HUP9901985A2 - Eljárás 3-fenil-1-[(metilén-dioxi)-fenil]-2-indánkarbonsav- és ciklopentapiridin-származékok, és intermedierjeik előállítására, valamint új intermedierjeik - Google Patents

Eljárás 3-fenil-1-[(metilén-dioxi)-fenil]-2-indánkarbonsav- és ciklopentapiridin-származékok, és intermedierjeik előállítására, valamint új intermedierjeik

Info

Publication number
HUP9901985A2
HUP9901985A2 HU9901985A HUP9901985A HUP9901985A2 HU P9901985 A2 HUP9901985 A2 HU P9901985A2 HU 9901985 A HU9901985 A HU 9901985A HU P9901985 A HUP9901985 A HU P9901985A HU P9901985 A2 HUP9901985 A2 HU P9901985A2
Authority
HU
Hungary
Prior art keywords
atom
intermediates
cyclopentapyridine
methylenedioxyphenyl
indane
Prior art date
Application number
HU9901985A
Other languages
English (en)
Inventor
Yemane Woldeselassie Andemichael
Neil Howard Baine
William Morrow Clark
Conrad John Kowalski
Michael Anthony Mcguire
Robert John Mills
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of HUP9901985A2 publication Critical patent/HUP9901985A2/hu

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/08—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing alicyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/26—Halogenosulfates, i.e. monoesters of halogenosulfuric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/65—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C07D233/38—One oxygen atom with acyl radicals or hetero atoms directly attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Abstract

A találmány szerinti eljárással előállítható vegyületek (1) általánősképletében (1) A, B, C vagy D szénatőm, vagy A, B, C és D közül hárőm szénatőm, és a negyedik nitrőgénatőm; R1 jelentése (a) (a) általánős képletű csőpőrt, amelyben R3 és R4 hidrőgénatőm,hidrőxil-, alkőxicsőpőrt, flűőratőm, triflűőr-metil- vagyalkilcsőpőrt; és R5 karbőxi-metőxi- vagy 2-hidrőxi-etőxi-csőpőrt; R2 jelentése (b) (b) általánős képletű csőpőrt, amelyben R3 és R4 a fentiekbenmeghatárőzőtt; és Z hidrőgénatőm, hidrőxil- vagy 1-5 szénatőmős alkőxicsőpőrt. Atalálmány tárgyát képezi a fenti vegyületek gyógyászatilag elfőgadhatósóinak és intermedierjeinek előállítása is. ŕ
HU9901985A 1995-11-08 1996-11-08 Eljárás 3-fenil-1-[(metilén-dioxi)-fenil]-2-indánkarbonsav- és ciklopentapiridin-származékok, és intermedierjeik előállítására, valamint új intermedierjeik HUP9901985A2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US634595P 1995-11-08 1995-11-08

Publications (1)

Publication Number Publication Date
HUP9901985A2 true HUP9901985A2 (hu) 1999-09-28

Family

ID=21720444

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9901985A HUP9901985A2 (hu) 1995-11-08 1996-11-08 Eljárás 3-fenil-1-[(metilén-dioxi)-fenil]-2-indánkarbonsav- és ciklopentapiridin-származékok, és intermedierjeik előállítására, valamint új intermedierjeik

Country Status (23)

Country Link
US (3) US6147232A (hu)
EP (1) EP0880518B1 (hu)
JP (1) JP2000500444A (hu)
KR (1) KR19990067376A (hu)
CN (1) CN1084742C (hu)
AR (1) AR005237A1 (hu)
AT (1) ATE236151T1 (hu)
AU (1) AU711450B2 (hu)
BR (1) BR9611540A (hu)
CO (1) CO4761056A1 (hu)
CZ (1) CZ141598A3 (hu)
DE (1) DE69627199T2 (hu)
ES (1) ES2191121T3 (hu)
HK (1) HK1016588A1 (hu)
HU (1) HUP9901985A2 (hu)
IL (1) IL124312A0 (hu)
NO (1) NO982090L (hu)
NZ (1) NZ323790A (hu)
PL (1) PL326699A1 (hu)
TR (1) TR199800839T2 (hu)
TW (1) TW466236B (hu)
WO (1) WO1997017342A1 (hu)
ZA (1) ZA969408B (hu)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11514676A (ja) * 1996-08-09 1999-12-14 メルク エンド カンパニー インコーポレーテッド 立体選択的脱酸素化反応
US20060281723A1 (en) * 1999-04-16 2006-12-14 Kafrissen Michael E Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
CN102887808B (zh) * 2012-10-26 2014-12-10 华东师范大学 一种多取代茚醇衍生物的制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates
US4073912A (en) * 1976-10-12 1978-02-14 Smithkline Corporation Piperidylidene derivatives of benzo-fused xanthenes, thioxanthenes and dibenzoxepins and antipsychotic use thereof
AU669866B2 (en) * 1991-11-05 1996-06-27 Smithkline Beecham Corporation Endothelin receptor antagonists
US5389620A (en) * 1993-08-18 1995-02-14 Banyu Pharmaceutical Co., Ltd. Endothelin antagonistic heteroaromatic ring-fused cyclopentene derivatives
US6143907A (en) * 1995-11-08 2000-11-07 Smithkline Beecham Corporation 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives
ZA969363B (en) * 1995-11-08 1997-11-18 Smithkline Beecham Corp An improved process for preparing aromatic ring-fused cyclopentane derivatives.
US6022972A (en) * 1997-08-08 2000-02-08 Merck & Co., Inc. Pyridine propanoic acid derivatives
US6031101A (en) * 1998-04-09 2000-02-29 Merck & Co., Inc. Oxidation process using tempo
US6172231B1 (en) * 1998-04-09 2001-01-09 Merck & Co., Inc. Oxidation process using periodic acid

Also Published As

Publication number Publication date
AU1082097A (en) 1997-05-29
CZ141598A3 (cs) 1998-11-11
CO4761056A1 (es) 1999-04-27
TR199800839T2 (hu) 1998-08-21
WO1997017342A1 (en) 1997-05-15
ES2191121T3 (es) 2003-09-01
AR005237A1 (es) 1999-04-28
IL124312A0 (en) 1998-12-06
JP2000500444A (ja) 2000-01-18
EP0880518A1 (en) 1998-12-02
EP0880518A4 (en) 1999-07-28
KR19990067376A (ko) 1999-08-16
CN1206415A (zh) 1999-01-27
NO982090L (no) 1998-07-07
DE69627199D1 (de) 2003-05-08
US6288247B1 (en) 2001-09-11
MX9803646A (es) 1998-10-31
AU711450B2 (en) 1999-10-14
BR9611540A (pt) 1999-03-02
US6479659B2 (en) 2002-11-12
PL326699A1 (en) 1998-10-26
ZA969408B (en) 1997-06-10
CN1084742C (zh) 2002-05-15
US6147232A (en) 2000-11-14
HK1016588A1 (en) 1999-11-05
DE69627199T2 (de) 2004-01-29
ATE236151T1 (de) 2003-04-15
EP0880518B1 (en) 2003-04-02
NZ323790A (en) 2000-02-28
TW466236B (en) 2001-12-01
NO982090D0 (no) 1998-05-07
US20020087011A1 (en) 2002-07-04

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