ES2387910T3 - Catequinas para el tratamiento de la fibrilogénesis en la enfermedad de Alzheimer, la enfermedad de Parkinson, la amiloidosis sistémica AA y otros trastornos amiloides - Google Patents

Catequinas para el tratamiento de la fibrilogénesis en la enfermedad de Alzheimer, la enfermedad de Parkinson, la amiloidosis sistémica AA y otros trastornos amiloides Download PDF

Info

Publication number
ES2387910T3
ES2387910T3 ES02721413T ES02721413T ES2387910T3 ES 2387910 T3 ES2387910 T3 ES 2387910T3 ES 02721413 T ES02721413 T ES 02721413T ES 02721413 T ES02721413 T ES 02721413T ES 2387910 T3 ES2387910 T3 ES 2387910T3
Authority
ES
Spain
Prior art keywords
amyloid
disease
green tea
catechin
epicatechin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES02721413T
Other languages
English (en)
Spanish (es)
Inventor
Gerardo M. Castillo
Paula Y. Choi
Joel A. Cummings
Beth P. Nguyen
Alan D. Snow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ProteoTech Inc
Original Assignee
ProteoTech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ProteoTech Inc filed Critical ProteoTech Inc
Application granted granted Critical
Publication of ES2387910T3 publication Critical patent/ES2387910T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pyrane Compounds (AREA)
ES02721413T 2001-03-15 2002-03-15 Catequinas para el tratamiento de la fibrilogénesis en la enfermedad de Alzheimer, la enfermedad de Parkinson, la amiloidosis sistémica AA y otros trastornos amiloides Expired - Lifetime ES2387910T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US27686601P 2001-03-15 2001-03-15
US276866P 2001-03-15
US33896901P 2001-12-10 2001-12-10
US338969P 2001-12-10
PCT/US2002/007755 WO2003013442A2 (en) 2001-03-15 2002-03-15 Catechins for the treatment of fibrillogenesis in alzheimer's disease, parkinson's disease, systemic aa amyloidosis, and other amyloid disorders

Publications (1)

Publication Number Publication Date
ES2387910T3 true ES2387910T3 (es) 2012-10-03

Family

ID=26958170

Family Applications (1)

Application Number Title Priority Date Filing Date
ES02721413T Expired - Lifetime ES2387910T3 (es) 2001-03-15 2002-03-15 Catequinas para el tratamiento de la fibrilogénesis en la enfermedad de Alzheimer, la enfermedad de Parkinson, la amiloidosis sistémica AA y otros trastornos amiloides

Country Status (9)

Country Link
EP (1) EP1372682B1 (enExample)
JP (1) JP2004537576A (enExample)
AT (1) ATE555807T1 (enExample)
CA (1) CA2440293C (enExample)
DK (1) DK1372682T3 (enExample)
ES (1) ES2387910T3 (enExample)
NZ (1) NZ528321A (enExample)
PT (1) PT1372682E (enExample)
WO (1) WO2003013442A2 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7514107B2 (en) 2002-03-21 2009-04-07 Mars, Incorporated Treatment of diseases involving defective gap junctional communication
US7491699B2 (en) 2002-12-09 2009-02-17 Ramot At Tel Aviv University Ltd. Peptide nanostructures and methods of generating and using the same
WO2004060791A1 (en) 2003-01-07 2004-07-22 Ramot At Tel Aviv University Ltd. Peptide nanostructures encapsulating a foreign material and method of manufacturing same
EP1663199B1 (en) * 2003-09-25 2013-04-03 Tel Aviv University Future Technology Development L.P. Compositions and methods using same for treating amyloid-associated diseases
WO2005031362A2 (en) 2003-10-02 2005-04-07 Ramot At Tel Aviv University Ltd. Novel antibacterial agents and methods of identifying and utilizing same
EP1713457A2 (de) * 2004-02-11 2006-10-25 Max-Delbrück-Centrum Für Molekulare Medizin Neue arzneimittel und diagnostische zusammensetzungen f r be handlung und diagnose von neurodegenerativen erkrankungen und amyloid-krankheiten
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
US20100040558A1 (en) * 2005-04-26 2010-02-18 University Of South Florida Green tea polyphenol alpha secretase enhancers and methods of use
JP2007022946A (ja) * 2005-07-14 2007-02-01 Mitsui Norin Co Ltd マクロファージ遊走阻止因子の酵素活性阻害剤
US10004828B2 (en) 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
GB2463833B (en) * 2007-06-26 2012-02-08 Parkinson S Inst Compositions that prevent or reverse alpha-synuclein fibrillation for use in the treatment of neurological disorders
JP5738755B2 (ja) * 2008-05-09 2015-06-24 アイカーン スクール オブ メディシン アット マウント シナイ 神経変性疾患を予防および治療するための方法
JP6068484B2 (ja) 2011-10-24 2017-01-25 ソム、イノベーション、バイオテック、ソシエダッド、リミターダＳｏｍ Ｉｎｎｏｖａｔｉｏｎ Ｂｉｏｔｅｃｈ， Ｓ．Ｌ． トランスサイレチン関連アミロイドーシスの新規療法
US20180271927A1 (en) * 2015-05-27 2018-09-27 Nippon Paper Industries Co., Ltd. Brain function-protecting agent
KR102441381B1 (ko) * 2016-07-18 2022-09-07 (주)아모레퍼시픽 3-O-갈로일-3,3',5,5',7-펜타하이드록시플라반(3-O-galloyl-3,3',5,5',7- pentahydroxyflavan)을 포함하는 인지 기능 개선용 조성물
JPWO2019054461A1 (ja) * 2017-09-15 2020-08-27 株式会社明治 神経機能の維持または回復用組成物
CN109799352B (zh) * 2019-01-29 2022-03-08 北京健坤禾润科技有限公司 化学发光试剂及其在免疫检测中应用
JP2025513275A (ja) * 2022-04-20 2025-04-24 サンテック メディカル，インコーポレイティド 中枢神経系疾患の治療方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1275905B1 (it) * 1995-03-14 1997-10-24 Indena Spa Frazioni polifenoliche di te', loro uso e formulazioni che le contengono
JPH10245342A (ja) * 1997-03-03 1998-09-14 Mitsui Norin Kk β−アミロイド蛋白の神経細胞毒性低減剤
WO1998051302A1 (en) * 1997-05-15 1998-11-19 University Of Washington Composition and methods for treating alzheimer's disease and other amyloidoses
US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
EP1246632A4 (en) * 1999-12-30 2004-08-18 Proteotech Inc CATECHINE AND GREEN TEA EXTRACT FOR TREATING AMYLOIDOSES IN GENERAL OR. AT ALZHEIMER

