ES2196530T3 - Compuestos de ruptura para inactivar patogenos. - Google Patents
Compuestos de ruptura para inactivar patogenos.Info
- Publication number
- ES2196530T3 ES2196530T3 ES98901776T ES98901776T ES2196530T3 ES 2196530 T3 ES2196530 T3 ES 2196530T3 ES 98901776 T ES98901776 T ES 98901776T ES 98901776 T ES98901776 T ES 98901776T ES 2196530 T3 ES2196530 T3 ES 2196530T3
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- methods
- materials
- nucleic acid
- inactivate pathogens
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 244000052769 pathogen Species 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 230000000415 inactivating effect Effects 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 239000012620 biological material Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 210000003743 erythrocyte Anatomy 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Analytical Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77988597A | 1997-01-06 | 1997-01-06 | |
| US77983097A | 1997-01-07 | 1997-01-07 | |
| US4369697P | 1997-04-15 | 1997-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2196530T3 true ES2196530T3 (es) | 2003-12-16 |
Family
ID=27366374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98901776T Expired - Lifetime ES2196530T3 (es) | 1997-01-06 | 1998-01-06 | Compuestos de ruptura para inactivar patogenos. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1021414B1 (enExample) |
| JP (2) | JP4551502B2 (enExample) |
| CN (2) | CN1248245B (enExample) |
| AT (1) | ATE243198T1 (enExample) |
| AU (1) | AU744089C (enExample) |
| CA (1) | CA2276532C (enExample) |
| DE (1) | DE69815703T2 (enExample) |
| ES (1) | ES2196530T3 (enExample) |
| WO (1) | WO1998030545A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2276532C (en) * | 1997-01-06 | 2008-06-17 | Cerus Corporation | Frangible compounds for pathogen inactivation |
| CN1203900C (zh) | 1998-01-06 | 2005-06-01 | 塞鲁斯公司 | 用于淬灭生物材料中病原体灭活剂的方法 |
| JP2002517435A (ja) | 1998-06-11 | 2002-06-18 | シーラス コーポレイション | 動脈平滑筋細胞の増殖阻害のためのアルキル化化合物の使用 |
| US7498156B2 (en) | 1998-07-21 | 2009-03-03 | Caridianbct Biotechnologies, Llc | Use of visible light at wavelengths of 500 to 550 nm to reduce the number of pathogens in blood and blood components |
| US7049110B2 (en) | 1998-07-21 | 2006-05-23 | Gambro, Inc. | Inactivation of West Nile virus and malaria using photosensitizers |
| US6403359B1 (en) | 1998-09-25 | 2002-06-11 | V. I. TECHNOLOGIES, Inc. | Solid phase quenching systems |
| US6150109A (en) | 1999-01-25 | 2000-11-21 | V. I. TECHNOLOGIES, Inc. | Lipophilic quenching of viral inactivating agents |
| US7220747B2 (en) | 1999-07-20 | 2007-05-22 | Gambro, Inc. | Method for preventing damage to or rejuvenating a cellular blood component using mitochondrial enhancer |
| US7094378B1 (en) | 2000-06-15 | 2006-08-22 | Gambro, Inc. | Method and apparatus for inactivation of biological contaminants using photosensitizers |
| US20020042043A1 (en) * | 2000-05-31 | 2002-04-11 | Adonis Stassinopoulos | Preparation of a pathogen inactivated solution of red blood cells having reduced immunogenicity |
| US9044523B2 (en) | 2000-06-15 | 2015-06-02 | Terumo Bct, Inc. | Reduction of contaminants in blood and blood products using photosensitizers and peak wavelengths of light |
| DE10051628B4 (de) * | 2000-10-18 | 2007-06-06 | Fresenius Hemocare Beteiligungs Gmbh | Einzelsträngiges Oligonukleotid und dessen Verwendung |
| CA2434256A1 (en) * | 2000-12-21 | 2003-07-31 | David Cook | Methods for inactivation of pathogens in biological materials |
| PT1592441E (pt) | 2003-02-06 | 2012-05-21 | Aduro Biotech | Listeria atenuada relativamente à entrada em células não patogénicas, vacinas compreendendo a listeria e métodos para sua utilização |
| WO2004084936A2 (en) * | 2003-02-06 | 2004-10-07 | Cerus Corporation | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US7695725B2 (en) | 2003-02-06 | 2010-04-13 | Aduro Biotech | Modified free-living microbes, vaccine compositions and methods of use thereof |
| US7842289B2 (en) | 2003-12-24 | 2010-11-30 | Aduro Biotech | Recombinant nucleic acid molecules, expression cassettes, and bacteria, and methods of use thereof |
| CA2585621C (en) | 2004-10-29 | 2015-12-15 | Cerus Corporation | Improved quenching methods for red blood cell inactivation process |
