ES2212092T3 - Heperpolarizador de alto volumen para gases nobles polarizados por spin. - Google Patents
Heperpolarizador de alto volumen para gases nobles polarizados por spin.Info
- Publication number
- ES2212092T3 ES2212092T3 ES97917681T ES97917681T ES2212092T3 ES 2212092 T3 ES2212092 T3 ES 2212092T3 ES 97917681 T ES97917681 T ES 97917681T ES 97917681 T ES97917681 T ES 97917681T ES 2212092 T3 ES2212092 T3 ES 2212092T3
- Authority
- ES
- Spain
- Prior art keywords
- gas
- polarization
- pumping
- noble
- chamber
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007789 gas Substances 0.000 title claims abstract description 370
- 230000002102 hyperpolarization Effects 0.000 claims abstract description 118
- 238000000034 method Methods 0.000 claims abstract description 111
- 238000009825 accumulation Methods 0.000 claims abstract description 33
- 238000005086 pumping Methods 0.000 claims description 159
- 230000010287 polarization Effects 0.000 claims description 157
- 229910052756 noble gas Inorganic materials 0.000 claims description 125
- 150000001340 alkali metals Chemical group 0.000 claims description 82
- 229910052783 alkali metal Inorganic materials 0.000 claims description 66
- 230000003287 optical effect Effects 0.000 claims description 62
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 58
- 229910052724 xenon Inorganic materials 0.000 claims description 49
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 claims description 46
- 229910052734 helium Inorganic materials 0.000 claims description 42
- 239000001307 helium Substances 0.000 claims description 35
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 35
- 229910052751 metal Inorganic materials 0.000 claims description 32
- 239000002184 metal Substances 0.000 claims description 32
- 230000005855 radiation Effects 0.000 claims description 30
- 229910052757 nitrogen Inorganic materials 0.000 claims description 29
- 239000001257 hydrogen Substances 0.000 claims description 19
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 14
- 230000008569 process Effects 0.000 claims description 11
- 238000012544 monitoring process Methods 0.000 claims description 9
- 230000000155 isotopic effect Effects 0.000 claims description 7
- 238000007906 compression Methods 0.000 claims description 2
- 230000006835 compression Effects 0.000 claims description 2
- 238000013270 controlled release Methods 0.000 claims 1
- 230000005291 magnetic effect Effects 0.000 abstract description 22
- 238000000746 purification Methods 0.000 abstract description 7
- 230000015572 biosynthetic process Effects 0.000 abstract description 5
- 241001465754 Metazoa Species 0.000 abstract description 2
- 230000007717 exclusion Effects 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 129
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 description 33
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 description 32
- 239000000203 mixture Substances 0.000 description 31
- 229910052701 rubidium Inorganic materials 0.000 description 31
- 238000004519 manufacturing process Methods 0.000 description 28
- 239000011521 glass Substances 0.000 description 25
- 239000012535 impurity Substances 0.000 description 21
- 150000002835 noble gases Chemical class 0.000 description 21
- 238000010521 absorption reaction Methods 0.000 description 17
- 238000010926 purge Methods 0.000 description 17
- 238000003860 storage Methods 0.000 description 16
- 239000000463 material Substances 0.000 description 15
- 238000000711 polarimetry Methods 0.000 description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000000523 sample Substances 0.000 description 12
