ES2400302T8 - Nuevos métodos para construir bibliotecas de paquetes genéticos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas - Google Patents

Nuevos métodos para construir bibliotecas de paquetes genéticos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas Download PDF

Info

Publication number
ES2400302T8
ES2400302T8 ES01927108T ES01927108T ES2400302T8 ES 2400302 T8 ES2400302 T8 ES 2400302T8 ES 01927108 T ES01927108 T ES 01927108T ES 01927108 T ES01927108 T ES 01927108T ES 2400302 T8 ES2400302 T8 ES 2400302T8
Authority
ES
Spain
Prior art keywords
polypeptides
peptides
proteins
new methods
genetic packages
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES01927108T
Other languages
English (en)
Other versions
ES2400302T3 (es
Inventor
Robert C. Ladner
Edward Hirsch Cohen
Horacio Gabriel Nastri
Kristin L. Rookey
Rene Hoet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dyax Corp
Original Assignee
Dyax Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dyax Corp filed Critical Dyax Corp
Application granted granted Critical
Publication of ES2400302T3 publication Critical patent/ES2400302T3/es
Publication of ES2400302T8 publication Critical patent/ES2400302T8/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
ES01927108T 2000-04-17 2001-04-17 Nuevos métodos para construir bibliotecas de paquetes génicos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas Expired - Lifetime ES2400302T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19806900P 2000-04-17 2000-04-17
US198069P 2000-04-17
PCT/US2001/012454 WO2001079481A2 (en) 2000-04-17 2001-04-17 Methods of constructing display libraries of genetic packages for members of a diverse family of peptides

Publications (2)

Publication Number Publication Date
ES2400302T3 ES2400302T3 (es) 2013-04-09
ES2400302T8 true ES2400302T8 (es) 2013-04-25

Family

ID=22731873

Family Applications (3)

Application Number Title Priority Date Filing Date
ES10156326T Expired - Lifetime ES2393535T3 (es) 2000-04-17 2001-04-17 Nuevos métodos para construir bibliotecas de paquetes genéticos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas
ES01927108T Expired - Lifetime ES2400302T3 (es) 2000-04-17 2001-04-17 Nuevos métodos para construir bibliotecas de paquetes génicos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas
ES10179786.8T Expired - Lifetime ES2531551T3 (es) 2000-04-17 2001-04-17 Métodos para construir bibliotecas de presentación de paquetes genéticos para miembros de una familia diversa de péptido

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES10156326T Expired - Lifetime ES2393535T3 (es) 2000-04-17 2001-04-17 Nuevos métodos para construir bibliotecas de paquetes genéticos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES10179786.8T Expired - Lifetime ES2531551T3 (es) 2000-04-17 2001-04-17 Métodos para construir bibliotecas de presentación de paquetes genéticos para miembros de una familia diversa de péptido

Country Status (10)

Country Link
US (2) US20040029113A1 (es)
EP (4) EP1276855B1 (es)
JP (3) JP5149476B2 (es)
AU (3) AU5358901A (es)
CA (2) CA2798625C (es)
DK (3) DK2199393T3 (es)
ES (3) ES2393535T3 (es)
HK (2) HK1145515A1 (es)
PT (1) PT2308982E (es)
WO (1) WO2001079481A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696251B1 (en) * 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
US6759243B2 (en) * 1998-01-20 2004-07-06 Board Of Trustees Of The University Of Illinois High affinity TCR proteins and methods
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
WO2001079481A2 (en) 2000-04-17 2001-10-25 Dyax Corp. Methods of constructing display libraries of genetic packages for members of a diverse family of peptides
WO2001098366A2 (en) * 2000-06-19 2001-12-27 Dyax Corp. Enterokinase cleavage sequences and their use
EP1360288B1 (en) 2000-12-18 2011-02-16 Dyax Corp. Focused libraries of genetic packages
AU2016225923B2 (en) * 2001-04-17 2018-07-05 Takeda Pharmaceutical Company Limited Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
AU2013205033B2 (en) * 2001-04-17 2016-06-09 Takeda Pharmaceutical Company Limited Novel Methods of Constructing Libraries Comprising Displayed and/or Expressed Members of a Diverse Family of Peptides, Polypeptides or Proteins and the Novel Libraries
US20040005709A1 (en) * 2001-10-24 2004-01-08 Hoogenboom Henricus Renerus Jacobus Mattheus Hybridization control of sequence variation
US7135310B2 (en) 2002-04-24 2006-11-14 The Regents Of The University Of California Method to amplify variable sequences without imposing primer sequences
US20040067532A1 (en) 2002-08-12 2004-04-08 Genetastix Corporation High throughput generation and affinity maturation of humanized antibody
CA2555489C (en) * 2004-02-10 2012-05-08 Japan Science And Technology Agency Method of converting base in dna sequence
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
US8691730B2 (en) 2007-09-14 2014-04-08 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
FR2924440B1 (fr) * 2007-12-04 2015-01-09 Pf Medicament Nouveau procede de generation et de criblage d'une banque d'anticorps
US9873957B2 (en) 2008-03-13 2018-01-23 Dyax Corp. Libraries of genetic packages comprising novel HC CDR3 designs
CA2968164C (en) 2008-04-24 2019-08-20 Dyax Corp. Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs
WO2010003316A1 (en) * 2008-07-10 2010-01-14 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids
US20110082054A1 (en) * 2009-09-14 2011-04-07 Dyax Corp. Libraries of genetic packages comprising novel hc cdr3 designs
EP2593594B1 (en) 2010-07-16 2017-09-27 Adimab, LLC Antibody libraries
WO2015172080A1 (en) 2014-05-08 2015-11-12 Fluidigm Corporation Integrated single cell sequencing

