ES2242196T3 - Vectores adenovirales que comprenden un "elemento respuesta". - Google Patents
Vectores adenovirales que comprenden un "elemento respuesta".Info
- Publication number
- ES2242196T3 ES2242196T3 ES96923418T ES96923418T ES2242196T3 ES 2242196 T3 ES2242196 T3 ES 2242196T3 ES 96923418 T ES96923418 T ES 96923418T ES 96923418 T ES96923418 T ES 96923418T ES 2242196 T3 ES2242196 T3 ES 2242196T3
- Authority
- ES
- Spain
- Prior art keywords
- baselineskip
- cells
- adenovirus
- gene
- psa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
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| ES (1) | ES2242196T3 (enExample) |
| MX (1) | MX9800145A (enExample) |
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| US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| US6057299A (en) * | 1994-01-13 | 2000-05-02 | Calydon, Inc. | Tissue-specific enhancer active in prostate |
| US5998205A (en) * | 1994-11-28 | 1999-12-07 | Genetic Therapy, Inc. | Vectors for tissue-specific replication |
| US6638762B1 (en) | 1994-11-28 | 2003-10-28 | Genetic Therapy, Inc. | Tissue-vectors specific replication and gene expression |
| EP1445322B2 (en) | 1995-06-15 | 2012-06-06 | Crucell Holland B.V. | Packaging systems for human recombinant adenovirus to be used in gene therapy |
| FR2735789B1 (fr) * | 1995-06-23 | 1997-07-25 | Centre Nat Rech Scient | Adenovirus recombinants, leur utilisation pour preparer des aav, lignee cellulaire complementaire et compositions pharmaceutiques les contenant |
| US6676935B2 (en) * | 1995-06-27 | 2004-01-13 | Cell Genesys, Inc. | Tissue specific adenoviral vectors |
| US20020068049A1 (en) * | 1998-09-10 | 2002-06-06 | Henderson Daniel R. | Tissue specific adenoviral vectors |
| US7011976B1 (en) | 1997-03-03 | 2006-03-14 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US7001764B2 (en) * | 1995-06-27 | 2006-02-21 | Cell Genesys, Inc. | Compositions comprising tissue specific adenoviral vectors |
| US6197293B1 (en) * | 1997-03-03 | 2001-03-06 | Calydon, Inc. | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof |
| US6254862B1 (en) | 1997-03-03 | 2001-07-03 | Calydon, Inc. | Adenovirus vectors specific for cells expressing alpha-fetoprotein and methods of use thereof |
| US6110702A (en) * | 1996-03-27 | 2000-08-29 | The Regents Of The University Of California | PSA positive regulating (PSAR) sequences and uses thereof |
| AUPO023496A0 (en) * | 1996-05-31 | 1996-06-27 | Commonwealth Scientific And Industrial Research Organisation | Modified small RNA viruses |
| US6610839B1 (en) | 1997-08-14 | 2003-08-26 | Geron Corporation | Promoter for telomerase reverse transcriptase |
| US5772993A (en) * | 1997-01-21 | 1998-06-30 | The University Of Virginia Patent Foundation | Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues |
| US6403370B1 (en) * | 1997-02-10 | 2002-06-11 | Genstar Therapeutics Corporation | Oncolytic/immunogenic complementary-adenoviral vector system |
| US6100444A (en) * | 1997-02-11 | 2000-08-08 | University Of Rochester Medical Center | Prostate specific regulatory nucleic acid sequences and transgenic non-human animals expressing prostate specific antigen |
| AU744725B2 (en) * | 1997-03-03 | 2002-02-28 | Cold Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
| JP2002514075A (ja) * | 1997-03-03 | 2002-05-14 | セル ジェネシス，インコーポレイティド | 癌胎児性抗原を発現する細胞に特異的なアデノウイルスベクターおよびその使用方法 |
