CN102137843A - 作为mek激酶抑制剂的异吲哚酮衍生物及其使用方法 - Google Patents
作为mek激酶抑制剂的异吲哚酮衍生物及其使用方法 Download PDFInfo
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- CN102137843A CN102137843A CN2009801337804A CN200980133780A CN102137843A CN 102137843 A CN102137843 A CN 102137843A CN 2009801337804 A CN2009801337804 A CN 2009801337804A CN 200980133780 A CN200980133780 A CN 200980133780A CN 102137843 A CN102137843 A CN 102137843A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (3)
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| US61/077,432 | 2008-07-01 | ||
| PCT/US2009/049449 WO2010003022A1 (en) | 2008-07-01 | 2009-07-01 | Isoindolone derivatives as mek kinase inhibitors and methods of use |
Publications (1)
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| CN102137843A true CN102137843A (zh) | 2011-07-27 |
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| EP (1) | EP2307364B1 (enExample) |
| JP (1) | JP5615274B2 (enExample) |
| KR (1) | KR20110028376A (enExample) |
| CN (1) | CN102137843A (enExample) |
| AU (1) | AU2009266953A1 (enExample) |
| BR (1) | BRPI0910200A2 (enExample) |
| CA (1) | CA2727252A1 (enExample) |
| CL (1) | CL2010001637A1 (enExample) |
| ES (1) | ES2426096T3 (enExample) |
| IL (1) | IL209892A0 (enExample) |
| MX (1) | MX2010014565A (enExample) |
| PE (1) | PE20110424A1 (enExample) |
| RU (1) | RU2495028C2 (enExample) |
| WO (1) | WO2010003022A1 (enExample) |
| ZA (1) | ZA201008962B (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103922992A (zh) * | 2014-04-25 | 2014-07-16 | 温州大学 | 一种抗癌活性吲哚酮衍生物、合成方法及其用途 |
| WO2015058589A1 (zh) * | 2013-10-25 | 2015-04-30 | 上海恒瑞医药有限公司 | 吡啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN104860869A (zh) * | 2015-04-03 | 2015-08-26 | 北京大学 | 具有mek激酶抑制功能的化合物及其制备方法与应用 |
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| CA2806734A1 (en) | 2010-07-26 | 2012-02-09 | Biomatrica, Inc. | Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures |
| CN102020651B (zh) | 2010-11-02 | 2012-07-18 | 北京赛林泰医药技术有限公司 | 6-芳基氨基吡啶酮甲酰胺mek抑制剂 |
| CA2890238A1 (en) | 2012-11-02 | 2014-05-08 | Merck Patent Gmbh | Method of reducing adverse effects in a cancer patient undergoing treatment with a mek inhibitor |
| EP2934572A4 (en) | 2012-12-20 | 2016-11-23 | Biomatrica Inc | FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS |
| CA2915250A1 (en) | 2013-06-13 | 2015-01-08 | Biomatrica, Inc. | Cell stabilization |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| RS59007B1 (sr) | 2014-02-03 | 2019-08-30 | Vitae Pharmaceuticals Llc | Dihidropirolopiridinski inhibitori ror-gama |
| CN113826612B (zh) | 2014-06-10 | 2022-11-22 | 生物马特里卡公司 | 在环境温度下稳定凝血细胞 |
| WO2015196072A2 (en) | 2014-06-19 | 2015-12-23 | Whitehead Institute For Biomedical Research | Uses of kinase inhibitors for inducing and maintaining pluripotency |
| EA031967B1 (ru) | 2014-10-14 | 2019-03-29 | Вайтаи Фармасьютиклз, Инк. | ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ |
| US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
| US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| TN2017000483A1 (en) | 2015-05-20 | 2019-04-12 | Amgen Inc | Triazole agonists of the apj receptor. |
| WO2017024018A1 (en) | 2015-08-05 | 2017-02-09 | Vitae Pharmaceuticals, Inc. | Modulators of ror-gamma |
| WO2017033113A1 (en) | 2015-08-21 | 2017-03-02 | Acerta Pharma B.V. | Therapeutic combinations of a mek inhibitor and a btk inhibitor |
| KR20180086221A (ko) | 2015-11-20 | 2018-07-30 | 비타이 파마슈티컬즈, 인코포레이티드 | Ror-감마의 조절물질 |
| BR112018011639A2 (pt) | 2015-12-08 | 2018-11-27 | Biomatrica Inc | redução de taxa de sedimentação de eritrócitos |
| TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ＲＯＲ－γ調節劑 |
| KR20180134347A (ko) | 2016-04-15 | 2018-12-18 | 제넨테크, 인크. | 암의 진단 및 치료 방법 |
| WO2017192485A1 (en) | 2016-05-03 | 2017-11-09 | Amgen Inc. | Heterocyclic triazole compounds as agonists of the apj receptor |
| US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
| US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
| US11191762B2 (en) | 2016-11-16 | 2021-12-07 | Amgen Inc. | Alkyl substituted triazole compounds as agonists of the APJ Receptor |
| WO2018093580A1 (en) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Triazole pyridyl compounds as agonists of the apj receptor |
