ES2463818T3 - Dispositivo que se aplicará a una barrera biológica - Google Patents

Dispositivo que se aplicará a una barrera biológica Download PDF

Info

Publication number
ES2463818T3
ES2463818T3 ES10183463.8T ES10183463T ES2463818T3 ES 2463818 T3 ES2463818 T3 ES 2463818T3 ES 10183463 T ES10183463 T ES 10183463T ES 2463818 T3 ES2463818 T3 ES 2463818T3
Authority
ES
Spain
Prior art keywords
substance
solid
acicular
droplet
droplets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES10183463.8T
Other languages
English (en)
Spanish (es)
Inventor
Dr. Andrew Kirby
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Functional Microstructures Ltd
Original Assignee
Functional Microstructures Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0418246.5A external-priority patent/GB0418246D0/en
Priority claimed from GBGB0427762.0A external-priority patent/GB0427762D0/en
Application filed by Functional Microstructures Ltd filed Critical Functional Microstructures Ltd
Application granted granted Critical
Publication of ES2463818T3 publication Critical patent/ES2463818T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C37/00—Component parts, details, accessories or auxiliary operations, not covered by group B29C33/00 or B29C35/00
    • B29C37/0053—Moulding articles characterised by the shape of the surface, e.g. ribs, high polish
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/124—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified
    • B29C64/129—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask
    • B29C64/135—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using layers of liquid which are selectively solidified characterised by the energy source therefor, e.g. by global irradiation combined with a mask the energy source being concentrated, e.g. scanning lasers or focused light sources
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C35/00—Heating, cooling or curing, e.g. crosslinking or vulcanising; Apparatus therefor
    • B29C35/02—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould
    • B29C35/08—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation
    • B29C35/0805—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation
    • B29C2035/0827—Heating or curing, e.g. crosslinking or vulcanizing during moulding, e.g. in a mould by wave energy or particle radiation using electromagnetic radiation using UV radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/759—Needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Optics & Photonics (AREA)
  • Materials Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Mechanical Engineering (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
ES10183463.8T 2004-08-16 2005-08-16 Dispositivo que se aplicará a una barrera biológica Expired - Lifetime ES2463818T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0418246 2004-08-16
GBGB0418246.5A GB0418246D0 (en) 2004-08-16 2004-08-16 Method for producing microneedles, microimplants and arrays thereof
GBGB0427762.0A GB0427762D0 (en) 2004-12-17 2004-12-17 Device and method for transport across barrier
GB0427762 2004-12-17

Publications (1)

Publication Number Publication Date
ES2463818T3 true ES2463818T3 (es) 2014-05-29

Family

ID=35447243

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10183463.8T Expired - Lifetime ES2463818T3 (es) 2004-08-16 2005-08-16 Dispositivo que se aplicará a una barrera biológica

Country Status (7)