- 238000013459 approach Methods 0.000 description 11
- 125000004429 atom Chemical group 0.000 description 11
- 230000008901 benefit Effects 0.000 description 11
- 238000002595 magnetic resonance imaging Methods 0.000 description 11
- 238000003491 array Methods 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 10
- 239000006200 vaporizer Substances 0.000 description 10
- -1 129 Xe Chemical class 0.000 description 9
- 239000007788 liquid Substances 0.000 description 9
- 238000010992 reflux Methods 0.000 description 8
- 229910052792 caesium Inorganic materials 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000028161 membrane depolarization Effects 0.000 description 7
- 230000003595 spectral effect Effects 0.000 description 7
- 230000008033 biological extinction Effects 0.000 description 6
- TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 description 6
- 230000001667 episodic effect Effects 0.000 description 6
- 238000003384 imaging method Methods 0.000 description 6
- 238000009434 installation Methods 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 238000000926 separation method Methods 0.000 description 6
- 238000013461 design Methods 0.000 description 5
- 230000005284 excitation Effects 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 150000002431 hydrogen Chemical class 0.000 description 5
- 239000011159 matrix material Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- 239000006096 absorbing agent Substances 0.000 description 4
- 230000015556 catabolic process Effects 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000006731 degradation reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 230000005484 gravity Effects 0.000 description 4
- 230000001965 increasing effect Effects 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 230000036961 partial effect Effects 0.000 description 4
- 230000035699 permeability Effects 0.000 description 4
- 230000035939 shock Effects 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000012546 transfer Methods 0.000 description 4
- 241001448434 Pirex Species 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 230000005465 channeling Effects 0.000 description 3
- 239000000356 contaminant Substances 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 230000001066 destructive effect Effects 0.000 description 3
- SWQJXJOGLNCZEY-BJUDXGSMSA-N helium-3 atom Chemical compound [3He] SWQJXJOGLNCZEY-BJUDXGSMSA-N 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 238000009428 plumbing Methods 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 238000011084 recovery Methods 0.000 description 3
- 230000003068 static effect Effects 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- FHNFHKCVQCLJFQ-YPZZEJLDSA-N xenon-129 atom Chemical compound [129Xe] FHNFHKCVQCLJFQ-YPZZEJLDSA-N 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 2
- 101100421536 Danio rerio sim1a gene Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000006117 anti-reflective coating Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000007872 degassing Methods 0.000 description 2
- 230000002999 depolarising effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000008246 gaseous mixture Substances 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 239000010931 gold Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 230000031700 light absorption Effects 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000005298 paramagnetic effect Effects 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 229920003023 plastic Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
