ES2475741T3 - Ciclopropil dicarboxamidas y análogos que presentan actividades antic�ncer y antiproliferativas - Google Patents
Ciclopropil dicarboxamidas y análogos que presentan actividades antic�ncer y antiproliferativas Download PDFInfo
- Publication number
- ES2475741T3 ES2475741T3 ES11719421.7T ES11719421T ES2475741T3 ES 2475741 T3 ES2475741 T3 ES 2475741T3 ES 11719421 T ES11719421 T ES 11719421T ES 2475741 T3 ES2475741 T3 ES 2475741T3
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- cyclopropane
- dicarboxamide
- compound
- fluorophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 230000001028 anti-proliverative effect Effects 0.000 title description 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 title description 3
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- 150000001875 compounds Chemical class 0.000 claims abstract description 153
- 150000003839 salts Chemical class 0.000 claims abstract description 41
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 31
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims abstract description 29
- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 26
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 22
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 18
- 125000002947 alkylene group Chemical group 0.000 claims abstract description 17
- 150000002367 halogens Chemical class 0.000 claims abstract description 17
- 125000003118 aryl group Chemical group 0.000 claims abstract description 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 15
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 13
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims abstract description 9
- 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims abstract description 8
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- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims abstract description 6
- 125000003454 indenyl group Chemical group C1(C=CC2=CC=CC=C12)* 0.000 claims abstract description 6
- 125000001624 naphthyl group Chemical group 0.000 claims abstract description 6
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims abstract description 6
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- WOVFQJQCMLCIDS-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyridin-4-yl)oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 WOVFQJQCMLCIDS-UHFFFAOYSA-N 0.000 claims description 6
- GNNDEPIMDAZHRQ-UHFFFAOYSA-N 1-n'-[4-[2-(cyclopropanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)C4CC4)N=CC=3)=C(F)C=2)F)CC1 GNNDEPIMDAZHRQ-UHFFFAOYSA-N 0.000 claims description 6
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- CIVOREZLHOQUQB-CQSZACIVSA-N 1-n'-[2,5-difluoro-4-[2-[[(2r)-2-methoxypropanoyl]amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)[C@@H](C)OC)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 CIVOREZLHOQUQB-CQSZACIVSA-N 0.000 claims description 4
- ASBXOTJHWOHLPN-UHFFFAOYSA-N 1-n'-[4-[2-(2,2-dimethylpropanoylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C(C)(C)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 ASBXOTJHWOHLPN-UHFFFAOYSA-N 0.000 claims description 4
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- XGGWHIQZALFGOB-UHFFFAOYSA-N 1-n'-[2,5-difluoro-4-[2-(2-methylpropanoylamino)pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C(C)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 XGGWHIQZALFGOB-UHFFFAOYSA-N 0.000 claims description 3
- PORMSSHVBFZGAT-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyridin-4-yl)oxy-2,5-difluorophenyl]-1-n-phenylcyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC=CC=3)=C(F)C=2)F)=C1 PORMSSHVBFZGAT-UHFFFAOYSA-N 0.000 claims description 3
