ES2452830T3 - Utilización de compuestos 1-fenil-3-dimetilamino-propano para la terapia del dolor neuropático - Google Patents
Utilización de compuestos 1-fenil-3-dimetilamino-propano para la terapia del dolor neuropático Download PDFInfo
- Publication number
- ES2452830T3 ES2452830T3 ES08716394.5T ES08716394T ES2452830T3 ES 2452830 T3 ES2452830 T3 ES 2452830T3 ES 08716394 T ES08716394 T ES 08716394T ES 2452830 T3 ES2452830 T3 ES 2452830T3
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- Prior art keywords
- pain
- neuropathic pain
- dimethylamino
- diabetic
- animals
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- 235000019426 modified starch Nutrition 0.000 description 1
- 235000013379 molasses Nutrition 0.000 description 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 1
- 229960003086 naltrexone Drugs 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 229940105631 nembutal Drugs 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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- 230000007823 neuropathy Effects 0.000 description 1
- 229940121367 non-opioid analgesics Drugs 0.000 description 1
- 239000002767 noradrenalin uptake inhibitor Substances 0.000 description 1
- 229940127221 norepinephrine reuptake inhibitor Drugs 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003402 opiate agonist Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 208000035824 paresthesia Diseases 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
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- 229920001277 pectin Polymers 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 239000008024 pharmaceutical diluent Substances 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- LFSXCDWNBUNEEM-UHFFFAOYSA-N phthalazine Chemical compound C1=NN=CC2=CC=CC=C21 LFSXCDWNBUNEEM-UHFFFAOYSA-N 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
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- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 239000001103 potassium chloride Substances 0.000 description 1
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- 229960002816 potassium chloride Drugs 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000026416 response to pain Effects 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 210000003497 sciatic nerve Anatomy 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960002668 sodium chloride Drugs 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000000392 somatic effect Effects 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
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- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 230000003637 steroidlike Effects 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229960005126 tapentadol Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000005329 tetralinyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
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- 238000005303 weighing Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102007012165 | 2007-03-12 | ||
| DE102007012165A DE102007012165A1 (de) | 2007-03-12 | 2007-03-12 | Verwendung von 1-Phenyl-3-dimethylamino-propanverbindungen zur Therapie des Neuropathieschmerzes |
| PCT/EP2008/001884 WO2008110323A1 (de) | 2007-03-12 | 2008-03-10 | Verwendung von 1-phenyl-3-dimethylamino-propanverbindungen zur therapie des neuropathieschmerzes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2452830T3 true ES2452830T3 (es) | 2014-04-02 |
Family
ID=39345501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08716394.5T Active ES2452830T3 (es) | 2007-03-12 | 2008-03-10 | Utilización de compuestos 1-fenil-3-dimetilamino-propano para la terapia del dolor neuropático |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20080269326A1 (OSRAM) |
| EP (1) | EP2117525B1 (OSRAM) |
| JP (5) | JP2010520907A (OSRAM) |
| CA (1) | CA2680771C (OSRAM) |
| CY (1) | CY1115455T1 (OSRAM) |
| DE (1) | DE102007012165A1 (OSRAM) |
| DK (1) | DK2117525T3 (OSRAM) |
| ES (1) | ES2452830T3 (OSRAM) |
| HR (1) | HRP20140280T1 (OSRAM) |
| PL (1) | PL2117525T3 (OSRAM) |
| PT (1) | PT2117525E (OSRAM) |
| SI (1) | SI2117525T1 (OSRAM) |
| WO (1) | WO2008110323A1 (OSRAM) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2992877A1 (en) | 2010-06-15 | 2016-03-09 | Grünenthal GmbH | Pharmaceutical combination for the treatment of pain |
| CN110015955A (zh) * | 2010-07-23 | 2019-07-16 | 格吕伦塔尔有限公司 | 3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的盐或共晶体 |
