ES2280758T5 - Vectores sitio-específicos de integración en listeria y procedimientos para la utilización de los mismos. - Google Patents
Vectores sitio-específicos de integración en listeria y procedimientos para la utilización de los mismos. Download PDFInfo
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- ES2280758T5 ES2280758T5 ES03736520T ES03736520T ES2280758T5 ES 2280758 T5 ES2280758 T5 ES 2280758T5 ES 03736520 T ES03736520 T ES 03736520T ES 03736520 T ES03736520 T ES 03736520T ES 2280758 T5 ES2280758 T5 ES 2280758T5
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- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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| Application Number | Priority Date | Filing Date | Title |
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| US10/136,860 US7425449B2 (en) | 2002-04-30 | 2002-04-30 | Site specific Listeria integration vectors and methods for using the same |
| US136860 | 2002-04-30 |
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| ES2280758T3 ES2280758T3 (es) | 2007-09-16 |
| ES2280758T5 true ES2280758T5 (es) | 2011-05-04 |
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| JP (1) | JP2005523716A (https=) |
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| DE (1) | DE60311252T3 (https=) |
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| US7794729B2 (en) | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US7820180B2 (en) | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| WO2001072329A1 (en) | 2000-03-29 | 2001-10-04 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| US7700344B2 (en) | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| US7780961B2 (en) * | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| US7425449B2 (en) * | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
| WO2003102168A1 (en) * | 2002-05-29 | 2003-12-11 | The Regents Of The University Of California | Attenuated listeria spp. and methods for using the same |
| CA2506031A1 (en) * | 2002-11-15 | 2004-06-03 | Vib Vzw | Self-containing lactobacillus strain comprising a thya mutation and therapeutic applications thereof |
| US7833775B2 (en) * | 2003-02-06 | 2010-11-16 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| KR101192652B1 (ko) * | 2003-02-06 | 2012-10-19 | 앤저 테라퓨틱스 인코퍼레이티드 | 비포식 세포로의 침투가 약화된 리스테리아, 리스테리아를 포함하는 백신, 및 그것의 사용방법 |
| US7695725B2 (en) * | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| EP1644492B1 (en) | 2003-06-18 | 2009-01-07 | Genelux Corporation | Modified recombinant vaccinia viruses, uses thereof |
| AU2004281834A1 (en) * | 2003-10-15 | 2005-04-28 | Cerus Corporation | Listeria-based EphA2 vaccines |
| US7842289B2 (en) * | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| US8906664B2 (en) | 2004-08-13 | 2014-12-09 | The Trustees Of The University Of Pennsylvania | Methods for constructing antibiotic resistance free vaccines |
| WO2006045110A2 (en) * | 2004-10-18 | 2006-04-27 | Medimmune, Inc. | High cell density process for growth of listeria |
| AU2006319216B2 (en) | 2005-11-29 | 2012-09-13 | Intrexon Actobiotics Nv | Induction of mucosal tolerance to antigens |
| US20070207171A1 (en) * | 2006-03-01 | 2007-09-06 | Cerus Corporation | Engineered listeria and methods of use thereof |
| WO2007103225A2 (en) * | 2006-03-01 | 2007-09-13 | Anza Therapeutics, Inc. | Engineered listeria and methods of use thereof |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| DK2977456T3 (en) | 2006-08-15 | 2018-01-22 | Univ Pennsylvania | Compositions comprising HMW-MAA and fragments thereof for the treatment of cancer |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| EP2426142A3 (en) | 2006-10-16 | 2012-06-13 | Genelux Corporation | Modified vaccinia virus strains for use in a diagnostic and therapeutic method |
| US8277797B2 (en) | 2006-11-22 | 2012-10-02 | The Regents Of The University Of California | Interferon-β production modulating Listeria strains and methods for using same |
