ES2191121T3 - Un procedimiento para preparar derivados de acido 3-fenil-1-metilendioxifenil-indano-2-carboxilico. - Google Patents
Un procedimiento para preparar derivados de acido 3-fenil-1-metilendioxifenil-indano-2-carboxilico.Info
- Publication number
- ES2191121T3 ES2191121T3 ES96940864T ES96940864T ES2191121T3 ES 2191121 T3 ES2191121 T3 ES 2191121T3 ES 96940864 T ES96940864 T ES 96940864T ES 96940864 T ES96940864 T ES 96940864T ES 2191121 T3 ES2191121 T3 ES 2191121T3
- Authority
- ES
- Spain
- Prior art keywords
- indano
- methylendioxyphenyl
- carboxyl
- phenyl
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C305/00—Esters of sulfuric acids
- C07C305/26—Halogenosulfates, i.e. monoesters of halogenosulfuric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
- C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/32—One oxygen atom
- C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE HA INVENTADO UN PROCESO MEJORADO PARA LA PREPARACION DE DERIVADOS DE CICLOPENTANOS FUSIONADOS A UN ANILLO AROMATICO. LOS COMPUESTOS PREFERENTES PREPARADOS SEGUN ESTA INVENCION SON DERIVADO DE CARBOXILATOS DE INDANO Y DE CICLOPENTANO[B]PIRIDINA. LOS COMPUESTOS MAS PREFERENTES PREPARADOS SEGUN ESTA INVENCION SON ACIDO (+)(1S, 2R, 3S) - 3 - [2 - (2 - HIDROXIET - 1- ILOXI) 4 - METOXIFENIL] - 1 - (3,4 - METILENDIOXIFENIL) - 5 - (PROP 1- ILOXI)INDANO - 2 - CARBOXILICO Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO Y ACIDO (+)(1S, 2R, 3S) - 3 - (2 CARBOXIMETOXI - 4- METOXIFENIL) - 1- (3,4 - METILENDIOXIFENIL) 5 - (PROP - 1 - ILOXI)INDANO - 2 - CARBOXILICO Y LAS SALES FARMACEUTICAMENTE ACEPTABLES DEL MISMO. TAMBIEN SE HAN INVENTADO NUEVOS INTERMEDIOS UTILES EN LA PREPARACION DE ESTOS COMPUESTOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US634595P | 1995-11-08 | 1995-11-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2191121T3 true ES2191121T3 (es) | 2003-09-01 |
Family
ID=21720444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96940864T Expired - Lifetime ES2191121T3 (es) | 1995-11-08 | 1996-11-08 | Un procedimiento para preparar derivados de acido 3-fenil-1-metilendioxifenil-indano-2-carboxilico. |
Country Status (23)
Country | Link |
---|---|
US (3) | US6147232A (es) |
EP (1) | EP0880518B1 (es) |
JP (1) | JP2000500444A (es) |
KR (1) | KR19990067376A (es) |
CN (1) | CN1084742C (es) |
AR (1) | AR005237A1 (es) |
AT (1) | ATE236151T1 (es) |
AU (1) | AU711450B2 (es) |
BR (1) | BR9611540A (es) |
CO (1) | CO4761056A1 (es) |
CZ (1) | CZ141598A3 (es) |
DE (1) | DE69627199T2 (es) |
ES (1) | ES2191121T3 (es) |
HK (1) | HK1016588A1 (es) |
HU (1) | HUP9901985A2 (es) |
IL (1) | IL124312A0 (es) |
NO (1) | NO982090L (es) |
NZ (1) | NZ323790A (es) |
PL (1) | PL326699A1 (es) |
TR (1) | TR199800839T2 (es) |
TW (1) | TW466236B (es) |
WO (1) | WO1997017342A1 (es) |
ZA (1) | ZA969408B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998006700A1 (en) * | 1996-08-09 | 1998-02-19 | Merck & Co., Inc. | Stereoselective deoxygenation reaction |
