ES2235499T3 - Uso de derivados de propionil l-carnitina y de acetil l-carnitina en la preparacion de medicamentos con actividad anticancerigena. - Google Patents
Uso de derivados de propionil l-carnitina y de acetil l-carnitina en la preparacion de medicamentos con actividad anticancerigena.Info
- Publication number
- ES2235499T3 ES2235499T3 ES99936973T ES99936973T ES2235499T3 ES 2235499 T3 ES2235499 T3 ES 2235499T3 ES 99936973 T ES99936973 T ES 99936973T ES 99936973 T ES99936973 T ES 99936973T ES 2235499 T3 ES2235499 T3 ES 2235499T3
- Authority
- ES
- Spain
- Prior art keywords
- carnitine
- taxol
- acetyl
- treatment
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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Landscapes
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| IT98RM000511 IT1302121B1 (it) | 1998-07-30 | 1998-07-30 | Associazione ad attivita' antineoplastica sostanzialmente priva deglieffetti tossici o collaterali causati dai farmaci antineoplastici |
| ITRM990206 | 1999-04-07 | ||
| IT1999RM000206 IT1306124B1 (it) | 1999-04-07 | 1999-04-07 | Uso di alcanoil l-carnitine nella preparazione di medicamenti adattivita' antitumorale. |
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| US20030199535A1 (en) * | 1998-07-30 | 2003-10-23 | Claudio Cavazza | Method for preventing and/or treating peripheral neuropathies induced by the administration of an anticancer agent |
| IT1302289B1 (it) * | 1998-09-30 | 2000-09-05 | Univ Catania | Composizioni farmaceutiche ad attivita' antineoplastica |
| US20070037777A1 (en) * | 2005-08-12 | 2007-02-15 | Immunopath Profile, Inc. | Lipid-containing compositions and methods of using them |
| DE19959546A1 (de) * | 1999-12-09 | 2001-06-21 | Rhone Poulenc Rorer Gmbh | Pharmazeutische Zubereitung zur Behandlung von Tumorerkrankungen |
| UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
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| US20050004012A1 (en) * | 2001-10-19 | 2005-01-06 | Ramon Mangues | Use of aplidine for the treatment of pancreatic cancer |
| ITRM20020306A1 (it) | 2002-05-31 | 2003-12-01 | Sigma Tau Ind Farmaceuti | Esteri in posizione 20 di camptotecine. |
| SI1603584T1 (sl) | 2003-03-12 | 2009-02-28 | Dana Farber Cancer Inst Inc | Aplidin za zdravljenje multiple mieloma |
| US8314144B2 (en) * | 2004-02-12 | 2012-11-20 | Defiante Farmaceutica, S.A. | Compounds having antitumor activity |
| US20050215640A1 (en) | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| US20050232911A1 (en) * | 2004-04-19 | 2005-10-20 | Schreiber Brian D | Prevention and treatment of metabolic abnormalities associated with excess intramyocellular lipid |
| ES2548432T3 (es) | 2005-12-19 | 2015-10-16 | Abbott Laboratories | Uso de beta-hidroxi-beta-metilbutirato para modular el desequilibrio en la producción de citoquinas de tipo 1 y tipo 2 |
| ITMI20070817A1 (it) | 2007-04-19 | 2008-10-20 | Farmacetika Ltd | Composizione farmaceutica comprendente l-carnitina ed un agente antagonista dei recettori adenosinici di membrana, loro derivati e/o sali farmaceuticamente accettabili, e uso degli stessi nella preparazione di farmaci con effetto non tossico di inibi |
| CA2698129A1 (en) * | 2007-08-31 | 2009-03-05 | Kyushu University, National University Corporation | Prophylactic or alleviating agent for peripheral nerve disorder induced by anti-cancer agent |