Country Link
US (1) US8192787B2 (OSRAM)
EP (3) EP1786580B1 (OSRAM)
JP (1) JP5082053B2 (OSRAM)
AT (1) ATE490037T1 (OSRAM)
DE (1) DE602005025138D1 (OSRAM)
ES (1) ES2463818T3 (OSRAM)
WO (1) WO2006018642A1 (OSRAM)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
CN100460028C (zh) * 2006-12-08 2009-02-11 中国科学院上海微系统与信息技术研究所 一种用于药物传输的微针阵列及其制作方法
EP2127693A1 (en) * 2007-01-29 2009-12-02 Medrx Co., Ltd. Process for producing microneedle of thermosensitive substance
JP4959363B2 (ja) * 2007-02-14 2012-06-20 凸版印刷株式会社 針状体の製造方法
JP4978243B2 (ja) * 2007-03-06 2012-07-18 凸版印刷株式会社 針状体および針状体製造方法
JP2010535591A (ja) * 2007-08-06 2010-11-25 トランスダーム， インコーポレイテッド ポリマー膜から形成される微小針アレイ
KR20100037389A (ko) * 2008-10-01 2010-04-09 연세대학교 산학협력단 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법
CN102238938A (zh) * 2008-10-02 2011-11-09 Nurim-Mwellness株式会社 制备固体微结构的方法和基于该方法制备的固体微结构
WO2010137319A1 (ja) * 2009-05-27 2010-12-02 株式会社メドレックス 剣山型マイクロニードルの製造方法およびマイクロニードル
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
KR101254240B1 (ko) * 2010-12-17 2013-04-12 주식회사 라파스 마이크로구조체 제조방법
KR101180032B1 (ko) * 2010-07-12 2012-09-05 인싸이토(주) 외형 조절이 가능한 중공형 마이크로니들의 제조방법
HK1209658A1 (en) 2012-05-01 2016-04-08 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Tip-loaded microneedle arrays for transdermal insertion
WO2014153228A1 (en) * 2013-03-14 2014-09-25 Perryman Laura Tyler Miniature implantable device and methods
US10245436B2 (en) 2012-07-17 2019-04-02 Stimwave Technologies Incorporated Miniature implantable device and methods
US9974936B2 (en) * 2013-02-22 2018-05-22 Juvic Inc. Method for manufacturing microstructure using negative pressure and microstructure manufactured therefor
US20160279401A1 (en) 2015-03-27 2016-09-29 Allergan, Inc. Dissolvable microneedles for skin treatment
US10441768B2 (en) 2015-03-18 2019-10-15 University of Pittsburgh—of the Commonwealth System of Higher Education Bioactive components conjugated to substrates of microneedle arrays
JP2016195651A (ja) * 2015-04-02 2016-11-24 日本写真印刷株式会社 マイクロニードルシート
WO2017066768A1 (en) 2015-10-16 2017-04-20 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Mullti-component biio-active drug delivery and controlled release to the skin by microneedle array devices
US11744889B2 (en) 2016-01-05 2023-09-05 University of Pittsburgh—of the Commonwealth System of Higher Education Skin microenvironment targeted delivery for promoting immune and other responses
CN108601727B (zh) * 2016-02-15 2021-10-22 上海交通大学 一种快速打印微针贴剂的方法
KR102408362B1 (ko) * 2016-05-20 2022-06-13 주식회사 라파스 마이크로니들 제조방법
KR101816922B1 (ko) * 2016-05-20 2018-01-09 주식회사 라파스 마이크로니들 제조방법
EP3582752A1 (en) 2017-02-17 2019-12-25 Allergan, Inc. Microneedle array with active ingredient
CN109420245A (zh) * 2017-08-30 2019-03-05 优微（珠海）生物科技有限公司 可溶性微针的制造方法
EP3969099B1 (en) 2019-05-16 2025-12-17 University of Pittsburgh - of the Commonwealth System of Higher Education Microneedle arrays with undercut features for cutaneous and non-cutaneous drug delivery
GB2586475A (en) * 2019-08-20 2021-02-24 Innoture Ip Ltd Methods
GB2586474A (en) * 2019-08-20 2021-02-24 Innoture Ip Ltd Method of manufacturing microstructures
CN112618922A (zh) * 2020-12-30 2021-04-09 上海心至医疗科技有限公司 一种药物球囊的制备方法、制备得到的药物球囊及其应用

