ES2371287T3 - Expresión diferencial de la citocina en cáncer humano. - Google Patents

Expresión diferencial de la citocina en cáncer humano. Download PDF

Info

Publication number
ES2371287T3
ES2371287T3 ES07764767T ES07764767T ES2371287T3 ES 2371287 T3 ES2371287 T3 ES 2371287T3 ES 07764767 T ES07764767 T ES 07764767T ES 07764767 T ES07764767 T ES 07764767T ES 2371287 T3 ES2371287 T3 ES 2371287T3
Authority
ES
Spain
Prior art keywords
tumor
cytokine
agent
cells
neutralizing agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES07764767T
Other languages
English (en)
Spanish (es)
Inventor
Giorgio Stassi
Christian Gieffers
Oliver Hill
Meinolf Thiemann
Matilde Todaro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apogenix AG
Original Assignee
Apogenix AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogenix AG filed Critical Apogenix AG
Application granted granted Critical
Publication of ES2371287T3 publication Critical patent/ES2371287T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
ES07764767T 2006-06-21 2007-06-21 Expresión diferencial de la citocina en cáncer humano. Active ES2371287T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06012754 2006-06-21
EP06012754 2006-06-21

Publications (1)

Publication Number Publication Date
ES2371287T3 true ES2371287T3 (es) 2011-12-29

Family

ID=38359749

Family Applications (1)

Application Number Title Priority Date Filing Date
ES07764767T Active ES2371287T3 (es) 2006-06-21 2007-06-21 Expresión diferencial de la citocina en cáncer humano.

Country Status (12)

Country Link
US (1) US20090324616A1 (enExample)
EP (1) EP2041576B1 (enExample)
JP (1) JP2010514409A (enExample)
CN (1) CN101529253A (enExample)
AT (1) ATE520032T1 (enExample)
AU (1) AU2007263265A1 (enExample)
BR (1) BRPI0713484A2 (enExample)
CA (1) CA2656379A1 (enExample)
DK (1) DK2041576T3 (enExample)
ES (1) ES2371287T3 (enExample)
RU (1) RU2009101783A (enExample)
WO (1) WO2007147600A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100297110A1 (en) * 2006-03-22 2010-11-25 Apogenix Gmbh Antibody specific for human il-4 for the treatment of cancer
CA2656135A1 (en) * 2006-07-06 2008-01-10 Apogenix Gmbh Human il-4 muteins in cancer therapy
CA2878992C (en) * 2012-07-18 2020-09-22 Apogenix Gmbh Composition comprising a mixture of cd95-fc isoforms
US11299528B2 (en) 2014-03-11 2022-04-12 D&D Pharmatech Inc. Long acting TRAIL receptor agonists for treatment of autoimmune diseases
ES2841075T3 (es) * 2014-10-24 2021-07-07 Calidi Biotherapeutics Inc Enfoque de inmunoterapia de combinación para el tratamiento del cáncer
JP6788663B2 (ja) 2015-08-11 2020-11-25 カリディ・バイオセラピューティクス・インコーポレイテッドCalidi Biotherapeutics,Inc. 癌処置のための天然痘ワクチン
CN108601819B (zh) 2015-12-17 2022-03-15 约翰霍普金斯大学 用死亡受体激动剂改善系统性硬化症
JP7281795B2 (ja) 2016-04-07 2023-05-26 ザ・ジョンズ・ホプキンス・ユニバーシティー 膵炎および疼痛をデス受容体アゴニストで処置するための組成物および方法
EP4053557A1 (en) * 2016-11-24 2022-09-07 Huvet Bio, Inc. Il-29 as a marker for a pancreatic disease
CN111051349A (zh) * 2017-09-06 2020-04-21 弗雷德哈钦森癌症研究中心 Strep-tag特异性嵌合受体及其用途
US11505782B2 (en) 2018-06-04 2022-11-22 Calidi Biotherapeutics, Inc. Cell-based vehicles for potentiation of viral therapy