- PRXXUUDSMHUXSS-UHFFFAOYSA-N 1-n'-[4-[2-(cyclobutanecarbonylamino)pyridin-4-yl]oxy-2,5-difluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=CC(F)=CC=C1NC(=O)C1(C(=O)NC=2C(=CC(OC=3C=C(NC(=O)C4CCC4)N=CC=3)=C(F)C=2)F)CC1 PRXXUUDSMHUXSS-UHFFFAOYSA-N 0.000 claims description 3
- 206010027406 Mesothelioma Diseases 0.000 claims description 3
- WLBRCFBAWZUERA-CYBMUJFWSA-N 1-n'-[2,5-difluoro-4-[2-[[(2r)-2-hydroxypropanoyl]amino]pyridin-4-yl]oxyphenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)[C@H](O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)F)=C1 WLBRCFBAWZUERA-CYBMUJFWSA-N 0.000 claims description 2
- VJSYQFGUDJRCMR-UHFFFAOYSA-N 1-n'-[4-(2-acetamidopyridin-4-yl)oxy-5-chloro-2-fluorophenyl]-1-n-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide Chemical compound C1=NC(NC(=O)C)=CC(OC=2C(=CC(NC(=O)C3(CC3)C(=O)NC=3C=CC(F)=CC=3)=C(F)C=2)Cl)=C1 VJSYQFGUDJRCMR-UHFFFAOYSA-N 0.000 claims description 2
- FWYCTAYGNLLRHZ-UHFFFAOYSA-N 2-fluoro-2-methylpropanamide Chemical compound CC(C)(F)C(N)=O FWYCTAYGNLLRHZ-UHFFFAOYSA-N 0.000 claims description 2
- MTEZLAATISORQK-UHFFFAOYSA-N 2-methoxyacetamide Chemical compound COCC(N)=O MTEZLAATISORQK-UHFFFAOYSA-N 0.000 claims description 2
- 208000014018 liver neoplasm Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
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- 208000033781 Thyroid carcinoma Diseases 0.000 claims 1
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- 201000004101 esophageal cancer Diseases 0.000 claims 1
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 118
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 52
- IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 52
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32954810P | 2010-04-29 | 2010-04-29 | |
| US329548P | 2010-04-29 | ||
| PCT/US2011/034556 WO2011137342A1 (en) | 2010-04-29 | 2011-04-29 | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activites |
Publications (1)
| Publication Number | Publication Date |
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| ES2475741T3 true ES2475741T3 (es) | 2014-07-11 |
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| ES11719421.7T Active ES2475741T3 (es) | 2010-04-29 | 2011-04-29 | Ciclopropil dicarboxamidas y análogos que presentan actividades antic�ncer y antiproliferativas |
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| JP (1) | JP5795630B2 (OSRAM) |
| KR (1) | KR20130109943A (OSRAM) |
| CN (1) | CN103068384B (OSRAM) |
| AU (1) | AU2011245248B2 (OSRAM) |
| BR (1) | BR112012027743A2 (OSRAM) |
| CA (1) | CA2800569A1 (OSRAM) |
| DK (1) | DK2563362T3 (OSRAM) |
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| PH (1) | PH12012502142A1 (OSRAM) |
| PT (1) | PT2563362E (OSRAM) |
| RU (1) | RU2012151012A (OSRAM) |
| SG (2) | SG10201503394PA (OSRAM) |
| WO (1) | WO2011137342A1 (OSRAM) |
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| AU2009308853A1 (en) * | 2008-10-29 | 2010-05-06 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| US20120058985A1 (en) * | 2010-04-29 | 2012-03-08 | Deciphera Pharmaceuticals, Llc | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities |
| CN102702121B (zh) * | 2012-04-06 | 2016-04-13 | 浙江工业大学 | 一种化合物间羟基苯基四嗪二甲酰胺及制备和应用 |
| CN102702120A (zh) * | 2012-04-06 | 2012-10-03 | 浙江工业大学 | 一种新化合物邻羟基苯基四嗪二甲酰胺及制备和应用 |
| AU2013259583A1 (en) | 2012-05-08 | 2014-11-13 | The Regents Of The University Of California | Alpha 7 nicotinic acetylcholine allosteric modulators, their derivatives and uses thereof |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| EP3696276A1 (en) | 2013-02-25 | 2020-08-19 | Novartis AG | Novel androgen receptor mutation |
| US9193719B2 (en) * | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