US20060281723A1 (en) * | 1999-04-16 | 2006-12-14 | Kafrissen Michael E | Folic acid-containing pharmaceutical compositions, and related methods and delivery systems |
CN102887808B (zh) * | 2012-10-26 | 2014-12-10 | 华东师范大学 | 一种多取代茚醇衍生物的制备方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3997540A (en) * | 1975-07-21 | 1976-12-14 | Burroughs Wellcome Co. | O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates |
US4073912A (en) * | 1976-10-12 | 1978-02-14 | Smithkline Corporation | Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof |
JP2667294B2 (ja) * | 1991-11-05 | 1997-10-27 | スミスクライン・ビーチャム・コーポレイション | エンドセリン受容体拮抗剤 |
US5389620A (en) * | 1993-08-18 | 1995-02-14 | Banyu Pharmaceutical Co., Ltd. | Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives |
ZA969363B (en) * | 1995-11-08 | 1997-11-18 | Smithkline Beecham Corp | An improved process for preparing aromatic ring-fused cyclopentane derivatives. |
WO1997017341A1 (en) * | 1995-11-08 | 1997-05-15 | Smithkline Beecham Corporation | A process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives |
US6022972A (en) * | 1997-08-08 | 2000-02-08 | Merck & Co., Inc. | Pyridine propanoic acid derivatives |
US6172231B1 (en) * | 1998-04-09 | 2001-01-09 | Merck & Co., Inc. | Oxidation process using periodic acid |
US6031101A (en) * | 1998-04-09 | 2000-02-29 | Merck & Co., Inc. | Oxidation process using tempo |
-
1996
- 1996-11-08 PL PL96326699A patent/PL326699A1/xx unknown
- 1996-11-08 ZA ZA969408A patent/ZA969408B/xx unknown
- 1996-11-08 BR BR9611540A patent/BR9611540A/pt not_active Application Discontinuation
- 1996-11-08 HU HU9901985A patent/HUP9901985A2/hu unknown
- 1996-11-08 NZ NZ323790A patent/NZ323790A/en unknown
- 1996-11-08 AR ARP960105121A patent/AR005237A1/es unknown
- 1996-11-08 WO PCT/US1996/018846 patent/WO1997017342A1/en not_active Application Discontinuation
- 1996-11-08 US US09/068,581 patent/US6147232A/en not_active Expired - Fee Related
- 1996-11-08 AU AU10820/97A patent/AU711450B2/en not_active Ceased
- 1996-11-08 CZ CZ981415A patent/CZ141598A3/cs unknown
- 1996-11-08 TR TR1998/00839T patent/TR199800839T2/xx unknown
- 1996-11-08 JP JP9518416A patent/JP2000500444A/ja not_active Ceased
- 1996-11-08 EP EP96940864A patent/EP0880518B1/en not_active Expired - Lifetime
- 1996-11-08 IL IL12431296A patent/IL124312A0/xx unknown
- 1996-11-08 KR KR1019980703386A patent/KR19990067376A/ko not_active Application Discontinuation
- 1996-11-08 AT AT96940864T patent/ATE236151T1/de not_active IP Right Cessation
- 1996-11-08 CN CN96199421A patent/CN1084742C/zh not_active Expired - Fee Related
- 1996-11-08 CO CO96059112A patent/CO4761056A1/es unknown
- 1996-11-08 ES ES96940864T patent/ES2191121T3/es not_active Expired - Lifetime
- 1996-11-08 DE DE69627199T patent/DE69627199T2/de not_active Expired - Fee Related
-
1997
- 1997-01-23 TW TW086100704A patent/TW466236B/zh not_active IP Right Cessation
-
1998
- 1998-05-07 NO NO982090A patent/NO982090L/no unknown
-
1999
- 1999-04-12 HK HK99101514A patent/HK1016588A1/xx not_active IP Right Cessation
