ES2199154T3 - Metodo y dispositivo para mezclar y aplicar componentes de viscosidades diferentes, tales como adhesivos para tejidos. - Google Patents
Metodo y dispositivo para mezclar y aplicar componentes de viscosidades diferentes, tales como adhesivos para tejidos.Info
- Publication number
- ES2199154T3 ES2199154T3 ES00916967T ES00916967T ES2199154T3 ES 2199154 T3 ES2199154 T3 ES 2199154T3 ES 00916967 T ES00916967 T ES 00916967T ES 00916967 T ES00916967 T ES 00916967T ES 2199154 T3 ES2199154 T3 ES 2199154T3
- Authority
- ES
- Spain
- Prior art keywords
- component
- viscous
- channel
- thrombin
- flow
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract description 9
- 239000000853 adhesive Substances 0.000 title description 6
- 239000004744 fabric Substances 0.000 title description 3
- 239000003106 tissue adhesive Substances 0.000 claims abstract description 10
- 239000007788 liquid Substances 0.000 claims abstract description 6
- 108010049003 Fibrinogen Proteins 0.000 claims description 24
- 102000008946 Fibrinogen Human genes 0.000 claims description 24
- 229940012952 fibrinogen Drugs 0.000 claims description 24
- 108090000190 Thrombin Proteins 0.000 claims description 20
- 229960004072 thrombin Drugs 0.000 claims description 20
- 230000000979 retarding effect Effects 0.000 claims 1
- 239000000463 material Substances 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 description 8
- 230000001070 adhesive effect Effects 0.000 description 5
- 230000003111 delayed effect Effects 0.000 description 3
- 238000010348 incorporation Methods 0.000 description 3
- 229920002994 synthetic fiber Polymers 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 238000003825 pressing Methods 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000007921 spray Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- NTXGQCSETZTARF-UHFFFAOYSA-N buta-1,3-diene;prop-2-enenitrile Chemical compound C=CC=C.C=CC#N NTXGQCSETZTARF-UHFFFAOYSA-N 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001934 delay Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- ZEKANFGSDXODPD-UHFFFAOYSA-N glyphosate-isopropylammonium Chemical compound CC(C)N.OC(=O)CNCP(O)(O)=O ZEKANFGSDXODPD-UHFFFAOYSA-N 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000098 polyolefin Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000009966 trimming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
- B65D81/325—Containers having parallel or coaxial compartments, provided with a piston or a movable bottom for discharging contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00491—Surgical glue applicators
- A61B2017/00495—Surgical glue applicators for two-component glue
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Surgical Instruments (AREA)
- Coating Apparatus (AREA)
- Application Of Or Painting With Fluid Materials (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Treatment Of Fiber Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0049899A ATA49899A (de) | 1999-03-19 | 1999-03-19 | Verfahren und vorrichtung zum mischen von komponenten |
| AT49899 | 1999-03-19 | ||
| US09/527,973 US6620125B1 (en) | 1999-03-19 | 2000-03-17 | Method and device for mixing and applying components of differing viscosities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2199154T3 true ES2199154T3 (es) | 2004-02-16 |
Family
ID=29718082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00916967T Expired - Lifetime ES2199154T3 (es) | 1999-03-19 | 2000-03-17 | Metodo y dispositivo para mezclar y aplicar componentes de viscosidades diferentes, tales como adhesivos para tejidos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6620125B1 (enExample) |
| EP (1) | EP1162916B1 (enExample) |
| JP (1) | JP4156198B2 (enExample) |
| AT (2) | ATA49899A (enExample) |
| AU (1) | AU3812400A (enExample) |