- 230000029058 respiratory gaseous exchange Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 239000005368 silicate glass Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000000859 sublimation Methods 0.000 description 2
- 230000008022 sublimation Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- XMTQQYYKAHVGBJ-UHFFFAOYSA-N 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYLUREA Chemical compound CN(C)C(=O)NC1=CC=C(Cl)C(Cl)=C1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N 0.000 description 1
- 229910000906 Bronze Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920002449 FKM Polymers 0.000 description 1
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 description 1
- WXNXCEHXYPACJF-ZETCQYMHSA-N N-acetyl-L-leucine Chemical compound CC(C)C[C@@H](C(O)=O)NC(C)=O WXNXCEHXYPACJF-ZETCQYMHSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- IGLNJRXAVVLDKE-NJFSPNSNSA-N Rubidium-87 Chemical compound [87Rb] IGLNJRXAVVLDKE-NJFSPNSNSA-N 0.000 description 1
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- YZCKVEUIGOORGS-NJFSPNSNSA-N Tritium Chemical compound [3H] YZCKVEUIGOORGS-NJFSPNSNSA-N 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- 238000000862 absorption spectrum Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 239000012496 blank sample Substances 0.000 description 1
- 239000010974 bronze Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000001427 coherent effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 238000005094 computer simulation Methods 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000010411 cooking Methods 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- KUNSUQLRTQLHQQ-UHFFFAOYSA-N copper tin Chemical compound [Cu].[Sn] KUNSUQLRTQLHQQ-UHFFFAOYSA-N 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
- 238000005138 cryopreservation Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- LIKFHECYJZWXFJ-UHFFFAOYSA-N dimethyldichlorosilane Chemical compound C[Si](C)(Cl)Cl LIKFHECYJZWXFJ-UHFFFAOYSA-N 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 239000005293 duran Substances 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000005294 ferromagnetic effect Effects 0.000 description 1
- 239000003302 ferromagnetic material Substances 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007511 glassblowing Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 238000011005 laboratory method Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000000155 melt Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000010355 oscillation Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 1
- 108010014374 puros Proteins 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000005258 radioactive decay Effects 0.000 description 1
- 238000012958 reprocessing Methods 0.000 description 1
- IGLNJRXAVVLDKE-IGMARMGPSA-N rubidium-85 atom Chemical compound [85Rb] IGLNJRXAVVLDKE-IGMARMGPSA-N 0.000 description 1
- 230000003584 silencer Effects 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/919—Isotope
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S62/00—Refrigeration
- Y10S62/923—Inert gas
- Y10S62/925—Xenon or krypton
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Inorganic Insulating Materials (AREA)
- Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/622,863 US5642625A (en) | 1996-03-29 | 1996-03-29 | High volume hyperpolarizer for spin-polarized noble gas |
| US622863 | 1996-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2212092T3 true ES2212092T3 (es) | 2004-07-16 |
Family
ID=24495796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97917681T Expired - Lifetime ES2212092T3 (es) | 1996-03-29 | 1997-03-27 | Heperpolarizador de alto volumen para gases nobles polarizados por spin. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5642625A (enExample) |