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US596271A (en) * 1897-12-28 l-anohestee
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
CH0229046H1 (de) 1985-03-30 1998-07-15 Stuart Alan Kauffman Method for obtaining dna, rna, peptides, polypeptinique. des or proteins by means of a dna recombinant tech
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
US5223409A (en) * 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5688666A (en) 1988-10-28 1997-11-18 Genentech, Inc. Growth hormone variants with altered binding properties
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
US6969586B1 (en) 1989-05-16 2005-11-29 Scripps Research Institute Method for tapping the immunological repertoire
US6680192B1 (en) 1989-05-16 2004-01-20 Scripps Research Institute Method for producing polymers having a preselected activity
US6291161B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertiore
US6291159B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
US6291158B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for tapping the immunological repertoire
US6291160B1 (en) 1989-05-16 2001-09-18 Scripps Research Institute Method for producing polymers having a preselected activity
EP0440147B2 (de) 1990-02-01 2014-05-14 Siemens Healthcare Diagnostics Products GmbH Herstellung und Verwendung von Genbanken menschlicher Antikörper ("Human-Antikörper-Bibliotheken")
DE4002897A1 (de) 1990-02-01 1991-08-08 Behringwerke Ag Herstellung und verwendung von genbanken synthetischer menschlicher antikoerper ("synthetische human-antikoerper-bibliotheken")
EP0527809B1 (en) 1990-04-05 1995-08-16 CREA, Roberto Walk-through mutagenesis
ATE167520T1 (de) * 1990-04-18 1998-07-15 Gist Brocades Nv Mutierte beta-lactamacylasegene
US6916605B1 (en) 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
GB9206318D0 (en) 1992-03-24 1992-05-06 Cambridge Antibody Tech Binding substances
GB9015198D0 (en) * 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US7063943B1 (en) 1990-07-10 2006-06-20 Cambridge Antibody Technology Methods for producing members of specific binding pairs
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
WO1992009690A2 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with altered binding properties
US5780279A (en) 1990-12-03 1998-07-14 Genentech, Inc. Method of selection of proteolytic cleavage sites by directed evolution and phagemid display
DK1471142T3 (da) 1991-04-10 2009-03-09 Scripps Research Inst Heterodimere receptor-biblioteker under anvendelse af fagemider
US5962255A (en) 1992-03-24 1999-10-05 Cambridge Antibody Technology Limited Methods for producing recombinant vectors
US5858657A (en) 1992-05-15 1999-01-12 Medical Research Council Methods for producing members of specific binding pairs
US6225447B1 (en) 1991-05-15 2001-05-01 Cambridge Antibody Technology Ltd. Methods for producing members of specific binding pairs
US6492160B1 (en) 1991-05-15 2002-12-10 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5871907A (en) 1991-05-15 1999-02-16 Medical Research Council Methods for producing members of specific binding pairs
DK0597960T3 (da) 1991-08-10 1999-09-13 Medical Res Council Behandling af cellepopulationer
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5872215A (en) 1991-12-02 1999-02-16 Medical Research Council Specific binding members, materials and methods
ES2313867T3 (es) 1991-12-02 2009-03-16 Medical Research Council Produccion de anticuerpos anti-auto de repertorios de segmentos de anticuerpo expresados en la superficie de fagos.
US5733743A (en) 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5869644A (en) 1992-04-15 1999-02-09 The Johns Hopkins University Synthesis of diverse and useful collections of oligonucleotidies