| WO2012051246A1 (en) | 2010-10-12 | 2012-04-19 | Ratiopharm Gmbh | Tapentadol hydrobromide and crystalline forms thereof |
| ES2910085T3 (es) * | 2011-03-04 | 2022-05-11 | Gruenenthal Gmbh | Composición farmacéutica acuosa semisólida que contiene tapentadol |
| CN103501775A (zh) * | 2011-03-04 | 2014-01-08 | 格吕伦塔尔有限公司 | 他喷他多的胃肠外给药 |
| JP2019142972A (ja) * | 2011-03-04 | 2019-08-29 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールの非経口的投与 |
| MX388963B (es) * | 2011-03-04 | 2025-03-20 | Gruenenthal Gmbh | Formulacion farmaceutica acuosa de tapentadol para administracion oral |
| EP3607943B1 (en) | 2011-04-05 | 2024-09-11 | Grünenthal GmbH | Tapentadol for use in treating pain associated with trigeminal neuralgia |
| ES2703282T3 (es) | 2011-04-05 | 2019-03-07 | Gruenenthal Gmbh | Tapentadol para prevenir la cronificación del dolor |
| US20120277319A1 (en) | 2011-04-29 | 2012-11-01 | Gruenenthal Gmbh | Use of Tapentadol for Inhibiting and/or Treating Depression and Anxiety |
| EP3300726A1 (en) | 2011-07-29 | 2018-04-04 | Grünenthal GmbH | Intrathecal or epidural administration of 3-[(1s,2s)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol |
| EP2617706B1 (en) | 2011-07-29 | 2017-09-06 | Anhui New Star Pharmaceutical Development Co., Ltd | Novel intermediate used for preparing tapentadol or analogues thereof |
| CN103159633B (zh) * | 2012-07-06 | 2015-08-12 | 江苏恩华药业股份有限公司 | 他喷他多的制备方法及用于制备他喷他多的化合物 |
| EP2808319A1 (en) | 2013-05-31 | 2014-12-03 | Arevipharma GmbH | 3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex |
| PE20171651A1 (es) | 2015-03-27 | 2017-11-13 | Gruenenthal Chemie | Formulacion estable para administracion parenteral de tapentadol |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| EP3585370A1 (en) | 2017-02-23 | 2020-01-01 | Grünenthal GmbH | Tapentadol as local anesthetic |
| CN114788814B (zh) * | 2021-01-26 | 2023-10-13 | 浙江创新生物有限公司 | 一种高稳定性的注射用达托霉素组合物及其制备方法和其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4426245A1 (de) * | 1994-07-23 | 1996-02-22 | Gruenenthal Gmbh | 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung |
| DK3241550T3 (da) * | 2002-11-22 | 2020-08-24 | Gruenenthal Gmbh | Anvendelse af (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol til behandling af inflammatoriske smerter |
| PL2012764T3 (pl) * | 2006-04-28 | 2011-04-29 | Gruenenthal Gmbh | Kombinacja farmaceutyczna zawierająca 3-(3-dimetyloamino-1-etylo-2-metylopropylo)fenol i Paracetamol |
-
2007
- 2007-03-12 DE DE102007012165A patent/DE102007012165A1/de not_active Withdrawn
-
2008
- 2008-03-10 JP JP2009553058A patent/JP2010520907A/ja active Pending
- 2008-03-10 WO PCT/EP2008/001884 patent/WO2008110323A1/de not_active Ceased
- 2008-03-10 HR HRP20140280AT patent/HRP20140280T1/hr unknown
- 2008-03-10 DK DK08716394.5T patent/DK2117525T3/da active
- 2008-03-10 CA CA2680771A patent/CA2680771C/en active Active
- 2008-03-10 SI SI200831144T patent/SI2117525T1/sl unknown
- 2008-03-10 EP EP08716394.5A patent/EP2117525B1/de active Active
- 2008-03-10 ES ES08716394.5T patent/ES2452830T3/es active Active
- 2008-03-10 PT PT87163945T patent/PT2117525E/pt unknown
- 2008-03-10 PL PL08716394T patent/PL2117525T3/pl unknown
- 2008-03-11 US US12/045,830 patent/US20080269326A1/en not_active Abandoned
-
2010
- 2010-08-04 US US12/850,208 patent/US8536130B2/en active Active
-
2013
- 2013-10-02 JP JP2013206992A patent/JP6081337B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-28 CY CY20141100171T patent/CY1115455T1/el unknown
-
2016
- 2016-01-07 JP JP2016001448A patent/JP2016056188A/ja active Pending
-
2017
- 2017-11-30 JP JP2017230230A patent/JP2018030886A/ja active Pending
-
2019
- 2019-08-21 JP JP2019150807A patent/JP6745959B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PL2117525T3 (pl) | 2014-05-30 |
| DE102007012165A1 (de) | 2008-09-18 |
| EP2117525B1 (de) | 2013-12-25 |
| HRP20140280T1 (hr) | 2014-04-25 |
| JP2010520907A (ja) | 2010-06-17 |
| JP6081337B2 (ja) | 2017-02-15 |
| DK2117525T3 (da) | 2014-02-03 |
| EP2117525A1 (de) | 2009-11-18 |
| US20100311842A1 (en) | 2010-12-09 |
| JP6745959B2 (ja) | 2020-08-26 |
| WO2008110323A1 (de) | 2008-09-18 |
| CY1115455T1 (el) | 2017-01-04 |
| JP2018030886A (ja) | 2018-03-01 |
| SI2117525T1 (sl) | 2014-03-31 |
| JP2013256540A (ja) | 2013-12-26 |
| US8536130B2 (en) | 2013-09-17 |
| CA2680771A1 (en) | 2008-09-18 |
| JP2019196405A (ja) | 2019-11-14 |
| JP2016056188A (ja) | 2016-04-21 |
| PT2117525E (pt) | 2014-02-14 |
| CA2680771C (en) | 2015-11-17 |
| US20080269326A1 (en) | 2008-10-30 |
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