CN101678030B - 核黄素在治疗高血压中的用途 - Google Patents

核黄素在治疗高血压中的用途 Download PDF

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Publication number
CN101678030B
CN101678030B CN2008800135209A CN200880013520A CN101678030B CN 101678030 B CN101678030 B CN 101678030B CN 2008800135209 A CN2008800135209 A CN 2008800135209A CN 200880013520 A CN200880013520 A CN 200880013520A CN 101678030 B CN101678030 B CN 101678030B
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CN
China
Prior art keywords
riboflavin
patient
mthfr
value
genotype
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2008800135209A
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English (en)
Chinese (zh)
Other versions
CN101678030A (zh
Inventor
玛丽·沃德
海伦妮·麦克纳尔蒂
杰拉尔丁·霍里根
肖恩·斯特兰
约翰·斯科特
约翰·珀维斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ulster University
College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
Original Assignee
Ulster University
College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin
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Application filed by Ulster University, College of the Holy and Undivided Trinity of Queen Elizabeth near Dublin filed Critical Ulster University
Publication of CN101678030A publication Critical patent/CN101678030A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008800135209A 2007-02-23 2008-02-22 核黄素在治疗高血压中的用途 Expired - Fee Related CN101678030B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0703514.0A GB0703514D0 (en) 2007-02-23 2007-02-23 Use of riboflavin
GB0703514.0 2007-02-23
PCT/EP2008/001437 WO2008101724A1 (en) 2007-02-23 2008-02-22 Use of riboflavin in the treatment of hypertension

Publications (2)

Publication Number Publication Date
CN101678030A CN101678030A (zh) 2010-03-24
CN101678030B true CN101678030B (zh) 2013-06-05

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ID=37945596

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CN2008800135209A Expired - Fee Related CN101678030B (zh) 2007-02-23 2008-02-22 核黄素在治疗高血压中的用途

Country Status (10)

Country Link
US (1) US20100324019A1 (enExample)
EP (1) EP2139488B1 (enExample)
JP (1) JP5577100B2 (enExample)
CN (1) CN101678030B (enExample)
CA (1) CA2679217C (enExample)
EA (1) EA019281B1 (enExample)
ES (1) ES2393144T3 (enExample)
GB (1) GB0703514D0 (enExample)
MX (1) MX2009009020A (enExample)
WO (1) WO2008101724A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104737023B (zh) * 2012-08-16 2017-07-28 重症监护诊断股份有限公司 预测患高血压风险的方法
CN103721259A (zh) * 2014-01-07 2014-04-16 深圳奥萨医药有限公司 血管紧张素ⅱ受体阻断剂/噻嗪类利尿剂/5-甲基四氢叶酸药物组合物
CN109295216A (zh) * 2018-11-06 2019-02-01 宁波艾捷康宁生物科技有限公司 预测高血压个体化药物药效的snp位点和检测试剂盒

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325725A (zh) * 2001-05-24 2001-12-12 魏振鸣 一种治疗冠心病的药物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4264601A (en) * 1979-06-12 1981-04-28 The Board Of Regents Of The University Of Oklahoma Antihypertensive agents and their use in treatment of hypertension
DE3682208D1 (de) * 1986-12-18 1991-11-28 Kurt Heinz Bauer Gegenueber lichteinfluss stabilisiertes nifedipin-konzentrat und verfahren zu seiner herstellung.
US6485959B1 (en) * 1998-10-07 2002-11-26 Cedars Sinai Medical Center Cell preconditioning and cryopresevation medium
WO2006085128A1 (en) * 2005-02-09 2006-08-17 Wockhardt Limited Cardiovascular therapeutic combinations
US7838526B2 (en) * 2005-08-05 2010-11-23 Esther Baldinger Method of treating neurological disorders

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325725A (zh) * 2001-05-24 2001-12-12 魏振鸣 一种治疗冠心病的药物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
左保华.核黄素对高血压患者有关病理因素的影响.《皖南医学院学报》.1998,第17卷(第2期),109-111. *

Also Published As

Publication number Publication date
US20100324019A1 (en) 2010-12-23
CA2679217A1 (en) 2008-08-28
EP2139488A1 (en) 2010-01-06
EA019281B1 (ru) 2014-02-28
GB0703514D0 (en) 2007-04-04
EP2139488B1 (en) 2012-08-15
CN101678030A (zh) 2010-03-24
WO2008101724A1 (en) 2008-08-28
EA200901145A1 (ru) 2010-02-26
JP2010519235A (ja) 2010-06-03
WO2008101724A8 (en) 2009-10-08
MX2009009020A (es) 2010-02-17
CA2679217C (en) 2016-05-17
JP5577100B2 (ja) 2014-08-20
ES2393144T3 (es) 2012-12-18

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Address after: British Londonderry

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Address before: British Londonderry

Applicant before: University OF ULSTER

Applicant before: WESTERN HEALTH AND SOCIAL CARE

Applicant before: THE PROVOST FELLOWS AND SCHOLARS OF THE College OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

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CF01 Termination of patent right due to non-payment of annual fee