ES2284537T3 - Proteinas de fusion bifuncionales recombinantes para la eliminacion de virus variables. - Google Patents

Proteinas de fusion bifuncionales recombinantes para la eliminacion de virus variables. Download PDF

Info

Publication number
ES2284537T3
ES2284537T3 ES00973003T ES00973003T ES2284537T3 ES 2284537 T3 ES2284537 T3 ES 2284537T3 ES 00973003 T ES00973003 T ES 00973003T ES 00973003 T ES00973003 T ES 00973003T ES 2284537 T3 ES2284537 T3 ES 2284537T3
Authority
ES
Spain
Prior art keywords
component
fusion protein
protein according
recombinant fusion
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00973003T
Other languages
English (en)
Spanish (es)
Inventor
Juraj Petrik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Troyanys Ltd
Original Assignee
Troyanys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Troyanys Ltd filed Critical Troyanys Ltd
Application granted granted Critical
Publication of ES2284537T3 publication Critical patent/ES2284537T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/155Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165Mumps or measles virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/12Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/58Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/40Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18422New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/18011Paramyxoviridae
    • C12N2760/18411Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Peptides Or Proteins (AREA)
ES00973003T 1999-11-02 2000-11-01 Proteinas de fusion bifuncionales recombinantes para la eliminacion de virus variables. Expired - Lifetime ES2284537T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9925966.5A GB9925966D0 (en) 1999-11-02 1999-11-02 Threapeutic vaccines against variable viruses and other targets
GB9925966 1999-11-02

Publications (1)

Publication Number Publication Date
ES2284537T3 true ES2284537T3 (es) 2007-11-16

Family

ID=10863838

Family Applications (1)

Application Number Title Priority Date Filing Date
ES00973003T Expired - Lifetime ES2284537T3 (es) 1999-11-02 2000-11-01 Proteinas de fusion bifuncionales recombinantes para la eliminacion de virus variables.

Country Status (11)

Country Link
US (1) US7390881B2 (enExample)
EP (1) EP1226256B1 (enExample)
JP (1) JP4768944B2 (enExample)
AT (1) ATE358727T1 (enExample)
AU (1) AU1156001A (enExample)
CA (1) CA2389339A1 (enExample)
DE (1) DE60034243T2 (enExample)
ES (1) ES2284537T3 (enExample)
GB (1) GB9925966D0 (enExample)
HK (1) HK1048335B (enExample)
WO (1) WO2001032893A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8029803B2 (en) 2002-06-20 2011-10-04 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US8007805B2 (en) * 2003-08-08 2011-08-30 Paladin Labs, Inc. Chimeric antigens for breaking host tolerance to foreign antigens
JP2007505836A (ja) * 2003-09-15 2007-03-15 アイディー バイオメディカル コーポレイション オブ ケベック 麻疹サブユニットワクチン
WO2006133497A1 (en) * 2005-06-15 2006-12-21 Adelaide Research & Innovation Pty Ltd Combination treatment
ES2337113B1 (es) * 2007-04-17 2011-01-24 Centre De Recerca En Sanitat Animal (Cresa) Empleo de la hemaglutinina del virus de la peste porcina africana como adyuvante.
US12624091B2 (en) 2019-04-04 2026-05-12 Vanderbilt University HIV/HCV cross-reactive antibodies and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2133339A1 (en) * 1992-04-08 1993-10-09 Jennifer S. Rota Wild-type measles virus glycoproteins: vaccine and detection method therefor
EP0966534B1 (en) * 1997-03-11 2005-02-02 Mayo Foundation for Medical Education and Research Compositions and methods for elimination of unwanted cells
WO1999064073A2 (en) 1998-06-11 1999-12-16 The Government Of The United States, Represented By The Secretary Of The Department Of Health And Huan Services Recombinant immunotoxin directed against the hiv-1 gp120 envelope glycoprotein
ATE407146T1 (de) 1999-03-16 2008-09-15 Us Gov Health & Human Serv Ein neues chimäres protein für die prävention und die behandlung einer hiv infektion

Also Published As

Publication number Publication date
JP2003514518A (ja) 2003-04-22
ATE358727T1 (de) 2007-04-15
JP4768944B2 (ja) 2011-09-07
EP1226256A1 (en) 2002-07-31
GB9925966D0 (en) 1999-12-29
US20050260220A1 (en) 2005-11-24
CA2389339A1 (en) 2001-05-10
HK1048335B (en) 2007-11-23
DE60034243T2 (de) 2007-12-20
AU1156001A (en) 2001-05-14
DE60034243D1 (de) 2007-05-16
WO2001032893A1 (en) 2001-05-10
HK1048335A1 (en) 2003-03-28
EP1226256B1 (en) 2007-04-04
US7390881B2 (en) 2008-06-24

Similar Documents

Publication Publication Date Title
CN111088283B (zh) mVSV病毒载体及其病毒载体疫苗、一种基于mVSV介导的新冠肺炎疫苗
CN113980140B (zh) 融合蛋白及其应用
ES2272012T5 (es) Proteinas de fusion que comprenden las proteinas tat y/o nef del vih-1.
JP3883569B2 (ja) 呼吸器多核体ウイルスプロテインgのペプチド断片、免疫原的薬剤、それを含む医薬組成物、および製造法
AU8812398A (en) Syncytial respiratory virus epitopes and antibodies comprising them, useful in diagnosis and therapy
JP2000253876A (ja) センダイウイルスベクターを用いたワクチンおよびワクチンタンパク質
WO2026051974A1 (zh) 呼吸道合胞病毒融合前f蛋白突变体及其应用
US20200109176A1 (en) Compositions And Methods For Making And Using Virus-Like Particles (VLPs)
CN116904486A (zh) 一种大别班达病毒mRNA及其药物组合物与应用
AU631894B2 (en) Conjugate immunogen for aids
RU2181379C2 (ru) Пептид (варианты) и способ его производства, фармацевтическое средство, антитело и способ его производства
EP0471407A2 (en) New embodiments of the HIV principal neutralizing determinant
US7390881B2 (en) Recombinant therapeutic fusion proteins
ES2260416T3 (es) Polipeptido que induce anticuerpos que neutralizan el vih.
JP3076050B2 (ja) アイメリア・テネラワクチン
JPH02283286A (ja) ヘモフイルス インフルエンザb型の膜タンパク及びペプチド
JP7651129B2 (ja) ウイルスの非構造タンパク質が担持された複合タンパク質単量体、当該単量体の会合体、及び当該会合体を有効成分とするコンポーネントワクチン
RU2642258C1 (ru) Рекомбинантный химерный полипептид-иммуноген nTBI, обладающий способностью индуцировать антитела, нейтрализующие вирус иммунодефицита человека 1 типа, и предназначенный для использования в качестве компонента вакцины против ВИЧ-1
CA3112040C (en) Compositions and methods for making and using virus-like particles (vlps)
US6861253B2 (en) Polypeptide inducing antibodies neutralizing HIV
CN117917429A (zh) 新型冠状病毒抗原组合物、其制备方法和应用
JP2022116482A (ja) SARS-CoV-2由来のアミノ酸配列およびその利用
HK1205148A1 (en) Proteins and methods used to prepare hepatitis e virus-like particles
GB2282378A (en) Conjugates of epitopes of HIV with a protein complex from Neisseria
HK1205148B (zh) 用於制备戊型肝炎病毒样颗粒的蛋白质和方法