ES2196785T3 - Derivados de 2-aminoquinalina que tienen actividad agonista del receptor d4. - Google Patents
Derivados de 2-aminoquinalina que tienen actividad agonista del receptor d4.Info
- Publication number
- ES2196785T3 ES2196785T3 ES99910210T ES99910210T ES2196785T3 ES 2196785 T3 ES2196785 T3 ES 2196785T3 ES 99910210 T ES99910210 T ES 99910210T ES 99910210 T ES99910210 T ES 99910210T ES 2196785 T3 ES2196785 T3 ES 2196785T3
- Authority
- ES
- Spain
- Prior art keywords
- group
- amino
- substituents
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto de la fórmula (I) o una sal del mismo donde - (R1)n representa 1 ó 2 sustituyentes, que pueden ser iguales o diferentes, del grupo alquilo C1-3 o alcoxi, halógeno, trifluorometilo, nitro, amino y mono- o di-alquil- amino (C1-2), o dos grupos R1 en átomos de carbono adyacentes, junto con el anillo de benceno, pueden formar el grupo benzodioxano o benzofurano, - X representa nitrógeno o carbono y la línea punteada puede representar un doble enlace, - (R2)p representa 0, 1 ó 2 sustituyentes, que pueden ser iguales o diferentes, del grupo metilo y etilo, o (R2)p es un puente de metileno o un puente de etileno, - R3 es hidrógeno o metilo, y - (R)m, representa 0, 1 ó 2 sustituyentes, que pueden ser iguales o diferentes, y pueden estar situados en todas las posiciones disponibles del grupo quinolilo, del grupo alquilo C1-3 o alcoxi, halógeno, trifluorometilo, nitro, amino y mono- o di-alquil-amino (C1-2), - entendiendo que R1 no puede representar o-OCH3 cuando X es nitrógeno, (R2)p y R3 son hidrógeno, m es 0, y n es 1.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98200399 | 1998-02-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196785T3 true ES2196785T3 (es) | 2003-12-16 |
Family
ID=8233375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99910210T Expired - Lifetime ES2196785T3 (es) | 1998-02-09 | 1999-02-05 | Derivados de 2-aminoquinalina que tienen actividad agonista del receptor d4. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6281216B1 (es) |
EP (1) | EP1054863B1 (es) |
JP (1) | JP4530535B2 (es) |
AT (1) | ATE239702T1 (es) |
AU (1) | AU2925799A (es) |
CA (1) | CA2320116C (es) |
DE (1) | DE69907636T2 (es) |
ES (1) | ES2196785T3 (es) |
WO (1) | WO1999040068A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6313141B1 (en) * | 1997-06-13 | 2001-11-06 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine D4 ligands |
DE60012355T2 (de) * | 1999-10-22 | 2005-12-22 | Sanofi-Aventis | Phenyl- und pyridyl-tetrahydro-pyridine mit tnf inhibitorischer wirkung |
EP1177792A3 (en) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Dopamine D4 Ligands for the treatment of novelty-seeking disorders |
FR2933977B1 (fr) | 2008-07-18 | 2013-04-26 | Centre Nat Rech Scient | Derives heterocycliques utiles dans le traitement des maladies neurodegeneratives |
WO2010135571A1 (en) * | 2009-05-20 | 2010-11-25 | Cylene Pharmaceuticals, Inc. | Novel protein kinase modulators |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5093333A (en) | 1991-04-29 | 1992-03-03 | American Home Products Corporation | N-substituted-2-aminoquinolines useful for treating hypofunction of the cholinergic system |
MX9201991A (es) | 1991-05-02 | 1992-11-01 | Jonh Wyeth & Brother Limited | Derivados de piperazina y procedimiento para su preparacion. |
SK284341B6 (sk) * | 1994-09-30 | 2005-02-04 | Pfizer Inc. | 2,7-Substituované oktahydro-1H-pyrido[1,2-a]pyrazínové deriváty a farmaceutické prostriedky na ich báze |
FR2734819B1 (fr) | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
HUP9900611A3 (en) * | 1995-12-21 | 2000-09-28 | Pfizer | 2,7-substituted octahydro-pyrrolo[1,2-a]pyrazine derivatives, pharmaceutical compositions containing them and intermediates for the preparation of the compounds |
TW593290B (en) * | 1996-05-10 | 2004-06-21 | Janssen Pharmaceutica Nv | Alkylaminobenzothiazole and -benzoxazole derivatives |
CA2293480A1 (en) * | 1997-06-13 | 1998-12-17 | Neurogen Corporation | 2-aminoalkylaminoquinolines as dopamine d4 ligands |
-
1999
- 1999-01-05 US US09/601,765 patent/US6281216B1/en not_active Expired - Lifetime
- 1999-02-05 AU AU29257/99A patent/AU2925799A/en not_active Abandoned
- 1999-02-05 CA CA2320116A patent/CA2320116C/en not_active Expired - Fee Related
- 1999-02-05 AT AT99910210T patent/ATE239702T1/de active
- 1999-02-05 EP EP99910210A patent/EP1054863B1/en not_active Expired - Lifetime
- 1999-02-05 ES ES99910210T patent/ES2196785T3/es not_active Expired - Lifetime
- 1999-02-05 DE DE69907636T patent/DE69907636T2/de not_active Expired - Lifetime
- 1999-02-05 WO PCT/EP1999/000855 patent/WO1999040068A2/en active Search and Examination
- 1999-02-05 JP JP2000530499A patent/JP4530535B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE239702T1 (de) | 2003-05-15 |
CA2320116C (en) | 2011-02-01 |
JP2002502843A (ja) | 2002-01-29 |
DE69907636T2 (de) | 2004-03-25 |
EP1054863B1 (en) | 2003-05-07 |
DE69907636D1 (de) | 2003-06-12 |
CA2320116A1 (en) | 1999-08-12 |
EP1054863A2 (en) | 2000-11-29 |
US6281216B1 (en) | 2001-08-28 |
WO1999040068A3 (en) | 1999-11-25 |
WO1999040068A2 (en) | 1999-08-12 |
AU2925799A (en) | 1999-08-23 |
JP4530535B2 (ja) | 2010-08-25 |
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