ES2393144T3 - Uso de riboflavina en el tratamiento de la hipertensión - Google Patents
Uso de riboflavina en el tratamiento de la hipertensión Download PDFInfo
- Publication number
- ES2393144T3 ES2393144T3 ES08715988T ES08715988T ES2393144T3 ES 2393144 T3 ES2393144 T3 ES 2393144T3 ES 08715988 T ES08715988 T ES 08715988T ES 08715988 T ES08715988 T ES 08715988T ES 2393144 T3 ES2393144 T3 ES 2393144T3
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- Prior art keywords
- riboflavin
- blood pressure
- mthfr
- product
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000002151 riboflavin Substances 0.000 title claims abstract description 68
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- 238000000546 chi-square test Methods 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000010219 correlation analysis Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000002825 functional assay Methods 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001631 hypertensive effect Effects 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 description 1
- 235000007635 levomefolic acid Nutrition 0.000 description 1
- 239000011578 levomefolic acid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000010197 meta-analysis Methods 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000035772 mutation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003287 riboflavins Chemical class 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
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- 208000019553 vascular disease Diseases 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0703514.0A GB0703514D0 (en) | 2007-02-23 | 2007-02-23 | Use of riboflavin |
| GB0703514 | 2007-02-23 | ||
| PCT/EP2008/001437 WO2008101724A1 (en) | 2007-02-23 | 2008-02-22 | Use of riboflavin in the treatment of hypertension |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2393144T3 true ES2393144T3 (es) | 2012-12-18 |
Family
ID=37945596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08715988T Active ES2393144T3 (es) | 2007-02-23 | 2008-02-22 | Uso de riboflavina en el tratamiento de la hipertensión |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100324019A1 (enExample) |
| EP (1) | EP2139488B1 (enExample) |
| JP (1) | JP5577100B2 (enExample) |
| CN (1) | CN101678030B (enExample) |
| CA (1) | CA2679217C (enExample) |
| EA (1) | EA019281B1 (enExample) |
| ES (1) | ES2393144T3 (enExample) |
| GB (1) | GB0703514D0 (enExample) |
| MX (1) | MX2009009020A (enExample) |
| WO (1) | WO2008101724A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104737023B (zh) * | 2012-08-16 | 2017-07-28 | 重症监护诊断股份有限公司 | 预测患高血压风险的方法 |
| CN103721259A (zh) * | 2014-01-07 | 2014-04-16 | 深圳奥萨医药有限公司 | 血管紧张素ⅱ受体阻断剂/噻嗪类利尿剂/5-甲基四氢叶酸药物组合物 |
| CN109295216A (zh) * | 2018-11-06 | 2019-02-01 | 宁波艾捷康宁生物科技有限公司 | 预测高血压个体化药物药效的snp位点和检测试剂盒 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4264601A (en) * | 1979-06-12 | 1981-04-28 | The Board Of Regents Of The University Of Oklahoma | Antihypertensive agents and their use in treatment of hypertension |
| DE3682208D1 (de) * | 1986-12-18 | 1991-11-28 | Kurt Heinz Bauer | Gegenueber lichteinfluss stabilisiertes nifedipin-konzentrat und verfahren zu seiner herstellung. |
| US6485959B1 (en) * | 1998-10-07 | 2002-11-26 | Cedars Sinai Medical Center | Cell preconditioning and cryopresevation medium |
| CN1136895C (zh) * | 2001-05-24 | 2004-02-04 | 魏振鸣 | 一种治疗冠心病的药物 |
| WO2006085128A1 (en) * | 2005-02-09 | 2006-08-17 | Wockhardt Limited | Cardiovascular therapeutic combinations |
| US7838526B2 (en) * | 2005-08-05 | 2010-11-23 | Esther Baldinger | Method of treating neurological disorders |
-
2007
- 2007-02-23 GB GBGB0703514.0A patent/GB0703514D0/en not_active Ceased
-
2008
- 2008-02-22 EA EA200901145A patent/EA019281B1/ru not_active IP Right Cessation
- 2008-02-22 EP EP08715988A patent/EP2139488B1/en not_active Not-in-force
- 2008-02-22 WO PCT/EP2008/001437 patent/WO2008101724A1/en not_active Ceased
- 2008-02-22 MX MX2009009020A patent/MX2009009020A/es active IP Right Grant
- 2008-02-22 CA CA2679217A patent/CA2679217C/en active Active
- 2008-02-22 CN CN2008800135209A patent/CN101678030B/zh not_active Expired - Fee Related
- 2008-02-22 JP JP2009550246A patent/JP5577100B2/ja not_active Expired - Fee Related
- 2008-02-22 US US12/528,105 patent/US20100324019A1/en not_active Abandoned
- 2008-02-22 ES ES08715988T patent/ES2393144T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20100324019A1 (en) | 2010-12-23 |
| CA2679217A1 (en) | 2008-08-28 |
| EP2139488A1 (en) | 2010-01-06 |
| EA019281B1 (ru) | 2014-02-28 |
| GB0703514D0 (en) | 2007-04-04 |
| CN101678030B (zh) | 2013-06-05 |
| EP2139488B1 (en) | 2012-08-15 |
| CN101678030A (zh) | 2010-03-24 |
| WO2008101724A1 (en) | 2008-08-28 |
| EA200901145A1 (ru) | 2010-02-26 |
| JP2010519235A (ja) | 2010-06-03 |
| WO2008101724A8 (en) | 2009-10-08 |
| MX2009009020A (es) | 2010-02-17 |
| CA2679217C (en) | 2016-05-17 |
| JP5577100B2 (ja) | 2014-08-20 |
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