ES2217396T3 - Utilizacion de il-7 en el tratamiento de las enfermedades auto-inmunes, en particular, la diabetes mellitus insulinodependiente. - Google Patents

Utilizacion de il-7 en el tratamiento de las enfermedades auto-inmunes, en particular, la diabetes mellitus insulinodependiente.

Info

Publication number
ES2217396T3
ES2217396T3 ES97907134T ES97907134T ES2217396T3 ES 2217396 T3 ES2217396 T3 ES 2217396T3 ES 97907134 T ES97907134 T ES 97907134T ES 97907134 T ES97907134 T ES 97907134T ES 2217396 T3 ES2217396 T3 ES 2217396T3
Authority
ES
Spain
Prior art keywords
autoimmune
cells
treatment
disease
auto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97907134T
Other languages
English (en)
Spanish (es)
Inventor
Jean-Francois Bach
Jean-Marc Gombert
Andre Herbelin
Michel Morre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Application granted granted Critical
Publication of ES2217396T3 publication Critical patent/ES2217396T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2046IL-7
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/461Cellular immunotherapy characterised by the cell type used
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/462Cellular immunotherapy characterized by the effect or the function of the cells
    • A61K39/4621Cellular immunotherapy characterized by the effect or the function of the cells immunosuppressive or immunotolerising
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/46Cellular immunotherapy
    • A61K39/464Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643Vertebrate antigens
    • A61K39/46433Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/38Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Transplantation (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
ES97907134T 1996-02-28 1997-02-26 Utilizacion de il-7 en el tratamiento de las enfermedades auto-inmunes, en particular, la diabetes mellitus insulinodependiente. Expired - Lifetime ES2217396T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9602501 1996-02-28
FR9602501A FR2745185B1 (fr) 1996-02-28 1996-02-28 Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant

Publications (1)

Publication Number Publication Date
ES2217396T3 true ES2217396T3 (es) 2004-11-01

Family

ID=9489676

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97907134T Expired - Lifetime ES2217396T3 (es) 1996-02-28 1997-02-26 Utilizacion de il-7 en el tratamiento de las enfermedades auto-inmunes, en particular, la diabetes mellitus insulinodependiente.

Country Status (13)

Country Link
US (2) US6713053B1 (fr)
EP (1) EP0883406B1 (fr)
JP (1) JP3138481B2 (fr)
AT (1) ATE264112T1 (fr)
AU (1) AU1929397A (fr)
BR (1) BR9707776A (fr)
DE (1) DE69728654T2 (fr)
DK (1) DK0883406T3 (fr)
ES (1) ES2217396T3 (fr)
FR (1) FR2745185B1 (fr)
NO (1) NO321569B1 (fr)
PT (1) PT883406E (fr)
WO (1) WO1997031648A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2745185B1 (fr) * 1996-02-28 1998-05-15 Sanofi Sa Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant
AR080291A1 (es) 2010-02-24 2012-03-28 Rinat Neuroscience Corp Anticuerpos antagonistas anti receptor de il-7 y procedimientos
EP2791322A1 (fr) 2011-12-12 2014-10-22 Cell Medica Limited Procédé de propagation de cellules t
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
US20150010519A1 (en) 2012-02-09 2015-01-08 Baylor College Of Medicine Pepmixes to generate multiviral ctls with broad specificity
CA2923314A1 (fr) 2013-09-05 2015-03-12 Sanford-Burnham Medical Research Institute Modulation des lymphocytes t .gamma..delta.
WO2017049291A1 (fr) 2015-09-18 2017-03-23 Baylor College Of Medicine Identification d'antigène immunogène à partir d'un pathogène et corrélation avec l'efficacité clinique

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032396A (en) * 1989-02-17 1991-07-16 Immunex Corporation IL-7 to stimulate platelet production
US5229115A (en) * 1990-07-26 1993-07-20 Immunex Corporation Adoptive immunotherapy with interleukin-7
US5474769A (en) * 1991-03-08 1995-12-12 Sterling Winthrop Inc. Treatment of microbial infection by monocyte stimulation with interleukin-7
US6576236B1 (en) * 1994-07-01 2003-06-10 Dana Farber Cancer Institute Methods for stimulating T cell responses by manipulating a common cytokine receptor γ chain
FR2745185B1 (fr) * 1996-02-28 1998-05-15 Sanofi Sa Utilisation de l'il-7 dans le traitement des maladies auto-immunes, en particulier le diabete mellitus insulinodependant