| EP (3) | EP0896655B1 (enExample) |
| JP (2) | JP4040095B2 (enExample) |
| AT (1) | ATE256274T1 (enExample) |
| AU (1) | AU709623B2 (enExample) |
| CA (1) | CA2250168C (enExample) |
| DE (1) | DE69726720T2 (enExample) |
| DK (1) | DK0896655T3 (enExample) |
| ES (1) | ES2212092T3 (enExample) |
| PT (1) | PT896655E (enExample) |
| WO (1) | WO1997037178A1 (enExample) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001503646A (ja) | 1996-03-29 | 2001-03-21 | ローレンス バークレー ナショナル ラボラトリィ | 過分極化希ガス存在下でのｎｍｒまたはｍｒｉの増強 |
| US8765099B2 (en) * | 1996-04-08 | 2014-07-01 | Koninklijke Philips N.V. | Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum |
| US5859762A (en) * | 1996-05-13 | 1999-01-12 | International Business Machines Corporation | Docking station for portable computers |
| US5934103A (en) * | 1997-04-22 | 1999-08-10 | Northrop Grumman Corporation | Method and apparatus for production of spin-polarized medical-grade xenon 129 gas by laser optical pumping |
| DK1015086T3 (da) | 1997-08-18 | 2007-10-22 | Univ Princeton | Spinpolarisering af en ædelgas via spinudveksling med optisk polariserede alkalimetaller |
| FR2768568B1 (fr) * | 1997-09-17 | 2000-02-25 | Centre Nat Rech Scient | Procede et equipement pour la preparation d'un gaz d'helium hyperpolarise a forte pression, application dudit procede |
| BR9814968A (pt) | 1997-11-14 | 2000-10-03 | Norbert Weiler | Aparelho para a administração de fluido, e, processo para produção de imagem de ressonância magnética. |
| US6307204B1 (en) * | 1997-11-14 | 2001-10-23 | Jasco Corporation | UV detector for liquid chromatography |
| DK1051602T3 (da) * | 1997-12-12 | 2003-08-11 | Medi Physics Inc | Fremgangsmåde, ved hjælp af hvilken en polariseret gas omfattende xenon bringes i fast form og optøs |
| WO1999034189A2 (en) * | 1997-12-12 | 1999-07-08 | Magnetic Imaging Technologies, Inc. | Process and device to solidify and thaw a polarized gas comprising xenon |
| EP1279912B1 (en) * | 1997-12-12 | 2005-03-02 | Medi-Physics, Inc. | Methods of collecting and thawing polarised gases, associated accumulators and heating jackets |
| US6079213A (en) * | 1997-12-12 | 2000-06-27 | Magnetic Imaging Technologies Incorporated | Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets |
| AU2003203796B2 (en) * | 1997-12-12 | 2006-10-12 | Medi-Physics, Inc. | Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products |
| WO1999047940A1 (en) | 1998-03-18 | 1999-09-23 | Magnetic Imaging Technologies Incorporated | MR METHODS FOR IMAGING PULMONARY AND CARDIAC VASCULATURE AND EVALUATING BLOOD FLOW USING DISSOLVED POLARIZED 129Xe |
| AU3386799A (en) * | 1998-04-13 | 1999-11-01 | Duke University | (in vivo) magnetic resonance vascular imaging using laser-polarized gas microbubbles |
| US6128918A (en) * | 1998-07-30 | 2000-10-10 | Medi-Physics, Inc. | Containers for hyperpolarized gases and associated methods |
| BR9912163A (pt) * | 1998-06-17 | 2001-04-10 | Medi Physics Inc | Recipientes resilientes para gases hiperpolarizados |
| US6423387B1 (en) | 1998-06-17 | 2002-07-23 | Medi-Physics, Inc. | Resilient containers for hyperpolarized gases and associated methods |
| EP1090250A1 (en) | 1998-06-17 | 2001-04-11 | Medi-Physics, Inc. | Hyperpolarized gas transport device and associated transport method |
| US6523356B2 (en) | 1998-09-30 | 2003-02-25 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6286319B1 (en) | 1998-09-30 | 2001-09-11 | Medi-Physics, Inc. | Meted hyperpolarized noble gas dispensing methods and associated devices |
