ES2370378T3 - Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de histamina h3. - Google Patents
Derivados sustituidos de piperidina espirocíclica como ligandos del receptor de histamina h3. Download PDFInfo
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- ES2370378T3 ES2370378T3 ES09706445T ES09706445T ES2370378T3 ES 2370378 T3 ES2370378 T3 ES 2370378T3 ES 09706445 T ES09706445 T ES 09706445T ES 09706445 T ES09706445 T ES 09706445T ES 2370378 T3 ES2370378 T3 ES 2370378T3
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- alkyl
- optionally substituted
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- methyl
- ethyl
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- 239000003446 ligand Substances 0.000 title description 9
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title description 6
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Classifications
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
Landscapes
- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
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| US6290908P | 2008-01-30 | 2008-01-30 | |
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| ES2370378T3 true ES2370378T3 (es) | 2011-12-14 |
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| UA95644C2 (ru) * | 2006-07-25 | 2011-08-25 | Сефалон, Инк. | Пиридазиноновые производные, фармацевтическая композиция и способ лечения заболеваний |
| CA2712885A1 (en) | 2008-01-30 | 2009-08-06 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine h3 antagonist activity |
| WO2009142732A2 (en) * | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| CA2726588C (en) | 2008-06-03 | 2019-04-16 | Karl Kossen | Compounds and methods for treating inflammatory and fibrotic disorders |
| TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
| TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| WO2012077655A1 (ja) * | 2010-12-07 | 2012-06-14 | 塩野義製薬株式会社 | Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体 |
| CA2827673C (en) | 2011-02-18 | 2020-10-27 | Novartis Pharma Ag | Mtor/jak inhibitor combination therapy |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| JP6643764B2 (ja) * | 2016-02-05 | 2020-02-12 | 国立大学法人岐阜大学 | 抗がん剤 |
| US12435078B2 (en) | 2017-09-18 | 2025-10-07 | Gfb (Abc), Llc | Pyridazinones and methods of use thereof |
| CN114728982A (zh) | 2019-10-31 | 2022-07-08 | 逃逸生物有限公司 | 固体形式的s1p-受体调节剂 |
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| CN101921279A (zh) * | 2003-10-01 | 2010-12-22 | 阿得罗公司 | 螺环杂环衍生物及其应用方法 |
| SE0403160D0 (sv) * | 2004-12-23 | 2004-12-23 | Biovitrum Ab | New compounds |
| US8158791B2 (en) * | 2005-11-10 | 2012-04-17 | Msd K.K. | Aza-substituted spiro derivatives |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
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Also Published As
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| EA018537B1 (ru) | 2013-08-30 |
| JP2011510992A (ja) | 2011-04-07 |
| HK1151526A1 (en) | 2012-02-03 |
| CN101932585B (zh) | 2013-07-10 |
| IL206914A (en) | 2013-03-24 |
| UA100877C2 (ru) | 2013-02-11 |
| EP2257553A1 (en) | 2010-12-08 |
| JP5524082B2 (ja) | 2014-06-18 |
| AU2009209235B2 (en) | 2013-07-18 |
| ZA201005136B (en) | 2013-12-23 |
| EP2257553B1 (en) | 2011-08-31 |
| CN101932585A (zh) | 2010-12-29 |
| AU2009209235A1 (en) | 2009-08-06 |
| MY150062A (en) | 2013-11-29 |
| US20100298332A1 (en) | 2010-11-25 |
| WO2009097309A1 (en) | 2009-08-06 |
| EA201070903A1 (ru) | 2011-02-28 |
| KR20100105789A (ko) | 2010-09-29 |
| US20130310389A1 (en) | 2013-11-21 |
| MX2010008382A (es) | 2010-11-25 |
| ATE522538T1 (de) | 2011-09-15 |
| NZ587034A (en) | 2011-12-22 |
| BRPI0905849A2 (pt) | 2015-06-30 |
| US8524713B2 (en) | 2013-09-03 |
| CA2712888A1 (en) | 2009-08-06 |
| IL206914A0 (en) | 2010-12-30 |
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