ES2458291T3 - Derivados de amidas aromáticas como inhibidores de la cinasa C-KIT - Google Patents
Derivados de amidas aromáticas como inhibidores de la cinasa C-KIT Download PDFInfo
- Publication number
- ES2458291T3 ES2458291T3 ES11161399.8T ES11161399T ES2458291T3 ES 2458291 T3 ES2458291 T3 ES 2458291T3 ES 11161399 T ES11161399 T ES 11161399T ES 2458291 T3 ES2458291 T3 ES 2458291T3
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- Prior art keywords
- phenyl
- mmol
- cyano
- cyclohex
- amide
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- 150000008430 aromatic amides Chemical class 0.000 title description 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 352
- -1 imidazolyl isoxazolyl Chemical group 0.000 claims abstract description 230
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 57
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 57
- 150000003839 salts Chemical class 0.000 claims abstract description 44
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 39
- 239000012453 solvate Substances 0.000 claims abstract description 38
- 125000002541 furyl group Chemical group 0.000 claims abstract description 32
- 229910052799 carbon Inorganic materials 0.000 claims abstract description 26
- 125000004076 pyridyl group Chemical group 0.000 claims abstract description 25
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 24
- 238000006467 substitution reaction Methods 0.000 claims abstract description 23
- 125000002883 imidazolyl group Chemical group 0.000 claims abstract description 22
- 125000000449 nitro group Chemical class [O-][N+](*)=O 0.000 claims abstract description 22
- 125000005942 tetrahydropyridyl group Chemical group 0.000 claims abstract description 22
- 125000002971 oxazolyl group Chemical group 0.000 claims abstract description 21
- 125000000168 pyrrolyl group Chemical group 0.000 claims abstract description 21
- 125000001376 1,2,4-triazolyl group Chemical group N1N=C(N=C1)* 0.000 claims abstract description 20
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 20
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- 238000001819 mass spectrum Methods 0.000 description 93
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Classifications
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| BR112014001977A2 (pt) | 2011-07-27 | 2017-02-21 | Ab Science | inibidores seletivos de proteína quinase |
| CN104370880A (zh) * | 2013-01-24 | 2015-02-25 | 韩冰 | 一类蛋白酶抑制剂及其制备方法和用途 |
| CN105658649B (zh) | 2013-07-22 | 2019-03-22 | 爱杜西亚药品有限公司 | 1-(哌嗪-1-基)-2-([1,2,4]三唑-1-基)-乙酮衍生物 |
| PE20171100A1 (es) | 2015-01-15 | 2017-08-07 | Idorsia Pharmaceuticals Ltd | Derivados de hidroxialquil-piperazina como moduladores del receptor cxcr3 |
| AR103399A1 (es) | 2015-01-15 | 2017-05-10 | Actelion Pharmaceuticals Ltd | Derivados de (r)-2-metil-piperazina como moduladores del receptor cxcr3 |
| CN105753770A (zh) * | 2015-05-27 | 2016-07-13 | 上海佐林生物医药有限公司 | 蛋白激酶抑制剂制备方法、中间体、制备方法及应用 |
| KR20210142154A (ko) | 2019-03-21 | 2021-11-24 | 옹쎄오 | 암 치료를 위한 키나제 억제제와 조합된 dbait 분자 |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
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| WO1993017715A1 (en) | 1992-03-05 | 1993-09-16 | Board Of Regents, The University Of Texas System | Diagnostic and/or therapeutic agents, targeted to neovascular endothelial cells |
| WO2000064946A2 (en) | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| DE19962924A1 (de) | 1999-12-24 | 2001-07-05 | Bayer Ag | Substituierte Oxazolidinone und ihre Verwendung |
| ITMI992711A1 (it) * | 1999-12-27 | 2001-06-27 | Novartis Ag | Composti organici |
| ATE375342T1 (de) * | 2002-08-02 | 2007-10-15 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazole und ihre verwendung als c-kit inhibitoren |
| US7718676B2 (en) * | 2003-10-23 | 2010-05-18 | Ab Science | 2-aminoaryloxazole compounds as tyrosine kinase inhibitors |
| GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
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| US20060281788A1 (en) * | 2005-06-10 | 2006-12-14 | Baumann Christian A | Synergistic modulation of flt3 kinase using a flt3 inhibitor and a farnesyl transferase inhibitor |
| AU2006304897B2 (en) * | 2005-10-18 | 2012-07-12 | Janssen Pharmaceutica N.V. | Method of inhibiting FLT3 kinase |
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| WO2007124316A1 (en) * | 2006-04-20 | 2007-11-01 | Janssen Pharmaceutica N.V. | Heterocyclic compounds as inhibitors of c-fms kinase |
| EP2016057A1 (en) * | 2006-04-20 | 2009-01-21 | Janssen Pharmaceutica N.V. | C-fms kinase inhibitors |
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- 2007-04-19 ES ES07760927T patent/ES2389678T3/es active Active
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