| US6237363B1 (en) | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6125654A (en) * | 1998-10-16 | 2000-10-03 | Syracuse University | Bulk production and usage of hyperpolarized 129 Xenon |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| EP1155339A1 (en) * | 1999-02-23 | 2001-11-21 | Medi-Physics, Inc. | Portable system for monitoring the polarization level of a hyperpolarized gas during transport |
| US6331774B1 (en) | 1999-04-30 | 2001-12-18 | Henry J. Stern | Nuclear decay laser and method |
| DE19927788C2 (de) * | 1999-06-18 | 2003-03-06 | Forschungszentrum Juelich Gmbh | Polarisator für die Polarisation eines Edelgases |
| US6408849B1 (en) * | 1999-06-18 | 2002-06-25 | Aeronex, Inc. | Recovery and purification of gases used in medical processes |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| DE19937566C2 (de) * | 1999-08-09 | 2001-06-28 | Forschungszentrum Juelich Gmbh | Hochdruckpolarisator für Edelgase und Verfahren zum Betreiben des Polarisators |
| US6648130B1 (en) | 1999-08-11 | 2003-11-18 | Medi-Physics, Inc. | Hyperpolarized gas transport and storage devices and associated transport and storage methods using permanent magnets |
| US6310480B1 (en) * | 1999-09-13 | 2001-10-30 | Foxboro Nmr Ltd | Flow-through probe for NMR spectrometers |
| DE19962330B4 (de) * | 1999-12-23 | 2004-02-19 | Ernst-Wilhelm Prof. Dr. Otten | Verfahren und Vorrichtung zur Bestimmung der Magnetisierung elektronen- oder kernspinpolarisierter Medien |
| DE10000675C2 (de) | 2000-01-11 | 2001-11-15 | Otten Ernst Wilhelm | Lineardurchführung, Vorrichtung und Verfahren zur hochproduktiven Erzeugung von hoch kernspinpolarisiertem Helium-3 Gas |
| GB0001727D0 (en) * | 2000-01-25 | 2000-03-15 | Oxford Instr Uk Ltd | Hyperpolarization of a noble gas |
| US6630126B2 (en) * | 2000-03-13 | 2003-10-07 | Medi-Physics, Inc. | Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products |
| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| WO2002004709A1 (en) | 2000-07-12 | 2002-01-17 | Hersman F William | Apparatus and method for polarizing polarizable nuclear species |
| EP1324690A1 (en) | 2000-07-13 | 2003-07-09 | Medi-Physics, Inc. | DIAGNOSTIC PROCEDURES USING ?129 XE SPECTROSCOPY CHARACTERISTIC CHEMICAL SHIFT TO DETECT PATHOLOGY i IN VIVO /i |
| US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
| US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
| US6652833B2 (en) * | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
| JP2004530474A (ja) | 2001-04-24 | 2004-10-07 | メディ−フィジックス・インコーポレイテッド | 過分極化希ガスを加湿するための方法および装置および関連加湿医薬等級吸入可能過分極化ガス産物 |
| GB0122270D0 (en) * | 2001-09-14 | 2001-11-07 | Secretary Trade Ind Brit | Measurement of the polaristion of a gas |
| US7179450B2 (en) * | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| EP1438600A2 (en) * | 2001-10-22 | 2004-07-21 | Medi-Physics, Inc. | Optical pumping modules, polarized gas blending and dispensing systems, and automated polarized gas distribution systems |
| WO2003036316A1 (en) * | 2001-10-22 | 2003-05-01 | Medi-Physics Inc. | Automated modular hyperpolarizers |
| JP4169122B2 (ja) * | 2002-02-26 | 2008-10-22 | 独立行政法人産業技術総合研究所 | 核スピン偏極希ガスの製造装置とこれを用いた偏極希ガスの製造方法 |
| US20040035182A1 (en) * | 2002-05-16 | 2004-02-26 | Steve Kadlecek | Methods and systems for determining polarization of a gas based on electron paramagnetic resonance |
| US7127934B2 (en) * | 2002-05-17 | 2006-10-31 | Medi-Physics, Inc. | Methods, systems, circuits, and computer program products for determining polarization of a gas |