| US20120093809A1 (en) * | 2008-12-01 | 2012-04-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of alkanoyl l-carnitine in combination with chemotherapeutic agents for the treatment of neoplasms |
| CN102060722B (zh) * | 2009-05-01 | 2014-06-11 | 常州高新技术产业开发区三维工业技术研究所有限公司 | 一种含砷化合物及其制备方法和用途 |
| US9693577B2 (en) | 2010-01-29 | 2017-07-04 | Abbott Laboratories | Method of preparing a nutritional powder comprising spray dried HMB |
| RU2012125881A (ru) | 2010-01-29 | 2014-03-10 | Эбботт Лэборетриз | Питательные эмульсии, содержащие бета-гидрокси-бета-метилбутират кальция (гмб кальция) |
| SG182808A1 (en) | 2010-01-29 | 2012-09-27 | Abbott Lab | Aseptically packaged nutritional liquids comprising hmb |
| TWI526161B (zh) | 2010-06-10 | 2016-03-21 | 亞培公司 | 包含鈣ｈｍｂ及可溶性蛋白質之實質上透明營養液 |
| DE102011008016A1 (de) * | 2011-01-06 | 2012-07-12 | Johannes F. Coy | Schokoladenmasse |
| KR20230116091A (ko) * | 2012-06-27 | 2023-08-03 | 아마젠티스 에스에이 | 우롤리틴 또는 이의 전구체를 투여에 의한 자가포식향상 또는 장수 증가 |
| ITPZ20130005A1 (it) * | 2013-07-05 | 2015-01-06 | Teodosio Antonio Ferrara | Metabolismo energetico e omeostasi |
| RU2554776C1 (ru) * | 2013-12-16 | 2015-06-27 | Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" СО РАМН | Средство для коррекции нарушений в легочной ткани при цитостатическом воздействии |
| MX2017013383A (es) | 2015-04-20 | 2017-12-07 | Tolero Pharmaceuticals Inc | Prediccion de respuesta a alvocidib mediante perfilado mitocondrial. |
| PL3298021T3 (pl) | 2015-05-18 | 2019-11-29 | Tolero Pharmaceuticals Inc | Proleki alvocidibu o zwiększonej biodostępności |
| MX2018001289A (es) | 2015-08-03 | 2018-04-30 | Tolero Pharmaceuticals Inc | Terapias de combinacion para el tratamiento del cancer. |
| KR101732483B1 (ko) * | 2016-07-06 | 2017-05-24 | 한국 한의학 연구원 | 연교 추출물을 유효성분으로 함유하는 말초신경병증 예방, 개선 또는 치료용 조성물 |
| WO2018094275A1 (en) | 2016-11-18 | 2018-05-24 | Tolero Pharmaceuticals, Inc. | Alvocidib prodrugs and their use as protein kinase inhibitors |
| WO2019055579A1 (en) | 2017-09-12 | 2019-03-21 | Tolero Pharmaceuticals, Inc. | TREATMENT REGIME FOR CANCERS THAT ARE INSENSITIVE TO BCL-2 INHIBITORS USING THE MCL-1 ALVOCIDIB INHIBITOR |
| AU2019391097B2 (en) | 2018-12-04 | 2025-07-03 | Sumitomo Pharma America, Inc. | CDK9 inhibitors and polymorphs thereof for use as agents for treatment of cancer |
| WO2020191326A1 (en) | 2019-03-20 | 2020-09-24 | Sumitomo Dainippon Pharma Oncology, Inc. | Treatment of acute myeloid leukemia (aml) with venetoclax failure |
| CN115177608B (zh) * | 2022-07-26 | 2023-12-05 | 南方医科大学南方医院 | 长链酰基肉碱类化合物在制备预防和/或治疗肝癌的药物中的应用 |
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| US4267163A (en) * | 1972-11-06 | 1981-05-12 | Biocarn Limited | Carnitine and its use in reducing cardiac toxicity |
| US4713370A (en) * | 1972-11-06 | 1987-12-15 | Felice Stephen L De | Carnitine and its use in reducing cardiac toxicity and as a synergist with cytostats |
| IT1169460B (it) * | 1982-09-13 | 1987-05-27 | Sigma Tau Ind Farmaceuti | Metodo e composizione per il trattamento di tumori |
| US4599352A (en) * | 1984-03-01 | 1986-07-08 | The United States Of America As Represented By The Department Of Health And Human Services | Antineoplastic platinum (IV) complexes and compositions |
| IT1196564B (it) * | 1986-08-04 | 1988-11-16 | Sigma Tau Ind Farmaceuti | Impiego di acetil l-carnitina nel trattamento terapeutico delle neuropatie periferiche |
| US4936823A (en) * | 1988-05-04 | 1990-06-26 | Triangle Research And Development Corp. | Transendoscopic implant capsule |