| EP1905837A1 (en) * | 1997-03-03 | 2008-04-02 | Cell Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
| US6432700B1 (en) * | 1997-03-03 | 2002-08-13 | Cell Genesys, Inc. | Adenovirus vectors containing heterologous transcription regulatory elements and methods of using same |
| IL120485A0 (en) | 1997-03-19 | 1997-07-13 | Yeda Res & Dev | Modulators of the function of receptors of the TNF/NGF receptor family and other proteins |
| JP4812914B2 (ja) * | 1997-06-23 | 2011-11-09 | ユニバーシティ オブ サスカチュワン | ウシアデノウイルスタイプ３ゲノム |
| EP1002103B1 (en) | 1997-08-04 | 2007-10-17 | Cell Genesys, Inc. | A human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof |
| US20030045492A1 (en) * | 1997-08-13 | 2003-03-06 | Tang De-Chu C. | Vaccination by topical application of recombinant vectors |
| US6716823B1 (en) | 1997-08-13 | 2004-04-06 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom, and uses thereof |
| US6348450B1 (en) | 1997-08-13 | 2002-02-19 | The Uab Research Foundation | Noninvasive genetic immunization, expression products therefrom and uses thereof |
| US20030125278A1 (en) * | 1997-08-13 | 2003-07-03 | Tang De-Chu C. | Immunization of animals by topical applications of a salmonella-based vector |
| US6706693B1 (en) | 1997-08-13 | 2004-03-16 | The Uab Research Foundation | Vaccination by topical application of genetic vectors |
| JP2002512938A (ja) * | 1997-09-19 | 2002-05-08 | ジヨンソン・アンド・ジヨンソン・リサーチ・ピーテイワイ・リミテツド | ヒトを対象としたトランスジェニック自家ｔ−細胞治療および関連する組成物およびキット |
| US7378244B2 (en) * | 1997-10-01 | 2008-05-27 | Geron Corporation | Telomerase promoters sequences for screening telomerase modulators |
| US7780962B2 (en) * | 1997-10-09 | 2010-08-24 | Wellstat Biologics Corporation | Treatment of neoplasms with RNA viruses |
| US20030044384A1 (en) * | 1997-10-09 | 2003-03-06 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US7470426B1 (en) * | 1997-10-09 | 2008-12-30 | Wellstat Biologics Corporation | Treatment of neoplasms with viruses |
| WO1999043697A1 (en) * | 1998-02-25 | 1999-09-02 | The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno | Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms |
| JP2002520069A (ja) * | 1998-07-14 | 2002-07-09 | メルク・アンド・カンパニー・インコーポレーテッド | アデノウイルスに基づくプロモーターアッセイ |
| US6900049B2 (en) | 1998-09-10 | 2005-05-31 | Cell Genesys, Inc. | Adenovirus vectors containing cell status-specific response elements and methods of use thereof |
| US7691370B2 (en) * | 1998-10-15 | 2010-04-06 | Canji, Inc. | Selectivity replicating viral vector |
| US6929946B1 (en) * | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
| US6495130B1 (en) | 1998-12-30 | 2002-12-17 | Calydon, Inc. | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
| US20060024273A1 (en) * | 1998-12-30 | 2006-02-02 | Henderson Daniel R | Target cell-specific adenoviral vectors containing E3 and methods of use thereof |
| AU4246900A (en) * | 1999-04-15 | 2000-11-02 | Pro-Virus, Inc. | Treatment of neoplasms with viruses |
| US20040009936A1 (en) * | 1999-05-03 | 2004-01-15 | Tang De-Chu C. | Vaccine and drug delivery by topical application of vectors and vector extracts |
| US6913922B1 (en) * | 1999-05-18 | 2005-07-05 | Crucell Holland B.V. | Serotype of adenovirus and uses thereof |
| US8063022B1 (en) | 1999-06-08 | 2011-11-22 | The Children's Hospital Of Philadelphia | Methods for preventing formation of inhibitory antibodies in the setting of gene therapy |