| DK1534990T3 (da) * | 2002-07-23 | 2007-02-19 | Medi Physics Inc | Automatiserede dynamiske trykfölsomme systemer til dispensering af hyperpolariseret gas og tilknyttede fremgangsmåder og computerprogramprodukter |
| KR100998461B1 (ko) | 2002-12-09 | 2010-12-06 | 카오카부시키가이샤 | 구상 주물사 및 그 제조방법 |
| EP1573349A1 (en) * | 2002-12-20 | 2005-09-14 | Medi-Physics, Inc. | Calibration of a polarization measurement station |
| JP3998243B2 (ja) * | 2003-01-10 | 2007-10-24 | 東横化学株式会社 | 核スピン偏極キセノンガスの製造方法及び製造装置 |
| CA2509801A1 (en) * | 2003-01-17 | 2004-08-05 | Medi-Physics Inc. | Method of producing optically pumped hyperpolarized gas |
| CA2509799A1 (en) * | 2003-01-17 | 2004-08-05 | Medi-Physics Inc. | Pump system and method for transferring hyperpolarized gases |
| US6919770B2 (en) * | 2003-03-11 | 2005-07-19 | Princeton University | Method and system for operating an atomic clock with reduced spin-exchange broadening of atomic clock resonances |
| US7275540B2 (en) * | 2003-04-22 | 2007-10-02 | Medi-Physics, Inc. | MRI/NMR-compatible, tidal volume control and measurement systems, methods, and devices for respiratory and hyperpolarized gas delivery |
| JP3978159B2 (ja) * | 2003-07-03 | 2007-09-19 | ジーイー・メディカル・システムズ・グローバル・テクノロジー・カンパニー・エルエルシー | 磁気共鳴撮像システム |
| US7262467B2 (en) * | 2003-09-10 | 2007-08-28 | Ixys Corporation | Over charge protection device |
| JP4555309B2 (ja) * | 2004-01-19 | 2010-09-29 | フォルシュングスツェントルム・ユーリッヒ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 原子核を超偏極する方法及びこの方法を実施する装置 |
| CA2564557A1 (en) * | 2004-04-21 | 2005-11-10 | University Of New Hampshire | Method and apparatus for accumulating hyperpolarized xenon |
| JP3863154B2 (ja) * | 2004-06-07 | 2006-12-27 | 独立行政法人科学技術振興機構 | 偏極キセノンの氷結・再ガス化装置および偏極キセノンの生成システム |
| DE102005017927A1 (de) * | 2005-04-18 | 2006-10-26 | Forschungszentrum Jülich GmbH | Hyperpolarisation von Li und weiteren Kernen |
| JP4696262B2 (ja) * | 2005-05-18 | 2011-06-08 | 独立行政法人産業技術総合研究所 | 超偏極希ガス製造装置及び超偏極希ガスを用いた核磁気共鳴分光装置並びに磁気共鳴イメージング装置 |
| WO2006131133A1 (de) | 2005-06-08 | 2006-12-14 | Limo Patentverwaltung Gmbh & Co. Kg | Optische bestrahlungsvorrichtung für die polarisation von alkaliatomen sowie eine vorrichtung zur hyperpolarisation von edelgasen |
| AU2007254464B2 (en) | 2006-02-21 | 2013-02-21 | Avrum Belzer | Hyperpolarization methods, systems and compositions |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| WO2008036369A2 (en) * | 2006-09-20 | 2008-03-27 | University Of New Hampshire | Thermal management technology for polarizing xenon |
| US8405022B2 (en) * | 2006-09-20 | 2013-03-26 | University Of New Hampshire | Thermal management technology for polarizing xenon |
| NZ575856A (en) * | 2006-10-03 | 2011-06-30 | Univ Duke | Assessing pulmonary gas transfer in lungs using hyperpolarized 129xe mri |
| JP4817317B2 (ja) * | 2006-11-24 | 2011-11-16 | 独立行政法人産業技術総合研究所 | 核スピン偏極希ガスの製造装置と核磁気共鳴分光装置並びに核磁気共鳴イメージング装置 |
| WO2009129265A1 (en) * | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| WO2009143368A2 (en) * | 2008-05-23 | 2009-11-26 | University Of Utah | Non-cryogenic storage cell for hyperpolarized 129xe |
| JP5191543B2 (ja) * | 2008-08-01 | 2013-05-08 | 国立大学法人大阪大学 | 偏極キセノンガスの濃縮方法、偏極キセノンガスの製造供給装置及びｍｒｉシステム |
| DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
| RU2531129C2 (ru) * | 2009-06-19 | 2014-10-20 | Конинклейке Филипс Электроникс Н.В. | Термометрия mri, объединенная с устройством гиперполяризации, использующим фотоны с орбитальным угловым моментом |
| EP2295998A1 (en) * | 2009-09-10 | 2011-03-16 | Koninklijke Philips Electronics N.V. | Magnetic resonance imaging system and magnet comprising a polarizer |
| JP5699725B2 (ja) * | 2011-03-23 | 2015-04-15 | セイコーエプソン株式会社 | ガスセル製造装置およびガスセルの製造方法 |
