ES2378242T3 - Hexapéptidos antimicrobianos - Google Patents

Hexapéptidos antimicrobianos Download PDF

Info

Publication number
ES2378242T3
ES2378242T3 ES06720369T ES06720369T ES2378242T3 ES 2378242 T3 ES2378242 T3 ES 2378242T3 ES 06720369 T ES06720369 T ES 06720369T ES 06720369 T ES06720369 T ES 06720369T ES 2378242 T3 ES2378242 T3 ES 2378242T3
Authority
ES
Spain
Prior art keywords
seq
hexapeptide
peptide
synthetic
hexapeptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES06720369T
Other languages
English (en)
Spanish (es)
Inventor
Timothy J. Falla
Lijuan Zhang
Scott M. Harris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Helix Biomedix Inc
Original Assignee
Helix Biomedix Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helix Biomedix Inc filed Critical Helix Biomedix Inc
Application granted granted Critical
Publication of ES2378242T3 publication Critical patent/ES2378242T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Birds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ES06720369T 2005-02-09 2006-02-07 Hexapéptidos antimicrobianos Expired - Lifetime ES2378242T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65127005P 2005-02-09 2005-02-09
US651270P 2005-02-09
PCT/US2006/004147 WO2006086321A2 (en) 2005-02-09 2006-02-07 Antimicrobial hexapeptides

Publications (1)

Publication Number Publication Date
ES2378242T3 true ES2378242T3 (es) 2012-04-10

Family

ID=36793611

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06720369T Expired - Lifetime ES2378242T3 (es) 2005-02-09 2006-02-07 Hexapéptidos antimicrobianos

Country Status (13)

