EA019281B1 - Применение рибофлавина в лечении гипертензии - Google Patents
Применение рибофлавина в лечении гипертензии Download PDFInfo
- Publication number
- EA019281B1 EA019281B1 EA200901145A EA200901145A EA019281B1 EA 019281 B1 EA019281 B1 EA 019281B1 EA 200901145 A EA200901145 A EA 200901145A EA 200901145 A EA200901145 A EA 200901145A EA 019281 B1 EA019281 B1 EA 019281B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- riboflavin
- blood pressure
- patient
- polymorphism
- treatment
- Prior art date
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- SGZAIDDFHDDFJU-UHFFFAOYSA-N candesartan Chemical compound CCOC1=NC2=CC=CC(C(O)=O)=C2N1CC(C=C1)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SGZAIDDFHDDFJU-UHFFFAOYSA-N 0.000 description 1
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- 239000008121 dextrose Substances 0.000 description 1
- 235000020930 dietary requirements Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
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- 238000000605 extraction Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000003205 genotyping method Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
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- 238000001361 intraarterial administration Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 235000007635 levomefolic acid Nutrition 0.000 description 1
- 239000011578 levomefolic acid Substances 0.000 description 1
- ZNOVTXRBGFNYRX-ABLWVSNPSA-N levomefolic acid Chemical compound C1NC=2NC(N)=NC(=O)C=2N(C)C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 ZNOVTXRBGFNYRX-ABLWVSNPSA-N 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
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- 229930182817 methionine Natural products 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 229960000619 nebivolol Drugs 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940097258 other antihypertensives in atc Drugs 0.000 description 1
- 238000007427 paired t-test Methods 0.000 description 1
- 239000006201 parenteral dosage form Substances 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960001085 piretanide Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 239000002901 radioactive waste Substances 0.000 description 1
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0703514.0A GB0703514D0 (en) | 2007-02-23 | 2007-02-23 | Use of riboflavin |
| PCT/EP2008/001437 WO2008101724A1 (en) | 2007-02-23 | 2008-02-22 | Use of riboflavin in the treatment of hypertension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200901145A1 EA200901145A1 (ru) | 2010-02-26 |
| EA019281B1 true EA019281B1 (ru) | 2014-02-28 |
Family
ID=37945596
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200901145A EA019281B1 (ru) | 2007-02-23 | 2008-02-22 | Применение рибофлавина в лечении гипертензии |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100324019A1 (enExample) |
| EP (1) | EP2139488B1 (enExample) |
| JP (1) | JP5577100B2 (enExample) |
| CN (1) | CN101678030B (enExample) |
| CA (1) | CA2679217C (enExample) |
| EA (1) | EA019281B1 (enExample) |
| ES (1) | ES2393144T3 (enExample) |
| GB (1) | GB0703514D0 (enExample) |
| MX (1) | MX2009009020A (enExample) |
| WO (1) | WO2008101724A1 (enExample) |
Families Citing this family (3)
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|---|---|---|---|---|
| CN104737023B (zh) * | 2012-08-16 | 2017-07-28 | 重症监护诊断股份有限公司 | 预测患高血压风险的方法 |
| CN103721259A (zh) * | 2014-01-07 | 2014-04-16 | 深圳奥萨医药有限公司 | 血管紧张素ⅱ受体阻断剂/噻嗪类利尿剂/5-甲基四氢叶酸药物组合物 |
| CN109295216A (zh) * | 2018-11-06 | 2019-02-01 | 宁波艾捷康宁生物科技有限公司 | 预测高血压个体化药物药效的snp位点和检测试剂盒 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002799A1 (en) * | 1979-06-12 | 1980-12-24 | D Trachewsky | Antihypertensive agents and their use in treatment of hypertension |
