ES2311537T3 - Utilizacion de nefiracetam en el tratamiento de la neurodegeneracion postquemica. - Google Patents
Utilizacion de nefiracetam en el tratamiento de la neurodegeneracion postquemica. Download PDFInfo
- Publication number
- ES2311537T3 ES2311537T3 ES01958395T ES01958395T ES2311537T3 ES 2311537 T3 ES2311537 T3 ES 2311537T3 ES 01958395 T ES01958395 T ES 01958395T ES 01958395 T ES01958395 T ES 01958395T ES 2311537 T3 ES2311537 T3 ES 2311537T3
- Authority
- ES
- Spain
- Prior art keywords
- nefiracetam
- treatment
- neurodegeneration
- recovery
- ischemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- NGHTXZCKLWZPGK-UHFFFAOYSA-N nefiracetam Chemical compound CC1=CC=CC(C)=C1NC(=O)CN1C(=O)CCC1 NGHTXZCKLWZPGK-UHFFFAOYSA-N 0.000 title claims abstract description 79
- 229950004663 nefiracetam Drugs 0.000 title claims abstract description 74
- 238000011282 treatment Methods 0.000 title claims abstract description 22
- 230000004770 neurodegeneration Effects 0.000 title claims abstract description 18
- 230000006872 improvement Effects 0.000 claims abstract description 28
- 238000011084 recovery Methods 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 239000003814 drug Substances 0.000 claims abstract description 15
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 208000028867 ischemia Diseases 0.000 claims description 34
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- IHLAQQPQKRMGSS-UHFFFAOYSA-N oxiracetam Chemical compound NC(=O)CN1CC(O)CC1=O IHLAQQPQKRMGSS-UHFFFAOYSA-N 0.000 description 2
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- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
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- 230000002555 anti-neurodegenerative effect Effects 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
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- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical class O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2001/007180 WO2003018005A1 (en) | 2001-08-22 | 2001-08-22 | use of nefiracetam for treating neurodegeneration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2311537T3 true ES2311537T3 (es) | 2009-02-16 |
Family
ID=11737657
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01958395T Expired - Lifetime ES2311537T3 (es) | 2001-08-22 | 2001-08-22 | Utilizacion de nefiracetam en el tratamiento de la neurodegeneracion postquemica. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20040192759A1 (enExample) |
| EP (1) | EP1420782B1 (enExample) |
| JP (1) | JP2005501108A (enExample) |
| AT (1) | ATE404192T1 (enExample) |
| CA (1) | CA2457982C (enExample) |
| DE (1) | DE60135390D1 (enExample) |
| ES (1) | ES2311537T3 (enExample) |
| WO (1) | WO2003018005A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060241144A1 (en) * | 2005-04-20 | 2006-10-26 | Albert Cha | Method for treating apathy syndrome |
| RU2329804C2 (ru) * | 2006-03-28 | 2008-07-27 | Валентина Ивановна Ахапкина | Вещество, обладающее нейротропной - нейромодуляторной активностью |
| BRPI0920342A2 (pt) * | 2008-10-16 | 2020-06-23 | The Johns Hopkins University | Uso de um inibidor da proteína vesicular sináptica 2a (sv2a) ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica para melhora da função cognitiva, uso de levitiracetam ou um sal farmaceuticamente aceitável do mesmo, uso de brivaracetam ou um sal farmaceuticamente aceitável do mesmo, uso do seletracetam ou um sal farmaceuticamente aceitável do mesmo |
| US8962676B2 (en) | 2009-10-22 | 2015-02-24 | University College Dublin, National University Of Ireland, Dublin | Causal therapy of diseases or conditions associated with CNS or PNS demyelination |
| EP2533645B1 (en) * | 2010-02-09 | 2016-07-27 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN105142623A (zh) | 2013-03-15 | 2015-12-09 | 艾吉因生物股份有限公司 | 用于改善认知功能的方法和组合物 |
| EP2968237A4 (en) | 2013-03-15 | 2016-08-31 | Univ Johns Hopkins | METHOD AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION |
| CN107810002B (zh) | 2015-05-22 | 2021-01-05 | 艾吉因生物股份有限公司 | 左乙拉西坦的延时释放药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4749700A (en) * | 1984-10-23 | 1988-06-07 | Nastech Pharmaceutical Co, Inc. | Novel methods of administering antihistamines, antinausea and antiemetic pharmaceutical agents and novel dosage forms containing same |
| SK279285B6 (sk) * | 1991-05-02 | 1998-09-09 | Daiichi Pharmaceutical Co. | Použitie n-(2,6-dimetylfenyl)-2-(2-oxo-1-pyrolidin |
| JP3388778B2 (ja) * | 1991-05-02 | 2003-03-24 | 第一製薬株式会社 | 脳血管性痴呆改善剤 |
| AU8131198A (en) * | 1997-07-15 | 1999-02-10 | Daiichi Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for amnesia |
| JPH1180027A (ja) * | 1997-09-12 | 1999-03-23 | Dai Ichi Seiyaku Co Ltd | 向知性薬 |
| US6423739B1 (en) * | 2000-02-23 | 2002-07-23 | Daiichi Pharmaceutical Co., Ltd. | Method for aiding cerebral recovery following neurodegeneration |
-
2001
- 2001-08-22 JP JP2003522525A patent/JP2005501108A/ja active Pending
- 2001-08-22 ES ES01958395T patent/ES2311537T3/es not_active Expired - Lifetime
- 2001-08-22 DE DE60135390T patent/DE60135390D1/de not_active Expired - Lifetime
- 2001-08-22 US US10/487,320 patent/US20040192759A1/en not_active Abandoned
- 2001-08-22 EP EP01958395A patent/EP1420782B1/en not_active Expired - Lifetime
- 2001-08-22 AT AT01958395T patent/ATE404192T1/de not_active IP Right Cessation
- 2001-08-22 WO PCT/JP2001/007180 patent/WO2003018005A1/en not_active Ceased
- 2001-08-22 CA CA002457982A patent/CA2457982C/en not_active Expired - Fee Related
-
2007
- 2007-09-28 US US11/863,808 patent/US20080076820A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20080076820A1 (en) | 2008-03-27 |
| CA2457982C (en) | 2009-11-03 |
| US20040192759A1 (en) | 2004-09-30 |
| JP2005501108A (ja) | 2005-01-13 |
| EP1420782A1 (en) | 2004-05-26 |
| CA2457982A1 (en) | 2003-03-06 |
| EP1420782B1 (en) | 2008-08-13 |
| DE60135390D1 (de) | 2008-09-25 |
| WO2003018005A1 (en) | 2003-03-06 |
| ATE404192T1 (de) | 2008-08-15 |
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| US20080076820A1 (en) | Method for treating neurodegeneration | |
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