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
JPS5428369A (en) 1977-08-03 1979-03-02 Yamakawa Tsuneko Method of forming needleelike projection of thermoplastic resin on sheet
JPS6216132A (ja) * 1985-07-12 1987-01-24 Shimano & Co Ltd 滑り止め突起を備えた釣竿の製造法
US5309909A (en) * 1992-05-22 1994-05-10 Physio-Control Corporation Combined skin preparation and monitoring electrode
US7422574B2 (en) 1995-05-19 2008-09-09 Applied Tissue Technologies, Llc Microseeding device for gene delivery by microneedle injection
JP2002517300A (ja) 1998-06-10 2002-06-18 ジョージア テック リサーチ コーポレイション 微小針デバイスおよび製造方法ならびにそれらの使用
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
AU5461300A (en) 1999-06-04 2000-12-28 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US8465468B1 (en) 2000-06-29 2013-06-18 Becton, Dickinson And Company Intradermal delivery of substances
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US20010053891A1 (en) 1999-12-30 2001-12-20 Ackley Donald E. Stacked microneedle systems
EP1276426A4 (en) 2000-03-09 2008-03-19 Nanopass Ltd SYSTEMS AND METHODS FOR TRANSPORTING FLUIDS THROUGH A BIOLOGICAL BARRIER AND TECHNIQUES FOR PRODUCING SUCH SYSTEMS
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
AU2001265056A1 (en) 2000-05-26 2001-12-11 The Procter And Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
WO2001093930A1 (en) 2000-06-02 2001-12-13 The University Of Utah Research Foundation Active needle devices with integrated functionality
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
WO2002015960A2 (en) 2000-08-21 2002-02-28 The Cleveland Clinic Foundation Microneedle array module and method of fabricating the same
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
WO2002028471A1 (de) * 2000-10-05 2002-04-11 Thomas Marsoner Medizinische injektionseinrichtung
WO2002045771A2 (en) 2000-11-09 2002-06-13 Biovalve Technologies, Inc. Microneedle adapter
WO2002064193A2 (en) 2000-12-14 2002-08-22 Georgia Tech Research Corporation Microneedle devices and production thereof
GB0030929D0 (en) 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US7027478B2 (en) 2000-12-21 2006-04-11 Biovalve Technologies, Inc. Microneedle array systems
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US7127284B2 (en) 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
AU2002327675A1 (en) 2001-09-19 2003-04-01 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US8920375B2 (en) 2001-09-21 2014-12-30 Valeritas, Inc. Gas pressure actuated microneedle arrays, and systems and methods relating to same
US20030135166A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
AU2002337788A1 (en) 2001-09-28 2003-04-07 Biovalve Technologies, Inc. Microneedle with membrane
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US6908453B2 (en) 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
WO2003061731A2 (en) 2002-01-22 2003-07-31 Endobionics, Inc. Methods and kits for delivering pharmaceutical agents into the coronary vascular adventitia
GB0201736D0 (en) 2002-01-25 2002-03-13 Glaxo Group Ltd DNA dosage forms
US7004928B2 (en) 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP4090018B2 (ja) 2002-02-18 2008-05-28 Ｆｏｒ Ｈｅａｄ株式会社 機能性マイクロパイル及びその製造方法
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
GB0216333D0 (en) 2002-07-13 2002-08-21 Univ Cranfield Substance - selective polymer membranes
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
AU2003270355A1 (en) 2002-09-06 2004-03-29 Massachusetts Institute Of Technology Needless drug injection device
WO2004033021A1 (en) 2002-10-07 2004-04-22 Biovalve Technologies, Inc. Microneedle array patch
IL152271A (en) * 2002-10-13 2006-04-10 Meir Hefetz Structures of micro needles and manufacturing methods
AU2003272053A1 (en) 2002-10-13 2004-05-04 Nano Pass Technologies Ltd. Polymer microneedles
KR100563330B1 (ko) 2003-01-16 2006-03-22 포스트마이크로 주식회사 Ｌｉｇａ공정을 이용한 폴리머 재질의 미세 바늘 어레이제조방법
JP2006516006A (ja) 2003-01-16 2006-06-15 ベクトン・ディキンソン・アンド・カンパニー 細ゲージのマイクロカニューレを用いる皮内細胞の送達
WO2004108203A1 (ja) 2003-06-10 2004-12-16 Medrx Co., Ltd. 経皮投薬用パッドベース、及び注射針
US7273474B2 (en) * 2003-06-17 2007-09-25 Industrial Technology Research Institute Flexible substrate structure for microneedle arrays and its manufacturing method

Also Published As

Publication number Publication date
EP1786580B1 (en) 2010-12-01
WO2006018642A1 (en) 2006-02-23
EP2289646A1 (en) 2011-03-02
EP2272430A1 (en) 2011-01-12
ATE490037T1 (de) 2010-12-15
EP1786580A1 (en) 2007-05-23
EP2289646B1 (en) 2014-02-12
US8192787B2 (en) 2012-06-05
JP2008509771A (ja) 2008-04-03
DE602005025138D1 (de) 2011-01-13
US20080299290A1 (en) 2008-12-04
JP5082053B2 (ja) 2012-11-28

Similar Documents

Publication Publication Date Title
ES2463818T3 (es) Dispositivo que se aplicará a una barrera biológica
US12064582B2 (en) Composite microneedle array including nanostructures thereon
JP6565906B2 (ja) 針状体の製造方法、及び針状体
ES2357079T3 (es) Procedimiento de producción de un microaguja o un microimplante.
EP2563454A2 (en) Injection molded microneedle array and method for forming the microneedle array