| CN103933563B (zh) | 2007-01-25 | 2016-09-28 | 英特瑞克斯顿阿克图比奥帝克斯有限公司 | 使用遗传修饰的乳杆菌通过抗原的粘膜递送治疗免疫疾病 |
| JP2010534058A (ja) * | 2007-04-16 | 2010-11-04 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 抗生物質耐性のないリステリア菌およびその構築および使用方法 |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| US20110129499A1 (en) | 2008-05-19 | 2011-06-02 | Paulo Maciag | Dual delivery system for heterologous antigens |
| PT2403935T (pt) | 2009-03-04 | 2017-09-22 | Univ Pennsylvania | Composições compreendendo fatores angiogénicos e metedos para a sua utilização |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| US9226958B2 (en) | 2010-10-01 | 2016-01-05 | University Of Georgia Research Foundation, Inc. | Use of Listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| AU2012229218B2 (en) | 2011-03-11 | 2017-03-02 | Advaxis, Inc. | Listeria-based adjuvants |
| FR2976811A1 (fr) | 2011-06-22 | 2012-12-28 | Lfb Biotechnologies | Utilisation d'un anticorps anti-cd20 a haute adcc pour le traitement de la maladie de waldenstrom |
| CN104411327A (zh) | 2012-03-12 | 2015-03-11 | 阿德瓦希斯公司 | 李斯特菌疫苗治疗以后的抑制细胞功能抑制 |
| HK1213008A1 (zh) * | 2012-11-06 | 2016-06-24 | 艾杜罗生物科技公司 | 兼性减毒细菌种类及其制备和使用方法 |
| NO339948B1 (no) * | 2013-12-20 | 2017-02-20 | Energynest As | Element for termisk energilager |
| FR3016633B1 (fr) | 2014-01-17 | 2018-04-13 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Immunoglobuline anti-toxine du charbon |
| US9976149B2 (en) | 2014-05-08 | 2018-05-22 | Ramot At Tel-Aviv University Ltd. | Modified listeria bacteria and uses thereof |
| WO2016073585A1 (en) | 2014-11-05 | 2016-05-12 | The Regents Of The University Of California | General secretory pathway (gsp) mutant listeria spp., and methods for making and using the same |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
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| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| AU3710597A (en) * | 1997-08-06 | 1999-03-01 | Laboratorio Medinfar-Produtos Farmaceuticos, Lda | Dna integration into "mycobacterium spp." genome by trans-complementation using a site-specific integration system |
| US6099848A (en) * | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US6004815A (en) | 1998-08-13 | 1999-12-21 | The Regents Of The University Of California | Bacteria expressing nonsecreted cytolysin as intracellular microbial delivery vehicles to eukaryotic cells |
| DE19949594A1 (de) * | 1999-10-14 | 2001-04-26 | Deutsches Krebsforsch | Rekombinante attenuierte Listerien zur Immuntherapie |
| AU2001242019A1 (en) | 2000-07-06 | 2002-02-05 | Xenogen Corporation | Compositions and methods for use thereof in modifying the genomes of microorganisms |
| US7425449B2 (en) * | 2002-04-30 | 2008-09-16 | The Regents Of The University Of California | Site specific Listeria integration vectors and methods for using the same |
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| ES2280758T3 (es) | 2007-09-16 |
| WO2003092600A3 (en) | 2004-04-08 |
| DE60311252T2 (de) | 2007-11-22 |
| AU2003237138B2 (en) | 2008-04-03 |
| US20150037369A1 (en) | 2015-02-05 |
| US7749510B2 (en) | 2010-07-06 |
| WO2003092600A2 (en) | 2003-11-13 |
| US20120321662A1 (en) | 2012-12-20 |
| AU2003237138A1 (en) | 2003-11-17 |
| US9556441B2 (en) | 2017-01-31 |
| US20170204423A1 (en) | 2017-07-20 |
| EP1504095B1 (en) | 2007-01-17 |
| DE60311252T3 (de) | 2011-06-30 |
| US20110027319A1 (en) | 2011-02-03 |
| ATE351913T1 (de) | 2007-02-15 |
| US8865469B2 (en) | 2014-10-21 |
| US20070059322A1 (en) | 2007-03-15 |
| US8192991B2 (en) | 2012-06-05 |
| CA2484185A1 (en) | 2003-11-13 |
| US7425449B2 (en) | 2008-09-16 |
| EP1504095A4 (en) | 2005-06-22 |
| US20030203472A1 (en) | 2003-10-30 |
| DE60311252D1 (de) | 2007-03-08 |
| JP2005523716A (ja) | 2005-08-11 |
| EP1504095B2 (en) | 2010-12-29 |
| EP1504095A2 (en) | 2005-02-09 |
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