ES2280099T5 - Composición higiénica bucal para el tratamiento del mal aliento. - Google Patents
Composición higiénica bucal para el tratamiento del mal aliento. Download PDFInfo
- Publication number
- ES2280099T5 ES2280099T5 ES98942969T ES98942969T ES2280099T5 ES 2280099 T5 ES2280099 T5 ES 2280099T5 ES 98942969 T ES98942969 T ES 98942969T ES 98942969 T ES98942969 T ES 98942969T ES 2280099 T5 ES2280099 T5 ES 2280099T5
- Authority
- ES
- Spain
- Prior art keywords
- chelate
- amino acid
- zinc
- composition
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- 229960003136 leucine Drugs 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- FJQXCDYVZAHXNS-UHFFFAOYSA-N methadone hydrochloride Chemical compound Cl.C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 FJQXCDYVZAHXNS-UHFFFAOYSA-N 0.000 description 1
- 150000007522 mineralic acids Chemical class 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- 229940051866 mouthwash Drugs 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 150000002843 nonmetals Chemical class 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 210000003254 palate Anatomy 0.000 description 1
- 235000008729 phenylalanine Nutrition 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000004224 potassium gluconate Substances 0.000 description 1
- 235000013926 potassium gluconate Nutrition 0.000 description 1
- 229960003189 potassium gluconate Drugs 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 229960001153 serine Drugs 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000000176 sodium gluconate Substances 0.000 description 1
- 235000012207 sodium gluconate Nutrition 0.000 description 1
- 229940005574 sodium gluconate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000019614 sour taste Nutrition 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
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- 235000007586 terpenes Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK199701149A DK176196B1 (da) | 1997-10-07 | 1997-10-07 | Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet |
| DK1149/97 | 1997-10-07 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2280099T3 ES2280099T3 (es) | 2007-09-01 |
| ES2280099T5 true ES2280099T5 (es) | 2011-05-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98942969T Expired - Lifetime ES2280099T5 (es) | 1997-10-07 | 1998-09-28 | Composición higiénica bucal para el tratamiento del mal aliento. |
Country Status (12)
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|---|---|
| US (1) | US6607711B2 (enExample) |
| EP (1) | EP1021158B9 (enExample) |
| AU (1) | AU757779B2 (enExample) |
| CA (1) | CA2304969C (enExample) |
| CY (1) | CY1106515T1 (enExample) |
| DE (1) | DE69836915T3 (enExample) |
| DK (2) | DK176196B1 (enExample) |
| ES (1) | ES2280099T5 (enExample) |
| NO (1) | NO315105B1 (enExample) |
| NZ (1) | NZ503647A (enExample) |
| WO (1) | WO1999017735A1 (enExample) |
| ZA (1) | ZA989150B (enExample) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6242009B1 (en) | 1999-04-20 | 2001-06-05 | Kareem I. Batarseh | Microbicidal formulations and methods to control microorganisms |
| KR100488609B1 (ko) | 1999-08-16 | 2005-05-11 | 피큐 홀딩, 인코포레이티드 | 양파 및 마늘 입냄새 감소를 위한 황 흡착제 |
| US7311925B2 (en) * | 2001-01-22 | 2007-12-25 | Michael A Zasloff | Methods and compositions for blocking microbial adherence to eukaryotic cells |
| US6630172B2 (en) | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
| CA2451833C (en) | 2001-05-15 | 2009-08-18 | The Procter & Gamble Company | Confectionery compositions comprising two metal cations |
| WO2002092037A1 (en) * | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Oral care confectionery compositions |
| WO2002092038A2 (en) | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Oral care compositions |
| WO2002092027A2 (en) | 2001-05-15 | 2002-11-21 | The Procter & Gamble Company | Confectionery compositions |
