ES2356383T3 - Expresión recombinante de variantes de proteína de cubierta de rubeola e1 como proteínas de fusión chaperonas, y utilización de las mismas en la detección de anticuerpos anti-rubeola. - Google Patents

Expresión recombinante de variantes de proteína de cubierta de rubeola e1 como proteínas de fusión chaperonas, y utilización de las mismas en la detección de anticuerpos anti-rubeola. Download PDF

Info

Publication number
ES2356383T3
ES2356383T3 ES06022216T ES06022216T ES2356383T3 ES 2356383 T3 ES2356383 T3 ES 2356383T3 ES 06022216 T ES06022216 T ES 06022216T ES 06022216 T ES06022216 T ES 06022216T ES 2356383 T3 ES2356383 T3 ES 2356383T3
Authority
ES
Spain
Prior art keywords
rubella
antigen
protein
soluble
chaperone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES06022216T
Other languages
English (en)
Spanish (es)
Inventor
Ralf Bollhagen
Alfred Engel
Elke Faatz
Peter Schaarschmidt
Christian Scholz
Barbara Upmeier
Toralf Zarnt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Original Assignee
F Hoffmann La Roche AG
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG, Roche Diagnostics GmbH filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2356383T3 publication Critical patent/ES2356383T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES06022216T 2005-10-26 2006-10-24 Expresión recombinante de variantes de proteína de cubierta de rubeola e1 como proteínas de fusión chaperonas, y utilización de las mismas en la detección de anticuerpos anti-rubeola. Active ES2356383T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05109993 2005-10-26
EP05109993 2005-10-26

Publications (1)

Publication Number Publication Date
ES2356383T3 true ES2356383T3 (es) 2011-04-07

Family

ID=37965193

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06022216T Active ES2356383T3 (es) 2005-10-26 2006-10-24 Expresión recombinante de variantes de proteína de cubierta de rubeola e1 como proteínas de fusión chaperonas, y utilización de las mismas en la detección de anticuerpos anti-rubeola.

Country Status (6)

Country Link
US (1) US7604935B2 (enExample)
JP (1) JP4116054B2 (enExample)
AT (1) ATE491030T1 (enExample)
CA (1) CA2562738C (enExample)
DE (1) DE602006018694D1 (enExample)
ES (1) ES2356383T3 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1971684B1 (en) * 2006-01-03 2011-10-05 Roche Diagnostics GmbH Chimaeric fusion protein with superior chaperone and folding activities
WO2009018500A1 (en) * 2007-07-31 2009-02-05 The Johns Hopkins University Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
WO2009074318A2 (en) * 2007-12-13 2009-06-18 Roche Diagnostics Gmbh Novel rubella e1 envelope protein variants and their use in the detection of anti-rubella antibodies
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
EP0299673A1 (en) 1987-07-08 1989-01-18 London Biotechnology Limited Rubella E1 glycoprotein antigens
WO1998013496A1 (en) 1996-09-26 1998-04-02 Medical Research Council Chaperone fragments
DE19649390A1 (de) 1996-11-29 1998-06-04 Boehringer Mannheim Gmbh Antigenspezifischer IgG-Nachweis
KR100702373B1 (ko) 2001-06-22 2007-04-02 에프. 호프만-라 로슈 아게 레트로바이러스 표면 당단백질을 함유하는 가용성 복합체

Also Published As

Publication number Publication date
ATE491030T1 (de) 2010-12-15
JP4116054B2 (ja) 2008-07-09
US7604935B2 (en) 2009-10-20
CA2562738C (en) 2011-07-12
JP2007117090A (ja) 2007-05-17
CA2562738A1 (en) 2007-04-26
DE602006018694D1 (de) 2011-01-20
US20070154883A1 (en) 2007-07-05

Similar Documents

Publication Publication Date Title
JP3443809B2 (ja) 免疫学的に重要なエピトープに相当するペプチドの決定方法、及び免疫学的に重要なエピトープに相当するビオチニル化ペプチド又は抗体の決定のための方法におけるその利用、その調製方法及びそれを含む組成物
ES2391623T3 (es) Complejo soluble que contiene una glicoproteína de superficie retroviral
IL126460A (en) Multiple epitope fusion protein
US8551696B2 (en) Rubella E1 envelope protein variants and their use in detection of anti-rubella antibodies
ES2561462T3 (es) Antígenos TpN47 de Treponema pallidum inmunorreactivos solubles
KR20180083941A (ko) 돌연변이된 hev 폴리펩타이드 및 항-hev 항체를 검정하기 위한 이의 용도
JPH09509052A (ja) 肝炎ｃ型ウイルスエンベロープ遺伝子用の哺乳動物発現系
AU655112B2 (en) HCV peptide antigens and method of determining HCV
US11078241B2 (en) Multi-epitope fusion protein of an HCV antigen and uses thereof
ES2356383T3 (es) Expresión recombinante de variantes de proteína de cubierta de rubeola e1 como proteínas de fusión chaperonas, y utilización de las mismas en la detección de anticuerpos anti-rubeola.
EP1780282B1 (en) Recombinant expression of Rubella E1 envelope protein variants as chaperone fusion-proteins, and their use in the detection of anti-Rubella antibodies
US7074555B2 (en) Detection of West Nile Virus
ES2363537T3 (es) Procedimiento y dispositivo para detectar el virus de la inmunodeficiencia felina.
KR20230054460A (ko) Hcv 재조합 항원 및 그의 돌연변이체
HK1148026B (en) Novel rubella e1 envelope protein variants and their use in the detection of antirubella antibodies
CN106699895A (zh) 一种新型融合抗原和包含其的检测试剂盒及应用
HK1138620A1 (zh) 作为重组蛋白和酶技术的工具的slpa
HK1138620B (en) Slpa as a tool for recombinant protein and enzyme technology