ES2434854T3 - Composiciones de polímero impregnado y dispositivos que las usan - Google Patents
Composiciones de polímero impregnado y dispositivos que las usan Download PDFInfo
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- ES2434854T3 ES2434854T3 ES06770045T ES06770045T ES2434854T3 ES 2434854 T3 ES2434854 T3 ES 2434854T3 ES 06770045 T ES06770045 T ES 06770045T ES 06770045 T ES06770045 T ES 06770045T ES 2434854 T3 ES2434854 T3 ES 2434854T3
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/127,058 US20060257355A1 (en) | 2005-05-10 | 2005-05-10 | Impregnated polymer compositions and devices using them |
| US127058 | 2005-05-10 | ||
| PCT/US2006/017501 WO2006121908A2 (en) | 2005-05-10 | 2006-05-05 | Impregnated polymer compositions and devices using them |
Publications (1)
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| ES2434854T3 true ES2434854T3 (es) | 2013-12-17 |
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| EP (1) | EP1888138B1 (enExample) |
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| WO (1) | WO2006121908A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858110B2 (en) * | 2003-08-11 | 2010-12-28 | Endo Pharmaceuticals Solutions, Inc. | Long term drug delivery devices with polyurethane based polymers and their manufacture |
| US20060286071A1 (en) * | 2005-06-21 | 2006-12-21 | Epstein Samuel J | Therapeutic pastes for medical device coating |
| EP2076211A4 (en) * | 2006-10-20 | 2015-07-22 | Elixir Medical Corp | LUMINOUS PROSTHESES AND METHODS OF COATING THEREOF |
| US7887830B2 (en) * | 2007-02-27 | 2011-02-15 | Boston Scientific Scimed, Inc. | Medical devices having polymeric regions based on styrene-isobutylene copolymers |
| JP2012504139A (ja) * | 2008-09-30 | 2012-02-16 | エンド ファーマスーティカルズ ソリューションズ インコーポレイテッド． | ヒストレリン送達用埋め込み可能型装置およびその使用方法 |
| WO2013146376A1 (ja) | 2012-03-27 | 2013-10-03 | テルモ株式会社 | コーティング組成物および医療機器 |
| US20140076029A1 (en) * | 2012-07-13 | 2014-03-20 | Shouyan Lee | Load-controlled accelerated wear testing system for heart valve prostheses and other cardiovascular devices |
| US10155100B2 (en) | 2014-03-27 | 2018-12-18 | Covidien Lp | Catheter positioning |
| CN110944689B (zh) | 2017-06-07 | 2022-12-09 | 施菲姆德控股有限责任公司 | 血管内流体运动设备、系统和使用方法 |
| EP3710076B1 (en) | 2017-11-13 | 2023-12-27 | Shifamed Holdings, LLC | Intravascular fluid movement devices, systems, and methods of use |
| WO2019152875A1 (en) | 2018-02-01 | 2019-08-08 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
| WO2020028537A1 (en) | 2018-07-31 | 2020-02-06 | Shifamed Holdings, Llc | Intravascaular blood pumps and methods of use |
| US12220570B2 (en) | 2018-10-05 | 2025-02-11 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| EP3996797A4 (en) | 2019-07-12 | 2023-08-02 | Shifamed Holdings, LLC | INTRAVASCULAR BLOOD PUMPS AND METHOD OF USE AND METHOD OF MAKING |
| US11654275B2 (en) | 2019-07-22 | 2023-05-23 | Shifamed Holdings, Llc | Intravascular blood pumps with struts and methods of use and manufacture |
| EP4010046A4 (en) | 2019-08-07 | 2023-08-30 | Calomeni, Michael | Catheter blood pumps and collapsible pump housings |
| WO2021062270A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible pump housings |
| WO2021062265A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Intravascular blood pump systems and methods of use and control thereof |
| WO2021062260A1 (en) | 2019-09-25 | 2021-04-01 | Shifamed Holdings, Llc | Catheter blood pumps and collapsible blood conduits |
| WO2021119478A1 (en) | 2019-12-11 | 2021-06-17 | Shifamed Holdings, Llc | Descending aorta and vena cava blood pumps |
| CN114948075B (zh) * | 2022-03-08 | 2025-08-05 | 向川 | 一种单髁膝关节置换术的股骨钻孔导引器及股骨钻骨套件 |