| US7666410B2 (en) | 2002-12-20 | 2010-02-23 | Kimberly-Clark Worldwide, Inc. | Delivery system for functional compounds |
| US7582308B2 (en) | 2002-12-23 | 2009-09-01 | Kimberly-Clark Worldwide, Inc. | Odor control composition |
| CA2535219A1 (en) | 2003-09-09 | 2005-03-24 | Dsm Ip Assets B.V. | Orally effective, essentially water-free topical agent containing one or several oxidation-sensitive substances |
| US7544204B2 (en) * | 2003-10-15 | 2009-06-09 | Valam Corporation | Control of halitosis-generating and other microorganisms in the non-dental upper respiratory tract |
| US7582485B2 (en) | 2003-10-16 | 2009-09-01 | Kimberly-Clark Worldride, Inc. | Method and device for detecting ammonia odors and helicobacter pylori urease infection |
| US7413550B2 (en) * | 2003-10-16 | 2008-08-19 | Kimberly-Clark Worldwide, Inc. | Visual indicating device for bad breath |
| US7837663B2 (en) | 2003-10-16 | 2010-11-23 | Kimberly-Clark Worldwide, Inc. | Odor controlling article including a visual indicating device for monitoring odor absorption |
| US7438875B2 (en) | 2003-10-16 | 2008-10-21 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using metal-modified silica particles |
| US7488520B2 (en) | 2003-10-16 | 2009-02-10 | Kimberly-Clark Worldwide, Inc. | High surface area material blends for odor reduction, articles utilizing such blends and methods of using same |
| US7141518B2 (en) * | 2003-10-16 | 2006-11-28 | Kimberly-Clark Worldwide, Inc. | Durable charged particle coatings and materials |
| US7794737B2 (en) * | 2003-10-16 | 2010-09-14 | Kimberly-Clark Worldwide, Inc. | Odor absorbing extrudates |
| US7678367B2 (en) | 2003-10-16 | 2010-03-16 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using metal-modified particles |
| US7754197B2 (en) | 2003-10-16 | 2010-07-13 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using coordinated polydentate compounds |
| US7879350B2 (en) | 2003-10-16 | 2011-02-01 | Kimberly-Clark Worldwide, Inc. | Method for reducing odor using colloidal nanoparticles |
| US20080008666A1 (en) * | 2004-03-12 | 2008-01-10 | Michael Phillips | Breath Test for Oral Malodor |
| US20090202453A1 (en) * | 2004-08-03 | 2009-08-13 | Hindustan Lever Limited | Oral Composition |
| US7582418B2 (en) * | 2004-11-03 | 2009-09-01 | Albion Laboratories, Inc. | Antimicrobial chelates |
| US20070048247A1 (en) * | 2005-08-31 | 2007-03-01 | Kimberly-Clark Worldwide, Inc. | Deodorizing tablets |
| US7687650B2 (en) | 2006-02-03 | 2010-03-30 | Jr Chem, Llc | Chemical compositions and methods of making them |
| US7897800B2 (en) * | 2006-02-03 | 2011-03-01 | Jr Chem, Llc | Chemical compositions and methods of making them |
| US7977103B2 (en) | 2006-04-20 | 2011-07-12 | Kimberly-Clark Worldwide, Inc. | Method for detecting the onset of ovulation |
| US8668902B2 (en) * | 2006-06-08 | 2014-03-11 | Vapor Shield, Inc. | Composition with activated carbon in oral treatment |
| US7470434B1 (en) * | 2007-07-28 | 2008-12-30 | Michael A Zasloff | Methods and compositions for blocking microbial adherence to eukaryotic cells |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US20090324517A1 (en) * | 2008-06-30 | 2009-12-31 | Dan Kline | Halitosis treatment |
| US20160184354A1 (en) | 2009-01-23 | 2016-06-30 | Jr Chem, Llc | Rosacea treatments and kits for performing them |
| EP2493446B1 (en) * | 2009-10-26 | 2018-03-21 | Colgate-Palmolive Company | Oral composition for treating oral malodor |
| WO2012015420A1 (en) * | 2010-07-30 | 2012-02-02 | Colgate-Palmolive Company | Mouthwash formulations for use with toothbrush delivery device |
| US8952057B2 (en) | 2011-01-11 | 2015-02-10 | Jr Chem, Llc | Compositions for anorectal use and methods for treating anorectal disorders |
| WO2012142474A2 (en) | 2011-04-13 | 2012-10-18 | Thermolife International, Llc | N-acetyl beta alanine methods of use |
