KR900003170A - 신규 화합물 - Google Patents
신규 화합물 Download PDFInfo
- Publication number
- KR900003170A KR900003170A KR1019890011058A KR890011058A KR900003170A KR 900003170 A KR900003170 A KR 900003170A KR 1019890011058 A KR1019890011058 A KR 1019890011058A KR 890011058 A KR890011058 A KR 890011058A KR 900003170 A KR900003170 A KR 900003170A
- Authority
- KR
- South Korea
- Prior art keywords
- hydroxy
- propoxy
- compound
- guanine
- oxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (15)
- 일반식(Ⅰ)의 화합물 또는 제약학적으로 허용가능한 그들의 염 :식중에서, R1은 히드록시, 아미노, 클로로 또는 OR7(애거시 R7은 C1-6알킬, 페닐부분이 할로, C1-4알킬 또는 C1-4알콕시기 중에서 선택된 하나 또는 두개의 치환체로 치환될 수 있는 페닐 또는 페닐 C1-2알킬기임)이고 ; R2는 아미노기이거나, R1이 히드록시 또는 아미노기일때, R2는 수소가 될수 있고 ; X는 -CH2CH2- 또는 구조(여기서 n은 1 또는 2이고; m은 0,1 또는 2이고 ; R3는 수소이거나 아실기이고; R4는 R5및 R6가 독립적으로 수소, C1-6알킬 및 임의로 치환된 페닐기로부터 선택된 일반식의 기임)의 부분이다.
- 제1항에 있어서, R1이 히드록시기이고, R2는 아미노기이거나, R1이 아미노기이고, R2는 수소인 화합물.
- 제1항 또는 제2항중 어느 한 항에 있어서, X가 -CH2CH2-인 화합물.
- 제1항 내지 제3항중 어느 한 항에 있어서, X가 제1항에서 정의된 것과 같은 구조(a)이고, n이 1인 화합물.
- 제1항 내지 제4항중 어느 한항에 있어서, R5및 R6모두가 수소인 화합물.
- 9-[3-(디에톡시포스포릴메톡시)프로폭시]구아닌, 9-[3-(포스포메톡시)프로폭시프로폭시]구아닌, 2,6-디아미노-9-[3-(디에톡시포스포릴메톡시)프로폭시]퓨린, 2,6-디아미노-9-[3-(포스포노메톡시)프로폭시]-퓨린, 9-[3-(디에톡시포스포릴메톡시)프로폭시]아데닌, 9-[3-(포스포노메톡시)프로폭시]아데닌, 9-[3-에톡시(히드록시)포스포릴메톡시]-구아닌, 2,6-디아미노-9-[(3-디에톡시포스포릴메톡시-2-히드록시메틸)프로폭시]퓨린, 2,6-디아미노-9-[(2-히드록시메틸-3-포스포노-메톡시)프로폭시]퓨린, 9-[(3-디에톡시포스포릴메톡시-2-히드록시-메틸)프로폭시]구아닌, 9-[(2-히드록시메틸-3-포스포노메톡시)프로폭시]-구아닌, 9-[(3-디에톡시포스포릴메톡시-2-히드록시-메틸)프로폭시]아데닌, 9-[(2-히드록시메틸-3-포스포노메톡시프로폭시]-아데닌, 9-[(3-에톡시(히드록시)포스포릴메톡시-2-히드록시메틸)프로폭시]구아닌, 9-(1-디에톡시포스포릴메톡시-3-히드록시프롭-2-옥시)구아닌, 9-(1-히드록시-3-포스포노메톡시프롭-2-옥시)-구아닌, 9-(1-디에톡시포스포릴메톡시-3-히드록시프롭-2-옥시)아데닌, 9-(1-히드록시-3-포스포노메톡시프롭-2-옥시)-아데닌, 2,6-디아미노-9-[1-(디에톡시포스포릴메톡시)-3-히드록시프롭-2-옥시]퓨린, 2,6-디아미노-9-[1-히드록시-3-(포스포노메톡시)-프롭-2-옥시]퓨린, 9-[2-히드록시-3-(포스포노메톡시)프로폭시]-구아닌, 9-[3-(디에톡시포스포릴메톡시)-2-히드록시-프로폭시]아데닌, 9-[2-히드록시-3-(포스포노메톡시)프로폭시]-아데닌, 9-[4-(디에톡시포스포릴메톡시)-1-히드록시부트-2-옥시]구아닌, 9-[1-히드록시-4-(포스포노메톡시)부트-2-옥시]-구아닌, 9-[4-(디에톡시포스포릴메톡시)-1-히드록시부트-2-옥시]아데닌 및 9-[1-히드록시-4-(포스포노메톡시)부트-2-옥시]-아데닌로 구성된 군으로부터 선택된 화합물.
