ES2261234T5 - Metabolitos de bupropion y metodos de sintesis y uso. - Google Patents
Metabolitos de bupropion y metodos de sintesis y uso. Download PDFInfo
- Publication number
- ES2261234T5 ES2261234T5 ES00957684T ES00957684T ES2261234T5 ES 2261234 T5 ES2261234 T5 ES 2261234T5 ES 00957684 T ES00957684 T ES 00957684T ES 00957684 T ES00957684 T ES 00957684T ES 2261234 T5 ES2261234 T5 ES 2261234T5
- Authority
- ES
- Spain
- Prior art keywords
- bupropion
- chlorophenyl
- tert
- pharmaceutically acceptable
- metabolite
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 238000000034 method Methods 0.000 title description 35
- 230000015572 biosynthetic process Effects 0.000 title description 9
- 238000003786 synthesis reaction Methods 0.000 title description 7
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- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000012453 solvate Substances 0.000 claims abstract description 18
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 claims abstract description 16
- 150000004677 hydrates Chemical class 0.000 claims abstract description 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 12
- NDPTTXIBLSWNSF-CABZTGNLSA-N (1r,2s)-2-(tert-butylamino)-1-(3-chlorophenyl)propan-1-ol Chemical compound CC(C)(C)N[C@@H](C)[C@H](O)C1=CC=CC(Cl)=C1 NDPTTXIBLSWNSF-CABZTGNLSA-N 0.000 claims abstract description 8
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- 229960004688 venlafaxine Drugs 0.000 claims description 2
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- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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US09/510,241 US6342496B1 (en) | 1999-03-01 | 2000-02-22 | Bupropion metabolites and methods of use |
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2000
- 2000-08-18 US US09/640,725 patent/US6337328B1/en not_active Expired - Lifetime
- 2000-08-23 DK DK00957684T patent/DK1259243T3/da active
- 2000-08-23 HU HU0300030A patent/HUP0300030A2/hu unknown
- 2000-08-23 DE DE60029139T patent/DE60029139T3/de not_active Expired - Lifetime
- 2000-08-23 WO PCT/US2000/023080 patent/WO2001062257A2/en active IP Right Grant
- 2000-08-23 PT PT00957684T patent/PT1259243E/pt unknown
- 2000-08-23 CA CA2400482A patent/CA2400482C/en not_active Expired - Fee Related
- 2000-08-23 EP EP00957684A patent/EP1259243B2/en not_active Expired - Lifetime
- 2000-08-23 EP EP05106426A patent/EP1602369B1/en not_active Expired - Lifetime
- 2000-08-23 CZ CZ20022857A patent/CZ302842B6/cs not_active IP Right Cessation
- 2000-08-23 DE DE60044152T patent/DE60044152D1/de not_active Expired - Lifetime
- 2000-08-23 AT AT00957684T patent/ATE331520T1/de not_active IP Right Cessation
- 2000-08-23 AU AU6926800A patent/AU6926800A/xx active Pending
- 2000-08-23 MX MXPA02008093A patent/MXPA02008093A/es active IP Right Grant
- 2000-08-23 PL PL357389A patent/PL202736B1/pl unknown
- 2000-08-23 AU AU2000269268A patent/AU2000269268B2/en not_active Ceased
- 2000-08-23 ES ES00957684T patent/ES2261234T5/es not_active Expired - Lifetime
- 2000-08-23 JP JP2001561322A patent/JP2003529563A/ja active Pending
- 2000-08-23 KR KR1020027010980A patent/KR100720290B1/ko not_active IP Right Cessation
- 2000-08-23 AT AT05106426T patent/ATE463247T1/de not_active IP Right Cessation
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2001
- 2001-11-16 US US09/987,931 patent/US20020052341A1/en not_active Abandoned
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2005
- 2005-10-20 US US11/253,689 patent/US20060058300A1/en not_active Abandoned
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2006
- 2006-09-14 CY CY20061101315T patent/CY1106160T1/el unknown
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2010
- 2010-01-22 US US12/692,545 patent/US20100125070A1/en not_active Abandoned
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