| US20120315224A1 (en) * | 2011-06-13 | 2012-12-13 | Ramirez Jose E | Appliances and compositions for oral use and methods for treating the oral mucosa, lips, and perioral regions |
| US9023420B2 (en) * | 2011-07-14 | 2015-05-05 | Universal Display Corporation | Composite organic/inorganic layer for organic light-emitting devices |
| MX340344B (es) * | 2011-12-21 | 2016-07-05 | Colgate Palmolive Co | Composiciones de cuidado oral. |
| WO2013171164A1 (en) | 2012-05-14 | 2013-11-21 | EJP Pharmaceutical ApS | Compositions and formulations for the treatment of halitosis |
| CN104853727B (zh) | 2012-12-19 | 2018-04-20 | 高露洁-棕榄公司 | 包含氧化锌和三甲基甘氨酸的口腔护理产品 |
| US9498421B2 (en) | 2012-12-19 | 2016-11-22 | Colgate-Palmolive Company | Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine |
| US9763865B2 (en) * | 2012-12-19 | 2017-09-19 | Colgate-Palmolive Company | Oral gel comprising zinc-amino acid complex |
| US9750670B2 (en) | 2012-12-19 | 2017-09-05 | Colgate-Palmolive Company | Zinc amino acid complex with cysteine |
| US9675823B2 (en) | 2012-12-19 | 2017-06-13 | Colgate-Palmolive Company | Two component compositions containing zinc amino acid halide complexes and cysteine |
| CA2892413C (en) | 2012-12-19 | 2019-09-17 | Colgate-Palmolive Company | Zinc amino acid halide mouthwashes |
| US9504858B2 (en) | 2012-12-19 | 2016-11-29 | Colgate-Palmolive Company | Zinc amino acid halide complex with cysteine |
| US10494589B2 (en) | 2012-12-19 | 2019-12-03 | Colgate-Palmolive Company | Method for indicating time for washing or indicating delivery of antibacterial agent |
| US10188112B2 (en) | 2012-12-19 | 2019-01-29 | Colgate-Palmolive Company | Personal cleansing compositions containing zinc amino acid/trimethylglycine halide |
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| CN104853812B (zh) | 2012-12-19 | 2018-07-10 | 高露洁-棕榄公司 | 具有蛋白质和止汗盐的止汗剂产品 |
| EP2934445B1 (en) | 2012-12-19 | 2017-10-04 | Colgate-Palmolive Company | Teeth whitening methods, visually perceptible signals and compositions therefor comprising zinc amino acid halides |
| RU2636612C2 (ru) | 2012-12-19 | 2017-11-24 | Колгейт-Палмолив Компани | Композиции для ухода за полостью рта, содержащие комплекс цинка с аминокислотой и галогенидом |
| CN107308013A (zh) | 2012-12-19 | 2017-11-03 | 高露洁-棕榄公司 | 锌‑赖氨酸络合物 |
| CN104853721B (zh) | 2012-12-19 | 2017-10-27 | 高露洁-棕榄公司 | 锌精氨酸/赖氨酸卤化物 |
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| MX368896B (es) * | 2012-12-19 | 2019-10-21 | Colgate Palmolive Co | Composiciones de dos componentes que contienen complejos de halogenuro de aminoacido de zinc y cisteina. |
| BR112015014453B1 (pt) | 2012-12-19 | 2019-06-11 | Colgate-Palmolive Company | Composição para higiene oral, complexo iônico, usos de um haleto de zinco tetrabásico em conjunto com trimetilglicina na forma de sal de adição de ácido e complexo |
| BR112016028541A2 (pt) * | 2014-06-18 | 2018-07-10 | Colgate Palmolive Co | pasta de dente compreendendo complexo de zinco-aminoácidos e fosfatos. |
| EP3377026B1 (en) * | 2015-12-22 | 2022-02-02 | Colgate-Palmolive Company | Oral care compositions comprising zinc amino acid halides |
| CA3041644C (en) * | 2016-10-24 | 2020-03-10 | Colgate-Palmolive Company | Oral care compositions and methods of use |
| USD825741S1 (en) | 2016-12-15 | 2018-08-14 | Water Pik, Inc. | Oral irrigator handle |
| EP3576714B1 (en) | 2017-02-02 | 2023-10-25 | Water Pik, Inc. | Tablet comprising abrasive for dental cleaning |
| AU2018236429B2 (en) | 2017-03-16 | 2023-02-02 | Water Pik, Inc. | Oral irrigator handle for use with oral agent |
| USD868243S1 (en) | 2018-03-16 | 2019-11-26 | Water Pik, Inc. | Oral irrigator tip |
| MX385756B (es) | 2018-03-29 | 2025-03-18 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encías. |
