ES2294816T3 - Antagonistas ciclicos de receptores de c5a y receptores acoplados a proteinas g. - Google Patents
Antagonistas ciclicos de receptores de c5a y receptores acoplados a proteinas g. Download PDFInfo
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- ES2294816T3 ES2294816T3 ES98930536T ES98930536T ES2294816T3 ES 2294816 T3 ES2294816 T3 ES 2294816T3 ES 98930536 T ES98930536 T ES 98930536T ES 98930536 T ES98930536 T ES 98930536T ES 2294816 T3 ES2294816 T3 ES 2294816T3
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-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPO7550 | 1997-06-25 | ||
| AUPO7550A AUPO755097A0 (en) | 1997-06-25 | 1997-06-25 | Receptor agonist and antagonist |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2294816T3 true ES2294816T3 (es) | 2008-04-01 |
Family
ID=3801840
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98930536T Expired - Lifetime ES2294816T3 (es) | 1997-06-25 | 1998-06-25 | Antagonistas ciclicos de receptores de c5a y receptores acoplados a proteinas g. |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | USRE41287E1 (https=) |
| EP (1) | EP1017713B1 (https=) |
| JP (1) | JP4686696B2 (https=) |
| AT (1) | ATE377606T1 (https=) |
| AU (2) | AUPO755097A0 (https=) |
| CY (1) | CY1107133T1 (https=) |
| DE (1) | DE69838678T2 (https=) |
| DK (1) | DK1017713T3 (https=) |
| ES (1) | ES2294816T3 (https=) |
| PT (1) | PT1017713E (https=) |
| WO (1) | WO1999000406A1 (https=) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPO755097A0 (en) * | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| AUPQ339899A0 (en) | 1999-10-13 | 1999-11-04 | University Of Queensland, The | Novel molecules |
| CA2418652C (en) | 2000-08-10 | 2010-03-23 | Mitsubishi Pharma Corporation | Novel 3-substituted urea derivatives and medicinal use thereof |
| US7855297B2 (en) | 2000-09-14 | 2010-12-21 | Mitsubishi Tanabe Pharma Corporation | Amide derivatives and medicinal use thereof |
| AUPR833401A0 (en) * | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| JP4290564B2 (ja) | 2002-03-19 | 2009-07-08 | チルドレンズ ホスピタル メディカル センター | Ｃ５ａアナフィラトキシンの突然変異タンパク質、このような突然変異タンパク質をコードする核酸分子ならびにＣ５ａアナフィラトキシンの突然変異タンパク質の医薬的使用 |
| WO2003084524A1 (en) * | 2002-03-29 | 2003-10-16 | Neurogen Corporation | Combination therapy for the treatment of conditions with pathogenic inflammatory components |
| AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| AU2002950657A0 (en) | 2002-08-08 | 2002-09-12 | Alchemia Limited | Derivatives of monosaccharides for drug discovery |
| AU2002951995A0 (en) | 2002-10-11 | 2002-10-31 | Alchemia Limited | Classes of compounds that interact with gpcrs |
| AU2003266858B2 (en) * | 2002-10-11 | 2006-09-14 | Vast Bioscience Pty Limited | Classes of compounds that interact with GPCRs |
| AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
| US7410945B2 (en) * | 2002-10-16 | 2008-08-12 | The University Of Queensland | Treatment of inflammatory bowel disease |
| AU2002952129A0 (en) * | 2002-10-17 | 2002-10-31 | The University Of Queensland | Treatment of hypersensitivity conditions |
| AU2003902354A0 (en) * | 2003-05-15 | 2003-05-29 | Harkin, Denis W. | Treatment of haemorrhagic shock |
| AU2003902586A0 (en) * | 2003-05-26 | 2003-06-12 | The University Of Queensland | Treatment of burns |
| WO2005014849A2 (en) * | 2003-07-03 | 2005-02-17 | Euro-Celtique, S.A. | Genes associated with responses to neuropathic pain |
| EP1498422A1 (de) * | 2003-07-17 | 2005-01-19 | Jerini AG | C5a-Rezeptor-Antagonisten |
| CA2579678A1 (en) * | 2004-10-04 | 2006-04-13 | Alchemia Limited | Selective inhibitors |
| CN101107264A (zh) * | 2005-01-17 | 2008-01-16 | 捷瑞尼股份公司 | C5a受体拮抗剂 |
| AU2006223108A1 (en) * | 2005-03-11 | 2006-09-21 | Potentia Pharmaceuticals, Inc. | Compositions comprising modulators of G-protein-coupled receptor for treatment of macular degeneration |
