ES2324966T3 - Derivados de acido oleanolico sustituido con ciano como inhibidores dela produccion de no. - Google Patents
Derivados de acido oleanolico sustituido con ciano como inhibidores dela produccion de no. Download PDFInfo
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- ES2324966T3 ES2324966T3 ES99928731T ES99928731T ES2324966T3 ES 2324966 T3 ES2324966 T3 ES 2324966T3 ES 99928731 T ES99928731 T ES 99928731T ES 99928731 T ES99928731 T ES 99928731T ES 2324966 T3 ES2324966 T3 ES 2324966T3
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Classifications
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- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
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- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
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- Hospice & Palliative Care (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
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| US335003 | 1994-11-09 | ||
| US9005398P | 1998-06-19 | 1998-06-19 | |
| US90053P | 1998-06-19 | ||
| US09/335,003 US6326507B1 (en) | 1998-06-19 | 1999-06-17 | Therapeutic compounds and methods of use |
Publications (1)
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| ES2324966T3 true ES2324966T3 (es) | 2009-08-20 |
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| ES99928731T Expired - Lifetime ES2324966T3 (es) | 1998-06-19 | 1999-06-18 | Derivados de acido oleanolico sustituido con ciano como inhibidores dela produccion de no. |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US6326507B1 (enExample) |
| EP (2) | EP2062577A1 (enExample) |
| JP (3) | JP4541548B2 (enExample) |
| AT (1) | ATE430563T1 (enExample) |
| CA (1) | CA2335505C (enExample) |
| CY (1) | CY1109256T1 (enExample) |
| DK (1) | DK1089724T3 (enExample) |
| ES (1) | ES2324966T3 (enExample) |
| PT (1) | PT1089724E (enExample) |
| WO (1) | WO1999065478A1 (enExample) |
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| US20040072138A1 (en) * | 1997-11-25 | 2004-04-15 | Medical University Of South Carolina | Attenuation of ischemia/reperfusion injury |
| US20080275104A1 (en) * | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| US6326507B1 (en) * | 1998-06-19 | 2001-12-04 | Trustees Of Dartmouth College | Therapeutic compounds and methods of use |
| EP1253921A4 (en) * | 2000-01-28 | 2004-10-13 | Merck & Co Inc | TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS |
| EP1395255A4 (en) * | 2000-11-28 | 2007-09-12 | Univ Texas | CDDO COMPOUNDS AND COMBINATION THERAPIES THEREOF |
| US7435755B2 (en) * | 2000-11-28 | 2008-10-14 | The Trustees Of Dartmouth College | CDDO-compounds and combination therapies thereof |
| US6777004B1 (en) * | 2001-03-30 | 2004-08-17 | Council Of Scientific & Industrial Research | Composition containing novel compound corniculatonin having antifungi properties and a process for preparing the same |
| KR100464063B1 (ko) * | 2001-11-21 | 2005-01-06 | 한국생명공학연구원 | 세포사멸 유도작용을 갖는 트리테르펜 화합물 |
| US7176237B2 (en) | 2002-01-15 | 2007-02-13 | The Trustees Of Dartmouth College | Tricyclic-bis-enone derivatives and methods of use thereof |
| CA2484989A1 (en) * | 2002-05-02 | 2003-11-27 | The Washington University | Methods and compositions for treating t cell mediated inflammatory/autoimmune diseases and disorders in subjects having a glucocorticoid regulation deficiency |
| AU2003303128A1 (en) * | 2002-05-13 | 2004-08-13 | Trustees Of Dartmouth College | Inhibitors and methods of use thereof |
| AU2004279256B2 (en) * | 2003-10-10 | 2008-04-17 | Sk Chemicals Co., Ltd. | Triterpene compounds which are effective on improvement of brain function |
| WO2005042002A2 (en) * | 2003-10-30 | 2005-05-12 | Entelos, Inc. | Treatment of rhematoid arthritis with flip antagonists |
| US7551346B2 (en) * | 2003-11-05 | 2009-06-23 | E Ink Corporation | Electro-optic displays, and materials for use therein |
| US20070270350A1 (en) * | 2003-12-23 | 2007-11-22 | Musc Foundation For Research Development | Methods and Compositions for the Prevention and Treatment of Inflammatory Diseases or Conditions |
| US7638331B2 (en) | 2004-01-02 | 2009-12-29 | The Administration of the Tulane Rducation Fund | Directed apoptosis in COX-2 overexpressing cancer cells through expression targeted gene delivery |
| WO2006006152A2 (en) * | 2004-07-08 | 2006-01-19 | Ramot At Tel-Aviv University Ltd | Treatment of disorders and diseases of the colon |
| CA2600276C (en) * | 2005-03-08 | 2013-01-08 | Mitsui Norin Co., Ltd | Polyphenol coxib combinations and methods |
| US20100190735A1 (en) * | 2006-03-28 | 2010-07-29 | Myrex Pharmaceuticals Inc. | Mouthwash and Method of Using Same for the Treatment of Mucositis or Stomatitis |