| CA (1) | CA2364697C (enExample) |
| DE (1) | DE60003005T2 (enExample) |
| DK (1) | DK1162916T3 (enExample) |
| ES (1) | ES2199154T3 (enExample) |
| PT (1) | PT1162916E (enExample) |
| WO (1) | WO2000056221A1 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4809535B2 (ja) * | 2001-02-21 | 2011-11-09 | 株式会社エイチ・エス・ピー | 殺菌水の連続生成装置 |
| WO2002067785A2 (en) * | 2001-02-27 | 2002-09-06 | Tyco Healthcare Group Lp | External mixer assembly |
| EP1917914B1 (en) | 2001-02-27 | 2009-07-08 | Tyco Healthcare Group Lp | External mixer assembly |
| DE10112904C5 (de) | 2001-03-15 | 2010-04-22 | 3M Espe Ag | Dynamischer Mischer und Verfahren zum Mischen von mindestens zwei Pastenkomponenten |
| US6852099B2 (en) * | 2002-06-04 | 2005-02-08 | Baxter International Inc. | Device for controllably applying liquids to body surfaces |
| ATE297249T1 (de) * | 2003-08-14 | 2005-06-15 | 3M Espe Ag | Mischelement für einen mehrkomponentenpastenmischer, und mischer mit diesem mischelement |
| EP1588779A1 (en) * | 2004-04-19 | 2005-10-26 | 3M Espe AG | Dynamic mixer |
| US7597687B2 (en) | 2004-10-29 | 2009-10-06 | Spinal Restoration, Inc. | Injection of fibrin sealant including an anesthetic in spinal applications |
| US8419722B2 (en) * | 2004-10-29 | 2013-04-16 | Spinal Restoration, Inc. | Apparatus and method for injection of fibrin sealant in spinal applications |
| US8206448B2 (en) | 2004-10-29 | 2012-06-26 | Spinal Restoration, Inc. | Injection of fibrin sealant using reconstituted components in spinal applications |
| EP1640060A1 (en) | 2004-09-22 | 2006-03-29 | 3M Espe Ag | Mixer for multi-component pastes, kit, and method of mixing paste components |
| EP1802385B1 (en) * | 2004-09-22 | 2008-01-23 | 3M Espe AG | Mixer for multi-component pastes, kit, and method of mixing paste components |
| JP4975627B2 (ja) | 2004-10-07 | 2012-07-11 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー | 医療用途のための多糖ベースのポリマー組織接着剤 |
| US8790632B2 (en) | 2004-10-07 | 2014-07-29 | Actamax Surgical Materials, Llc | Polymer-based tissue-adhesive form medical use |
| US7837986B2 (en) * | 2004-12-01 | 2010-11-23 | E. I. Du Pont De Nemours And Company | Protein-based polymer tissue adhesives for medical use |
| CA2598700A1 (en) * | 2005-02-24 | 2006-08-31 | Boston Scientific Santa Rosa Corporation | Constant force material delivery system and method |
| US7468049B2 (en) * | 2005-06-14 | 2008-12-23 | Rieke Corporation | Dual syringe adapter |
| US8679537B2 (en) * | 2005-08-24 | 2014-03-25 | Actamaz Surgical Materials, LLC | Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive |
| US8679536B2 (en) * | 2005-08-24 | 2014-03-25 | Actamax Surgical Materials, Llc | Aldol-crosslinked polymeric hydrogel adhesives |
| JP2007054787A (ja) * | 2005-08-26 | 2007-03-08 | Polymer Systems:Kk | 吐出ガン用ヘッド |
| CN102631226B (zh) | 2006-01-17 | 2014-11-05 | 巴克斯特国际公司 | 用于混合的装置、系统和方法 |
| US20090038701A1 (en) | 2006-01-17 | 2009-02-12 | Baxter International Inc. | Device, system and method for mixing |
| EP2099845B1 (en) * | 2006-11-27 | 2020-12-23 | Actamax Surgical Materials LLC | Multi-functional polyalkylene oxides, hydrogels and tissue adhesives |
| US20090035249A1 (en) * | 2007-08-02 | 2009-02-05 | Bhatia Sujata K | Method of inhibiting proliferation of Escherichia coli |
| DE102007000802A1 (de) * | 2007-10-01 | 2009-04-02 | Hilti Aktiengesellschaft | Foliengebinde mit nebeneinander angeordneten Folienbeutelkammern |
| WO2009064963A2 (en) * | 2007-11-14 | 2009-05-22 | E. I. Du Pont De Nemours And Company | Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use |
| US8753670B2 (en) | 2008-03-26 | 2014-06-17 | Baxter International Inc. | Fibrin foam and process |
| US8512740B2 (en) * | 2008-03-26 | 2013-08-20 | Baxter International Inc. | Fibrin foam and process for making |