| EP1739078A1 (de) | 2005-05-30 | 2007-01-03 | Jerini AG | C5a-Rezeptor-Antagonisten |
| US20070292421A1 (en) * | 2005-07-28 | 2007-12-20 | Feinberg Bruce B | Method for treating preeclampsia |
| US8168584B2 (en) | 2005-10-08 | 2012-05-01 | Potentia Pharmaceuticals, Inc. | Methods of treating age-related macular degeneration by compstatin and analogs thereof |
| PL2148691T3 (pl) | 2007-02-05 | 2015-12-31 | Apellis Pharmaceuticals Inc | Analogi kompstatyny do stosowania w leczeniu stanów zapalnych układu oddechowego |
| WO2009015087A2 (en) * | 2007-07-20 | 2009-01-29 | Potentia Pharmaceuticals, Inc. | Compositions and methods for treatment of trauma |
| EP2278987A4 (en) * | 2008-03-28 | 2012-08-22 | Apellis Ag | MODULATION AND REPLY / IMPROVEMENT OF THE COMPLEMENTARY SYSTEM IN THE TREATMENT OF TRAUMATISM |
| US20100000605A1 (en) * | 2008-07-02 | 2010-01-07 | Saint-Gobain Performance Plastics Chaineux | Framed device, seal, and method for manufacturing same |
| LT2894165T (lt) | 2008-11-10 | 2023-03-10 | Alexion Pharmaceuticals, Inc. | Būdai ir kompozicijos, skirti su komplementu susijusių sutrikimų gydymui |
| AU2011207441A1 (en) * | 2010-01-22 | 2012-08-09 | The Trustees Of The University Of Pennsylvania | Methods of treating or preventing periodontitis and diseases associated with periodontitis |
| EP2824111B1 (en) | 2010-04-30 | 2017-03-22 | Alexion Pharmaceuticals, Inc. | Anti-C5A Antibodies and Methods for Using the Antibodies |
| AU2011276445A1 (en) | 2010-06-29 | 2013-02-21 | Board Of Regents Of The University Of Nebraska | Analogs of C5a and methods of using same |
| EP2468295A1 (en) * | 2010-12-21 | 2012-06-27 | Affiris AG | Vaccines based on peptides of the complement protein C5a |
| CN103796667A (zh) | 2011-06-22 | 2014-05-14 | 艾普莱斯制药公司 | 用补体抑制剂治疗慢性障碍的方法 |
| US9289467B2 (en) | 2011-08-10 | 2016-03-22 | Case Western Reserve University | Compositions and methods for treating bone conditions |
| US20150241429A1 (en) * | 2012-09-11 | 2015-08-27 | Hospital For Special Surgery | Irhom2 inhibition for the treatment of complement mediated disorders |
| ES2879430T3 (es) | 2012-11-15 | 2021-11-22 | Apellis Pharmaceuticals Inc | Análogos de compstatina de acción prolongada y composiciones y métodos relacionados |
| WO2014152391A1 (en) | 2013-03-15 | 2014-09-25 | Apellis Pharmaceuticals, Inc. | Cell-penetrating compstatin analogs and uses thereof |
| CA2908552A1 (en) * | 2013-04-02 | 2014-10-09 | The Scripps Research Institute | Uses of cyclic peptides for treating and preventing atherosclerosis |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| EP3359555B1 (en) | 2015-10-07 | 2023-12-20 | Apellis Pharmaceuticals, Inc. | Dosing regimens |
| US20190270778A1 (en) | 2016-07-29 | 2019-09-05 | Pfizer Inc. | Cyclic Peptides As C5a Receptor Antagonists |
| US20200057046A1 (en) | 2016-10-27 | 2020-02-20 | Alexion Pharmaceuticals, Inc. | Assay for c5b-9 deposition in complement-associated disorders |
| TWI826364B (zh) | 2017-04-03 | 2023-12-21 | 德商因夫萊亞斯有限公司 | 活性抑制劑於發炎性疾病之治療 |
| US10376595B2 (en) | 2017-04-03 | 2019-08-13 | Inflarx Gmbh | Treatment of inflammatory diseases with inhibitors of C5a activity |
| JP2020516607A (ja) | 2017-04-07 | 2020-06-11 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 投与レジメンならびに関連組成物および方法 |
| EP3642230A1 (en) | 2017-06-23 | 2020-04-29 | InflaRx GmbH | Treatment of inflammatory diseases with inhibitors of c5a activity |
| AU2018386304B2 (en) | 2017-12-15 | 2023-12-07 | Apellis Pharmaceuticals, Inc. | Dosing regimens and related compositions and methods |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| EP4126222A1 (en) | 2020-03-27 | 2023-02-08 | InflaRx GmbH | Inhibitors of c5a for the treatment of corona virus infection |