| US8698493B2 (en) * | 2011-08-05 | 2014-04-15 | Wisconsin Alumni Research Foundation | Noble gas magnetic resonator |
| CN102981190B (zh) * | 2012-12-13 | 2016-08-10 | 吉林大学 | 光泵磁力仪吸收室吸收比的测试装置及测试方法 |
| JPWO2014132651A1 (ja) * | 2013-02-28 | 2017-02-02 | 国立大学法人京都大学 | アルカリ金属セルの製造方法、アルカリ金属の製造方法、およびアルカリ金属ガス含有セル |
| DE102013013197A1 (de) | 2013-08-09 | 2015-02-12 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Arbeit, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt Braunschweig und Berlin | Verfahren und Vorrichtung zum kryogenfreien Aufkonzentrieren eines hyperpolarisierten Gases in einem kontinuierlich fließenden Gasstrom und Verwendung |
| EP3107583B1 (en) * | 2014-02-21 | 2019-05-29 | Duke University | Hyperpolarized noble gas production systems with nanocluster suppression, detection and/or filtering and related methods and devices |
| US10126438B2 (en) | 2014-09-19 | 2018-11-13 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| CN104913798B (zh) * | 2015-05-13 | 2017-11-07 | 北京航天控制仪器研究所 | 一种制备原子气室的原子分装器及原子气室的制备方法 |
| US11754652B2 (en) | 2016-09-15 | 2023-09-12 | University Of Virginia Patent Foundation | Systems and methods for polarized nuclear imaging and spectroscopy |
| US10520561B2 (en) * | 2017-09-27 | 2019-12-31 | General Electric Company | System and method for hyperpolarizing a substance and quenching radicals therein |
| CN108051220B (zh) * | 2017-12-08 | 2019-12-13 | 北京卫星环境工程研究所 | 电推进航天器点火试验用圆柱筒体型氙泵、冷板及抽气系统 |
| US11944424B2 (en) | 2018-05-18 | 2024-04-02 | Duke University | Dynamic 129Xe gas exchange spectroscopy |
| CN111799010B (zh) * | 2020-06-29 | 2025-02-25 | 散裂中子源科学中心 | 一种氦三中子极化装置 |
| WO2023224674A2 (en) * | 2021-12-09 | 2023-11-23 | The Regents Of The University Of California | Rapidly enhanced spin polarization injection in an optically pumped spin ratchet |
| WO2023234979A2 (en) * | 2021-12-20 | 2023-12-07 | The Regents Of The University Of California | High field magnetometry with hyperpolarized nuclear spins |
| CN114644322B (zh) * | 2022-04-15 | 2024-02-06 | 宁波诺丁汉大学 | 超极化稀有气体生产设备 |
| EP4662448A1 (en) * | 2023-02-09 | 2025-12-17 | Polarean, Inc. | Cryo-collection systems, related methods and hyperpolarizers with the cryo-collection systems |
| WO2025151298A1 (en) | 2024-01-10 | 2025-07-17 | Polarean, Inc. | Hyperpolarizers with a load-lock chamber for alkali metal |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2426764C2 (de) * | 1974-06-01 | 1981-07-09 | Kernforschungsanlage Jülich GmbH, 5170 Jülich | Verfahren zum Abtrennen von Krypton aus einem radioaktiven Abgasgemisch und Gastrennanlage zum Durchführen des Verfahrens |
| US4417909A (en) * | 1978-12-04 | 1983-11-29 | Airco, Inc. | Gas separation process |
| US4369048A (en) * | 1980-01-28 | 1983-01-18 | Dallas T. Pence | Method for treating gaseous effluents emitted from a nuclear reactor |
| US4599462A (en) * | 1983-05-25 | 1986-07-08 | University Of Utah | Methods for making solid solutions from normally immiscible components and for modifying the surface structure of solid materials |
| DE3518283C2 (de) * | 1985-05-22 | 1994-09-22 | Messer Griesheim Gmbh | Verfahren zur Entfernung leichter flüchtiger Verunreinigungen aus Gasen |
| US4971258A (en) * | 1988-08-26 | 1990-11-20 | Ihi Master Metal Ltd. | Method of making high-purity fine particles of reactive metals and manufacturing vessel therefor |
| US4977749A (en) * | 1989-04-25 | 1990-12-18 | Sercel Jeffrey P | Apparatus and method for purification of gases used in exciplex (excimer) lasers |
| US5073896A (en) * | 1991-04-18 | 1991-12-17 | Lumonics Inc. | Purification of laser gases |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| US5612103A (en) * | 1995-06-07 | 1997-03-18 | Princeton University | Coatings for production of hyperpolarized noble gases |