| US8551136B2 (en) | 2008-07-17 | 2013-10-08 | Actamax Surgical Materials, Llc | High swell, long-lived hydrogel sealant |
| US20100015231A1 (en) * | 2008-07-17 | 2010-01-21 | E.I. Du Pont De Nemours And Company | Low swell, long-lived hydrogel sealant |
| JP5191317B2 (ja) * | 2008-08-29 | 2013-05-08 | テルモ株式会社 | ノズルの製造方法 |
| EP2328483B1 (de) * | 2008-09-22 | 2017-01-11 | Medmix Systems AG | Anschlussstück mit mischelement für austraganordnung |
| JP5255386B2 (ja) * | 2008-09-24 | 2013-08-07 | テルモ株式会社 | 塗布具 |
| JP5255387B2 (ja) * | 2008-09-25 | 2013-08-07 | テルモ株式会社 | 塗布具 |
| WO2010059279A2 (en) * | 2008-11-19 | 2010-05-27 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether |
| US8466327B2 (en) | 2008-11-19 | 2013-06-18 | Actamax Surgical Materials, Llc | Aldehyde-functionalized polyethers and method of making same |
| US20100160960A1 (en) * | 2008-12-19 | 2010-06-24 | E. I. Du Pont De Nemours And Company | Hydrogel tissue adhesive having increased degradation time |
| EP2411448B1 (en) | 2009-03-27 | 2013-03-20 | Actamax Surgical Materials LLC | Polyglycerol aldehydes |
| EP2411062B1 (en) | 2009-03-27 | 2014-08-20 | Actamax Surgical Materials LLC | Tissue adhesive and sealant comprising polyglycerol aldehyde |
| US20100246316A1 (en) * | 2009-03-31 | 2010-09-30 | Baxter International Inc. | Dispenser, kit and mixing adapter |
| EP2416811B1 (en) | 2009-04-09 | 2015-09-09 | Actamax Surgical Materials LLC | Hydrogel tissue adhesive having reduced degradation time |
| JP5872463B2 (ja) | 2009-07-02 | 2016-03-01 | アクタマックス サージカル マテリアルズ リミテッド ライアビリティカンパニー | 医療用ヒドロゲル組織接着剤 |
| WO2011002956A1 (en) | 2009-07-02 | 2011-01-06 | E. I. Du Pont De Nemours And Company | Aldehyde-functionalized polysaccharides |
| US8580950B2 (en) | 2009-07-02 | 2013-11-12 | Actamax Surgical Materials, Llc | Aldehyde-functionalized polysaccharides |
| US8796242B2 (en) | 2009-07-02 | 2014-08-05 | Actamax Surgical Materials, Llc | Hydrogel tissue adhesive for medical use |
| CA2766229A1 (en) | 2009-09-08 | 2011-03-17 | Baxter International Inc. | Reconstitution and applicator system for wound sealant product |
| US9498271B2 (en) * | 2009-10-29 | 2016-11-22 | Cook Medical Technologies Llc | Coaxial needle cannula with distal spiral mixer and side ports for fluid injection |
| US20110144297A1 (en) * | 2009-12-15 | 2011-06-16 | E. I. Du Pont De Nemours And Company | Rapid thermal conversion of a polyamic acid fiber to a polyimide fiber |
| US8641661B2 (en) | 2010-01-05 | 2014-02-04 | Baxter International Inc. | Mixing system, kit and mixer adapter |
| CA2726566A1 (en) * | 2010-01-11 | 2011-07-11 | Baxter International Inc. | Pipette system, pipette tip assembly and kit |
| KR101786786B1 (ko) * | 2010-01-28 | 2017-10-18 | 옴릭스 바이오파머슈티컬스 리미티드 | 개선된 피브린 밀봉 방법 |
| WO2011134059A1 (en) * | 2010-04-28 | 2011-11-03 | Integra Adhesives Inc. | Apparatus for mixing and dispensing multiple flowable components |
| US9999410B2 (en) * | 2012-03-20 | 2018-06-19 | St. Jude Medical Puerto Rico Llc | Systems and methods for sequential mixing of activator in bioadhesive delivery device |
| JP2013202201A (ja) * | 2012-03-28 | 2013-10-07 | Terumo Corp | 医療用長尺体 |
| US9066636B2 (en) | 2012-06-26 | 2015-06-30 | Gojo Industries, Inc. | Grit and foam dispenser |
| US9381005B2 (en) | 2012-10-26 | 2016-07-05 | Baxter International Inc. | Spray head for two component mixer |
| US8859705B2 (en) | 2012-11-19 | 2014-10-14 | Actamax Surgical Materials Llc | Hydrogel tissue adhesive having decreased gelation time and decreased degradation time |
| US20160184474A1 (en) | 2013-07-29 | 2016-06-30 | Actamax Surgical Materials, Llc | Low swell tissue adhesive and sealant formulations |
| US9572555B1 (en) * | 2015-09-24 | 2017-02-21 | Ethicon, Inc. | Spray or drip tips having multiple outlet channels |
| IL261190A (en) | 2018-08-16 | 2019-01-31 | Omrix Biopharmaceuticals Ltd | Stable liquid preparations of thrombin |