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| DE3682208D1 (de) * | 1986-12-18 | 1991-11-28 | Kurt Heinz Bauer | Gegenueber lichteinfluss stabilisiertes nifedipin-konzentrat und verfahren zu seiner herstellung. |
| US6485959B1 (en) * | 1998-10-07 | 2002-11-26 | Cedars Sinai Medical Center | Cell preconditioning and cryopresevation medium |
| CN1136895C (zh) * | 2001-05-24 | 2004-02-04 | 魏振鸣 | 一种治疗冠心病的药物 |
| WO2006085128A1 (en) * | 2005-02-09 | 2006-08-17 | Wockhardt Limited | Cardiovascular therapeutic combinations |
| US7838526B2 (en) * | 2005-08-05 | 2010-11-23 | Esther Baldinger | Method of treating neurological disorders |
-
2007
- 2007-02-23 GB GBGB0703514.0A patent/GB0703514D0/en not_active Ceased
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2008
- 2008-02-22 EA EA200901145A patent/EA019281B1/ru not_active IP Right Cessation
- 2008-02-22 EP EP08715988A patent/EP2139488B1/en not_active Not-in-force
- 2008-02-22 WO PCT/EP2008/001437 patent/WO2008101724A1/en not_active Ceased
- 2008-02-22 MX MX2009009020A patent/MX2009009020A/es active IP Right Grant
- 2008-02-22 CA CA2679217A patent/CA2679217C/en active Active
- 2008-02-22 CN CN2008800135209A patent/CN101678030B/zh not_active Expired - Fee Related
- 2008-02-22 JP JP2009550246A patent/JP5577100B2/ja not_active Expired - Fee Related
- 2008-02-22 US US12/528,105 patent/US20100324019A1/en not_active Abandoned
- 2008-02-22 ES ES08715988T patent/ES2393144T3/es active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002799A1 (en) * | 1979-06-12 | 1980-12-24 | D Trachewsky | Antihypertensive agents and their use in treatment of hypertension |
Non-Patent Citations (5)
| Title |
|---|
| FROSST P. ET AL.: "A CANDIDATE GENETIC RISK FACTOR FOR VASCULAR DISEASE: A COMMON MUTATION IN METHYLENETETRAHYDROFOLATE REDUCTASE", NATURE GENETICS, NEW YORK, NY, US, vol. 10, no. 1, May 1995 (1995-05), pages 111-113, XP000198175, ISSN: 1061-4036, cited in the application, the whole document * |
| HUSTAD STEINAR ET AL.: "Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism", CLINICAL CHEMISTRY, vol. 46, no. 8, Part 1, August 2000 (2000-08), pages 1065-1071, XP002475249, ISSN: 0009-9147, the whole document * |
| MCNULTY HELENE ET AL.: "Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism", CIRCULATION, AMERICAN HEART ASSOCIATION, DALLAS, TX, US, vol. 113, no. 1, 3 January 2006 (2006-01-03), pages 74-80, XP009098142, ISSN: 0009-7322, the whole document * |
| MUDA PIIBE ET AL.: "Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients", JOURNAL OF HYPERTENSION, vol. 21, no. 12, December 2003 (2003-12), pages 2329-2333, XP009098148, ISSN: 0263-6352, the whole document * |
| UELAND P.M. ET AL.: "Biological and clinical implications of the MTHFR C677T polymorphism", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER, HAYWARTH, GB, vol. 22, no. 4, 1 April 2001 (2001-04-01), pages 195-201, XP004231954, ISSN: 0165-6147, the whole document * |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100324019A1 (en) | 2010-12-23 |
| CA2679217A1 (en) | 2008-08-28 |
| EP2139488A1 (en) | 2010-01-06 |
| GB0703514D0 (en) | 2007-04-04 |
| CN101678030B (zh) | 2013-06-05 |
| EP2139488B1 (en) | 2012-08-15 |
| CN101678030A (zh) | 2010-03-24 |
| WO2008101724A1 (en) | 2008-08-28 |
| EA200901145A1 (ru) | 2010-02-26 |
| JP2010519235A (ja) | 2010-06-03 |
| WO2008101724A8 (en) | 2009-10-08 |
| MX2009009020A (es) | 2010-02-17 |
| CA2679217C (en) | 2016-05-17 |
| JP5577100B2 (ja) | 2014-08-20 |
| ES2393144T3 (es) | 2012-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |