ES2261663T3 - Uso de sustancias neuroactivas para el tratamiento de la enfermedad de parkinson y combinacion de medicamentos. - Google Patents
Uso de sustancias neuroactivas para el tratamiento de la enfermedad de parkinson y combinacion de medicamentos.Info
- Publication number
- ES2261663T3 ES2261663T3 ES02724212T ES02724212T ES2261663T3 ES 2261663 T3 ES2261663 T3 ES 2261663T3 ES 02724212 T ES02724212 T ES 02724212T ES 02724212 T ES02724212 T ES 02724212T ES 2261663 T3 ES2261663 T3 ES 2261663T3
- Authority
- ES
- Spain
- Prior art keywords
- substance
- combination
- haloperidol
- parkinson
- disease
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000126 substance Substances 0.000 title claims abstract description 74
- 239000003814 drug Substances 0.000 title claims abstract description 24
- 208000018737 Parkinson disease Diseases 0.000 title claims abstract description 13
- 239000002858 neurotransmitter agent Substances 0.000 claims abstract description 16
- 230000030214 innervation Effects 0.000 claims abstract description 12
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical class C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims abstract description 8
- 230000001242 postsynaptic effect Effects 0.000 claims abstract description 8
- 239000003210 dopamine receptor blocking agent Substances 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims description 72
- 229960003878 haloperidol Drugs 0.000 claims description 36
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims description 16
- 229960001252 methamphetamine Drugs 0.000 claims description 12
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- 208000024891 symptom Diseases 0.000 claims description 9
- 229960003638 dopamine Drugs 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
- 201000010099 disease Diseases 0.000 claims description 6
- 230000000561 anti-psychotic effect Effects 0.000 claims description 4
- 239000005557 antagonist Substances 0.000 claims description 3
- 230000003291 dopaminomimetic effect Effects 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 230000008569 process Effects 0.000 description 7
- 210000004556 brain Anatomy 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 230000008901 benefit Effects 0.000 description 5
- 238000011161 development Methods 0.000 description 5
- 230000018109 developmental process Effects 0.000 description 5
- 210000001577 neostriatum Anatomy 0.000 description 5
- 108020003175 receptors Proteins 0.000 description 5
- 102000005962 receptors Human genes 0.000 description 5
- 230000008521 reorganization Effects 0.000 description 5
- 239000000164 antipsychotic agent Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 230000001684 chronic effect Effects 0.000 description 4
- 230000001447 compensatory effect Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000002483 medication Methods 0.000 description 4
- 210000000653 nervous system Anatomy 0.000 description 4
- 230000000750 progressive effect Effects 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 206010034010 Parkinsonism Diseases 0.000 description 3
- 241000700159 Rattus Species 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 229940005529 antipsychotics Drugs 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000008923 dopaminergic innervation Effects 0.000 description 3
- 230000005284 excitation Effects 0.000 description 3
- 230000001002 morphogenetic effect Effects 0.000 description 3
- 230000001537 neural effect Effects 0.000 description 3
- 210000002569 neuron Anatomy 0.000 description 3
- 230000000638 stimulation Effects 0.000 description 3
- 108050004812 Dopamine receptor Proteins 0.000 description 2
- 102000015554 Dopamine receptor Human genes 0.000 description 2
- 241000699684 Meriones unguiculatus Species 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 230000003542 behavioural effect Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 210000005064 dopaminergic neuron Anatomy 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 238000007912 intraperitoneal administration Methods 0.000 description 2
- LKPFBGKZCCBZDK-UHFFFAOYSA-N n-hydroxypiperidine Chemical class ON1CCCCC1 LKPFBGKZCCBZDK-UHFFFAOYSA-N 0.000 description 2
- 230000004766 neurogenesis Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 210000002442 prefrontal cortex Anatomy 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 210000000225 synapse Anatomy 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000003363 transsynaptic effect Effects 0.000 description 2
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 1
- NFDXQGNDWIPXQL-UHFFFAOYSA-N 1-cyclooctyldiazocane Chemical class C1CCCCCCC1N1NCCCCCC1 NFDXQGNDWIPXQL-UHFFFAOYSA-N 0.000 description 1
- 101800005049 Beta-endorphin Proteins 0.000 description 1
- 102100040999 Catechol O-methyltransferase Human genes 0.000 description 1
- 108020002739 Catechol O-methyltransferase Proteins 0.000 description 1
- 101150049660 DRD2 gene Proteins 0.000 description 1
- HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 1
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 1
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 1
- 102000010909 Monoamine Oxidase Human genes 0.000 description 1
- 108010062431 Monoamine oxidase Proteins 0.000 description 1
- 208000019430 Motor disease Diseases 0.000 description 1
- HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 1
- 150000001204 N-oxides Chemical class 0.000 description 1
- 208000012902 Nervous system disease Diseases 0.000 description 1
- 208000025966 Neurological disease Diseases 0.000 description 1
- 241000206755 Palmaria Species 0.000 description 1
- 102100027467 Pro-opiomelanocortin Human genes 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-N Tyramine Natural products NCCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-N 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 229940065524 anticholinergics inhalants for obstructive airway diseases Drugs 0.000 description 1
- 239000000935 antidepressant agent Substances 0.000 description 1
- 229940005513 antidepressants Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000003376 axonal effect Effects 0.000 description 1
- 230000028600 axonogenesis Effects 0.000 description 1
- WOPZMFQRCBYPJU-NTXHZHDSSA-N beta-endorphin Chemical compound C([C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CC=CC=C1 WOPZMFQRCBYPJU-NTXHZHDSSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 229960004170 clozapine Drugs 0.000 description 1
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 description 1
- 230000001054 cortical effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000003001 depressive effect Effects 0.000 description 1
- 229960003914 desipramine Drugs 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000003371 gabaergic effect Effects 0.000 description 1
- 230000000848 glutamatergic effect Effects 0.000 description 1
- 210000000020 growth cone Anatomy 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 208000013403 hyperactivity Diseases 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000003999 initiator Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000002474 noradrenergic effect Effects 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 230000005868 ontogenesis Effects 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 239000002464 receptor antagonist Substances 0.000 description 1
- 229940044551 receptor antagonist Drugs 0.000 description 1
- 230000001373 regressive effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 210000004281 subthalamic nucleus Anatomy 0.000 description 1
- 230000000946 synaptic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229960003732 tyramine Drugs 0.000 description 1
- DZGWFCGJZKJUFP-UHFFFAOYSA-O tyraminium Chemical compound [NH3+]CCC1=CC=C(O)C=C1 DZGWFCGJZKJUFP-UHFFFAOYSA-O 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4515—Non condensed piperidines, e.g. piperocaine having a butyrophenone group in position 1, e.g. haloperidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10111486 | 2001-03-09 | ||
DE10111486A DE10111486A1 (de) | 2001-03-09 | 2001-03-09 | Verwendung einer oder mehrerer neuroaktiver Substanzen zur Behandlung der Parkinsonschen Krankheit |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2261663T3 true ES2261663T3 (es) | 2006-11-16 |
Family
ID=7676934
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES02724212T Expired - Lifetime ES2261663T3 (es) | 2001-03-09 | 2002-03-08 | Uso de sustancias neuroactivas para el tratamiento de la enfermedad de parkinson y combinacion de medicamentos. |
Country Status (11)
Country | Link |
---|---|
US (1) | US20040147613A1 (da) |
EP (1) | EP1377294B1 (da) |
JP (1) | JP2004526723A (da) |
KR (1) | KR20040007464A (da) |
AT (1) | ATE320810T1 (da) |
AU (1) | AU2002254935A1 (da) |
DE (2) | DE10111486A1 (da) |
DK (1) | DK1377294T3 (da) |
ES (1) | ES2261663T3 (da) |
PT (1) | PT1377294E (da) |
WO (1) | WO2002072094A2 (da) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877802B2 (en) * | 2005-07-28 | 2014-11-04 | Duke Univerity | Antiparkinsonian action of phenylisopropylamines |
JP5756105B2 (ja) * | 2009-07-31 | 2015-07-29 | クレラ インコーポレイティッド | パーキンソン病の治療のための組成物および方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LU77658A1 (de) * | 1977-06-30 | 1979-03-26 | Byk Gulden Lomberg Chem Fab | Alkylsubstituierte piperidin-n-oxide,verfahren zu ihrer herstellung,ihre verwendung und sie enthaltende arzneimittel |
US5602150A (en) * | 1992-10-02 | 1997-02-11 | Research Foundation For Mental Hygiene, Inc. | Treatment of central nervous system disorders associated with psychotic behavior and dementia with a combination of neuroleptic drugs and taurine, or derivatives thereof, to prevent the development of tardive dyskinesia |
