ES2513291T3 - Derivados alquinilo útiles como inhibidores de la DPP-1 - Google Patents

Derivados alquinilo útiles como inhibidores de la DPP-1 Download PDF

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Publication number
ES2513291T3
ES2513291T3 ES10774098.7T ES10774098T ES2513291T3 ES 2513291 T3 ES2513291 T3 ES 2513291T3 ES 10774098 T ES10774098 T ES 10774098T ES 2513291 T3 ES2513291 T3 ES 2513291T3
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Prior art keywords
phenyl
4alkyl
ethyl
oxy
piperidin
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Spanish (es)
Inventor
Michael H. Parker
Dennis J. Hlasta
Yifang Huang
Allen B. Reitz
Edward C. Lawson
Carsten Schubert
Eric Strobel
Brett Tounge
Kimberly White
Michael P. Winters
Shyamali Ghosh
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Janssen Pharmaceutica NV
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Janssen Pharmaceutica NV
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and unsaturated
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
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ES10774098.7T 2009-10-29 2010-10-28 Derivados alquinilo útiles como inhibidores de la DPP-1 Active ES2513291T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25617109P 2009-10-29 2009-10-29
US256171P 2009-10-29
PCT/US2010/054445 WO2011059731A1 (en) 2009-10-29 2010-10-28 Alkynyl derivatives useful as dpp-1 inhibitors

Publications (1)

Publication Number Publication Date
ES2513291T3 true ES2513291T3 (es) 2014-10-24

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ES10774098.7T Active ES2513291T3 (es) 2009-10-29 2010-10-28 Derivados alquinilo útiles como inhibidores de la DPP-1

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US (1) US8633322B2 (enExample)
EP (1) EP2493571B1 (enExample)
JP (1) JP5815542B2 (enExample)
CN (1) CN102596321B (enExample)
AU (1) AU2010319927B2 (enExample)
ES (1) ES2513291T3 (enExample)
WO (1) WO2011059731A1 (enExample)

Families Citing this family (6)

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Publication number Priority date Publication date Assignee Title
WO2012119941A1 (en) 2011-03-04 2012-09-13 Prozymex A/S Peptidyl nitrilcompounds as peptidase inhibitors
EP2825533B1 (en) 2012-03-13 2016-10-19 Basf Se Fungicidal pyrimidine compounds
AR091858A1 (es) 2012-07-25 2015-03-04 Sova Pharmaceuticals Inc INHIBIDORES DE CISTATIONIN-g-LIASA (CSE)
CA2923101A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
WO2015036059A1 (en) 2013-09-16 2015-03-19 Basf Se Fungicidal pyrimidine compounds
EP4497473A3 (en) 2020-08-26 2025-04-23 Haisco Pharmaceuticals Pte. Ltd. Nitrile derivative that acts as inhibitor of dipeptidyl peptidase 1 and use thereof

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US548021A (en) * 1895-10-15 Wiiitfield potter toomee
US4847241A (en) * 1985-08-14 1989-07-11 G. D. Searle & Co. Fluorenyl substituted tyrosyl dipeptide amides which are useful in treating pain
CA2099994C (en) 1991-03-06 2003-05-20 Robert B. Garland Phenyl amidines derivatives useful as platelet aggregation inhibitors
US5424334A (en) 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
DE4321502A1 (de) 1993-06-29 1995-01-12 Bayer Ag Alkinol-substituierte Peptide, Verfahren zu ihrer Herstellung und ihre Verwendung als antiretrovirale Mittel
AU6490396A (en) 1995-07-14 1997-02-18 Smithkline Beecham Corporation Substituted-pent-4-ynoic acids
NZ318926A (en) 1995-08-30 1999-04-29 Searle & Co Alpha v beta 3 integrin (vitronectin) inhibitors or anatagonists derived from benzoic acid for treating diseases of cell adhesion
JP2002145897A (ja) 2000-11-10 2002-05-22 Kyorin Pharmaceut Co Ltd アミノ酸誘導体及びその製造法
CA2480378A1 (en) * 2002-05-07 2003-11-20 Neurosearch A/S Novel azacyclic ethynyl derivatives
DE60226906D1 (de) * 2002-07-31 2008-07-10 Ranbaxy Lab Ltd 3,6-disubstituierte azabicyclo ä3.1.0ühexanderivate, die sich als muscarinrezeptorantagonisten eignen
US20040186151A1 (en) * 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
AU2004210711B2 (en) * 2003-02-12 2010-07-08 Transtech Pharma, Inc. Substituted azole derivatives as therapeutic agents
US20070155803A1 (en) * 2003-05-30 2007-07-05 Prozymex A/S Protease inhibitors
US7638513B2 (en) * 2004-06-02 2009-12-29 Schering Corporation Compounds for the treatment of inflammatory disorders
DE102005009784B4 (de) * 2005-03-03 2009-06-18 Technische Universität Darmstadt Peptid-Mimetika, Verfahren zur deren Herstellung, diese enthaltende pharmazeutische Zusammensetzung und deren Verwendung als Inhibitoren von Proteasomen und zur Induktion von Apoptose
KR20080004550A (ko) * 2005-03-30 2008-01-09 콘포마 세러퓨틱스 코포레이션 Ｈｓｐ９０-억제제로서 알키닐 피롤로피리미딘 및 관련유사체
BRPI0708942A2 (pt) 2006-03-21 2011-06-14 Joyant Pharmaceuticals Inc composto promotor de apoptose, uso e mÉtodo de produÇço do mesmo e composiÇço farmacÊutica
US7678894B2 (en) 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
TW200922556A (en) 2007-08-20 2009-06-01 Glaxo Group Ltd Novel cathepsin C inhibitors and their use
BRPI0820665A2 (pt) 2007-12-12 2018-05-29 Astrazeneca Ab compostos de peptidil nitrilas, processos para fabricação dos mesmos, composição farmacêutica, combinação e uso de ditos compostos

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