ES2426096T3 - Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización - Google Patents
Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización Download PDFInfo
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- ES2426096T3 ES2426096T3 ES09774472T ES09774472T ES2426096T3 ES 2426096 T3 ES2426096 T3 ES 2426096T3 ES 09774472 T ES09774472 T ES 09774472T ES 09774472 T ES09774472 T ES 09774472T ES 2426096 T3 ES2426096 T3 ES 2426096T3
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- Prior art keywords
- alkyl
- cr14r15
- cr19r20
- nhc
- carbocyclyl
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
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| US7743208P | 2008-07-01 | 2008-07-01 | |
| US77432P | 2008-07-01 | ||
| PCT/US2009/049449 WO2010003022A1 (en) | 2008-07-01 | 2009-07-01 | Isoindolone derivatives as mek kinase inhibitors and methods of use |
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| ES2426096T3 true ES2426096T3 (es) | 2013-10-21 |
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| ES09774472T Active ES2426096T3 (es) | 2008-07-01 | 2009-07-01 | Derivados de isoindolona como inhibidores de la quinasa MEK y métodos de utilización |
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| EP (1) | EP2307364B1 (enExample) |
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| MX (1) | MX2010014565A (enExample) |
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| WO (1) | WO2010003022A1 (enExample) |
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| EP2598660B1 (en) | 2010-07-26 | 2017-03-15 | Biomatrica, INC. | Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures |
| CA2806734A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
| CA2890238A1 (en) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
| EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS |
| CA2915250A1 (en) | 2013-06-13 | 2015-01-08 | Biomatrica, Inc. | Cell stabilization |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| KR102222569B1 (ko) * | 2013-10-25 | 2021-03-05 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 피리딘의 케톤 유도체의 제조 방법 및 제약 용도 |
| RS59007B1 (sr) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals Llc | Dihidropirolopiridinski inhibitori ror-gama |
| CN103922992B (zh) * | 2014-04-25 | 2015-09-02 | 温州大学 | 一种抗癌活性吲哚酮衍生物、合成方法及其用途 |
| CN113826612B (zh) | 2014-06-10 | 2022-11-22 | 生物马特里卡公司 | 在环境温度下稳定凝血细胞 |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| EA031967B1 (ru) | 2014-10-14 | 2019-03-29 | Вайтаи Фармасьютиклз, Инк. | ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
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- 2009-07-01 PE PE2010001200A patent/PE20110424A1/es not_active Application Discontinuation
- 2009-07-01 JP JP2011516857A patent/JP5615274B2/ja not_active Expired - Fee Related
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| CN102137843A (zh) | 2011-07-27 |
| CA2727252A1 (en) | 2010-01-07 |
| CL2010001637A1 (es) | 2011-07-15 |
| MX2010014565A (es) | 2011-03-04 |
| KR20110028376A (ko) | 2011-03-17 |
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| WO2010003022A1 (en) | 2010-01-07 |
| RU2495028C2 (ru) | 2013-10-10 |
| BRPI0910200A2 (pt) | 2015-09-29 |
| WO2010003022A8 (en) | 2010-09-30 |
| EP2307364A1 (en) | 2011-04-13 |
| ZA201008962B (en) | 2012-03-28 |
| JP5615274B2 (ja) | 2014-10-29 |
| IL209892A0 (en) | 2011-02-28 |
| US20110124622A1 (en) | 2011-05-26 |
| AU2009266953A2 (en) | 2011-01-27 |
| AU2009266953A1 (en) | 2010-01-07 |
| US8492427B2 (en) | 2013-07-23 |
| RU2011103434A (ru) | 2012-08-10 |
| PE20110424A1 (es) | 2011-07-22 |
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