| US5617860A (en) * | 1995-06-07 | 1997-04-08 | Smithsonian Astrophysical Observatory | Method and system for producing polarized 129 Xe gas |
-
1996
- 1996-03-29 US US08/622,863 patent/US5642625A/en not_active Expired - Lifetime
-
1997
- 1997-03-27 CA CA002250168A patent/CA2250168C/en not_active Expired - Lifetime
- 1997-03-27 EP EP97917681A patent/EP0896655B1/en not_active Expired - Lifetime
- 1997-03-27 JP JP53544897A patent/JP4040095B2/ja not_active Expired - Fee Related
- 1997-03-27 EP EP07008501A patent/EP1816423A3/en not_active Withdrawn
- 1997-03-27 PT PT97917681T patent/PT896655E/pt unknown
- 1997-03-27 EP EP03077456A patent/EP1386618A3/en not_active Withdrawn
- 1997-03-27 ES ES97917681T patent/ES2212092T3/es not_active Expired - Lifetime
- 1997-03-27 AU AU25943/97A patent/AU709623B2/en not_active Ceased
- 1997-03-27 AT AT97917681T patent/ATE256274T1/de active
- 1997-03-27 WO PCT/US1997/005084 patent/WO1997037178A1/en not_active Ceased
- 1997-03-27 DK DK97917681T patent/DK0896655T3/da active
- 1997-03-27 DE DE69726720T patent/DE69726720T2/de not_active Expired - Lifetime
-
2007
- 2007-08-22 JP JP2007216201A patent/JP4350775B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2594397A (en) | 1997-10-22 |
| JP2000507689A (ja) | 2000-06-20 |
| JP2008055157A (ja) | 2008-03-13 |
| DE69726720D1 (de) | 2004-01-22 |
| ATE256274T1 (de) | 2003-12-15 |
| JP4350775B2 (ja) | 2009-10-21 |
| DE69726720T2 (de) | 2004-10-28 |
| EP0896655B1 (en) | 2003-12-10 |
| US5642625A (en) | 1997-07-01 |
| DK0896655T3 (da) | 2004-04-13 |
| EP1816423A2 (en) | 2007-08-08 |
| EP0896655A1 (en) | 1999-02-17 |
| CA2250168C (en) | 2002-05-28 |
| EP1386618A3 (en) | 2004-03-24 |
| EP1816423A3 (en) | 2011-12-21 |
| CA2250168A1 (en) | 1997-10-09 |
| EP0896655A4 (en) | 2000-07-12 |
| WO1997037178A1 (en) | 1997-10-09 |
| PT896655E (pt) | 2004-04-30 |
| EP1386618A2 (en) | 2004-02-04 |
| JP4040095B2 (ja) | 2008-01-30 |
| AU709623B2 (en) | 1999-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2212092T3 (es) | Heperpolarizador de alto volumen para gases nobles polarizados por spin. | |
| US5809801A (en) | Cryogenic accumulator for spin-polarized xenon-129 | |
| AU757090B2 (en) | Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products | |
| Rosen et al. | Polarized Xe 129 optical pumping/spin exchange and delivery system for magnetic resonance spectroscopy and imaging studies | |
| US6667008B2 (en) | Hyperpolarized noble gas extraction methods, masking methods, and associated transport containers | |
| Kuzma et al. | Fast nuclear spin relaxation in hyperpolarized solid 129 Xe | |
| ES2245981T3 (es) | Procedimientos de difusion de dosis de gas noble hiperpolarizado y dispositivos asociados. | |
| Lee et al. | Hyperpolarised gas filling station for medical imaging using polarised 129Xe and 3He | |
| US7495435B2 (en) | Method for the hyperpolarisation of atomic nuclei and device for implementing the method | |
| Fujiwara et al. | Relaxation behavior of laser-polarized 129Xe gas: size dependency and wall effect of the T1 relaxation time in glass and gelatin bulbs | |
| KR20050088359A (ko) | 광학 펌핑되는 초분극된 가스 제조 방법 | |
| CA2349069C (en) | Cryogenic accumulator for spin-polarized xenon-129 | |
| WO1999034189A2 (en) | Process and device to solidify and thaw a polarized gas comprising xenon | |
| EP1279912B1 (en) | Methods of collecting and thawing polarised gases, associated accumulators and heating jackets | |
| WO2025151298A1 (en) | Hyperpolarizers with a load-lock chamber for alkali metal |