| US20170079966A1 (en) * | 2014-10-14 | 2017-03-23 | Deciphera Pharmaceuticals, Llc | Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression |
| EP3206752A1 (en) * | 2014-10-14 | 2017-08-23 | Deciphera Pharmaceuticals, LLC | Inhibition of trk kinase mediated tumor growth and disease progression |
| WO2016061231A1 (en) * | 2014-10-14 | 2016-04-21 | Deciphera Pharmaceuticals, Llc | Inhibition of tumor cell interactions with the microenvironment resulting in a reduction in tumor growth and disease progression |
| TW201808906A (zh) | 2016-03-16 | 2018-03-16 | 拜耳作物科學股份有限公司 | 作為殺蟲劑之經取代吡啶化合物 |
| CN106349158B (zh) * | 2016-08-03 | 2020-02-28 | 杭州市西溪医院 | 一种c-Met小分子抑制剂、含其的药物组合物及其药学应用 |
| CN107793363B (zh) * | 2016-09-06 | 2021-02-26 | 上海医药工业研究院 | 一种取代芳胺基芳杂环类化合物及其作为抗肿瘤药物的应用 |
| CN106831707B (zh) * | 2016-12-28 | 2019-09-20 | 杭州市西溪医院 | 作为c-Met激酶抑制剂的苯并杂环类衍生物及其医疗用途 |
| US10180422B1 (en) | 2017-08-22 | 2019-01-15 | Scripps Health | Methods of treating a neuroendocrine tumor |
| CN109988108B (zh) * | 2017-12-29 | 2022-04-29 | 江苏豪森药业集团有限公司 | 一种卡博替尼的制备方法 |
| KR102708050B1 (ko) | 2018-01-31 | 2024-09-24 | 데시페라 파마슈티칼스, 엘엘씨. | 비만 세포증의 치료를 위한 병용 요법 |
| WO2019152711A1 (en) | 2018-01-31 | 2019-08-08 | Diciphera Pharmaceuticals Llc. | Combination therapy for the treatment of gastrointestinal stromal tumors |
| SMT202500389T1 (it) | 2018-12-28 | 2025-11-10 | Deciphera Pharmaceuticals Llc | Inibitori di csf1r per l'uso nel trattamento di tumori tenosinoviali a cellule giganti |
| PE20220592A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de heteroarilaminopirimidina amida y metodos de uso de estos |
| HUE065486T2 (hu) | 2019-05-10 | 2024-05-28 | Deciphera Pharmaceuticals Llc | Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai |
| CA3143489A1 (en) | 2019-06-17 | 2020-12-24 | Deciphera Pharmaceuticals, Llc | Aminopyrimidine amide autophagy inhibitors and methods of use thereof |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| CA3150433A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
| CN115243681B (zh) | 2019-12-30 | 2024-08-16 | 德西费拉制药有限责任公司 | 1-(4-溴-5-(1-乙基-7-(甲氨基)-2-侧氧基-1,2-二氢-1,6-萘啶-3-基)-2-氟苯基)-3-苯基脲的组合物 |
| JP2023549540A (ja) | 2020-11-18 | 2023-11-27 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 |
| KR20240133793A (ko) | 2021-12-09 | 2024-09-04 | 데시페라 파마슈티칼스, 엘엘씨. | Raf 키나아제 억제제 및 그 사용 방법 |
| CN114394940B (zh) * | 2022-01-26 | 2024-01-16 | 武汉工程大学 | 一种环丙基-1,1二酰胺类化合物及其制备方法和应用 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| US20250205161A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| TW200538097A (en) * | 2004-02-27 | 2005-12-01 | Eisai Co Ltd | Novel pyridine derivative and pyrimidine derivative |
| US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| ES2424651T3 (es) | 2005-08-24 | 2013-10-07 | Eisai R&D Management Co., Ltd. | Nuevo derivado de piridina y derivado de pirimidina (3) |
| JP2009526761A (ja) | 2006-01-30 | 2009-07-23 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環式チオフェン化合物および使用の方法 |
| JP5190365B2 (ja) | 2006-08-23 | 2013-04-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | フェノキシピリジン誘導体の塩またはその結晶およびそれらの製造方法 |
| US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
| US7790756B2 (en) | 2006-10-11 | 2010-09-07 | Deciphera Pharmaceuticals, Llc | Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases |
| WO2008046216A1 (en) | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Kinase inhibitors and uses thereof |
| KR20090090365A (ko) | 2007-02-23 | 2009-08-25 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | Ｈｇｆｒ 유전자 증폭 세포주에 대하여 우수한 세포 증식 억제 효과 및 항종양 효과를 나타내는 피리딘 유도체 또는 피리미딘 유도체 |
| JP2010538094A (ja) | 2007-09-06 | 2010-12-09 | アレイ バイオファーマ、インコーポレイテッド | チロシンキナーゼ阻害剤としてのピラゾロピリジン類 |
