ES2426096T3 - Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización - Google Patents

Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización Download PDF

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Publication number
ES2426096T3
ES2426096T3 ES09774472T ES09774472T ES2426096T3 ES 2426096 T3 ES2426096 T3 ES 2426096T3 ES 09774472 T ES09774472 T ES 09774472T ES 09774472 T ES09774472 T ES 09774472T ES 2426096 T3 ES2426096 T3 ES 2426096T3
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ES
Spain
Prior art keywords
alkyl
cr14r15
cr19r20
nhc
carbocyclyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09774472T
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English (en)
Spanish (es)
Inventor
Emanuela Gancia
Robert Andrew HEALD
Philip Jackson
Stephen Price
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
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Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41128054&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2426096(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
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Publication of ES2426096T3 publication Critical patent/ES2426096T3/es
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
ES09774472T 2008-07-01 2009-07-01 Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización Active ES2426096T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7743208P 2008-07-01 2008-07-01
US77432P 2008-07-01
PCT/US2009/049449 WO2010003022A1 (en) 2008-07-01 2009-07-01 Isoindolone derivatives as mek kinase inhibitors and methods of use

Publications (1)

Publication Number Publication Date
ES2426096T3 true ES2426096T3 (es) 2013-10-21

Family

ID=41128054

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09774472T Active ES2426096T3 (es) 2008-07-01 2009-07-01 Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización

Country Status (16)

Country Link
US (1) US8492427B2 (enExample)
EP (1) EP2307364B1 (enExample)
JP (1) JP5615274B2 (enExample)
KR (1) KR20110028376A (enExample)
CN (1) CN102137843A (enExample)
AU (1) AU2009266953A1 (enExample)
BR (1) BRPI0910200A2 (enExample)
CA (1) CA2727252A1 (enExample)
CL (1) CL2010001637A1 (enExample)
ES (1) ES2426096T3 (enExample)
IL (1) IL209892A0 (enExample)
MX (1) MX2010014565A (enExample)
PE (1) PE20110424A1 (enExample)
RU (1) RU2495028C2 (enExample)
WO (1) WO2010003022A1 (enExample)
ZA (1) ZA201008962B (enExample)

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US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
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EP3541792B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
US11046680B1 (en) 2016-11-16 2021-06-29 Amgen Inc. Heteroaryl-substituted triazoles as APJ receptor agonists
US10906890B2 (en) 2016-11-16 2021-02-02 Amgen Inc. Triazole phenyl compounds as agonists of the APJ receptor
EP3541803B1 (en) 2016-11-16 2020-12-23 Amgen Inc. Triazole pyridyl compounds as agonists of the apj receptor
WO2018093577A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Cycloalkyl substituted triazole compounds as agonists of the apj receptor
RU2742234C1 (ru) 2017-06-23 2021-02-03 Систоун Фармасьютикалс Кумариноподобное циклическое соединение в качестве ингибитора мек и его применение
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
CN115716826A (zh) 2017-07-24 2023-02-28 生命医药有限责任公司 RORγ的抑制剂
KR102811888B1 (ko) 2017-09-08 2025-05-27 에프. 호프만-라 로슈 아게 암의 진단 및 치료 방법
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JP2024521788A (ja) 2021-05-27 2024-06-04 ミラティ セラピューティクス， インコーポレイテッド 併用療法
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Also Published As

Publication number Publication date
US8492427B2 (en) 2013-07-23
CL2010001637A1 (es) 2011-07-15
AU2009266953A2 (en) 2011-01-27
WO2010003022A1 (en) 2010-01-07
ZA201008962B (en) 2012-03-28
BRPI0910200A2 (pt) 2015-09-29
KR20110028376A (ko) 2011-03-17
JP5615274B2 (ja) 2014-10-29
JP2011526924A (ja) 2011-10-20
RU2495028C2 (ru) 2013-10-10
PE20110424A1 (es) 2011-07-22
CN102137843A (zh) 2011-07-27
AU2009266953A1 (en) 2010-01-07
EP2307364A1 (en) 2011-04-13
RU2011103434A (ru) 2012-08-10
WO2010003022A8 (en) 2010-09-30
IL209892A0 (en) 2011-02-28
EP2307364B1 (en) 2013-06-19
US20110124622A1 (en) 2011-05-26
MX2010014565A (es) 2011-03-04
CA2727252A1 (en) 2010-01-07

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