-
2000
- 2000-03-08 US US09/521,172 patent/US6288247B1/en not_active Expired - Fee Related
-
2001
- 2001-09-10 US US09/949,577 patent/US6479659B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CO4761056A1 (es) | 1999-04-27 |
CN1206415A (zh) | 1999-01-27 |
AR005237A1 (es) | 1999-04-28 |
CN1084742C (zh) | 2002-05-15 |
CZ141598A3 (cs) | 1998-11-11 |
DE69627199T2 (de) | 2004-01-29 |
JP2000500444A (ja) | 2000-01-18 |
BR9611540A (pt) | 1999-03-02 |
AU711450B2 (en) | 1999-10-14 |
IL124312A0 (en) | 1998-12-06 |
PL326699A1 (en) | 1998-10-26 |
US20020087011A1 (en) | 2002-07-04 |
AU1082097A (en) | 1997-05-29 |
US6147232A (en) | 2000-11-14 |
ATE236151T1 (de) | 2003-04-15 |
HUP9901985A2 (hu) | 1999-09-28 |
MX9803646A (es) | 1998-10-31 |
KR19990067376A (ko) | 1999-08-16 |
TR199800839T2 (es) | 1998-08-21 |
EP0880518A4 (en) | 1999-07-28 |
HK1016588A1 (en) | 1999-11-05 |
DE69627199D1 (de) | 2003-05-08 |
US6288247B1 (en) | 2001-09-11 |
ZA969408B (en) | 1997-06-10 |
EP0880518A1 (en) | 1998-12-02 |
EP0880518B1 (en) | 2003-04-02 |
WO1997017342A1 (en) | 1997-05-15 |
NZ323790A (en) | 2000-02-28 |
US6479659B2 (en) | 2002-11-12 |
NO982090D0 (no) | 1998-05-07 |
NO982090L (no) | 1998-07-07 |
TW466236B (en) | 2001-12-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE60113514D1 (de) | 2-oxo-1-pyrrolidinderivate, verfahren zu ihrer herstellung und ihre verwendung | |
LU91145I2 (fr) | FIROCOXIB facultativement sous forme d'un sel pharmaceutiquement acceptable (PREVICOX). | |
ES2159717T3 (es) | Derivados de acido 5-(piperidinil-1 sustituido en posicion 4)-3-aril-pentanoico como antagonistas de los receptores de taquiquinina. | |
NO970581L (no) | Fremgangsmåte for fremstilling av 4-oksoimidazoliniumsalter | |
ES2191121T3 (es) | Un procedimiento para preparar derivados de acido 3-fenil-1-metilendioxifenil-indano-2-carboxilico. | |
HUP9802180A1 (hu) | Eljárás karbazolszármazék előállítására és az intermedierek | |
AU6220300A (en) | Benzofurylpiperazine serotonin agonists | |
BR9811348A (pt) | Compostos derivados de indol, processo para preparação dos mesmos, e, composições farmacêuticas. | |
NO20016151L (no) | Fremstilling av substituerte piperidin-4-oner | |
AR010615A1 (es) | Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno | |
ES2157318T3 (es) | Derivados de difeniloxazolina. | |
SE9701438D0 (sv) | A new process | |
PT98688A (pt) | Processo para a preparacao de composicoes farmaceuticas contendo 5-(2-cloro-1-hidroxietil)-4-metiltiazol | |
ATE252566T1 (de) | Herstellung von 2-(2-arylmorpholin-2- yl)ethanolderivaten und zwischenprodukte | |
ES2117557B1 (es) | Nuevo procedimiento de obtencion de (-)-trans -n-p-fluorobenzoilmetil-4-(p-fluorofenil)-3- ((3,4-(metilendioxi)fenoxi ) metil)-piperidina. | |
ES2037667T3 (es) | Procedimiento para la obtencion de indolinas. | |
ES2006440A4 (es) | 5-(fenil o fenoxialquil)-3-(2-furanil o 2-tienil)-3-(1himidazol-1-ilmetil)-2-metilisoxazolidinas. | |
ECSP982668A (es) | Metodo para la sintesis de derivados de quinolina |