JPH08502260A (ja) 1992-09-30 1996-03-12 ザ スクリップス リサーチ インスティテュート ヒト免疫不全ウイルスに対するヒト中和モノクローナル抗体
GB9225453D0 (en) 1992-12-04 1993-01-27 Medical Res Council Binding proteins
CA2150262C (en) 1992-12-04 2008-07-08 Kaspar-Philipp Holliger Multivalent and multispecific binding proteins, their manufacture and use
US5422253A (en) 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
KR100310739B1 (ko) 1993-02-04 2002-05-30 알란 스코브 단백질재생을위한개선된방법
US5714320A (en) * 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
DK0720624T3 (da) 1993-09-22 1999-08-09 Medical Res Council Omdirigering af antistoffer
US5702892A (en) 1995-05-09 1997-12-30 The United States Of America As Represented By The Department Of Health And Human Services Phage-display of immunoglobulin heavy chain libraries
US6828422B1 (en) 1995-08-18 2004-12-07 Morphosys Ag Protein/(poly)peptide libraries
DK0859841T3 (da) 1995-08-18 2002-09-09 Morphosys Ag Protein/(poly)peptidbiblioteker
US5972693A (en) 1995-10-24 1999-10-26 Curagen Corporation Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
FR2741892B1 (fr) * 1995-12-04 1998-02-13 Pasteur Merieux Serums Vacc Procede de preparation d'une banque multicombinatoire de vecteurs d'expression de genes d'anticorps, banque et systemes d'expression d'anticorps "coliclonaux" obtenus
US5962271A (en) * 1996-01-03 1999-10-05 Cloutech Laboratories, Inc. Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end
DE19624562A1 (de) 1996-06-20 1998-01-02 Thomas Dr Koehler Verfahren zur Bestimmung von Konzentrationsverhältnissen zweier sich um mindestens ein Nucleotid unterscheidender Nucleinsäuren und Testkit zur Durchführung des Verfahrens
SK284879B6 (sk) 1996-06-24 2006-01-05 Zlb Behring Ag Polypeptidy so schopnosťou tvorby väzbových štruktúr na antigén so špecificitou pre Rhesus D antigény, DNA kódujúce také polypeptidy, spôsob ich prípravy a použitie
GB9712818D0 (en) 1996-07-08 1997-08-20 Cambridge Antibody Tech Labelling and selection of specific binding molecules
US5858671A (en) 1996-11-01 1999-01-12 The University Of Iowa Research Foundation Iterative and regenerative DNA sequencing method
JP2002514919A (ja) 1997-04-04 2002-05-21 バイオサイト ダイアグノスティックス，インコーポレイテッド 多価ライブラリーおよびポリクローナルライブラリー
US6057098A (en) 1997-04-04 2000-05-02 Biosite Diagnostics, Inc. Polyvalent display libraries
EP1007967A2 (en) 1997-08-04 2000-06-14 Ixsys, Incorporated Methods for identifying ligand specific binding molecules
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US7244826B1 (en) * 1998-04-24 2007-07-17 The Regents Of The University Of California Internalizing ERB2 antibodies
EP1115854A1 (en) * 1998-09-25 2001-07-18 G.D. Searle & Co. Method of producing permuteins by scanning permutagenesis
US6531580B1 (en) 1999-06-24 2003-03-11 Ixsys, Inc. Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same
PT1144607E (pt) 1999-07-20 2009-04-22 Morphosys Ag Novos métodos para apresentar (poli)peptídeos/ proteínas em partículas bacteriofágicas através de ligações dissulfureto
US6238904B1 (en) * 1999-09-23 2001-05-29 New England Biolabs, Inc. Type II restriction endonuclease, HpyCH4III, obtainable from Helicobacter pylori CH4 and a process for producing the same
US8288322B2 (en) 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
WO2001079481A2 (en) 2000-04-17 2001-10-25 Dyax Corp. Methods of constructing display libraries of genetic packages for members of a diverse family of peptides
US20050158838A1 (en) 2000-06-19 2005-07-21 Dyax Corp., A Delaware Corporation Novel enterokinase cleavage sequences
EP1360288B1 (en) 2000-12-18 2011-02-16 Dyax Corp. Focused libraries of genetic packages
DE10230997A1 (de) 2001-10-26 2003-07-17 Ribopharma Ag Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels

Also Published As

Publication number Publication date
JP5956413B2 (ja) 2016-07-27
EP2308982A1 (en) 2011-04-13
ES2531551T3 (es) 2015-03-17
US9382535B2 (en) 2016-07-05
JP5599745B2 (ja) 2014-10-01
JP2014064586A (ja) 2014-04-17
US20060166252A1 (en) 2006-07-27
EP2199393A1 (en) 2010-06-23
HK1145515A1 (en) 2011-04-21
CA2798625A1 (en) 2001-10-25
CA2406236A1 (en) 2001-10-25
WO2001079481A3 (en) 2002-07-04
EP1276855A2 (en) 2003-01-22
EP1276855B1 (en) 2012-10-24
AU2007211861B2 (en) 2009-06-11
JP2003530853A (ja) 2003-10-21
ES2400302T3 (es) 2013-04-09
US20040029113A1 (en) 2004-02-12
EP2295580A1 (en) 2011-03-16
CA2798625C (en) 2017-01-24
DK1276855T3 (da) 2012-11-26
WO2001079481A8 (en) 2002-12-19
EP2199393B1 (en) 2012-10-31
PT2308982E (pt) 2015-03-04
ES2393535T3 (es) 2012-12-26
HK1156656A1 (en) 2012-06-15
JP2011135893A (ja) 2011-07-14
CA2406236C (en) 2013-02-19
AU2001253589B2 (en) 2007-08-16
DK2308982T3 (da) 2015-03-02
JP5149476B2 (ja) 2013-02-20
WO2001079481A2 (en) 2001-10-25
EP2308982B1 (en) 2014-11-26
DK2199393T3 (da) 2012-11-26
AU5358901A (en) 2001-10-30
AU2007211861A1 (en) 2007-09-06

Similar Documents

Publication Publication Date Title
ES2400302T8 (es) Nuevos métodos para construir bibliotecas de paquetes genéticos que presentan de forma colectiva los miembros de una familia diversa de péptidos, polipéptidos o proteínas
NO20030418D0 (no) Nytt farmasöytisk preparat
DK1527035T3 (da) Kontinuerlig fremgangsmåde til alkyleringen af carbonhydrider
NO20032736D0 (no) Pyrazolforbindelser nyttige som proteinkinaseinhibitorer
NO20031190D0 (no) Pyrazolforbindelser nyttige som proteinkinaseinhibitorer
NO20030139D0 (no) Farmasöytiske preparater inneholdende DDS forbindelser
DK1214097T3 (da) Nukleinsyrer kodende for polyepitop-polypeptider
DK1534511T3 (da) Emballage til præfabrikerede fibercementprodukter
DE50100076D1 (de) Kartuschenkolben
DE50302914D1 (de) Polymerisierbare mischungen
DE60206867D1 (de) Wiederverwendbares Raumtransportsystem
IS7153A (is) Aðferð til framleiðslu á 14-hýdroxýnormorfínon afleiðu
NO20031647D0 (no) Blandinger omfattende modafinilforbindelser
NO20025168D0 (no) DNA som koder for et nytt PROST 03 polypeptid
DE60225517D1 (de) Strukturmaterial für stopfbüchsenpackung
FI20002262A (fi) Menetelmä proteiinin rakenteen muuttamiseksi
NO20022542D0 (no) DNA som koder for et nytt PROST-Ets-polypeptid
NO20016074D0 (no) Armeringsstang for forsterkning av materialer
NO20020618D0 (no) Armeringsstang for forsterkning av materialer
ITMI20000334A0 (it) Procedimento di preparazione di miscele cementizie
UA5950S (uk) Пакувальний матеріал для будівельної суміші
ES1046585Y (es) Molde para fabricacion de vigas de hormigon armado.
PT9664T (pt) Suportes para produtos aromaticos
FR2831887B1 (fr) Coculture nerf-muscle contractile transportable
UA4470S (uk) Упаковка для ліків