| AU2018415259B2 (en) | 2018-03-29 | 2022-04-28 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| AU2018415261B2 (en) | 2018-03-29 | 2021-11-04 | The Procter & Gamble Company | Oral care compositions for promoting gum health |
| MX384946B (es) | 2018-03-29 | 2025-03-14 | Procter & Gamble | Composiciones para el cuidado bucal para promover la salud de las encías. |
| AU2019468797A1 (en) | 2019-09-30 | 2022-03-17 | The Procter & Gamble Company | Dentifrice compositions for treatment of dental biofilm |
| WO2021062607A1 (en) | 2019-09-30 | 2021-04-08 | The Procter & Gamble Company | Oral care compositions comprising hops beta acid and amino acid |
| MX2022003757A (es) | 2019-09-30 | 2022-04-18 | Procter & Gamble | Composiciones para el cuidado bucal con actividad anticaries. |
| CN114466640B (zh) | 2019-09-30 | 2025-01-14 | 宝洁公司 | 用于处理牙科生物膜的洁牙剂组合物 |
| US12441615B2 (en) | 2021-02-11 | 2025-10-14 | Thermolife International, Llc | Method of administering nitric oxide gas |
| AU2021377897A1 (en) | 2020-11-12 | 2024-09-12 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| US11865139B2 (en) | 2020-11-12 | 2024-01-09 | Thermolife International, Llc | Method of treating migraines and headaches |
| WO2025016962A1 (en) * | 2023-07-20 | 2025-01-23 | Unilever Ip Holdings B.V. | Use of oral care composition comprising a zinc compound for absorbing odours in the mouth |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3655868A (en) | 1970-11-30 | 1972-04-11 | Harold N Vagenius | Oral deodorant |
| US4425325A (en) * | 1979-06-20 | 1984-01-10 | Lever Brothers Company | Oral compositions |
| US4339432A (en) | 1979-06-20 | 1982-07-13 | Lever Brothers Company | Oral mouthwash containing zinc and glycine |
| US4416867A (en) | 1979-06-20 | 1983-11-22 | Lever Brothers Company | Oral compositions |
| US4314991A (en) | 1980-07-25 | 1982-02-09 | Johnson & Johnson Products Inc. | Sulfonated polyamino acids as dental plaque barriers |
| US5409905A (en) | 1981-01-05 | 1995-04-25 | Eby, Iii; George A. | Cure for commond cold |
| US4956385A (en) | 1981-07-31 | 1990-09-11 | Eby Iii George A | Method for reducing the duration of the common cold |
| US5002970A (en) * | 1981-07-31 | 1991-03-26 | Eby Iii George A | Flavor masked ionizable zinc compositions for oral absorption |
| DE3578313D1 (de) | 1984-02-20 | 1990-07-26 | Blendax Werke Schneider Co | Mittel zur oralen hygiene. |
| CA1243952A (en) * | 1984-06-11 | 1988-11-01 | John C. Godfrey | Flavor of zinc supplements for oral use |
| US4758439A (en) | 1984-06-11 | 1988-07-19 | Godfrey Science & Design, Inc. | Flavor of zinc supplements for oral use |
| US4652444A (en) | 1984-12-14 | 1987-03-24 | National Research Laboratories | Methods and compositions for treating dental structures |
| US4689214A (en) | 1985-04-16 | 1987-08-25 | Colgate-Palmolive Company | Composition to counter breath odor |
| US4599152A (en) † | 1985-05-24 | 1986-07-08 | Albion Laboratories | Pure amino acid chelates |
| US4814164A (en) | 1986-03-10 | 1989-03-21 | Colgate-Palmolive Company | Solid antitartar mouth deodorant composition |
| US4814163A (en) | 1986-03-10 | 1989-03-21 | Colgate-Palmolive Company | Solid antitartar mouth deodorant |
| JPH0747531B2 (ja) | 1986-06-27 | 1995-05-24 | ライオン株式会社 | 口腔用組成物 |
| NO159694C (no) * | 1986-06-27 | 1989-02-01 | Synnoeve Assev | Tann- og munnbehandlingspreparat. |
| US4830716B1 (en) † | 1986-07-03 | 1999-12-07 | Albion Int | Preparation of pharmaceutical grade amino acid chelates |
| GB8729564D0 (en) | 1987-12-18 | 1988-02-03 | Unilever Plc | Oral compositions |
| US5059416A (en) | 1989-06-26 | 1991-10-22 | Warner-Lambert Company | Zinc compound delivery system with improved taste and texture |
| GB8922594D0 (en) | 1989-10-06 | 1989-11-22 | Unilever Plc | Oral compositions |
| US4992259A (en) | 1990-01-03 | 1991-02-12 | Johnson & Johnson Consumer Products, Inc. | Stable oral composition of zinc |
