KR20100105789A - 히스타민-3（ｈ3）수용체 리간드로서의 치환된 스피로사이클릭 피페리딘 유도체 - Google Patents
히스타민-3（ｈ3）수용체 리간드로서의 치환된 스피로사이클릭 피페리딘 유도체 Download PDFInfo
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- KR20100105789A KR20100105789A KR1020107019040A KR20107019040A KR20100105789A KR 20100105789 A KR20100105789 A KR 20100105789A KR 1020107019040 A KR1020107019040 A KR 1020107019040A KR 20107019040 A KR20107019040 A KR 20107019040A KR 20100105789 A KR20100105789 A KR 20100105789A
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- alkyl
- compound
- optionally substituted
- methyl
- ethyl
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Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
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| HRP20130044T1 (hr) | 2006-07-25 | 2013-02-28 | Cephalon, Inc. | Derivati piridizinona |
| EP2752406A1 (en) | 2008-01-30 | 2014-07-09 | Cephalon, Inc. | Substituted pyridazine derivatives which have histamine H3 antagonist activity |
| WO2009142732A2 (en) * | 2008-05-20 | 2009-11-26 | Cephalon, Inc. | Substituted pyridazinone derivatives as histamine-3 (h3) receptor ligands |
| CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
| TWI522361B (zh) | 2010-07-09 | 2016-02-21 | 艾伯維公司 | 作為s1p調節劑的稠合雜環衍生物 |
| TW201643169A (zh) | 2010-07-09 | 2016-12-16 | 艾伯維股份有限公司 | 作為s1p調節劑的螺-哌啶衍生物 |
| TW201206893A (en) | 2010-07-09 | 2012-02-16 | Abbott Healthcare Products Bv | Bisaryl (thio) morpholine derivatives as S1P modulators |
| WO2012077655A1 (ja) * | 2010-12-07 | 2012-06-14 | 塩野義製薬株式会社 | Ｇｐｒ１１９アゴニスト活性を有するスピロ誘導体 |
| ES2547916T3 (es) | 2011-02-18 | 2015-10-09 | Novartis Pharma Ag | Terapia de combinación de inhibidores de mTOR/JAK |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| MX382781B (es) | 2014-04-02 | 2025-03-13 | Intermune Inc | Piridinonas anti-fibroticas. |
| JP6643764B2 (ja) * | 2016-02-05 | 2020-02-12 | 国立大学法人岐阜大学 | 抗がん剤 |
| EP3684364A4 (en) | 2017-09-18 | 2021-06-02 | Goldfinch Bio, Inc. | PYRIDAZINONE AND METHOD OF USE THEREOF |
| US11535632B2 (en) | 2019-10-31 | 2022-12-27 | ESCAPE Bio, Inc. | Solid forms of an S1P-receptor modulator |
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| NZ546834A (en) * | 2003-10-01 | 2010-03-26 | Adolor Corp | Spirocyclic heterocyclic derivatives and methods of their use |
| SE0403160D0 (sv) * | 2004-12-23 | 2004-12-23 | Biovitrum Ab | New compounds |
| ES2381205T3 (es) * | 2005-11-10 | 2012-05-24 | Msd K.K. | Derivado espiro aza-sustituido |
| WO2007063385A2 (en) * | 2005-12-01 | 2007-06-07 | Pfizer Products Inc. | Spirocyclic amine histamine-3 receptor antagonists |
| WO2007088462A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Spirochromane antagonists of the h-3 receptor |
-
2009
- 2009-01-28 UA UAA201010456A patent/UA100877C2/ru unknown
- 2009-01-28 ES ES09706445T patent/ES2370378T3/es active Active
- 2009-01-28 AT AT09706445T patent/ATE522538T1/de not_active IP Right Cessation
- 2009-01-28 BR BRPI0905849-4A patent/BRPI0905849A2/pt not_active IP Right Cessation
- 2009-01-28 KR KR1020107019040A patent/KR20100105789A/ko not_active Ceased
- 2009-01-28 AU AU2009209235A patent/AU2009209235B2/en not_active Ceased
- 2009-01-28 MY MYPI2010003298A patent/MY150062A/en unknown
- 2009-01-28 EP EP09706445A patent/EP2257553B1/en not_active Not-in-force
- 2009-01-28 CN CN2009801037142A patent/CN101932585B/zh not_active Expired - Fee Related
- 2009-01-28 JP JP2010545098A patent/JP5524082B2/ja not_active Expired - Fee Related
- 2009-01-28 NZ NZ587034A patent/NZ587034A/en not_active IP Right Cessation
- 2009-01-28 EA EA201070903A patent/EA018537B1/ru not_active IP Right Cessation
- 2009-01-28 MX MX2010008382A patent/MX2010008382A/es active IP Right Grant
- 2009-01-28 CA CA2712888A patent/CA2712888A1/en not_active Abandoned
- 2009-01-28 WO PCT/US2009/032195 patent/WO2009097309A1/en not_active Ceased
-
2010
- 2010-07-08 IL IL206914A patent/IL206914A/en not_active IP Right Cessation
- 2010-07-19 ZA ZA2010/05136A patent/ZA201005136B/en unknown
- 2010-07-29 US US12/846,108 patent/US8524713B2/en active Active
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2013
- 2013-07-24 US US13/949,323 patent/US20130310389A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100298332A1 (en) | 2010-11-25 |
| EP2257553B1 (en) | 2011-08-31 |
| MY150062A (en) | 2013-11-29 |
| CN101932585B (zh) | 2013-07-10 |
| IL206914A0 (en) | 2010-12-30 |
| ZA201005136B (en) | 2013-12-23 |
| HK1151526A1 (en) | 2012-02-03 |
| WO2009097309A1 (en) | 2009-08-06 |
| AU2009209235A1 (en) | 2009-08-06 |
| ES2370378T3 (es) | 2011-12-14 |
| IL206914A (en) | 2013-03-24 |
| EA201070903A1 (ru) | 2011-02-28 |
| MX2010008382A (es) | 2010-11-25 |
| US8524713B2 (en) | 2013-09-03 |
| ATE522538T1 (de) | 2011-09-15 |
| UA100877C2 (ru) | 2013-02-11 |
| BRPI0905849A2 (pt) | 2015-06-30 |
| NZ587034A (en) | 2011-12-22 |
| AU2009209235B2 (en) | 2013-07-18 |
| EP2257553A1 (en) | 2010-12-08 |
| US20130310389A1 (en) | 2013-11-21 |
| EA018537B1 (ru) | 2013-08-30 |
| CN101932585A (zh) | 2010-12-29 |
| CA2712888A1 (en) | 2009-08-06 |
| JP2011510992A (ja) | 2011-04-07 |
| JP5524082B2 (ja) | 2014-06-18 |
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