Also Published As

Publication number Publication date
NZ528321A (en) 2006-09-29
WO2003013442A2 (en) 2003-02-20
JP2004537576A (ja) 2004-12-16
ATE555807T1 (de) 2012-05-15
EP1372682B1 (en) 2012-05-02
CA2440293C (en) 2012-01-24
DK1372682T3 (da) 2012-08-20
EP1372682A2 (en) 2004-01-02
WO2003013442A3 (en) 2003-05-30
EP1372682A4 (en) 2005-10-19
CA2440293A1 (en) 2003-02-20
PT1372682E (pt) 2012-08-03

Similar Documents

Publication Publication Date Title
Han et al. Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy
US20120252886A1 (en) Catechins for the treatment of amyloidosis
Yan et al. The protective effect and its mechanism of 3-n-butylphthalide pretreatment on cerebral ischemia reperfusion injury in rats.
Edrees et al. Curcumin alleviates colistin-induced nephrotoxicity and neurotoxicity in rats via attenuation of oxidative stress, inflammation and apoptosis
Zhao et al. Malvidin alleviates mitochondrial dysfunction and ROS accumulation through activating AMPK-α/UCP2 axis, thereby resisting inflammation and apoptosis in SAE mice
Yao et al. Quercetin attenuates cell apoptosis in focal cerebral ischemia rat brain via activation of BDNF–TrkB–PI3K/Akt signaling pathway
Peng et al. Gastrodin alleviates cerebral ischemic damage in mice by improving anti-oxidant and anti-inflammation activities and inhibiting apoptosis pathway
Chen et al. Tea polyphenols alleviate motor impairments, dopaminergic neuronal injury, and cerebral α-synuclein aggregation in MPTP-intoxicated parkinsonian monkeys
Wang et al. α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation
ES2295078T3 (es) Compuestos aromaticos polihidroxilados para el tratamiento de amiloidosis y enefermedades fibrilares de alfasinucleina.
Wagner et al. Comparative study of quercetin and its two glycoside derivatives quercitrin and rutin against methylmercury (MeHg)-induced ROS production in rat brain slices
ES2285772T3 (es) Composicion y metodos para tratar la enfermedad de alzheimer y otras amiloidosis.
EP1372682B1 (en) Catechins for the treatment of fibrillogenesis in alzheimer's disease, parkinson's disease, systemic aa amyloidosis, and other amyloid disorders
Zhang et al. Protective effects of low molecular weight chondroitin sulfate on amyloid beta (Aβ)-induced damage in vitro and in vivo
Baluchnejadmojarad et al. Troxerutin exerts neuroprotection in 6-hydroxydopamine lesion rat model of Parkinson’s disease: Possible involvement of PI3K/ERβ signaling
Rasool et al. Oxidative stress and dopaminergic metabolism: a major PD pathogenic mechanism and basis of potential antioxidant therapies
Qiao et al. Herbacetin induces apoptosis in HepG2 cells: Involvements of ROS and PI3K/Akt pathway
Kim et al. Kaempferol stimulation of autophagy regulates the ferroptosis under the oxidative stress as mediated with AMP-activated protein kinase
Liu et al. Mailuoning oral liquid attenuates convalescent cerebral ischemia by inhibiting AMPK/mTOR-associated apoptosis and promoting CREB/BDNF-mediated neuroprotection
D’Amico et al. Açai berry mitigates Parkinson’s disease progression showing dopaminergic neuroprotection via nrf2-HO1 pathways
Li et al. Neuroprotective effects of genistein-3′-sodium sulfonate on focal cerebral ischemia in rats
Kim et al. Acer okamotoanum and isoquercitrin improve cognitive function via attenuation of oxidative stress in high fat diet-and amyloid beta-induced mice
Zhou et al. Orally administrated pterostilbene attenuates acute cerebral ischemia–reperfusion injury in a dose-and time-dependent manner in mice
Afewerky et al. Sodium–calcium exchanger isoform-3 targeted Withania somnifera (L.) Dunal therapeutic intervention ameliorates cognition in the 5xFAD mouse model of Alzheimer’s disease
Lee et al. 4-O-methylhonokiol attenuated β-amyloid-induced memory impairment through reduction of oxidative damages via inactivation of p38 MAP kinase