ES2196676T3 - Nuevos derivados de arabinosiladenina. - Google Patents
Nuevos derivados de arabinosiladenina.Info
- Publication number
- ES2196676T3 ES2196676T3 ES99111945T ES99111945T ES2196676T3 ES 2196676 T3 ES2196676 T3 ES 2196676T3 ES 99111945 T ES99111945 T ES 99111945T ES 99111945 T ES99111945 T ES 99111945T ES 2196676 T3 ES2196676 T3 ES 2196676T3
- Authority
- ES
- Spain
- Prior art keywords
- virus
- ara
- present
- ada
- metabolism
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
EL OBJETO DE LA PRESENTE INVENCION ES OBTENER UN DERIVADO PARA - A CON UNA RESISTENCIA AL METABOLISMO MEDIANTE ADA Y UNA ACCION ANTIVIRAL SUFICIENTE. UN NUEVO DERIVADO DE PARABINOSILADENINA 2 - SUSTITUIDA REPRESENTADO POR LA FORMULA (I) Y LAS SALES FARMACEUTICAMENTE ACEPTABLES E HIDRATOS DEL MISMO. [EN LA FORMULA, Z ES ALQUILO QUE TIENE MAS DE 4 ATOMOS DE CARBONO, ALQUENILO O ALQUINILO Y R ES HIDROGENO O ALQUILO INFERIOR]. LOS COMPUESTOS DE LA PRESENTE INVENCION SON DERIVADOS PARA - A CON UNA RESISTENCIA AL METABOLISMO MEDIANTE ADA Y UNA ACCION ANTIVIRAL SUFICIENTE CON LO QUE SE RESUELVEN LOS PROBLEMAS ENCONTRADOS HASTA LA FECHA. LOS COMPUESTOS DE LA PRESENTE INVENCION SON UTILES COMO AGENTES TERAPEUTICOS O PREVENTIVOS PPARA ENFERMEDADES INFECTADAS POR UN VIRUS ADN TALES COMO EL VIRUS DEL HERPES SIMPLE (HSV), HERPESVIRUS, CITOMEGALOVIRUS (CMV), ADENOVIRUS, VIRUS DE LA HEPATITIS O VIRUS DE LA VIRUELA. EN COMPPARACION CON PARA - A, NO SOLO MUESTRAN UN BUEN COMPORTAMIENTO EN SANGRE CON UNA PROPIEDAD DE SUSTENTACION EXCELENTE SINO QUE TAMBIEN SON CAPACES DE SER ADMISTRADOS POR VIA ORAL CON LO QUE SU UTILIDAD ES MUY ALTA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP17720998A JP3619017B2 (ja) | 1998-06-24 | 1998-06-24 | 新規アラビノシルアデニン誘導体 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196676T3 true ES2196676T3 (es) | 2003-12-16 |
Family
ID=16027087
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99111945T Expired - Lifetime ES2196676T3 (es) | 1998-06-24 | 1999-06-23 | Nuevos derivados de arabinosiladenina. |
Country Status (9)
Country | Link |
---|---|
US (1) | US6242429B1 (es) |
EP (1) | EP0967220B1 (es) |
JP (1) | JP3619017B2 (es) |
KR (1) | KR100624050B1 (es) |
CN (1) | CN1146573C (es) |
AT (1) | ATE236923T1 (es) |
DE (1) | DE69906625T2 (es) |
ES (1) | ES2196676T3 (es) |
TW (1) | TW564249B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000044763A2 (en) * | 1999-02-01 | 2000-08-03 | University Of Virginia Patent Foundation | Compositions for treating inflammatory response |
EP1420021A1 (en) * | 1999-05-25 | 2004-05-19 | The Penn State Research Foundation | DNA Methyltransferase inhibitors |
JP2003501431A (ja) * | 1999-05-25 | 2003-01-14 | ザ ペン ステート リサーチ ファウンデイション | Dnaメチル基転移酵素阻害剤 |
JP4138662B2 (ja) | 2002-01-10 | 2008-08-27 | ザ・ペンシルバニア・ステイト・リサーチ・フアウンデイシヨン | アルキルジアリールボリネートおよび錯化ジアリールボロン酸を調製するための方法。 |
CA2486339A1 (en) | 2002-05-17 | 2003-11-27 | Neurogen Corporation | Substituted ring-fused imidazole derivates: gabaa receptor ligands |
KR20040036417A (ko) * | 2002-10-25 | 2004-04-30 | 정낙신 | 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물 |
WO2006040558A1 (en) * | 2004-10-15 | 2006-04-20 | Astrazeneca Ab | Substituted adenines and the use thereof |
WO2007119624A1 (ja) * | 2006-04-13 | 2007-10-25 | National University Corporaton Hokkaido University | 抗ヘルペスウイルス活性を有するヌクレオシド誘導体 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5545625A (en) | 1978-09-26 | 1980-03-31 | Ajinomoto Co Inc | 2-methyl-n6-substituted adenine-arabinoside and its preparation |
JPS55160797A (en) * | 1979-05-31 | 1980-12-13 | Ajinomoto Co Inc | Purine nucleoside derivative |
AU575438B2 (en) | 1984-10-26 | 1988-07-28 | Warner-Lambert Company | N6 - substituted deoxyribose analogues of adenosines |
JPS6299395A (ja) | 1985-10-25 | 1987-05-08 | Yamasa Shoyu Co Ltd | 2−アルキニルアデノシンおよび抗高血圧剤 |
AU8276187A (en) | 1986-10-31 | 1988-05-25 | Warner-Lambert Company | Selected n6-substituted adenosines having selective a2 binding activity |
US4843066A (en) | 1986-11-27 | 1989-06-27 | Nippon Zoki Pharmaceutical Co., Ltd. | Novel adenosine derivatives and pharmaceutical composition containing them as an active ingredient |
DE3739366A1 (de) * | 1987-04-10 | 1988-10-27 | Boehringer Mannheim Gmbh | Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel |
GB8712745D0 (en) | 1987-05-30 | 1987-07-01 | Wellcome Found | Antiviral compounds |
GB2226027B (en) | 1988-12-13 | 1992-05-20 | Sandoz Ltd | Adenosine derivatives,their production and use |
JPH0725785B2 (ja) | 1989-01-11 | 1995-03-22 | 日本臓器製薬株式会社 | アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物 |
ES2095960T3 (es) | 1990-09-25 | 1997-03-01 | Rhone Poulenc Rorer Int | Compuestos que tienen propiedades antihipertensivas y antiisquemicas. |
HUT61567A (en) | 1990-12-07 | 1993-01-28 | Sandoz Ag | Process for producing new pharmaceutical compositions comprising 2'-o-alkyladenosine derivatives and for producing 6-cyclohexyl-2'-o-methyladenosinehydrate |
US5705491A (en) * | 1992-10-27 | 1998-01-06 | Nippon Zoki Pharmaceutical Co., Ltd. | Adenosine deaminase inhibitor |
-
1998
- 1998-06-24 JP JP17720998A patent/JP3619017B2/ja not_active Expired - Fee Related
-
1999
- 1999-06-22 KR KR1019990023448A patent/KR100624050B1/ko not_active IP Right Cessation
- 1999-06-23 AT AT99111945T patent/ATE236923T1/de not_active IP Right Cessation
- 1999-06-23 DE DE69906625T patent/DE69906625T2/de not_active Expired - Fee Related
- 1999-06-23 TW TW088110523A patent/TW564249B/zh not_active IP Right Cessation
- 1999-06-23 ES ES99111945T patent/ES2196676T3/es not_active Expired - Lifetime
- 1999-06-23 EP EP99111945A patent/EP0967220B1/en not_active Expired - Lifetime
- 1999-06-24 CN CNB991089081A patent/CN1146573C/zh not_active Expired - Fee Related
- 1999-06-24 US US09/339,257 patent/US6242429B1/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0967220B1 (en) | 2003-04-09 |
ATE236923T1 (de) | 2003-04-15 |
US6242429B1 (en) | 2001-06-05 |
CN1146573C (zh) | 2004-04-21 |
JP3619017B2 (ja) | 2005-02-09 |
KR100624050B1 (ko) | 2006-09-19 |
DE69906625D1 (de) | 2003-05-15 |
EP0967220A1 (en) | 1999-12-29 |
TW564249B (en) | 2003-12-01 |
JP2000007695A (ja) | 2000-01-11 |
DE69906625T2 (de) | 2004-02-05 |
CN1242373A (zh) | 2000-01-26 |
KR20000006339A (ko) | 2000-01-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR100279953B1 (ko) | 항-b형 간염 바이러스제 및 항-사람 면역결핍 바이러스제로서의 l-2',3'-디데옥시 누클레오시드 유사체 | |
CA1314551C (en) | Poly-4-aminopyrrole-2-carboxamido derivatives and their use as site specific alkylating agents | |
KR930019213A (ko) | 간염치료에 유용한 1,3-옥사티올란류 | |
ATE68180T1 (de) | Morpholinoethylester von mycophenolsaeure und ihre derivate, ihre herstellung und verwendung in pharmazeutische zusammensetzungen. | |
KR900701815A (ko) | 피리미딘 유도체 | |
PL366726A1 (en) | 4'-substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus | |
CA2322008A1 (en) | 2'-fluoronucleosides | |
MY128463A (en) | 4' substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus | |
KR900003170A (ko) | 신규 화합물 | |
ATE116654T1 (de) | Carbocyclische nukleoside und nukleotide. | |
ES2196676T3 (es) | Nuevos derivados de arabinosiladenina. | |
BRPI0413430A (pt) | derivados de amida | |
IL121305A0 (en) | Neuraminic acid derivatives and pharmaceutical compositions containing the same | |
KR930004296A (ko) | 신규(2-알킬-3-피리딜)메틸피페라진 유도체 | |
CO5160292A1 (es) | Composicion farmaceutica que contiene derivados de 2-tienil- imidazolo[4,5]piridina, util para el tratamiento de infeccio nes virales | |
ATE109770T1 (de) | Derivate der coffeinsäure und pharmazeutische zusammensetzungen, die sie enthalten. | |
KR910014119A (ko) | 항-고혈압 활성을 갖는 티아졸리딘 유도체 및 그의 치료용도 | |
KR860008973A (ko) | 2-피롤리돈 유도체 | |
WO2002085358A2 (en) | Antiviral agents and methods of treating viral infections | |
DE69110528T2 (de) | Chirale 2-(Phosphonomethoxy)propyl-Guanine als antivirale Agentien. | |
ES556551A0 (es) | Un procedimiento para preparar un derivado de 1,5-benzotiazepina | |
KR900012925A (ko) | 인돌 유도체 | |
KR890002103A (ko) | 피페리딘 유도체, 그의제법 및 도르지발 38 | |
KR900018093A (ko) | 2',3'-디데히드로-2',3'-디데옥시뉴클레오사이드류의 전구체 | |
KR910004621A (ko) | 신규 화합물 |