Country Link
US (1) US7407940B2 (https=)
EP (1) EP1853620B1 (https=)
JP (1) JP5335241B2 (https=)
KR (1) KR101306643B1 (https=)
CN (1) CN101155825B (https=)
AT (1) ATE540969T1 (https=)
AU (1) AU2006212922B2 (https=)
CA (1) CA2597191C (https=)
DK (1) DK1853620T3 (https=)
ES (1) ES2378242T3 (https=)
PL (1) PL1853620T3 (https=)
SI (1) SI1853620T1 (https=)
WO (1) WO2006086321A2 (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070207112A1 (en) * 2005-12-07 2007-09-06 Grant Industries, Inc. Anti-acne composition
IL172896A0 (en) * 2005-12-29 2006-06-11 Yeda Res & Dev Cxcr4 inhibition
CA2822302A1 (en) 2006-02-13 2007-08-23 Alethia Biotherapeutics Inc. Methods of impairing osteoclast differentiation
US8168181B2 (en) * 2006-02-13 2012-05-01 Alethia Biotherapeutics, Inc. Methods of impairing osteoclast differentiation using antibodies that bind siglec-15
MX2009005000A (es) 2006-11-10 2009-10-12 Cara Therapeutics Inc Amidas de peptidos sinteticos.
US8236766B2 (en) * 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7842662B2 (en) * 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
US7713937B2 (en) * 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
WO2008140834A2 (en) * 2007-01-16 2008-11-20 The Regents Of The University Of California Novel antimicrobial peptides
KR100879221B1 (ko) 2007-11-12 2009-01-19 아주대학교산학협력단 식물병원성 세균에 대한 항미생물 펩티드 krs22
KR100879220B1 (ko) 2007-11-12 2009-01-19 아주대학교산학협력단 식물병원성 세균에 대한 항미생물 펩티드 kcm21
GB0724951D0 (en) 2007-12-20 2008-01-30 Lytix Biopharma As Compounds
WO2009146885A2 (en) * 2008-06-02 2009-12-10 Spiderbiotech S.R.L. Lipidated antibacterial peptides
GB0818072D0 (en) 2008-10-02 2008-11-05 Lytix Biopharma As Compounds
GB0818074D0 (en) * 2008-10-02 2008-11-05 Lytix Biopharma As Treatment of biofilms
GB0918579D0 (en) * 2009-10-22 2009-12-09 Imp Innovations Ltd Gadd45beta targeting agents
JP2013511554A (ja) * 2009-11-23 2013-04-04 パラティン テクノロジーズ,インコーポレイテッド メラノコルチン−1受容体特異的線状ペプチド
WO2013086003A1 (en) * 2011-12-05 2013-06-13 The Ohio State University Antimicrobial agent, bacterial strain, biosynthesis, and methods of use
EP2820150A1 (en) * 2012-03-01 2015-01-07 Novo Nordisk A/S N-terminally modified oligopeptides and uses thereof
US9493562B2 (en) 2012-07-19 2016-11-15 Alethia Biotherapeutics Inc. Anti-Siglec-15 antibodies
FR3002452B1 (fr) * 2013-02-28 2016-02-12 Dermaconcept Jmc Composition dermatologique antimicrobienne topique
TWI577697B (zh) * 2013-11-28 2017-04-11 國立清華大學 耐高鹽及抗蛋白之抗菌胜肽及其製造方法
KR102092831B1 (ko) 2015-01-16 2020-03-24 가부시키가이샤 만다무 클렌징 로션, 시트 화장료 및 미용 방법
US9738684B2 (en) 2015-06-29 2017-08-22 Council Of Scientific & Industrial Research N-terminally modified linear and branched polyamine conjugated peptidomimetics as antimicrobials agents
KR101855170B1 (ko) * 2015-11-18 2018-05-08 (주)노바셀테크놀로지 신규 항균 펩타이드 및 그의 용도
CN109942713A (zh) * 2018-12-28 2019-06-28 广州医科大学 新型抗菌肽及其应用
KR102170236B1 (ko) 2019-03-19 2020-10-29 (주)노바셀테크놀로지 신규 다중 기능성 펩타이드 및 그의 용도
US12329822B2 (en) 2019-05-06 2025-06-17 Université De Genve Antimicrobial tailored chitosan
CN115135665A (zh) * 2019-12-30 2022-09-30 俄亥俄州国家创新基金会 包含细胞穿透肽的环状蛋白
CN110950932B (zh) * 2020-01-09 2023-04-18 福州大学 一种修饰肽的制备及其应用
KR102220323B1 (ko) * 2020-05-15 2021-02-26 (주)노바셀테크놀로지 신규 다중 기능성 펩타이드 및 그의 용도
KR102429281B1 (ko) * 2020-05-25 2022-08-05 (주)노바셀테크놀로지 신규 안구건조증 치료용 약학적 조성물
KR102486996B1 (ko) * 2020-09-04 2023-01-10 서울대학교병원 펩타이드 및 이를 포함하는 피부 주름 개선용 조성물 및 대사성 질환 치료용 조성물
CN111925422B (zh) * 2020-09-17 2021-05-18 张雪山 抗菌肽及其在制备药物或化妆品中的应用
CN113248572B (zh) * 2021-04-30 2023-04-11 重庆理工大学 一种抗多重耐药菌环肽及其应用
CZ309857B6 (cs) * 2022-03-31 2023-12-20 Contipro A.S. Hexapeptid, kompozice zahrnující tento hexapeptid a jejich topické použití
CN116332777A (zh) * 2023-02-20 2023-06-27 华中科技大学 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用
CN116041422B (zh) * 2023-03-31 2023-06-16 四川大学 自组装抗菌肽及其组合物、药物载体、载药体系和用途
CN119390761B (zh) * 2024-10-24 2025-12-16 兰州大学 基于芳香基团诱导的自组装抗菌短肽及其应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4355104A (en) * 1980-06-17 1982-10-19 Kabigen Ab Bacteriolytic proteins
US4520016A (en) * 1980-06-17 1985-05-28 Kabigen Ab Bacteriolytic proteins
KR970006154B1 (ko) * 1987-07-06 1997-04-24 루이지아나 스테이트 유니버시티 아그리컬춰럴 앤드 메카니칼 컬리지 용해성 펩티드에 의한 진핵 병원체와 신생물의 억제 및 섬유아세포와 임파구의 자극
US5861478A (en) * 1987-07-06 1999-01-19 Helix Biomedix, Inc. Lytic peptides
CA1327311C (en) * 1987-07-06 1994-03-01 Jesse M. Jaynes Therapeutic antimicrobial polypeptides, their use and methods for preparation
DE69034085T2 (de) 1989-04-10 2004-05-27 Helix BioMedix, Inc., Bothell Lytsche und proliferative Peptide und deren Verwendung als Pharmaka und Phytopharmaka
CA2107674A1 (en) * 1991-04-08 1992-10-09 W. Lee Maloy Novel peptide compositions and uses therefor
US5561107A (en) * 1993-06-04 1996-10-01 Demeter Biotechnologies, Ltd. Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides
AU7050294A (en) * 1993-06-04 1995-01-03 Demeter Biotechnologies, Ltd. Method of treating pulmonary disease states with non-naturally occurring amphipathic peptides
US5955573A (en) * 1993-06-04 1999-09-21 Demegen, Inc. Ubiquitin-lytic peptide fusion gene constructs, protein products deriving therefrom, and methods of making and using same
AU1086595A (en) * 1993-11-08 1995-05-29 Demeter Biotechnologies, Ltd. Methylated lysine-rich lytic peptides and method of making same by reductive alkylation
AU693518B2 (en) * 1994-01-18 1998-07-02 Magainin Pharmaceuticals, Inc. Ion-channel forming amphiphilic peptides having n-terminal modifications
US5789542A (en) * 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
IL114697A0 (en) 1994-07-22 1995-11-27 Demeter Biotech Ltd Polypeptides comprising ubiquitin-lytic peptide fusion protein products deriving therefrom their preparation and use
WO1997004008A1 (en) * 1995-07-20 1997-02-06 Xoma Corporation Anti-fungal peptides
WO1997021728A1 (en) * 1995-12-12 1997-06-19 Karolinska Innovations Ab PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b)
US6566334B1 (en) * 1997-02-06 2003-05-20 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Short amphipathic peptides with activity against bacteria and intracellular pathogens
US6635740B1 (en) * 1997-03-27 2003-10-21 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Ligand/lytic peptide compositions and methods of use
AU2631501A (en) 2000-01-06 2001-07-16 Monsanto Technology Llc Preparation of deallergenized proteins and permuteins
IL153359A0 (en) * 2000-06-16 2003-07-06 Hercules Inc Peptides, compositions and methods for the treatment of burkholderia cepacia
JP2004535392A (ja) * 2001-05-04 2004-11-25 ザ スクリプス リサーチ インスティチュート 抗菌ペプチドおよび組成物