| US5308627A (en) | 1990-08-07 | 1994-05-03 | Umbdenstock Jr Anthony J | Nutritional supplement for optimizing cellular health |
| FR2678828B1 (fr) | 1991-07-12 | 1995-02-10 | Oreal | Composition a usage buccal destinee a inhiber ou detruire la mauvaise haleine et procede d'hygiene buccale pour detruire la mauvaise haleine. |
| US5286480A (en) | 1992-06-29 | 1994-02-15 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
| EP0675706A1 (en) | 1992-12-18 | 1995-10-11 | The Procter & Gamble Company | Oral compositions containing antiplaque, anticalculus agents |
| US5405836A (en) | 1993-03-02 | 1995-04-11 | Nabisco, Inc. | Pet foods with water-soluble zinc compound coating for controlling malodorous breath |
| US5389360A (en) * | 1993-05-13 | 1995-02-14 | The Procter & Gamble Company | Oral compositions |
| EP0697861B1 (en) | 1993-05-13 | 1998-08-26 | Unilever N.V. | Oral compositions containing triclosan for the treatment of aphthous ulcers |
| AU6910294A (en) | 1993-05-19 | 1994-12-12 | Church & Dwight Company, Inc. | Oral care compositions containing zinc oxide particles and sodium bicarbonate |
| EP0719131A1 (en) | 1993-09-16 | 1996-07-03 | Unilever N.V. | Oral compositions containing stannous compounds |
| EP0658565A1 (en) | 1993-12-17 | 1995-06-21 | Unilever Plc | Oral products |
| US5504055A (en) | 1994-03-15 | 1996-04-02 | J.H. Biotech, Inc. | Metal amino acid chelate |
| CA2154860A1 (en) | 1994-07-26 | 1996-01-27 | Todd W. Domke | Oral care products containing zinc-polyamine complex and pyrophosphate |
| US5596016A (en) | 1994-08-19 | 1997-01-21 | Albion International, Inc. | 1,2-disubstituted aromatic chelates |
| AU3471195A (en) * | 1994-08-22 | 1996-03-14 | Quest International B.V. | Breath malodour reduction |
| US5516925A (en) | 1994-08-23 | 1996-05-14 | Albion International, Inc. | Amino acid chelates having improved palatability |
| EP0721774B1 (en) | 1994-12-12 | 2002-10-02 | Unilever N.V. | Anti-microbial compositions |
-
1997
- 1997-10-07 DK DK199701149A patent/DK176196B1/da not_active IP Right Cessation
-
1998
- 1998-09-28 AU AU90920/98A patent/AU757779B2/en not_active Ceased
- 1998-09-28 WO PCT/IB1998/001503 patent/WO1999017735A1/en not_active Ceased
- 1998-09-28 NZ NZ503647A patent/NZ503647A/en unknown
- 1998-09-28 EP EP98942969A patent/EP1021158B9/en not_active Expired - Lifetime
- 1998-09-28 DE DE69836915T patent/DE69836915T3/de not_active Expired - Lifetime
- 1998-09-28 CA CA002304969A patent/CA2304969C/en not_active Expired - Fee Related
- 1998-09-28 ES ES98942969T patent/ES2280099T5/es not_active Expired - Lifetime
- 1998-10-07 ZA ZA989150A patent/ZA989150B/xx unknown
-
1999
- 1999-12-30 US US09/475,122 patent/US6607711B2/en not_active Expired - Fee Related
-
2000
- 2000-04-06 NO NO20001775A patent/NO315105B1/no not_active IP Right Cessation
-
2002
- 2002-04-23 DK DK200200116U patent/DK200200116U4/da not_active IP Right Cessation
-
2007
- 2007-04-17 CY CY20071100525T patent/CY1106515T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO315105B1 (no) | 2003-07-14 |
| DK200200116U4 (da) | 2004-12-10 |
| EP1021158B9 (en) | 2011-09-14 |
| US6607711B2 (en) | 2003-08-19 |
| DE69836915T2 (de) | 2007-10-04 |
| EP1021158B2 (en) | 2010-12-29 |
| DK200200116U1 (enExample) | 2002-04-23 |
| CA2304969C (en) | 2003-04-01 |
| EP1021158A1 (en) | 2000-07-26 |
| NO20001775L (no) | 2000-05-25 |
| AU757779B2 (en) | 2003-03-06 |
| NO20001775D0 (no) | 2000-04-06 |
| ZA989150B (en) | 1999-04-07 |
| CY1106515T1 (el) | 2012-01-25 |
| DK114997A (da) | 1999-04-08 |
| US20030012744A1 (en) | 2003-01-16 |
| WO1999017735A1 (en) | 1999-04-15 |
| CA2304969A1 (en) | 1999-04-15 |
| DE69836915D1 (de) | 2007-03-08 |
| DK176196B1 (da) | 2007-01-08 |
| DE69836915T3 (de) | 2012-05-24 |
| EP1021158B1 (en) | 2007-01-17 |
| NZ503647A (en) | 2001-10-26 |
| ES2280099T3 (es) | 2007-09-01 |
| AU9092098A (en) | 1999-04-27 |
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