AU1129295A (en) * | 1993-01-06 | 1996-05-23 | Neurogen Corporation | Certain tricyclic substituted diazabicyclo{3.2.1} octane derivatives |
JPH10502923A (ja) * | 1994-07-15 | 1998-03-17 | パーデュー・リサーチ・ファンデーション | ジヒドレキシジンおよびその置換類似体の光学活性異性体 |
EP0942726A2 (en) * | 1996-12-24 | 1999-09-22 | Fujisawa Pharmaceutical Co., Ltd. | Use of aminopiperazine derivatives |
EP1042004A4 (en) * | 1997-12-31 | 2004-08-25 | Direct Therapeutics Inc | METHOD FOR TISSUE PERFUSION |
MXPA02001719A (es) * | 1999-08-18 | 2003-09-25 | Childrens Medical Center | METODOS, COMPOSICIONES Y EQUIPOS PARA PROMOVER LA RECUPERACION DEL DAnO AL SISTEMA NERVIOSO CENTRAL. |
-
2001
- 2001-03-09 DE DE10111486A patent/DE10111486A1/de not_active Withdrawn
-
2002
- 2002-03-08 WO PCT/EP2002/002571 patent/WO2002072094A2/de active IP Right Grant
- 2002-03-08 AU AU2002254935A patent/AU2002254935A1/en not_active Abandoned
- 2002-03-08 JP JP2002571053A patent/JP2004526723A/ja active Pending
- 2002-03-08 US US10/469,833 patent/US20040147613A1/en not_active Abandoned
- 2002-03-08 AT AT02724212T patent/ATE320810T1/de not_active IP Right Cessation
- 2002-03-08 DE DE50206139T patent/DE50206139D1/de not_active Expired - Fee Related
- 2002-03-08 EP EP02724212A patent/EP1377294B1/de not_active Expired - Lifetime
- 2002-03-08 ES ES02724212T patent/ES2261663T3/es not_active Expired - Lifetime
- 2002-03-08 DK DK02724212T patent/DK1377294T3/da active
- 2002-03-08 KR KR10-2003-7011884A patent/KR20040007464A/ko not_active Application Discontinuation
- 2002-03-08 PT PT02724212T patent/PT1377294E/pt unknown
Also Published As
Publication number | Publication date |
---|---|
DE50206139D1 (de) | 2006-05-11 |
DE10111486A1 (de) | 2002-10-02 |
JP2004526723A (ja) | 2004-09-02 |
WO2002072094A2 (de) | 2002-09-19 |
AU2002254935A1 (en) | 2002-09-24 |
EP1377294B1 (de) | 2006-03-22 |
KR20040007464A (ko) | 2004-01-24 |
US20040147613A1 (en) | 2004-07-29 |
PT1377294E (pt) | 2006-08-31 |
EP1377294A2 (de) | 2004-01-07 |
DK1377294T3 (da) | 2006-07-24 |
WO2002072094A3 (de) | 2003-01-23 |
ATE320810T1 (de) | 2006-04-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2289745T3 (es) | Metodo para tratar cefaleas vasculares. | |
JP4154237B2 (ja) | 異痛症および他の種々のタイプの慢性疼痛または幻肢痛を治療するための化合物のペプチドクラスの新規使用 | |
Sessle | Mechanisms of oral somatosensory and motor functions and their clinical correlates | |
Stahl | Basic psychopharmacology of antidepressants, part 1: Antidepressants have seven distinct mechanisms of action | |
ES2273764T3 (es) | Nuevos tratamientos que utilizan derivados de fenetilamina. | |
ES2426008T5 (es) | Tratamiento de síntomas de la enfermedad de Parkinson con ligandos del receptor de histamina H3 de alquilaminas no imidazólicas | |
AU721942B2 (en) | Use of K-252A derivative for the treatment of peripheral or central nerve disorders, and cytokine overproduction | |
US20060293309A1 (en) | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors | |
Sudoh et al. | Neurologic and histopathologic evaluation after high-volume intrathecal amitriptyline | |
PT87542B (pt) | Processo de preparacao de um medicamento a base de derivados da indolona para o tratamento da doenca de parkinson | |
DE69926804T2 (de) | Vorrichtungen zur behandlung und diagnose des restless leg syndroms | |
ES2323269T3 (es) | Uso de la pipamperona y un sndri, snri o ssri para el tratamiento de los trastornos del estado del animo y la ansiedad. | |
DE60120109T2 (de) | Verfahren zur herstellung von optisch reinem (r)- und (s)- didesmethylsibutramin | |
BRPI0411079A (pt) | composições farmacêuticas compreendendo atorvastatina, fabricadas sem granulação | |
BR112019009449A2 (pt) | tratamento de doenças do snc com estimulantes de sgc | |
PT1745786E (pt) | Compostos neuroprotetores e composições farmacêuticas que os compreendem | |
US6835728B2 (en) | Drug combination for the treatment of depression and related disorders comprising mirtazapine | |
ES2262801T3 (es) | Uso de un compuesto de carbamato para la prevencion o el tratamiento de trastorno bipolar. | |
ES2261663T3 (es) | Uso de sustancias neuroactivas para el tratamiento de la enfermedad de parkinson y combinacion de medicamentos. | |
ES2242605T3 (es) | Uso de desoxipeganina para el tratamiento de la demencia de alzheimer. | |
ES2280602T3 (es) | Uso de 2-(5-(4-fluorofenil)-3-piridilmetilaminometil)-cromano y sus sales fisiologicamente aceptables. | |
KR100614504B1 (ko) | 임상적 우울증 치료를 위한 디옥시페가닌의 용도 | |
ES2232128T3 (es) | Nuevas combinaciones de farmacos de un inhibidor de la recaptacion de noradrenalina (n.a.r.i.), preferentemente reboxetina y pindolol. | |
JP5163986B2 (ja) | フェニル酪酸ナトリウムを使用する、薬物依存症又はアルコール依存症或いは躁うつ病の予防又は治療のための医薬組成物 | |
US7468434B2 (en) | Diazene-bridge crown ether lithium compounds and methods for their use |