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU643427B2 (en) * 1988-10-31 1993-11-18 Immunex Corporation Interleukin-4 receptors
DE4137333A1 (de) * 1991-11-13 1993-05-19 W Prof Dr Sebald Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
US6534051B1 (en) * 1992-11-20 2003-03-18 University Of Medicine And Dentistry Of New Jersey Cell type specific gene transfer using retroviral vectors containing antibody-envelope fusion proteins and wild-type envelope fusion proteins
HU222041B1 (hu) 1993-09-07 2003-04-28 Smithkline Beecham Corporation Az IL4 által kőzvetített rendellenességek kezelésére használható rekombináns 1L4 antitestek, eljárás ezek előállítására, alkalmazására és az őket tartalmazó gyógyszerkészítmények
DE4423131A1 (de) * 1994-07-01 1996-01-04 Bayer Ag Neue hIL-4-Mutantenproteine als Antagonisten oder partielle Agonisten des humanen Interleukin 4
CZ1497A3 (en) * 1994-07-05 1997-05-14 Steeno Res Group As Polypeptide, its use and pharmaceutical composition based thereon, a nucleotide sequence and antibody
JPH10503371A (ja) * 1994-07-29 1998-03-31 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規化合物
US5710023A (en) * 1996-03-01 1998-01-20 Genetics Institute, Inc. IL-13 cytokine receptor chain
US6664227B1 (en) * 1996-03-01 2003-12-16 Genetics Institute, Llc Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
US20030124125A1 (en) * 1996-04-05 2003-07-03 South Alabama Medical Science Foundation Oncofetal antigen specific T-lymphocyte mediated immune response: manipulation and uses of oncofetal antigen specific CD4, CD8 cytotoxic and suppressor T cells and interleukin-10
US6028176A (en) * 1996-07-19 2000-02-22 Bayer Corporation High-affinity interleukin-4 muteins
CA2309598A1 (en) * 1997-11-10 1999-05-20 Mochida Pharmaceutical Co., Ltd. Preventives and remedies for diffuse lung disease
JPH11312463A (ja) * 1998-04-28 1999-11-09 Hitachi Ltd 配線基板およびそれを用いたガス放電型表示装置
KR20020091170A (ko) * 2000-03-31 2002-12-05 아이덱 파마슈티칼즈 코포레이션 B 세포 림프종의 치료를 위한 항-사이토카인 항체 또는길항제 및 항-cd20의 조합된 사용
US20020076409A1 (en) * 2000-07-12 2002-06-20 March Carl J. Method for treating cancer
US20040023338A1 (en) * 2001-10-26 2004-02-05 Heavner George A. IL-4 mutein proteins, antibodies, compositions, methods and uses
WO2003035847A2 (en) * 2001-10-26 2003-05-01 Centocor, Inc. Il-13 mutein proteins, antibodies, compositions, methods and uses
EP1444989A1 (en) * 2003-02-07 2004-08-11 Giorgio Dr. Stassi Sensitizing cells for apoptosis by selectively blocking cytokines
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
US7501121B2 (en) * 2004-06-17 2009-03-10 Wyeth IL-13 binding agents
EP1824886B1 (en) * 2004-11-17 2010-12-22 Amgen Inc. Fully human monoclonal antibodies to il-13
US20070122855A1 (en) * 2005-11-28 2007-05-31 Targetgen Inc. Methods for diagnosing hepatocellular carcinoma
US20100297110A1 (en) * 2006-03-22 2010-11-25 Apogenix Gmbh Antibody specific for human il-4 for the treatment of cancer
CA2656135A1 (en) * 2006-07-06 2008-01-10 Apogenix Gmbh Human il-4 muteins in cancer therapy

Also Published As

Publication number Publication date
CN101529253A (zh) 2009-09-09
RU2009101783A (ru) 2010-07-27
US20090324616A1 (en) 2009-12-31
BRPI0713484A2 (pt) 2012-11-06
EP2041576A2 (en) 2009-04-01
CA2656379A1 (en) 2007-12-27
EP2041576B1 (en) 2011-08-10
AU2007263265A1 (en) 2007-12-27
WO2007147600A3 (en) 2008-04-10
JP2010514409A (ja) 2010-05-06
DK2041576T3 (da) 2011-12-05
WO2007147600A2 (en) 2007-12-27
ATE520032T1 (de) 2011-08-15

Similar Documents

Publication Publication Date Title
ES2371287T3 (es) Expresión diferencial de la citocina en cáncer humano.
Silva-Santos et al. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer
Wei et al. Tumor microenvironment regulation by the endoplasmic reticulum stress transmission mediator Golgi protein 73 in mice
ES2813360T3 (es) Diana terapéutica y diagnóstica para el cáncer que comprende reactivos de unión a DLL3
ES2420582T3 (es) La neutralización de la actividad de CD95 bloquea la invasión de células de glioblastoma in vivo
US20150118244A1 (en) Anti-tumor antibodies as predictive or prognostic biomarkers of efficacy and survival in ipilimumab-treated patients
JP7032396B2 (ja) T細胞応答を促進するための方法
JP2006519190A (ja) サイトカインを選択的にブロックすることによる、アポトーシスに対する感作細胞
JP2016501843A (ja) 癌治療および判断ターゲットとしてのly75
Kiewlich et al. Anti-EphA2 antibodies decrease EphA2 protein levels in murine CT26 colorectal and human MDA-231 breast tumors but do not inhibit tumor growth
CA3076997C (en) Anti-ckap4 monoclonal antibody
CN111781359A (zh) 用于预测免疫疗法的临床效果的方法
KR20210136071A (ko) 암을 치료하는데 있어서 증진된 효능을 위한 il-4/il-13 경로 억제제
CN101679485B (zh) 骨桥蛋白的功能表位、针对该单位的单克隆抗体及它们的应用
KR20140004552A (ko) 페리오스틴에 대한 압타머 및 이를 포함하는 항암제 조성물
US20190351024A1 (en) Immunocytokines with progressive activation mechanism
Liu et al. Desensitization of T lymphocyte function by CXCR3 ligands in human hepatocellular carcinoma
US20220056123A1 (en) Use of il-1beta binding antibodies
ES2937862T3 (es) Predicción de respondedores a terapia con ciclofosfamida
ES2868998T3 (es) Anticuerpo biespecífico que se une a NAALADL2 Y CD3 para el uso como agente terapéutico en el tratamiento del cáncer de próstata
US20170247469A1 (en) Modulation of ptpra to treat arthritis
JP2011522872A (ja) エフリンa型受容体7タンパク質
KR20240176948A (ko) 소세포폐암 진단 및 치료를 위한 타겟으로서 클라우딘-3의 용도
CN107604064B (zh) Ccl20在肿瘤化疗疗效评估和肿瘤治疗中的应用
Gameiro Improving feline mammary carcinoma treatment through HER2-related immunochemotherapy agents and biomarkers