JP4116054B2 - シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 - Google Patents

シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 Download PDF

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JP4116054B2
JP4116054B2 JP2006290414A JP2006290414A JP4116054B2 JP 4116054 B2 JP4116054 B2 JP 4116054B2 JP 2006290414 A JP2006290414 A JP 2006290414A JP 2006290414 A JP2006290414 A JP 2006290414A JP 4116054 B2 JP4116054 B2 JP 4116054B2
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rubella
antigen
soluble
protein
region
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Japanese (ja)
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JP2007117090A5 (enExample
JP2007117090A (ja
Inventor
ボルハゲン ラルフ
エンゲル アルフレッド
ファッツ エルケ
シャーツミッド ペーター
ショルツ クリスティアン
アプマイアー バルバラ
ツァルント トラルフ
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2006290414A 2005-10-26 2006-10-25 シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途 Active JP4116054B2 (ja)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05109993 2005-10-26

Publications (3)

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JP2007117090A JP2007117090A (ja) 2007-05-17
JP2007117090A5 JP2007117090A5 (enExample) 2008-04-24
JP4116054B2 true JP4116054B2 (ja) 2008-07-09

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JP2006290414A Active JP4116054B2 (ja) 2005-10-26 2006-10-25 シャペロン融合タンパク質としての風疹ｅ１エンベロープタンパク質変異体の組換え発現、可溶性で天然様かつ免疫反応性の抗原コンホメーションへのそのリフォールディングならびに抗風疹抗体の検出におけるその用途

Country Status (6)

Country Link
US (1) US7604935B2 (enExample)
JP (1) JP4116054B2 (enExample)
AT (1) ATE491030T1 (enExample)
CA (1) CA2562738C (enExample)
DE (1) DE602006018694D1 (enExample)
ES (1) ES2356383T3 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4871960B2 (ja) * 2006-01-03 2012-02-08 エフ．ホフマン−ラ ロシュ アーゲー 優れたシャペロン活性およびフォールディング活性を有するキメラ融合タンパク質
EP2178896A1 (en) * 2007-07-31 2010-04-28 The Johns Hopkins University Polypeptide-nucleic acid conjugate for immunoprophylaxis or immunotherapy for neoplastic or infectious disorders
CN101939330B (zh) * 2007-12-13 2014-06-04 霍夫曼-拉罗奇有限公司 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途
AR086250A1 (es) * 2011-05-05 2013-11-27 Hoffmann La Roche Polipeptido de fusion presentador de una secuencia de aminoacidos y utilizacion del mismo

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2095818B (en) 1981-03-27 1985-10-02 Exxon Research Engineering Co Staged adsorption/resorption heat pump
EP0299673A1 (en) 1987-07-08 1989-01-18 London Biotechnology Limited Rubella E1 glycoprotein antigens
JP2001501093A (ja) 1996-09-26 2001-01-30 メディカル リサーチ カウンシル シャペロン断片
DE19649390A1 (de) 1996-11-29 1998-06-04 Boehringer Mannheim Gmbh Antigenspezifischer IgG-Nachweis
ATE522603T1 (de) 2001-06-22 2011-09-15 Hoffmann La Roche Löslicher komplex, der retrovirale oberflächen- glykoproteine und fkpa oder slyd enthält

Also Published As

Publication number Publication date
ES2356383T3 (es) 2011-04-07
ATE491030T1 (de) 2010-12-15
CA2562738A1 (en) 2007-04-26
US7604935B2 (en) 2009-10-20
US20070154883A1 (en) 2007-07-05
DE602006018694D1 (de) 2011-01-20
CA2562738C (en) 2011-07-12
JP2007117090A (ja) 2007-05-17

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