| KR101896430B1 (ko) | 2008-04-09 | 2018-09-10 | 세루스 코포레이션 | 적혈구 병원체 불활성화를 위한 개선된 퀀칭 방법 |
| AU2014216178B2 (en) | 2013-02-15 | 2018-06-28 | KALA BIO, Inc. | Therapeutic compounds and uses thereof |
| US9688688B2 (en) | 2013-02-20 | 2017-06-27 | Kala Pharmaceuticals, Inc. | Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof |
| EP2958895B1 (en) | 2013-02-20 | 2020-08-19 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| US9890173B2 (en) | 2013-11-01 | 2018-02-13 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA2928658A1 (en) | 2013-11-01 | 2015-05-07 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CN104788373A (zh) * | 2015-05-06 | 2015-07-22 | 武汉大学 | 化合物s-303盐酸盐的合成方法 |
| EA201890149A1 (ru) | 2015-06-26 | 2018-07-31 | Сирус Корпорейшн | Композиции криопреципитатов и способы их получения |
| CN104991033A (zh) * | 2015-08-05 | 2015-10-21 | 上海海虹实业(集团)巢湖今辰药业有限公司 | 一种采用一测多评法测定川芎挥发油成分的方法 |
| US10799533B2 (en) | 2015-10-23 | 2020-10-13 | Cerus Corporation | Plasma compositions and methods of use thereof |
| CA3036340A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| AU2017324713B2 (en) | 2016-09-08 | 2020-08-13 | KALA BIO, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| CA3036065A1 (en) | 2016-09-08 | 2018-03-15 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| AU2017382449B2 (en) | 2016-12-23 | 2024-10-24 | Cerus Corporation | Systems and methods for testing and screening using compound bound substrates |
| BR112019018273A2 (pt) | 2017-03-03 | 2020-07-14 | Cerus Corporation | kits e métodos para preparação de composições de plaquetas inativadas por patógenos |
| TWI821233B (zh) | 2017-12-29 | 2023-11-11 | 美商西勒斯股份有限公司 | 用於處理生物流體之方法、藉由該方法製備之病原體去活生物流體、及用於處理生物流體之系統 |
| CA3143213A1 (en) | 2019-06-22 | 2020-12-30 | Cerus Corporation | Biological fluid treatment systems |
| WO2020264421A1 (en) | 2019-06-28 | 2020-12-30 | Cerus Corporation | System and methods for implementing a biological fluid treatment device |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994020090A1 (en) * | 1993-03-17 | 1994-09-15 | Steritech, Inc. | Decontaminating clinical samples |
| US5691132A (en) * | 1994-11-14 | 1997-11-25 | Cerus Corporation | Method for inactivating pathogens in red cell compositions using quinacrine mustard |
| DE4444045C2 (de) * | 1994-12-10 | 1997-04-17 | Behringwerke Ag | Verfahren zur Inaktivierung von Viren mit Hilfe von Acridin oder Acridinderivaten |
| AU722811B2 (en) * | 1995-06-07 | 2000-08-10 | Cerus Corporation | Treating red blood cell solutions with anti-viral agents |
| CA2276532C (en) * | 1997-01-06 | 2008-06-17 | Cerus Corporation | Frangible compounds for pathogen inactivation |
-
1998
- 1998-01-06 CA CA002276532A patent/CA2276532C/en not_active Expired - Fee Related
- 1998-01-06 CN CN988027348A patent/CN1248245B/zh not_active Expired - Lifetime
- 1998-01-06 WO PCT/US1998/000532 patent/WO1998030545A1/en not_active Ceased
- 1998-01-06 DE DE69815703T patent/DE69815703T2/de not_active Expired - Lifetime
- 1998-01-06 ES ES98901776T patent/ES2196530T3/es not_active Expired - Lifetime
- 1998-01-06 AU AU58217/98A patent/AU744089C/en not_active Expired
- 1998-01-06 JP JP53119998A patent/JP4551502B2/ja not_active Expired - Lifetime
- 1998-01-06 CN CN2009101633119A patent/CN101676268B/zh not_active Expired - Lifetime
- 1998-01-06 EP EP98901776A patent/EP1021414B1/en not_active Expired - Lifetime
- 1998-01-06 AT AT98901776T patent/ATE243198T1/de not_active IP Right Cessation
-
2009
- 2009-12-17 JP JP2009286996A patent/JP5244083B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU744089B2 (en) | 2002-02-14 |
| JP2001508449A (ja) | 2001-06-26 |
| ATE243198T1 (de) | 2003-07-15 |
| CA2276532A1 (en) | 1998-07-16 |
| EP1021414B1 (en) | 2003-06-18 |
| HK1026702A1 (en) | 2000-12-22 |
| JP5244083B2 (ja) | 2013-07-24 |
| CN101676268A (zh) | 2010-03-24 |
| WO1998030545A1 (en) | 1998-07-16 |
| JP2010095527A (ja) | 2010-04-30 |
| CA2276532C (en) | 2008-06-17 |
| JP4551502B2 (ja) | 2010-09-29 |
| CN1248245B (zh) | 2012-07-04 |
| AU5821798A (en) | 1998-08-03 |
| DE69815703T2 (de) | 2004-06-03 |
| AU744089C (en) | 2003-07-31 |
| DE69815703D1 (de) | 2003-07-24 |
| HK1188441A1 (en) | 2014-05-02 |
| CN101676268B (zh) | 2013-09-25 |
| CN1248245A (zh) | 2000-03-22 |
| EP1021414A1 (en) | 2000-07-26 |
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