| WO2008064133A1 (en) | 2006-11-17 | 2008-05-29 | Trustees Of Dartmouth College | Synthesis and biological activities of new tricyclic-bis-enones (tbes) |
| US8921340B2 (en) | 2006-11-17 | 2014-12-30 | Trustees Of Dartmouth College | Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions |
| US8299046B2 (en) * | 2006-11-17 | 2012-10-30 | Trustees Of Dartmouth College | Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth |
| WO2008112887A1 (en) * | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| US8088824B2 (en) | 2007-08-15 | 2012-01-03 | Reata Pharmaceuticals Inc. | Forms of CDDO methyl ester |
| US20090048205A1 (en) * | 2007-08-15 | 2009-02-19 | Colin Meyer | Combination therapy with synthetic triterpenoids and gemcitabine |
| US7879369B2 (en) | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| WO2009058849A1 (en) * | 2007-10-29 | 2009-05-07 | University Of Rochester | Use of electrophilic compounds for inducing platelet production or maintaining platelet function |
| HUE043175T2 (hu) | 2008-01-11 | 2019-08-28 | Reata Pharmaceuticals Inc | Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében |
| ES2326065B1 (es) * | 2008-03-28 | 2010-07-08 | Consejo Superior De Investigaciones Cientificas (Csic) | Utilizacion de un triterpeno pentaciclico para la preparacion de una composicion farmaceutica destinada al tratamiento de la esclerosis multiple. |
| US8071632B2 (en) * | 2008-04-18 | 2011-12-06 | Reata Pharmaceuticals, Inc. | Antioxidant inflammation modulators: novel derivatives of oleanolic acid |
| MX339476B (es) | 2008-04-18 | 2016-05-27 | Reata Pharmaceuticals Inc | Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso. |
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-
1999
- 1999-06-17 US US09/335,003 patent/US6326507B1/en not_active Expired - Lifetime
- 1999-06-18 PT PT99928731T patent/PT1089724E/pt unknown
- 1999-06-18 DK DK99928731T patent/DK1089724T3/da active
- 1999-06-18 JP JP2000554358A patent/JP4541548B2/ja not_active Expired - Lifetime
- 1999-06-18 WO PCT/US1999/013635 patent/WO1999065478A1/en not_active Ceased
- 1999-06-18 EP EP09154222A patent/EP2062577A1/en not_active Withdrawn
- 1999-06-18 AT AT99928731T patent/ATE430563T1/de active
- 1999-06-18 EP EP99928731A patent/EP1089724B1/en not_active Expired - Lifetime
- 1999-06-18 CA CA2335505A patent/CA2335505C/en not_active Expired - Lifetime
- 1999-06-18 ES ES99928731T patent/ES2324966T3/es not_active Expired - Lifetime
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2001
- 2001-08-09 US US09/927,081 patent/US6552075B2/en not_active Expired - Lifetime
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2003
- 2003-03-24 US US10/395,372 patent/US7288568B2/en not_active Expired - Lifetime
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2005
- 2005-05-03 US US11/121,316 patent/US7863327B2/en not_active Expired - Fee Related
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2007
- 2007-10-29 US US11/927,418 patent/US8034955B2/en not_active Expired - Fee Related
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2009
- 2009-06-05 JP JP2009136739A patent/JP5210971B2/ja not_active Expired - Lifetime
- 2009-07-15 CY CY20091100756T patent/CY1109256T1/el unknown
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2011
- 2011-08-24 US US13/217,127 patent/US8586775B2/en not_active Expired - Fee Related
-
2012
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2013
- 2013-10-21 US US14/059,185 patent/US9278913B2/en not_active Expired - Fee Related
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| US20080234368A9 (en) | 2008-09-25 |
| US20020042535A1 (en) | 2002-04-11 |
| WO1999065478A1 (en) | 1999-12-23 |
| US20030236303A1 (en) | 2003-12-25 |
| US20140275618A1 (en) | 2014-09-18 |
| EP1089724A4 (en) | 2004-06-09 |
| US7863327B2 (en) | 2011-01-04 |
| US8586775B2 (en) | 2013-11-19 |
| JP2012144574A (ja) | 2012-08-02 |
| US20130237721A1 (en) | 2013-09-12 |
| US7288568B2 (en) | 2007-10-30 |
| PT1089724E (pt) | 2009-07-20 |
| JP5210971B2 (ja) | 2013-06-12 |
| CY1109256T1 (el) | 2014-07-02 |
| US20050288363A1 (en) | 2005-12-29 |
| JP4541548B2 (ja) | 2010-09-08 |
| EP1089724A1 (en) | 2001-04-11 |
| JP2002530272A (ja) | 2002-09-17 |
| US6552075B2 (en) | 2003-04-22 |
| ATE430563T1 (de) | 2009-05-15 |
| DK1089724T3 (da) | 2009-07-27 |
| CA2335505A1 (en) | 1999-12-23 |
| US20080220057A1 (en) | 2008-09-11 |
| US8034955B2 (en) | 2011-10-11 |
| CA2335505C (en) | 2010-06-15 |
| US6326507B1 (en) | 2001-12-04 |
| US9278913B2 (en) | 2016-03-08 |
| EP1089724B1 (en) | 2009-05-06 |
| JP2009242409A (ja) | 2009-10-22 |
| EP2062577A1 (en) | 2009-05-27 |
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