| EP3541792B1 (en) | 2016-11-16 | 2020-12-23 | Amgen Inc. | Triazole furan compounds as agonists of the apj receptor |
| MA46827A (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc | Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj |
| WO2018097945A1 (en) | 2016-11-16 | 2018-05-31 | Amgen Inc. | Heteroaryl-substituted triazoles as apj receptor agonists |
| RU2742234C1 (ru) | 2017-06-23 | 2021-02-03 | Систоун Фармасьютикалс | Кумариноподобное циклическое соединение в качестве ингибитора мек и его применение |
| MA49685A (fr) | 2017-07-24 | 2021-04-14 | Vitae Pharmaceuticals Llc | INHIBITEURS DE ROR gamma |
| WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
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| WO2019089335A1 (en) | 2017-11-03 | 2019-05-09 | Amgen Inc. | Fused triazole agonists of the apj receptor |
| EP3735404B1 (en) | 2018-01-02 | 2023-11-29 | Seal Rock Therapeutics, Inc. | Ask1 inhibitor compounds and uses thereof |
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| WO2019213006A1 (en) | 2018-05-01 | 2019-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the apj receptor |
| US12371667B2 (en) | 2021-05-13 | 2025-07-29 | Washington University | Enhanced methods for inducing and maintaining naive human pluripotent stem cells |
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| WO2024033381A1 (en) | 2022-08-10 | 2024-02-15 | Vib Vzw | Inhibition of tcf4/itf2 in the treatment of cancer |
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| PL401638A1 (pl) | 2002-03-13 | 2013-05-27 | Array Biopharma Inc. | N3 alkilowane pochodne benzimidazolu jako inhibitory MEK |
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| HRP20110498T1 (hr) | 2005-10-07 | 2011-08-31 | Exelixis | Azetidini kao inhibitori mek za liječenje proliferativnih bolesti |
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2009
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- 2009-07-01 JP JP2011516857A patent/JP5615274B2/ja not_active Expired - Fee Related
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- 2009-07-01 RU RU2011103434/04A patent/RU2495028C2/ru not_active IP Right Cessation
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2010
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- 2010-12-13 ZA ZA2010/08962A patent/ZA201008962B/en unknown
- 2010-12-30 CL CL2010001637A patent/CL2010001637A1/es unknown
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015058589A1 (zh) * | 2013-10-25 | 2015-04-30 | 上海恒瑞医药有限公司 | 吡啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN104936945A (zh) * | 2013-10-25 | 2015-09-23 | 上海恒瑞医药有限公司 | 吡啶酮类衍生物、其制备方法及其在医药上的应用 |
| CN104936945B (zh) * | 2013-10-25 | 2017-11-03 | 上海恒瑞医药有限公司 | 吡啶酮类衍生物、其制备方法及其在医药上的应用 |
| US9914703B2 (en) | 2013-10-25 | 2018-03-13 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof |
| US10064848B2 (en) | 2013-10-25 | 2018-09-04 | Shanghai Hengrui Pharmaceutical Co., Ltd. | Pyridic ketone derivatives, method of preparing same, and pharmaceutical application thereof |
| CN103922992A (zh) * | 2014-04-25 | 2014-07-16 | 温州大学 | 一种抗癌活性吲哚酮衍生物、合成方法及其用途 |
| CN103922992B (zh) * | 2014-04-25 | 2015-09-02 | 温州大学 | 一种抗癌活性吲哚酮衍生物、合成方法及其用途 |
| CN104860869A (zh) * | 2015-04-03 | 2015-08-26 | 北京大学 | 具有mek激酶抑制功能的化合物及其制备方法与应用 |
| CN104860869B (zh) * | 2015-04-03 | 2017-11-03 | 北京大学 | 具有mek激酶抑制功能的化合物及其制备方法与应用 |
Also Published As
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|---|---|
| CA2727252A1 (en) | 2010-01-07 |
| CL2010001637A1 (es) | 2011-07-15 |
| MX2010014565A (es) | 2011-03-04 |
| KR20110028376A (ko) | 2011-03-17 |
| JP2011526924A (ja) | 2011-10-20 |
| EP2307364B1 (en) | 2013-06-19 |
| WO2010003022A1 (en) | 2010-01-07 |
| RU2495028C2 (ru) | 2013-10-10 |
| BRPI0910200A2 (pt) | 2015-09-29 |
| WO2010003022A8 (en) | 2010-09-30 |
| EP2307364A1 (en) | 2011-04-13 |
| ZA201008962B (en) | 2012-03-28 |
| JP5615274B2 (ja) | 2014-10-29 |
| IL209892A0 (en) | 2011-02-28 |
| US20110124622A1 (en) | 2011-05-26 |
| AU2009266953A2 (en) | 2011-01-27 |
| AU2009266953A1 (en) | 2010-01-07 |
| US8492427B2 (en) | 2013-07-23 |
| RU2011103434A (ru) | 2012-08-10 |
| PE20110424A1 (es) | 2011-07-22 |
| ES2426096T3 (es) | 2013-10-21 |
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