| TW202208427A (zh) | 2020-05-06 | 2022-03-01 | 德商因夫萊亞斯有限公司 | 人源化抗ｃ５ａ抗體 |
| WO2021231720A1 (en) | 2020-05-15 | 2021-11-18 | Alexion Pharmaceuticals, Inc. | Method of using extracellular vesicles to detect complement activation, and uses thereof to assess and/or monitor treatment of a complement-mediated disease |
| WO2024238422A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of a panel of lectins for detection of complement biomarkers in urine extracellular vesicles |
| WO2024238421A1 (en) | 2023-05-12 | 2024-11-21 | Alexion Pharmaceuticals, Inc. | Use of biomarkers for the identification and treatment of complement-mediated disorders |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5386011A (en) | 1990-12-27 | 1995-01-31 | Abbott Laboratories | Hexapeptide anaphylatoxin-receptor ligands |
| NZ274917A (en) | 1993-12-06 | 1998-03-25 | Novartis Ag | Peptide analogs of human c5a (from complement system), their production, coding sequences and diagnostic and therapeutic uses |
| US5807824A (en) * | 1993-12-06 | 1998-09-15 | Ciba-Geigy Corporation | C5A receptor antagonists having substantially no agonist activity |
| US5614370A (en) * | 1994-03-18 | 1997-03-25 | Merck & Co., Inc. | Assay to identify human C5a antagonists and agonists |
| US5696230A (en) | 1994-08-31 | 1997-12-09 | The Board Of Regents Of The University Of Nebraska | High-affinity response-selective C-terminal analogs of C5a anaphylatoxin |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| AUPR833401A0 (en) | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| AUPS160602A0 (en) * | 2002-04-08 | 2002-05-16 | University Of Queensland, The | Therapeutic method |
| AU2002952086A0 (en) * | 2002-10-16 | 2002-11-07 | The University Of Queensland | Treatment of osteoarthritis |
-
1997
- 1997-06-25 AU AUPO7550A patent/AUPO755097A0/en not_active Abandoned
-
1998
- 1998-06-25 US US12/045,088 patent/USRE41287E1/en not_active Expired - Fee Related
- 1998-06-25 ES ES98930536T patent/ES2294816T3/es not_active Expired - Lifetime
- 1998-06-25 WO PCT/AU1998/000490 patent/WO1999000406A1/en not_active Ceased
- 1998-06-25 PT PT98930536T patent/PT1017713E/pt unknown
- 1998-06-25 AU AU80926/98A patent/AU744991B2/en not_active Ceased
- 1998-06-25 JP JP50515499A patent/JP4686696B2/ja not_active Expired - Fee Related
- 1998-06-25 AT AT98930536T patent/ATE377606T1/de active
- 1998-06-25 US US09/446,109 patent/US6821950B1/en not_active Expired - Lifetime
- 1998-06-25 DK DK98930536T patent/DK1017713T3/da active
- 1998-06-25 DE DE69838678T patent/DE69838678T2/de not_active Expired - Lifetime
- 1998-06-25 EP EP98930536A patent/EP1017713B1/en not_active Expired - Lifetime
-
2004
- 2004-09-10 US US10/937,852 patent/US20060160726A1/en not_active Abandoned
-
2008
- 2008-01-10 CY CY20081100033T patent/CY1107133T1/el unknown
- 2008-08-19 US US12/193,943 patent/US20090203760A1/en not_active Abandoned
-
2012
- 2012-01-12 US US13/348,869 patent/US20130005644A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1017713T3 (da) | 2008-02-11 |
| CY1107133T1 (el) | 2012-10-24 |
| US20090203760A1 (en) | 2009-08-13 |
| ATE377606T1 (de) | 2007-11-15 |
| US20130005644A1 (en) | 2013-01-03 |
| AUPO755097A0 (en) | 1997-07-17 |
| DE69838678T2 (de) | 2008-10-30 |
| AU8092698A (en) | 1999-01-19 |
| DE69838678D1 (de) | 2007-12-20 |
| US6821950B1 (en) | 2004-11-23 |
| US20060160726A1 (en) | 2006-07-20 |
| EP1017713A1 (en) | 2000-07-12 |
| USRE41287E1 (en) | 2010-04-27 |
| JP2002508767A (ja) | 2002-03-19 |
| EP1017713A4 (en) | 2002-07-24 |
| HK1029595A1 (en) | 2001-04-06 |
| EP1017713B1 (en) | 2007-11-07 |
| PT1017713E (pt) | 2007-12-18 |
| AU744991B2 (en) | 2002-03-07 |
| JP4686696B2 (ja) | 2011-05-25 |
| WO1999000406A1 (en) | 1999-01-07 |
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