Also Published As

Publication number Publication date
JP2008537537A (ja) 2008-09-18
WO2006086321A2 (en) 2006-08-17
CN101155825A (zh) 2008-04-02
CA2597191A1 (en) 2006-08-17
WO2006086321A3 (en) 2007-02-22
US20060229252A1 (en) 2006-10-12
PL1853620T3 (pl) 2012-07-31
AU2006212922A1 (en) 2006-08-17
AU2006212922B2 (en) 2011-04-21
CA2597191C (en) 2014-04-01
CN101155825B (zh) 2014-11-26
KR101306643B1 (ko) 2013-09-12
KR20070107748A (ko) 2007-11-07
DK1853620T3 (da) 2012-03-26
EP1853620A2 (en) 2007-11-14
EP1853620B1 (en) 2012-01-11
JP5335241B2 (ja) 2013-11-06
US7407940B2 (en) 2008-08-05
ATE540969T1 (de) 2012-01-15
SI1853620T1 (sl) 2012-03-30

Similar Documents

Publication Publication Date Title
ES2378242T3 (es) Hexapéptidos antimicrobianos
Moretta et al. Antimicrobial peptides: A new hope in biomedical and pharmaceutical fields
Kosikowska et al. Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003–2015)
JP6964577B2 (ja) 抗菌性ペプチド及びその使用方法
ES2264198T3 (es) Composiciones y metodos para tratar infecciones utilizando peptidos cationicos a solas o en combinacion con antibioticos.
CA2441562C (en) Short bioactive peptides and methods for their use
KR101922409B1 (ko) 화합물들 및 그 용도
JP5474827B2 (ja) 皮膚、粘膜、頭皮または爪の処置、保護または洗浄において有用なペプチド誘導体
Casciaro et al. Promising approaches to optimize the biological properties of the antimicrobial peptide esculentin-1a (1–21) NH2: amino acids substitution and conjugation to nanoparticles
Sharma et al. Short antimicrobial peptides
WO2004110341A2 (en) Antimicrobial and anticancer lipopeptides
JP2008514586A (ja) 新規な抗菌剤
Wu et al. Advances in the study of structural modification and biological activities of anoplin
Lalani et al. Challenges in dermal delivery of therapeutic antimicrobial protein and peptides
Falanga et al. Emerging therapeutic agents on the basis of naturally occurring antimicrobial peptides
JPH06511234A (ja) C末端置換を有する生物活性ペプチド組成物および治療法
WO2006127715A1 (en) Antimicrobial peptides
Adak et al. Effect of chirality and amphiphilicity on the antimicrobial activity of tripodal lysine-based peptides
US20050209157A1 (en) Short bioactive peptides and methods for their use
US20240254175A1 (en) Novel selective antimicrobial fusion peptides
Prusty Peptides and polypeptides
Gomes Piling-Peptide-Based Ionic Liquids Towards Healing of Complicated Skin Infections
Vogel et al. Antimicrobial Peptides: A New Hope in Biomedical and Pharmaceutical Fields
Klimova Antimicrobial Peptides-Amphibian Host Defense Peptides
HK1135330B (en) Short bioactive peptides and methods for their use