| DE19928342A1 (de) * | 1999-06-21 | 2000-12-28 | Deutsches Krebsforsch | Vektoren zur gentherapeutischen Tumorbehandlung |
| US8147822B1 (en) | 1999-09-17 | 2012-04-03 | Wellstat Biologics Corporation | Oncolytic virus |
| US7267978B1 (en) | 1999-10-14 | 2007-09-11 | The Regents Of The University Of California | Chimeric transcriptional regulatory element compositions and methods for increasing prostate-targeted gene expression |
| KR20080046750A (ko) * | 2000-03-24 | 2008-05-27 | 바이오스피어 메디칼 인코포레이티드 | 능동 색전화용 미소구 |
| US20030212022A1 (en) * | 2001-03-23 | 2003-11-13 | Jean-Marie Vogel | Compositions and methods for gene therapy |
| US6692736B2 (en) | 2000-03-24 | 2004-02-17 | Cell Genesys, Inc. | Cell-specific adenovirus vectors comprising an internal ribosome entry site |
| DE60137208D1 (de) | 2000-03-24 | 2009-02-12 | Cell Genesys Inc | Menschliche zellspezifische urotheliale regulatorische sequenzen der transkription des uroplakins, dessen vektoren und verwendungsverfahren |
| US6911200B2 (en) * | 2000-03-24 | 2005-06-28 | Cell Genesys, Inc. | Methods of treating neoplasia with combination of target-cell specific adenovirus, chemotherapy and radiation |
| US7048920B2 (en) * | 2000-03-24 | 2006-05-23 | Cell Genesys, Inc. | Recombinant oncolytic adenovirus for human melanoma |
| EP1283722A1 (en) * | 2000-03-31 | 2003-02-19 | Idec Pharmaceuticals Corporation | Combined use of anti-cytokine antibodies or antagonists and anti-cd20 for the treatment of b cell lymphoma |
| US20040101825A1 (en) * | 2001-09-26 | 2004-05-27 | Van Meir Erwin G. | Viruses targeted to hypoxic cells and tissues |
| US7285414B2 (en) * | 2000-09-26 | 2007-10-23 | Emory University | Viruses targeted to hypoxic cells and tissues |
| EP1207205A1 (en) * | 2000-11-20 | 2002-05-22 | Crucell Holland B.V. | Adenoviral replicons |
| AU2002235141A1 (en) | 2000-11-27 | 2002-06-03 | Geron Corporation | Glycosyltransferase vectors for treating cancer |
| AU2002229679B2 (en) * | 2000-12-28 | 2007-12-20 | Per Sonne Holm | Use of transcription factor YB-1 in adenoviral systems |
| EP1425413A2 (en) * | 2001-01-23 | 2004-06-09 | Irm, Llc | Genes overexpressed in prostate disorders as diagnostic and therapeutic targets |
| WO2002068627A2 (en) * | 2001-02-23 | 2002-09-06 | Novartis Ag | Vector constucts |
| JP2004536607A (ja) * | 2001-07-23 | 2004-12-09 | オニックス ファーマシューティカルズ，インコーポレイティド | 標的化されたヒト癌細胞において選択的に複製するウイルス変異体 |
| US20030099616A1 (en) * | 2001-07-25 | 2003-05-29 | Irving John M. | Dual specificity tumor killing vectors driven by the telomerase promoter |
| WO2003049763A1 (en) | 2001-12-12 | 2003-06-19 | Fh Faulding & Co Limited | Composition for the preservation of viruses |
| ES2335657T3 (es) * | 2002-04-25 | 2010-03-31 | Crucell Holland B.V. | Medios y metodos para la produccion de vectores de adenovirus. |
| CN1655827B (zh) | 2002-05-27 | 2010-06-23 | 佩尔·松内·霍尔姆 | 腺病毒和编码其的核酸的新应用 |
| US7364727B2 (en) * | 2002-07-22 | 2008-04-29 | Cell Genesys, Inc. | Metastatic colon cancer specific promoter and uses thereof |
| CA2421269A1 (en) | 2002-08-09 | 2004-02-09 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| US20050095705A1 (en) * | 2003-04-15 | 2005-05-05 | Michael Kadan | Method for production of oncolytic adenoviruses |
| US20050136035A1 (en) * | 2003-06-03 | 2005-06-23 | Derek Ko | Cell specific replication-competent viral vectors comprising a self processing peptide cleavage site |
