EA018537B1 - Замещенные спироциклические производные пиперидина как лиганды гистамин-3 (h) рецептора - Google Patents
Замещенные спироциклические производные пиперидина как лиганды гистамин-3 (h) рецептора Download PDFInfo
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- EA018537B1 EA018537B1 EA201070903A EA201070903A EA018537B1 EA 018537 B1 EA018537 B1 EA 018537B1 EA 201070903 A EA201070903 A EA 201070903A EA 201070903 A EA201070903 A EA 201070903A EA 018537 B1 EA018537 B1 EA 018537B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- ethyl
- alkyl
- spiro
- carbon atoms
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
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| US6290908P | 2008-01-30 | 2008-01-30 | |
| PCT/US2009/032195 WO2009097309A1 (en) | 2008-01-30 | 2009-01-28 | Substituted spirocyclic piperidine derivatives as histamine-3 (h3) receptor ligands |
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| EA201070903A1 EA201070903A1 (ru) | 2011-02-28 |
| EA018537B1 true EA018537B1 (ru) | 2013-08-30 |
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Families Citing this family (14)
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| HRP20130044T1 (hr) | 2006-07-25 | 2013-02-28 | Cephalon, Inc. | Derivati piridizinona |
| EP2752406A1 (en) | 2008-01-30 | 2014-07-09 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine H3 antagonist activity |
| WO2009142732A2 (en) * | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
| WO2012077655A1 (ja) * | 2010-12-07 | 2012-06-14 | 塩野義製薬株式会社 | Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体 |
| ES2547916T3 (es) | 2011-02-18 | 2015-10-09 | Novartis Pharma Ag | Terapia de combinación de inhibidores de mTOR/JAK |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| JP6643764B2 (ja) * | 2016-02-05 | 2020-02-12 | 国立大学法人岐阜大学 | 抗がん剤 |
| EP3684364A4 (en) | 2017-09-18 | 2021-06-02 | Goldfinch Bio, Inc. | PYRIDAZINONE AND METHOD OF USE THEREOF |
| US11535632B2 (en) | 2019-10-31 | 2022-12-27 | ESCAPE Bio, Inc. | Solid forms of an S1P-receptor modulator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2007055418A1 (ja) * | 2005-11-10 | 2007-05-18 | Banyu Pharmaceutical Co., Ltd. | アザ置換スピロ誘導体 |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
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| GB0313762D0 (en) * | 2003-06-13 | 2003-07-23 | Biofocus Plc | Compound libraries |
| NZ546834A (en) * | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
| SE0403160D0 (sv) * | 2004-12-23 | 2004-12-23 | Biovitrum Ab | New compounds |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007055418A1 (ja) * | 2005-11-10 | 2007-05-18 | Banyu Pharmaceutical Co., Ltd. | アザ置換スピロ誘導体 |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
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| IL206914A (en) | 2013-03-24 |
| EA201070903A1 (ru) | 2011-02-28 |
| MX2010008382A (es) | 2010-11-25 |
| US8524713B2 (en) | 2013-09-03 |
| ATE522538T1 (de) | 2011-09-15 |
| UA100877C2 (ru) | 2013-02-11 |
| BRPI0905849A2 (pt) | 2015-06-30 |
| KR20100105789A (ko) | 2010-09-29 |
| NZ587034A (en) | 2011-12-22 |
| AU2009209235B2 (en) | 2013-07-18 |
| EP2257553A1 (en) | 2010-12-08 |
| US20130310389A1 (en) | 2013-11-21 |
| CN101932585A (zh) | 2010-12-29 |
| CA2712888A1 (en) | 2009-08-06 |
| JP2011510992A (ja) | 2011-04-07 |
| JP5524082B2 (ja) | 2014-06-18 |
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