ES2498043T3

ES2498043T3 - Piperazinas novedosas, composiciones farmacéuticas y métodos de uso de las mismas

Piperazinas novedosas, composiciones farmacéuticas y métodos de uso de las mismas Download PDF

Info

Publication number: ES2498043T3
Authority: ES; Spain
Prior art keywords: methyl; yloxy; pyridin; piperazin; piperazine
Prior art date: 2006-06-06
Legal status : Active

Application number

ES07809388.7T

Other languages

English (en)

Spanish (es)

Inventor

Roger B. Clark

Daniel Elbaum

Current Assignee

Chiesi USA Inc

Original Assignee

Cornerstone Therapeutics Inc

Priority date

2006-06-06

Filing date

2007-06-06

Publication date

2014-09-24

2007-06-06 Application filed by Cornerstone Therapeutics Inc filed Critical Cornerstone Therapeutics Inc

2014-09-24 Application granted granted Critical

2014-09-24 Publication of ES2498043T3 publication Critical patent/ES2498043T3/es

Status Active legal-status Critical Current

2027-06-06 Anticipated expiration legal-status Critical

Links

238000000034 method Methods 0.000 title claims description 40
239000008194 pharmaceutical composition Substances 0.000 title claims description 16
150000004885 piperazines Chemical class 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 284
125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract description 91
125000006374 C2-C10 alkenyl group Chemical group 0.000 claims abstract description 81
125000000392 cycloalkenyl group Chemical group 0.000 claims abstract description 51
229910052717 sulfur Inorganic materials 0.000 claims abstract description 38
229910052760 oxygen Inorganic materials 0.000 claims abstract description 33
125000005865 C2-C10alkynyl group Chemical group 0.000 claims abstract description 31
229910052799 carbon Inorganic materials 0.000 claims abstract description 30
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 28
150000003839 salts Chemical class 0.000 claims abstract description 28
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 27
229910002091 carbon monoxide Inorganic materials 0.000 claims abstract description 7
-1 (pyridin-3-yloxy) methyl Chemical group 0.000 claims description 479
IVXQBCUBSIPQGU-UHFFFAOYSA-N piperazine-1-carboxamide Chemical compound NC(=O)N1CCNCC1 IVXQBCUBSIPQGU-UHFFFAOYSA-N 0.000 claims description 199
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 98
125000001072 heteroaryl group Chemical group 0.000 claims description 98
125000003118 aryl group Chemical group 0.000 claims description 82
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 56
125000005843 halogen group Chemical group 0.000 claims description 46
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238000011282 treatment Methods 0.000 claims description 22
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