Family Cites Families (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469827A (en) * | 1978-12-15 | 1984-09-04 | Hospal-Sodip Sa | Mixtures of polymers for medical use |
| JPH0622590B2 (ja) * | 1986-05-01 | 1994-03-30 | 宇部興産株式会社 | 人工血管及びその製造方法 |
| JPS63105767A (ja) * | 1986-10-24 | 1988-05-11 | 宇部興産株式会社 | 抗血液凝固性材料及びその製造方法 |
| JPH0624593B2 (ja) * | 1987-10-22 | 1994-04-06 | 宇部興産株式会社 | 抗血液凝固性材料 |
| JPH0624592B2 (ja) * | 1987-10-22 | 1994-04-06 | 宇部興産株式会社 | 抗血液凝固性材料 |
| US5135516A (en) * | 1989-12-15 | 1992-08-04 | Boston Scientific Corporation | Lubricious antithrombogenic catheters, guidewires and coatings |
| CA2033046C (en) * | 1990-01-12 | 1999-08-03 | Lowell Saferstein | Process for preparing a neutralized oxidized cellulose product and its method of use |
| JP2907492B2 (ja) * | 1990-06-06 | 1999-06-21 | 株式会社ジェイ・エム・エス | ヘパリン徐放性材料およびその製造法 |
| US5250649A (en) * | 1990-06-29 | 1993-10-05 | Becton, Dickinson And Company | Melt processable polyurethaneurea copolymers and method for their preparation |
| US6248129B1 (en) * | 1990-09-14 | 2001-06-19 | Quanam Medical Corporation | Expandable polymeric stent with memory and delivery apparatus and method |
| US6197325B1 (en) * | 1990-11-27 | 2001-03-06 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| DK0565604T3 (da) * | 1990-12-28 | 2000-03-06 | Boston Scient Corp | System til afgivelse af lægemidler |
| JPH06190032A (ja) * | 1991-06-07 | 1994-07-12 | Takeda Chem Ind Ltd | 抗凝血方法および抗凝血性高分子材料 |
| US5652014A (en) * | 1991-08-16 | 1997-07-29 | Galin; Miles A. | Medicament coated refractive anterior chamber ocular implant |
| US5573934A (en) * | 1992-04-20 | 1996-11-12 | Board Of Regents, The University Of Texas System | Gels for encapsulation of biological materials |
| US5342621A (en) * | 1992-09-15 | 1994-08-30 | Advanced Cardiovascular Systems, Inc. | Antithrombogenic surface |
| US20020055710A1 (en) * | 1998-04-30 | 2002-05-09 | Ronald J. Tuch | Medical device for delivering a therapeutic agent and method of preparation |
| US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
| US6191105B1 (en) * | 1993-05-10 | 2001-02-20 | Protein Delivery, Inc. | Hydrophilic and lipophilic balanced microemulsion formulations of free-form and/or conjugation-stabilized therapeutic agents such as insulin |
| US5618298A (en) * | 1993-10-23 | 1997-04-08 | Simon; Michael | Vascular prosthesis made of resorbable material |
| EP0698396B1 (en) * | 1994-08-12 | 2001-12-12 | Meadox Medicals, Inc. | Vascular graft impregnated with a heparin-containing collagen sealant |
| US6281015B1 (en) * | 1994-12-16 | 2001-08-28 | Children's Medical Center Corp. | Localized delivery of factors enhancing survival of transplanted cells |
| US6179817B1 (en) * | 1995-02-22 | 2001-01-30 | Boston Scientific Corporation | Hybrid coating for medical devices |
| US6231600B1 (en) * | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
| US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
| CA2251008C (en) * | 1996-04-05 | 2007-11-13 | The Board Of Trustees Of The University Of Illinois | Macromolecular complexes for drug delivery |
| US5876433A (en) * | 1996-05-29 | 1999-03-02 | Ethicon, Inc. | Stent and method of varying amounts of heparin coated thereon to control treatment |
| US6214375B1 (en) * | 1996-07-16 | 2001-04-10 | Generex Pharmaceuticals, Inc. | Phospholipid formulations |
| US6099525A (en) * | 1996-10-07 | 2000-08-08 | Cosmescu; Ioan | Removable shroud for receiving a pencil used in electro-surgery |
| US5728751A (en) * | 1996-11-25 | 1998-03-17 | Meadox Medicals, Inc. | Bonding bio-active materials to substrate surfaces |
| US6776792B1 (en) * | 1997-04-24 | 2004-08-17 | Advanced Cardiovascular Systems Inc. | Coated endovascular stent |
| US5879697A (en) * | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