| IT1235153B (it) * | 1988-11-15 | 1992-06-22 | Sigma Tau Ind Farmaceuti | Uso dell'acetil l-carnitina nel trattamento terapeutico della cataratta e composizioni farmaceutiche utili in tale trattamento |
| US5639737A (en) * | 1991-11-04 | 1997-06-17 | Co Enzyme Technology Ltd. | Method and compositions for treating malignant tumors and inhibiting growth and metastases of malignant tumors |
| FR2697752B1 (fr) * | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| FR2727117A1 (fr) * | 1994-11-18 | 1996-05-24 | Geffard Michel | Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun |
| IT1275434B (it) * | 1995-05-19 | 1997-08-07 | Farmila Farma Milano | Composizioni farmaceutiche e/o dietetiche ad attivita' antiossidante |
| IT1277898B1 (it) * | 1995-08-03 | 1997-11-12 | Mendes Srl | Uso di amminoacidi basici, di acil derivati di amminoacidi basici e di loro sali farmaceuticamente accettabili per la profilassi di malattie |
| IT1283951B1 (it) * | 1996-03-15 | 1998-05-07 | Mendes Srl | Uso della acetil l-carnitina o dei suoi sali farmacologicamente accettabili per il trattamento terapeutico o la profilassi di |
| DE19733305A1 (de) * | 1997-08-01 | 1999-02-04 | Asta Medica Ag | Pharmazeutische Zusammensetzung enthaltend Ifosfamid und Carnitin |
-
1999
- 1999-07-27 EP EP99936973A patent/EP1100589B1/en not_active Expired - Lifetime
- 1999-07-27 CA CA002338638A patent/CA2338638C/en not_active Expired - Fee Related
- 1999-07-27 AU AU51935/99A patent/AU764807B2/en not_active Ceased
- 1999-07-27 JP JP2000561989A patent/JP4703851B2/ja not_active Expired - Fee Related
- 1999-07-27 PT PT99936973T patent/PT1100589E/pt unknown
- 1999-07-27 WO PCT/IT1999/000242 patent/WO2000006134A2/en not_active Ceased
- 1999-07-27 AT AT99936973T patent/ATE287278T1/de active
- 1999-07-27 ES ES99936973T patent/ES2235499T3/es not_active Expired - Lifetime
- 1999-07-27 DE DE69923322T patent/DE69923322T2/de not_active Expired - Lifetime
- 1999-07-27 KR KR1020017001228A patent/KR100645980B1/ko not_active Expired - Fee Related
-
2001
- 2001-01-26 US US09/769,488 patent/US6610699B2/en not_active Expired - Fee Related
-
2006
- 2006-04-20 US US11/407,351 patent/US20060258744A1/en not_active Abandoned
-
2008
- 2008-04-09 US US12/078,991 patent/US20080194683A1/en not_active Abandoned
-
2009
- 2009-01-26 US US12/320,422 patent/US20090137619A1/en not_active Abandoned
- 2009-01-26 US US12/320,430 patent/US20090143464A1/en not_active Abandoned
-
2010
- 2010-08-13 JP JP2010181377A patent/JP2010254717A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20080194683A1 (en) | 2008-08-14 |
| CA2338638A1 (en) | 2000-02-10 |
| US6610699B2 (en) | 2003-08-26 |
| DE69923322D1 (de) | 2005-02-24 |
| JP2010254717A (ja) | 2010-11-11 |
| US20090143464A1 (en) | 2009-06-04 |
| WO2000006134A2 (en) | 2000-02-10 |
| ATE287278T1 (de) | 2005-02-15 |
| AU764807B2 (en) | 2003-08-28 |
| US20010044465A1 (en) | 2001-11-22 |
| EP1100589A2 (en) | 2001-05-23 |
| KR100645980B1 (ko) | 2006-11-14 |
| JP2002521428A (ja) | 2002-07-16 |
| WO2000006134A3 (en) | 2000-03-23 |
| US20090137619A1 (en) | 2009-05-28 |
| AU5193599A (en) | 2000-02-21 |
| PT1100589E (pt) | 2005-05-31 |
| US20060258744A1 (en) | 2006-11-16 |
| CA2338638C (en) | 2009-03-17 |
| KR20010072093A (ko) | 2001-07-31 |
| JP4703851B2 (ja) | 2011-06-15 |
| HK1035677A1 (en) | 2001-12-07 |
| EP1100589B1 (en) | 2005-01-19 |
| DE69923322T2 (de) | 2005-12-22 |
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