| US20250108142A1 (en) | 2023-09-28 | 2025-04-03 | Ethicon, Inc. | Methods for treating leakage from a gastrointestinal site |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2816518A (en) * | 1956-01-10 | 1957-12-17 | Daggett Chocolate Company | Ice cream blending apparatus |
| DE2127222A1 (de) * | 1971-06-02 | 1972-12-14 | Fischer, Artur, 7241 Tumlingen | Vorrichtung zur Herstellung einer KIe bebefestigung mit einem Mehrkomponenten kleber |
| FR2399861A1 (fr) * | 1977-08-12 | 1979-03-09 | Viellard Paul Henri | Dispositif pour melanger puis utiliser des matieres fluides livrees a l'usager dans des emballages separes |
| AT366916B (de) * | 1980-04-02 | 1982-05-25 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes auf basis von menschlichen oder tierischenproteinen |
| AT379311B (de) * | 1984-03-29 | 1985-12-27 | Immuno Ag | Vorrichtung zur applikation eines gewebeklebstoffes |
| US4978336A (en) * | 1987-09-29 | 1990-12-18 | Hemaedics, Inc. | Biological syringe system |
| CH674717A5 (en) * | 1987-11-10 | 1990-07-13 | Profil Ag | Mixing device for at least two cartridges - has mixing head, semi-outer welded shells, supplies, strips or screw conveyor |
| US5116315A (en) * | 1989-10-03 | 1992-05-26 | Hemaedics, Inc. | Biological syringe system |
| US4979942A (en) * | 1989-10-16 | 1990-12-25 | Johnson & Johnson Medical, Inc. | Two component syringe delivery system |
| US5370273A (en) * | 1991-10-16 | 1994-12-06 | Minnesota Mining And Manufacturing Company | Multi-component applicator assembly |
| AT400304B (de) | 1994-02-28 | 1995-12-27 | Immuno Ag | Vorrichtung zur applikation eines mehrkomponenten-gewebeklebstoffes |
| GB9510856D0 (en) * | 1995-05-27 | 1995-07-19 | Cussons Int Ltd | Cleaning composition |
| JP3077135B2 (ja) * | 1996-01-31 | 2000-08-14 | 花王株式会社 | 吐出容器 |
| US5814022A (en) * | 1996-02-06 | 1998-09-29 | Plasmaseal Llc | Method and apparatus for applying tissue sealant |
| US6047861A (en) * | 1998-04-15 | 2000-04-11 | Vir Engineering, Inc. | Two component fluid dispenser |
| JP2000126569A (ja) * | 1998-09-18 | 2000-05-09 | Sulzer Chemtech Ag | 複数の流動性成分の混合分配を行う装置 |
| US6328229B1 (en) * | 1998-12-18 | 2001-12-11 | Cohesion Technologies, Inc. | Low volume mixing spray head for mixing and dispensing of two reactive fluid components |
-
1999
- 1999-03-19 AT AT0049899A patent/ATA49899A/de not_active Application Discontinuation
-
2000
- 2000-03-17 AT AT00916967T patent/ATE241317T1/de active
- 2000-03-17 ES ES00916967T patent/ES2199154T3/es not_active Expired - Lifetime
- 2000-03-17 WO PCT/EP2000/002367 patent/WO2000056221A1/en not_active Ceased
- 2000-03-17 DE DE60003005T patent/DE60003005T2/de not_active Expired - Lifetime
- 2000-03-17 CA CA002364697A patent/CA2364697C/en not_active Expired - Fee Related
- 2000-03-17 US US09/527,973 patent/US6620125B1/en not_active Expired - Lifetime
- 2000-03-17 JP JP2000606130A patent/JP4156198B2/ja not_active Expired - Fee Related
- 2000-03-17 EP EP00916967A patent/EP1162916B1/en not_active Expired - Lifetime
- 2000-03-17 PT PT00916967T patent/PT1162916E/pt unknown
- 2000-03-17 AU AU38124/00A patent/AU3812400A/en not_active Abandoned
- 2000-03-17 DK DK00916967T patent/DK1162916T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000056221A1 (en) | 2000-09-28 |
| DK1162916T3 (da) | 2003-09-22 |
| EP1162916B1 (en) | 2003-05-28 |
| CA2364697A1 (en) | 2000-09-28 |
| ATA49899A (de) | 2002-06-15 |
| JP2002538923A (ja) | 2002-11-19 |
| EP1162916A1 (en) | 2001-12-19 |
| DE60003005T2 (de) | 2004-04-08 |
| DE60003005D1 (de) | 2003-07-03 |
| PT1162916E (pt) | 2003-10-31 |
| ATE241317T1 (de) | 2003-06-15 |
| AU3812400A (en) | 2000-10-09 |
| US6620125B1 (en) | 2003-09-16 |
| JP4156198B2 (ja) | 2008-09-24 |
| CA2364697C (en) | 2008-09-02 |
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