| JP2009132660A (ja) | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| JP2009203226A (ja) * | 2008-01-31 | 2009-09-10 | Eisai R & D Management Co Ltd | ピリジン誘導体およびピリミジン誘導体を含有するレセプターチロシンキナーゼ阻害剤 |
| US20100311972A1 (en) | 2008-02-18 | 2010-12-09 | Mitsuo Nagai | Method for producing phenoxypyridine derivative |
| TW201035017A (en) * | 2008-09-26 | 2010-10-01 | Smithkline Beecham Corp | Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide |
| AU2009308853A1 (en) * | 2008-10-29 | 2010-05-06 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| WO2010064300A1 (ja) | 2008-12-02 | 2010-06-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 食道癌治療用組成物 |
| JP2010178651A (ja) | 2009-02-04 | 2010-08-19 | Eisai R & D Management Co Ltd | Ｈｇｆｒ阻害物質の作用検定方法 |
| US20120058985A1 (en) * | 2010-04-29 | 2012-03-08 | Deciphera Pharmaceuticals, Llc | Cyclopropyl dicarboxamides and analogs exhibiting anti-cancer and anti-proliferative activities |
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2011
- 2011-04-29 US US13/098,243 patent/US20120058985A1/en not_active Abandoned
- 2011-04-29 PT PT117194217T patent/PT2563362E/pt unknown
- 2011-04-29 JP JP2013508280A patent/JP5795630B2/ja not_active Expired - Fee Related
- 2011-04-29 EP EP11719421.7A patent/EP2563362B1/en not_active Not-in-force
- 2011-04-29 CN CN201180031486.XA patent/CN103068384B/zh not_active Expired - Fee Related
- 2011-04-29 AU AU2011245248A patent/AU2011245248B2/en not_active Ceased
- 2011-04-29 BR BR112012027743A patent/BR112012027743A2/pt active Search and Examination
- 2011-04-29 DK DK11719421.7T patent/DK2563362T3/da active
- 2011-04-29 WO PCT/US2011/034556 patent/WO2011137342A1/en not_active Ceased
- 2011-04-29 SG SG10201503394PA patent/SG10201503394PA/en unknown
- 2011-04-29 PH PH1/2012/502142A patent/PH12012502142A1/en unknown
- 2011-04-29 KR KR1020127031316A patent/KR20130109943A/ko not_active Ceased
- 2011-04-29 RU RU2012151012/04A patent/RU2012151012A/ru not_active Application Discontinuation
- 2011-04-29 SG SG2012079760A patent/SG185073A1/en unknown
- 2011-04-29 CA CA2800569A patent/CA2800569A1/en not_active Abandoned
- 2011-04-29 ES ES11719421.7T patent/ES2475741T3/es active Active
- 2011-04-29 MX MX2012012571A patent/MX2012012571A/es active IP Right Grant
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2012
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- 2012-10-28 IL IL222728A patent/IL222728A0/en unknown
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2013
- 2013-12-20 US US14/136,295 patent/US20140194405A1/en not_active Abandoned
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2015
- 2015-01-22 US US14/602,781 patent/US20150218130A1/en not_active Abandoned
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| PH12012502142A1 (en) | 2017-04-21 |
| AU2011245248A1 (en) | 2012-12-20 |
| US20140194405A1 (en) | 2014-07-10 |
| MX2012012571A (es) | 2013-04-05 |
| SG10201503394PA (en) | 2015-06-29 |
| CN103068384B (zh) | 2015-03-11 |
| US20120322834A1 (en) | 2012-12-20 |
| AU2011245248B2 (en) | 2016-01-07 |
| RU2012151012A (ru) | 2014-06-10 |
| US20150218130A1 (en) | 2015-08-06 |
| US20120252849A1 (en) | 2012-10-04 |
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| JP2013525458A (ja) | 2013-06-20 |
| IL222728A0 (en) | 2012-12-31 |
| PT2563362E (pt) | 2014-07-11 |
| US20120058985A1 (en) | 2012-03-08 |
| BR112012027743A2 (pt) | 2017-03-14 |
| EP2563362A1 (en) | 2013-03-06 |
| HK1184392A1 (zh) | 2014-01-24 |
| CN103068384A (zh) | 2013-04-24 |
| WO2011137342A1 (en) | 2011-11-03 |
| EP2563362B1 (en) | 2014-03-12 |
| US8637672B2 (en) | 2014-01-28 |
| CA2800569A1 (en) | 2011-11-03 |
| JP5795630B2 (ja) | 2015-10-14 |
| SG185073A1 (en) | 2012-12-28 |
| KR20130109943A (ko) | 2013-10-08 |
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