| US7709224B2 (en) * | 2003-06-03 | 2010-05-04 | Biosante Pharmaceuticals, Inc. | Compositions and methods for enhanced expression of recombinant polypeptides from a single vector using a peptide cleavage site |
| US20050079158A1 (en) * | 2003-06-05 | 2005-04-14 | Shenzhen Allucks Biotech Co., Ltd. | Construct of anti-cancer recombinant adenovirus, method for preparing the same and use thereof |
| DE602004031681D1 (de) | 2003-07-21 | 2011-04-14 | Transgene Sa | Multifunktionelle Cytokine |
| US20050186178A1 (en) * | 2003-08-28 | 2005-08-25 | Ennist David L. | Oncolytic adenoviral vectors encoding GM-CSF |
| US7482156B2 (en) * | 2003-10-15 | 2009-01-27 | Cell Genesys, Inc. | Hepatocellular carcinoma specific promoter and uses thereof |
| WO2005051430A1 (de) | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| US7473418B2 (en) | 2004-03-25 | 2009-01-06 | Cell Genesys, Inc. | Pan cancer oncolytic vectors and methods of use thereof |
| US20050271622A1 (en) * | 2004-06-03 | 2005-12-08 | Shenzhen Allucks Biotech Co., Ltd. | Construct of tumor-selective recombinant adenovirus, method for preparing the same and use thereof |
| GB0416487D0 (en) * | 2004-07-23 | 2004-08-25 | Isis Innovation | Modified virus |
| US20090221477A1 (en) * | 2004-07-26 | 2009-09-03 | Asterion Limited | Linkers |
| US20060062764A1 (en) * | 2004-08-25 | 2006-03-23 | Seshidar-Reddy Police | Fiber-modified adenoviral vectors for enhanced transduction of tumor cells |
| CA2598806A1 (en) | 2005-02-23 | 2006-08-31 | Uab Research Foundation | Alkyl-glycoside enhanced vaccination |
| US20060205080A1 (en) * | 2005-03-01 | 2006-09-14 | David Frey | Formulations for therapeutic viruses having enhanced storage stability |
| MX2007013914A (es) | 2005-05-09 | 2008-02-22 | Biosphere Medical S A | Composiciones y metodos que usan microesferas y agentes de contraste no ionicos. |
| DK2118292T3 (da) | 2007-01-30 | 2011-10-24 | Transgene Sa | Papillomavirus E2-polypeptid der anvendes til vaccination |
| SG196837A1 (en) | 2009-01-20 | 2014-02-13 | Transgene Sa | Soluble icam-1 as biomarker for prediction of therapeutic response |
| EP2408904B1 (en) | 2009-03-20 | 2017-10-18 | Mesoblast, Inc. | Production of reprogrammed pluripotent cells |
| DK2411815T3 (en) | 2009-03-24 | 2015-11-30 | Transgene Sa | Biomarker MONITORING OF PATIENTS |
| DK2419728T3 (da) | 2009-04-17 | 2014-02-03 | Transgene Sa | Biomarkør til at overvåge patienter |
| RU2552292C2 (ru) | 2009-07-10 | 2015-06-10 | Трансжене Са | Биомаркер для отбора пациентов и связанные с ним способы |
| GB0919773D0 (en) | 2009-11-12 | 2009-12-30 | Univ Nottingham | Induced pluripotent stem cell |
| CN101899420A (zh) * | 2010-01-16 | 2010-12-01 | 韩从辉 | 一种靶向抗前列腺肿瘤的表达超抗原基因的双调控溶瘤腺病毒的制备方法 |
| US20130210663A1 (en) | 2010-08-04 | 2013-08-15 | Cizzle Biotechnology Limited | Methods and compounds for the diagnosis and treatment of cancer |
| GB201016852D0 (en) | 2010-10-07 | 2010-11-17 | Univ York | Cell differentiation |
| GB201102091D0 (en) | 2011-02-08 | 2011-03-23 | Univ Sheffield | Antigenic polypeptide |
| GB201102090D0 (en) | 2011-02-08 | 2011-03-23 | Univ Sheffield | Antigenic polypeptide |
| EP2912069B1 (en) | 2012-10-23 | 2019-07-31 | Emory University | Gm-csf and il-4 conjugates, compositions, and methods related thereto |
| WO2019056015A2 (en) | 2017-09-18 | 2019-03-21 | Children's Hospital Medical Center | STRONG ISOLATOR AND ITS USES IN GENE ADMINISTRATION |