| GB2325934A (en) * | 1997-06-03 | 1998-12-09 | Polybiomed Ltd | Treating metal surfaces to enhance bio-compatibility and/or physical characteristics |
| US6316522B1 (en) * | 1997-08-18 | 2001-11-13 | Scimed Life Systems, Inc. | Bioresorbable hydrogel compositions for implantable prostheses |
| US5854382A (en) * | 1997-08-18 | 1998-12-29 | Meadox Medicals, Inc. | Bioresorbable compositions for implantable prostheses |
| US6119028A (en) * | 1997-10-20 | 2000-09-12 | Alfred E. Mann Foundation | Implantable enzyme-based monitoring systems having improved longevity due to improved exterior surfaces |
| US6605751B1 (en) * | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
| CA2318736A1 (en) * | 1998-01-30 | 1999-08-05 | Michael Helmus | Enhanced biocompatibility coatings for medical implants |
| US6410044B1 (en) * | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
| US6258371B1 (en) * | 1998-04-03 | 2001-07-10 | Medtronic Inc | Method for making biocompatible medical article |
| US6187038B1 (en) * | 1998-04-08 | 2001-02-13 | Sulzer Carbomedics Inc. | Small bore biologic graft with therapeutic delivery system |
| US6013099A (en) * | 1998-04-29 | 2000-01-11 | Medtronic, Inc. | Medical device for delivering a water-insoluble therapeutic salt or substance |
| KR19990085365A (ko) * | 1998-05-16 | 1999-12-06 | 허영섭 | 지속적으로 약물 조절방출이 가능한 생분해성 고분자 미립구 및그 제조방법 |
| US6335029B1 (en) * | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
| US6299980B1 (en) * | 1998-09-29 | 2001-10-09 | Medtronic Ave, Inc. | One step lubricious coating |
| US6315210B1 (en) * | 1998-10-02 | 2001-11-13 | Lawler Manufacturing Co., Inc. | Thermostatic mixing valve |
| IL143962A0 (en) * | 1999-01-08 | 2002-04-21 | Emisphere Tech Inc | Polymeric delivery agents and delivery agent compounds |
| EP1175235A1 (en) * | 1999-04-22 | 2002-01-30 | Eidgenossisch Technische Hochschule Zurich | Modified protein matrices |
| WO2000064954A1 (en) * | 1999-04-22 | 2000-11-02 | Vanderbilt University | Polymeric encapsulation system promoting angiogenesis |
| US6258121B1 (en) * | 1999-07-02 | 2001-07-10 | Scimed Life Systems, Inc. | Stent coating |
| AU6526100A (en) * | 1999-08-06 | 2001-03-05 | Board Of Regents, The University Of Texas System | Drug releasing biodegradable fiber implant |
| SE9904475D0 (sv) * | 1999-12-08 | 1999-12-08 | Artursson | Nucleic acid delivery system |
| US6566345B2 (en) * | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
| US6749865B2 (en) * | 2000-02-15 | 2004-06-15 | Genzyme Corporation | Modification of biopolymers for improved drug delivery |
| KR100356643B1 (ko) * | 2000-03-31 | 2002-10-18 | 한국과학기술연구원 | 생리활성 물질이 결합된 생체적합성 의료용 금속 재료 및이의 제조 방법 |
| US6527801B1 (en) * | 2000-04-13 | 2003-03-04 | Advanced Cardiovascular Systems, Inc. | Biodegradable drug delivery material for stent |
| US6719970B1 (en) * | 2000-07-10 | 2004-04-13 | Alkermes Controlled Therapeutics, Inc. | Method of generating cartilage |
| US6773723B1 (en) * | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
| US7427394B2 (en) * | 2000-10-10 | 2008-09-23 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US6998115B2 (en) * | 2000-10-10 | 2006-02-14 | Massachusetts Institute Of Technology | Biodegradable poly(β-amino esters) and uses thereof |
| US6748954B2 (en) * | 2000-10-27 | 2004-06-15 | The Regents Of The University Of Michigan | Drug release from polymer matrices through mechanical stimulation |
| US20040030377A1 (en) * | 2001-10-19 | 2004-02-12 | Alexander Dubson | Medicated polymer-coated stent assembly |
| US20020087123A1 (en) * | 2001-01-02 | 2002-07-04 | Hossainy Syed F.A. | Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices |
| US6551578B2 (en) * | 2001-02-15 | 2003-04-22 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6749845B2 (en) * | 2001-02-15 | 2004-06-15 | Aeropharm Technology, Inc. | Modulated release particles for lung delivery |
| US6475468B2 (en) * | 2001-02-15 | 2002-11-05 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6485707B2 (en) * | 2001-02-15 | 2002-11-26 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6596262B2 (en) * | 2001-02-15 | 2003-07-22 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6544497B2 (en) * | 2001-02-15 | 2003-04-08 | Aeropharm Technology Incorporated | Modulated release particles for aerosol delivery |
| US6787179B2 (en) * | 2001-06-29 | 2004-09-07 | Ethicon, Inc. | Sterilization of bioactive coatings |
| JP2003086586A (ja) * | 2001-09-13 | 2003-03-20 | Murata Mfg Co Ltd | 配向性強誘電体薄膜素子及びその製造方法 |
| US20030083614A1 (en) * | 2001-10-30 | 2003-05-01 | Boehringer Ingelheim Pharma Kg | Controlled release endoprosthetic device |
| US20030088307A1 (en) * | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
| US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
| JP2004097267A (ja) * | 2002-09-05 | 2004-04-02 | National Cardiovascular Center | カフ部材 |
| US20040038303A1 (en) * | 2002-04-08 | 2004-02-26 | Unger Gretchen M. | Biologic modulations with nanoparticles |
| US6750291B2 (en) * | 2002-04-12 | 2004-06-15 | Pacific Corporation | Film-forming agent for drug delivery and preparation for percutaneous administration containing the same |
| AU2003265446A1 (en) * | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery system including a hydrophilic polymer, medical device, and method |
| AU2003258209A1 (en) * | 2002-08-13 | 2004-02-25 | Medtronic, Inc. | Active agent delivery systems, medical devices, and methods |
| US20040033251A1 (en) * | 2002-08-13 | 2004-02-19 | Medtronic, Inc. | Active agent delivery system including a polyurethane, medical device, and method |
| US7265097B2 (en) * | 2002-08-20 | 2007-09-04 | Chitogenics, Inc. | Methods of drug delivery using sulphated chitinous polymers |
| US20040054104A1 (en) * | 2002-09-05 | 2004-03-18 | Pacetti Stephen D. | Coatings for drug delivery devices comprising modified poly(ethylene-co-vinyl alcohol) |
| US6702850B1 (en) * | 2002-09-30 | 2004-03-09 | Mediplex Corporation Korea | Multi-coated drug-eluting stent for antithrombosis and antirestenosis |
| US20040111144A1 (en) * | 2002-12-06 | 2004-06-10 | Lawin Laurie R. | Barriers for polymeric coatings |
| US20040115164A1 (en) * | 2002-12-17 | 2004-06-17 | Pierce Ryan K. | Soft filament occlusive device delivery system |
| US20050079132A1 (en) * | 2003-04-08 | 2005-04-14 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US20040260318A1 (en) * | 2003-05-23 | 2004-12-23 | Angiotech International Ag | Anastomotic connector devices |
| US20050079131A1 (en) * | 2003-08-08 | 2005-04-14 | Lanza Gregory M. | Emulsion particles for imaging and therapy and methods of use thereof |
| WO2005074835A1 (en) * | 2004-02-02 | 2005-08-18 | Hydrophilix Corporation | Hydrophilic matrix for delivery of active agent and product containing same |
-
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2006
- 2006-05-05 WO PCT/US2006/017501 patent/WO2006121908A2/en not_active Ceased
- 2006-05-05 EP EP06770045.0A patent/EP1888138B1/en active Active
- 2006-05-05 ES ES06770045T patent/ES2434854T3/es active Active
- 2006-05-05 JP JP2008511204A patent/JP5368787B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5368787B2 (ja) | 2013-12-18 |
| EP1888138B1 (en) | 2013-09-04 |
| EP1888138A2 (en) | 2008-02-20 |
| JP2008544769A (ja) | 2008-12-11 |
| WO2006121908A3 (en) | 2007-04-19 |
| WO2006121908A2 (en) | 2006-11-16 |
| US20060257355A1 (en) | 2006-11-16 |
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