
ZA (1) ZA200707142B (enExample)

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TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
TWI377206B (en) 2005-04-06 2012-11-21 Theravance Inc Crystalline form of a quinolinone-carboxamide compound
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
GB0525068D0 (en) 2005-12-08 2006-01-18 Novartis Ag Organic compounds
US8338142B2 (en) * 2007-02-19 2012-12-25 Kaneka Corporation Method for producing optically active 3-aminopiperidine or salt thereof
CN102639526B (zh) * 2009-09-14 2014-06-04 苏文生命科学有限公司 作为5-ht4受体配体的1,2-二氢-2-氧代喹啉化合物
MX2017012474A (es) 2015-04-02 2018-01-11 Theravance Biopharma R&D Ip Llc Forma farmaceutica combinada de un antagonista de los receptores opioides mu y un agente opioide.
AU2023207844B2 (en) 2022-01-11 2025-02-20 Suven Life Sciences Limited PYRROLO[1,2-b]-2-PYRIDAZINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS

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Also Published As

Publication number Publication date
US7446114B2 (en) 2008-11-04
BRPI0608392A2 (pt) 2009-12-29
KR20070107807A (ko) 2007-11-07
US20090036483A1 (en) 2009-02-05
EP1871772A1 (en) 2008-01-02
IL185407A0 (en) 2008-01-06
AU2006218603A1 (en) 2006-09-08
MX2007010769A (es) 2008-03-07
ZA200707142B (en) 2008-10-29
NO20074884L (no) 2007-11-29
EA200701867A1 (ru) 2008-02-28
US20060199839A1 (en) 2006-09-07
US7875629B2 (en) 2011-01-25
EA013567B1 (ru) 2010-06-30
WO2006094063A1 (en) 2006-09-08
NZ560828A (en) 2011-01-28
CN101163701A (zh) 2008-04-16
EP1871772B1 (en) 2014-09-10
CA2599404A1 (en) 2006-09-08
JP5042043B2 (ja) 2012-10-03
JP2008531711A (ja) 2008-08-14

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