ES2489475T3 - Inhibidores MET para potenciar la eficacia de la radioterapia - Google Patents

Inhibidores MET para potenciar la eficacia de la radioterapia Download PDF

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Publication number
ES2489475T3
ES2489475T3 ES11158861.2T ES11158861T ES2489475T3 ES 2489475 T3 ES2489475 T3 ES 2489475T3 ES 11158861 T ES11158861 T ES 11158861T ES 2489475 T3 ES2489475 T3 ES 2489475T3
Authority
ES
Spain
Prior art keywords
met
met inhibitor
cdr
nucleotide sequence
sequence encoding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES11158861.2T
Other languages
English (en)
Spanish (es)
Inventor
Paolo Maria Comoglio
Carla Boccaccio
Fiorella Petronzelli
Rita De Santis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
METHERESIS TRANSLATIONAL RESEARCH SA
Metheresis Translational Res SA
Original Assignee
METHERESIS TRANSLATIONAL RESEARCH SA
Metheresis Translational Res SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by METHERESIS TRANSLATIONAL RESEARCH SA, Metheresis Translational Res SA filed Critical METHERESIS TRANSLATIONAL RESEARCH SA
Application granted granted Critical
Publication of ES2489475T3 publication Critical patent/ES2489475T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
ES11158861.2T 2011-03-18 2011-03-18 Inhibidores MET para potenciar la eficacia de la radioterapia Active ES2489475T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11158861.2A EP2500036B1 (en) 2011-03-18 2011-03-18 MET inhibitors for enhancing radiotherapy efficacy

Publications (1)

Publication Number Publication Date
ES2489475T3 true ES2489475T3 (es) 2014-09-02

Family

ID=44260211

Family Applications (1)

Application Number Title Priority Date Filing Date
ES11158861.2T Active ES2489475T3 (es) 2011-03-18 2011-03-18 Inhibidores MET para potenciar la eficacia de la radioterapia

Country Status (22)

Country Link
US (1) US20120237524A1 (cg-RX-API-DMAC7.html)
EP (1) EP2500036B1 (cg-RX-API-DMAC7.html)
JP (1) JP5671487B2 (cg-RX-API-DMAC7.html)
KR (1) KR101540838B1 (cg-RX-API-DMAC7.html)
CN (1) CN102688491A (cg-RX-API-DMAC7.html)
AU (1) AU2012201303B2 (cg-RX-API-DMAC7.html)
BR (1) BR102012006063B1 (cg-RX-API-DMAC7.html)
CA (1) CA2769991C (cg-RX-API-DMAC7.html)
CY (1) CY1115374T1 (cg-RX-API-DMAC7.html)
DK (1) DK2500036T3 (cg-RX-API-DMAC7.html)
EA (1) EA028590B1 (cg-RX-API-DMAC7.html)
ES (1) ES2489475T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20140729T1 (cg-RX-API-DMAC7.html)
IL (1) IL218293A (cg-RX-API-DMAC7.html)
MX (1) MX2012003084A (cg-RX-API-DMAC7.html)
PL (1) PL2500036T3 (cg-RX-API-DMAC7.html)
PT (1) PT2500036E (cg-RX-API-DMAC7.html)
RS (1) RS53468B (cg-RX-API-DMAC7.html)
SG (1) SG184637A1 (cg-RX-API-DMAC7.html)
SI (1) SI2500036T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201400106B (cg-RX-API-DMAC7.html)
ZA (1) ZA201201992B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9168300B2 (en) 2013-03-14 2015-10-27 Oncomed Pharmaceuticals, Inc. MET-binding agents and uses thereof
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
IT201800009282A1 (it) * 2018-10-09 2020-04-09 Metis Prec Medicine Sb Srl Nuovo agente terapeutico per il trattamento di un tumore e/o metastasi
CN110320365B (zh) * 2019-07-06 2022-07-22 湖南莱拓福生物科技有限公司 NF-κB RelA/p65蛋白位点特异性磷酸化诊断试剂盒
US11896682B2 (en) 2019-09-16 2024-02-13 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging and methods of use thereof
KR20250164828A (ko) 2023-03-30 2025-11-25 레볼루션 메디슨즈, 인크. Ras gtp 가수분해 유도를 위한 조성물 및 이의 용도
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025080946A2 (en) 2023-10-12 2025-04-17 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI310684B (en) * 2000-03-27 2009-06-11 Bristol Myers Squibb Co Synergistic pharmaceutical kits for treating cancer
WO2004072117A2 (en) * 2003-02-13 2004-08-26 Pharmacia Corporation Antibodies to c-met for the treatment of cancers
EP2341067A1 (en) * 2003-07-18 2011-07-06 Amgen, Inc Specific binding agents to hepatocyte growth factor
HN2004000285A (es) * 2003-08-04 2006-04-27 Pfizer Prod Inc ANTICUERPOS DIRIGIDOS A c-MET
BRPI0707480A8 (pt) * 2006-02-06 2022-11-08 Vertical Bio Ag Usos de um anticorpo monoclonal, um fragmento e/ou anticorpo geneticamente engenheirado ou humanizado, de uma seqüência de nucleotídeos e de um vetor, produto, e, método para triar compostos
EP2019116A1 (en) * 2007-07-26 2009-01-28 Helmholtz-Zentrum für Infektionsforschung GmbH Inhibitor of the met-receptor and its use

Also Published As

Publication number Publication date
EP2500036B1 (en) 2014-05-07
BR102012006063A8 (pt) 2022-11-08
IL218293A (en) 2016-06-30
SG184637A1 (en) 2012-10-30
SI2500036T1 (sl) 2014-09-30
BR102012006063B1 (pt) 2023-03-07
EA201200329A3 (ru) 2013-01-30
ZA201201992B (en) 2015-05-27
SMT201400106B (it) 2014-11-10
CN102688491A (zh) 2012-09-26
DK2500036T3 (da) 2014-08-04
PT2500036E (pt) 2014-08-25
HRP20140729T1 (hr) 2014-08-29
HK1174539A1 (en) 2013-06-14
EA028590B1 (ru) 2017-12-29
MX2012003084A (es) 2012-09-17
KR101540838B1 (ko) 2015-08-06
AU2012201303A1 (en) 2012-10-04
BR102012006063A2 (pt) 2021-11-16
EP2500036A1 (en) 2012-09-19
PL2500036T3 (pl) 2014-10-31
KR20120106582A (ko) 2012-09-26
AU2012201303B2 (en) 2013-11-07
CA2769991A1 (en) 2012-09-18
EA201200329A2 (ru) 2012-09-28
IL218293A0 (en) 2012-07-31
RS53468B (sr) 2014-12-31
CA2769991C (en) 2018-05-15
CY1115374T1 (el) 2017-01-04
JP5671487B2 (ja) 2015-02-18
US20120237524A1 (en) 2012-09-20
JP2012196206A (ja) 2012-10-18

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