| US12168042B2 (en) | 2019-06-28 | 2024-12-17 | Massachusetts Institute Of Technology | Circular strained zymogen compositions and methods of use |
| CN115315273A (zh) | 2020-01-14 | 2022-11-08 | 辛德凯因股份有限公司 | Il-2直向同源物及其使用方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9001828A (nl) * | 1990-08-15 | 1992-03-02 | Centraal Diergeneeskundig Inst | Werkwijze voor het wijzigen van het cel-, weefsel- of gastheertropisme van een microoerganisme; aldus verkregen gerecombineerd microorganisme en toepassing daarvan in de geneeskunde en diergeneeskunde. |
| FR2705686B1 (fr) * | 1993-05-28 | 1995-08-18 | Transgene Sa | Nouveaux adénovirus défectifs et lignées de complémentation correspondantes. |
| JP3875990B2 (ja) * | 1993-10-25 | 2007-01-31 | カンジ，インコーポレイテッド | 組換えアデノウイルスベクターおよび使用方法 |
| US5830686A (en) * | 1994-01-13 | 1998-11-03 | Calydon | Tissue-specific enhancer active in prostate |
| KR100285171B1 (ko) * | 1994-09-30 | 2001-03-15 | 모리시타 요이찌 | 테이프 접착장치 및 방법 |
| US5919652A (en) * | 1994-11-09 | 1999-07-06 | The Regents Of The University Of California | Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof |
| FI972225A7 (fi) * | 1994-11-28 | 1997-07-16 | Genetic Therapy Inc | Vektorit kudosspesifistä replikaatiota varten |
| CA2206205A1 (en) * | 1994-11-28 | 1996-06-06 | Genetic Therapy, Inc. | Tissue-specific treatment, diagnostic methods, and compositions using replication-deficient vectors |
| US20030026789A1 (en) * | 1995-05-03 | 2003-02-06 | Richard J. Gregory | Gene therapy using replication competent targeted adenoviral vectors |
| AU5750196A (en) * | 1995-05-18 | 1996-11-29 | Genetic Therapy, Inc. | Gene therapy of hepatocellular carcinoma through cancer-specific gene expression |
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1995
- 1995-06-27 US US08/495,034 patent/US5698443A/en not_active Expired - Fee Related
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1996
- 1996-06-26 DE DE69634752T patent/DE69634752T2/de not_active Expired - Fee Related
- 1996-06-26 ES ES96923418T patent/ES2242196T3/es not_active Expired - Lifetime
- 1996-06-26 AU AU63932/96A patent/AU729648B2/en not_active Ceased
- 1996-06-26 EP EP96923418A patent/EP0844888B1/en not_active Expired - Lifetime
- 1996-06-26 CA CA002222457A patent/CA2222457A1/en not_active Abandoned
- 1996-06-26 AT AT96923418T patent/ATE295739T1/de not_active IP Right Cessation
- 1996-06-26 JP JP50451797A patent/JP4117347B2/ja not_active Expired - Fee Related
- 1996-06-26 US US08/669,753 patent/US5871726A/en not_active Expired - Fee Related
- 1996-06-26 WO PCT/US1996/010838 patent/WO1997001358A1/en not_active Ceased
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1998
- 1998-01-07 MX MX9800145A patent/MX9800145A/es not_active IP Right Cessation
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|---|---|
| JP4117347B2 (ja) | 2008-07-16 |
| WO1997001358A1 (en) | 1997-01-16 |
| JPH11508770A (ja) | 1999-08-03 |
| MX9800145A (es) | 1998-11-30 |
| DE69634752D1 (de) | 2005-06-23 |
| US5871726A (en) | 1999-02-16 |
| EP0844888A4 (en) | 1999-11-03 |
| AU729648B2 (en) | 2001-02-08 |
| ATE295739T1 (de) | 2005-06-15 |
| EP0844888B1 (en) | 2005-05-18 |
| DE69634752T2 (de) | 2006-01-12 |
| US5698443A (en) | 1997-12-16 |
| EP0844888A1 (en) | 1998-06-03 |
| AU6393296A (en) | 1997-01-30 |
| CA2222457A1 (en) | 1997-01-16 |
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