Also Published As

Publication number Publication date
PT883406E (pt) 2004-08-31
NO983917L (no) 1998-10-28
WO1997031648A1 (fr) 1997-09-04
US6713053B1 (en) 2004-03-30
JP3138481B2 (ja) 2001-02-26
DE69728654D1 (de) 2004-05-19
BR9707776A (pt) 1999-07-27
FR2745185B1 (fr) 1998-05-15
EP0883406B1 (fr) 2004-04-14
NO983917D0 (no) 1998-08-26
FR2745185A1 (fr) 1997-08-29
US20040180037A1 (en) 2004-09-16
NO321569B1 (no) 2006-06-06
ATE264112T1 (de) 2004-04-15
EP0883406A1 (fr) 1998-12-16
DK0883406T3 (da) 2004-08-02
AU1929397A (en) 1997-09-16
JPH11508605A (ja) 1999-07-27
DE69728654T2 (de) 2005-03-24

Similar Documents

Publication Publication Date Title
ES2173953T5 (es) Uso del il-12 y antagonistas del il-12 para la fabricacion de una composicion farmaceutica para el tratamiento de enfermedades autoinmunes.
Shimizu et al. Induction of tumor immunity by removing CD25+ CD4+ T cells: a common basis between tumor immunity and autoimmunity
Chen et al. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model
Tanaka et al. A pivotal role of IL-12 in Th1-dependent mouse liver injury
JPH02503919A (ja) 自己抗原の経口投与による自己免疫疾患の治療法
Stallmach et al. An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn’s disease and experimental colitis in vivo
Maas et al. Immunotherapy of mice with a large burden of disseminated lymphoma with low-dose interleukin 2
JP2000509604A (ja) サプレッサー細胞集団を生成するためのインターロイキン―10の使用
US5624938A (en) Use of chloroquine to treat multiple sclerosis
JPH05508663A (ja) 哺乳動物における異系移植片拒否反応を抑制するための方法と組成物
JPH07505892A (ja) 多型性クラスiimhcアロペプチドを用いた増殖反応の抑制及び寛容の誘発
ES2217396T3 (es) Utilizacion de il-7 en el tratamiento de las enfermedades auto-inmunes, en particular, la diabetes mellitus insulinodependiente.
Pankewycz et al. A protective NOD islet‐infiltrating CD8+ T cell clone, IS 2.15, has in vitro immunosuppressive properties
Sugihara et al. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. Characterization of thyroiditis-inducing T cell lines and clones derived from thyroid lesions.
CN101126076A (zh) TGF-β诱导的调节T细胞及其形成方法和应用
Talpaz et al. The immune restorative effect of cimetidine administration in vivo on the local graft-versus-host reaction of cancer patients
Piguet GVHR elicited by products of class I or class II loci of the MHC: analysis of the response of mouse T lymphocytes to products of class I and class II loci of the MHC in correlation with GVHR-induced mortality, medullary aplasia, and enteropathy.
Ju et al. Inducer T-cell-mediated killing of antigen-presenting cells
Ten Berge et al. Evaluation of the immunosuppressive effects of cyclophosphamide in patients with multiple sclerosis.
ES2224105T3 (es) Cadena alfa soluble de receptores de celulas t y derivados utilizados como agentes profilacticos y terapeuticos para enfermedades autoinmunes.
WO2006052660A9 (fr) Blocage du recepteur il-7 pour supprimer l'immunite
Ranges et al. In vivo immunomodulation by monoclonal anti-L3T4: 1. Effects on humoral and cell-mediated immune response
Ito et al. Regulation of autoimmune diabetes by interleukin 3-dependent bone marrow-derived cells in NOD mice
WO2005004789A2 (fr) Methode de traitement de maladies s'accompagnant d'alterations de la composition qualitative ou quantitative de l'adn extracellulaire du sang
Sun et al. Human prolactin improves engraftment and reconstitution of human peripheral blood lymphocytes in SCID mice