- ⅰ) Q가 아미노기 또는 아미노 유도체, 예를들면, 포밀아미노와 같이, 환화되어 이미다졸 고리를 형성할 수 있는 기인 일반식의 화합물의 이미다졸 고리 닫힘 ; 또는 ⅱ) 축합제와 환화되어 2-R2' 치환체를 갖는 피리미딘 고리를 형성시켜, R1이 히드록시기이고 R2가 아미노기인 일반식(Ⅰ)의 화합물을 생성시키는, Y가 아미노기이거나, 알콕시기인 일반식의 화합물의 피리미딘 고리 닫힘; 또는 ⅲ) Z인 이탈기인 일반식의 측쇄 중간체와 일반식의 화합물을 축합시키고, 이때 일반식(Ⅱ)-(Ⅴ)에 있어서, R1'R2'X'R4'가 각각 R1,R2,R3및 R4또는 그들로 전환 가능한 기 또는 원자이고; 그 후에, 원하거나 필요하다면, R1',R2'X' 및/또는 R4'가 아닐때 R1'R2'X' 및/또는 R4'를 R1,R4,X 및/또는 R4로 각각 전환시키고/거나 R1,R2,X 및/또는 R4일때, R1',R2',X' 및/또는 R4'를 다른 R1,R2,X 및/또는 R4로 전환시키는 것중 어느 하나로 구성되는, 제1항에 따르는 화합물의 제조방법.
- 제7항에서 정의된 바와같은 일반식(Ⅱ)의 중간체 화합물.
- 제7항에서 정의된 바와같은 일반식(Ⅲ)의 중간체 화합물.
- X'가 X이거나 X내의 R3가 보호기로 대치되고, R4및 X가 제1항에서 정의된 바와 같은 일반식R4OCH2X'ONH2의 중간체 화합물.
- 디에틸 3-아미노옥시프로폭시메틸포스포네이트, 디에틸 2-아세톡시메틸-3-아미노옥시프로폭시메틸포스포네이트 및 디에틸 2-아미노옥시-3-t-부틸디메틸실릴옥시프로폭시메틸포스포네이트로 구성된 군으로부터 선택된 중간체 화합물.
- 제1항 내지 제6항중 어느 한 항에 따른 화합물 및 약제학적으로 허용 가능한 담체로 구성된 제약학적 조성물.
- 활성 치료 물질로서의 사용을 위한 제1항 내지 제6항중 어느 한 항에 따른 화합물.
- 비루스성 감염 치료 또는 신생물 질병 치료에 있어서의 사용을 위한 제1항 내지 제6항중 어느 한 항에 따른 화합물.
- 비루스 감염 또는 신생물 질병의 치료에 있어서의 사용을 위한 약제의 제조에 있어서 제1항 내지 제6항중 어느 한 항에 따른 화합물의 사용.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8818375 | 1988-08-02 | ||
GB888818375A GB8818375D0 (en) | 1988-08-02 | 1988-08-02 | Novel compounds |
GB888827724A GB8827724D0 (en) | 1988-11-28 | 1988-11-28 | Novel compounds |
GB8827724.9 | 1988-11-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900003170A true KR900003170A (ko) | 1990-03-23 |
Family
ID=26294230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890011058A KR900003170A (ko) | 1988-08-02 | 1989-08-01 | 신규 화합물 |
Country Status (8)
Country | Link |
---|---|
US (1) | US5055458A (ko) |
EP (1) | EP0353955A3 (ko) |
JP (1) | JPH0288591A (ko) |
KR (1) | KR900003170A (ko) |
AU (1) | AU614863B2 (ko) |
DK (1) | DK375989A (ko) |
NZ (1) | NZ230144A (ko) |
PT (1) | PT91330A (ko) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5247085A (en) * | 1987-11-30 | 1993-09-21 | Beecham Group P.L.C. | Antiviral purine compounds |
GB8907173D0 (en) * | 1989-03-30 | 1989-05-10 | Beecham Group Plc | Novel compounds |
GB8912043D0 (en) * | 1989-05-25 | 1989-07-12 | Beecham Group Plc | Novel compounds |
AU653542B2 (en) * | 1990-07-19 | 1994-10-06 | Beecham Group Plc | Antiviral phosphono-alken derivatives of purines |
DE69129650T2 (de) * | 1990-09-14 | 1999-03-25 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
US5208221A (en) * | 1990-11-29 | 1993-05-04 | Bristol-Myers Squibb Company | Antiviral (phosphonomethoxy) methoxy purine/pyrimidine derivatives |
GB9026164D0 (en) * | 1990-12-01 | 1991-01-16 | Beecham Group Plc | Pharmaceuticals |
GB9107896D0 (en) * | 1991-04-13 | 1991-05-29 | Smithkline Beecham Plc | Pharmaceuticals |
EP0531597A1 (en) * | 1991-09-12 | 1993-03-17 | Merrell Dow Pharmaceuticals Inc. | Novel unsaturated acyclic phosphonate derivatives of purine and pyrimidine |
GB9205917D0 (en) * | 1992-03-18 | 1992-04-29 | Smithkline Beecham Plc | Pharmaceuticals |
WO1994022864A1 (en) * | 1993-03-30 | 1994-10-13 | Sterling Winthrop Inc. | Acyclic nucleoside analogs and oligonucleotide sequences containing them |
US5817647A (en) * | 1993-04-01 | 1998-10-06 | Merrell Pharmaceuticals Inc. | Unsaturated acetylene phosphonate derivatives of purines |
JPH09506333A (ja) * | 1993-09-17 | 1997-06-24 | ギリアード サイエンシーズ,インコーポレイテッド | 治療化合物の投薬方法 |
US5798340A (en) | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
US5789589A (en) * | 1996-04-22 | 1998-08-04 | Drug Innovation & Design, Inc. | Guanine analog phosphates |
EP0981532B1 (en) * | 1997-05-15 | 2002-08-28 | Drug Innovation & Design, Inc. | Acyclovir diester derivatives |
US6180790B1 (en) | 1997-05-15 | 2001-01-30 | Drug Innovation And Design, Inc. | Methods of preparing acyclovir prodrugs |
US6653318B1 (en) * | 1999-07-21 | 2003-11-25 | Yale University | 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use |
CN100526315C (zh) | 2005-06-16 | 2009-08-12 | 浙江医药股份有限公司新昌制药厂 | N2-喹啉或异喹啉取代的嘌呤衍生物及其制备方法和其用途 |
CN101289449A (zh) | 2007-04-20 | 2008-10-22 | 浙江医药股份有限公司新昌制药厂 | 2,6-二含氮取代的嘌呤衍生物及其制备方法和应用 |
CA2819548C (en) | 2010-12-10 | 2019-04-09 | Sigmapharm Laboratories, Llc | Highly stable compositions of orally active nucleotide analogues or orally active nucleotide analogue prodrugs |
JP6122960B2 (ja) * | 2012-10-08 | 2017-04-26 | ダウ グローバル テクノロジーズ エルエルシー | 難燃性ポリウレタンフォーム用の有機リン化合物 |
US9523195B2 (en) | 2014-06-09 | 2016-12-20 | Johns Manville | Wall insulation boards with non-halogenated fire retardant and insulated wall systems |
US9815256B2 (en) | 2014-06-09 | 2017-11-14 | Johns Manville | Foam boards including non-halogenated fire retardants |
US9528269B2 (en) | 2014-06-09 | 2016-12-27 | Johns Manville | Roofing systems and roofing boards with non-halogenated fire retardant |
US9815966B2 (en) | 2014-07-18 | 2017-11-14 | Johns Manville | Spray foams containing non-halogenated fire retardants |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0138683A3 (en) * | 1983-09-30 | 1988-01-20 | Merck & Co. Inc. | Purine derivatives, their application in anti-viral compositions |
CS263951B1 (en) * | 1985-04-25 | 1989-05-12 | Antonin Holy | 9-(phosponylmethoxyalkyl)adenines and method of their preparation |
CS263952B1 (en) * | 1985-04-25 | 1989-05-12 | Holy Antonin | Remedy with antiviral effect |
MY101126A (en) * | 1985-12-13 | 1991-07-31 | Beecham Group Plc | Novel compounds |
GB8712744D0 (en) * | 1987-05-30 | 1987-07-01 | Beecham Group Plc | Active compounds |
GB8713695D0 (en) * | 1987-06-11 | 1987-07-15 | Beecham Group Plc | Process |
GB8724765D0 (en) * | 1987-10-22 | 1987-11-25 | Beecham Group Plc | Process |
PT89098B (pt) * | 1987-11-30 | 1993-03-31 | Beecham Group Plc | Processo para a preparacao de derivados de guanina |
-
1989
- 1989-07-27 EP EP19890307673 patent/EP0353955A3/en not_active Withdrawn
- 1989-07-28 US US07/387,068 patent/US5055458A/en not_active Expired - Fee Related
- 1989-07-31 NZ NZ230144A patent/NZ230144A/xx unknown
- 1989-07-31 AU AU39139/89A patent/AU614863B2/en not_active Ceased
- 1989-07-31 DK DK375989A patent/DK375989A/da not_active Application Discontinuation
- 1989-07-31 PT PT91330A patent/PT91330A/pt not_active Application Discontinuation
- 1989-08-01 KR KR1019890011058A patent/KR900003170A/ko not_active Application Discontinuation
- 1989-08-02 JP JP1201148A patent/JPH0288591A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK375989A (da) | 1990-02-03 |
AU614863B2 (en) | 1991-09-12 |
EP0353955A2 (en) | 1990-02-07 |
DK375989D0 (da) | 1989-07-31 |
PT91330A (pt) | 1990-03-08 |
EP0353955A3 (en) | 1991-08-14 |
US5055458A (en) | 1991-10-08 |
AU3913989A (en) | 1990-02-08 |
JPH0288591A (ja) | 1990-03-28 |
NZ230144A (en) | 1991-09-25 |
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