AR010615A1 - Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno - Google Patents

Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno

Info

Publication number
AR010615A1
AR010615A1 ARP970105369A ARP970105369A AR010615A1 AR 010615 A1 AR010615 A1 AR 010615A1 AR P970105369 A ARP970105369 A AR P970105369A AR P970105369 A ARP970105369 A AR P970105369A AR 010615 A1 AR010615 A1 AR 010615A1
Authority
AR
Argentina
Prior art keywords
procedure
hidroxibenzotiofeno
aminoetoxi
alcoxifenil
alcoxibenzotiofenos
Prior art date
Application number
ARP970105369A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR010615A1 publication Critical patent/AR010615A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Procedimiento para la preparacion de dichos benzotiofenos de formula (I) en donde los grupos R1 son iguales o diferentes y representan C1-C6caracterizado porque comprende: la ciclizacion de dialcoxi compuestos de formula (II) en presenciad e ácido metanosulfonico.
ARP970105369A 1996-11-19 1997-11-17 Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno AR010615A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3118196P 1996-11-19 1996-11-19

Publications (1)

Publication Number Publication Date
AR010615A1 true AR010615A1 (es) 2000-06-28

Family

ID=21858059

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970105369A AR010615A1 (es) 1996-11-19 1997-11-17 Procedimiento para preparar 3-(4-alcoxifenil)-6-alcoxibenzotiofenos y procesos para obtener compuestos de 2-(4-hidroxifenil)-3-(4-(2-aminoetoxi)benzoil)-6-hidroxibenzotiofeno

Country Status (23)

Country Link
US (1) US5969157A (es)
EP (1) EP0842930B1 (es)
JP (1) JP2001504497A (es)
KR (1) KR20000053333A (es)
CN (1) CN1130357C (es)
AR (1) AR010615A1 (es)
AT (1) ATE217620T1 (es)
AU (1) AU726401B2 (es)
BR (1) BR9712773A (es)
CA (1) CA2271922A1 (es)
CO (1) CO4920247A1 (es)
DE (1) DE69712590T2 (es)
DK (1) DK0842930T3 (es)
ES (1) ES2173399T3 (es)
HU (1) HUP9904510A3 (es)
ID (1) ID18917A (es)
IL (1) IL129868A (es)
PE (1) PE16799A1 (es)
PT (1) PT842930E (es)
SI (1) SI0842930T1 (es)
TW (1) TW461888B (es)
WO (1) WO1998022456A1 (es)
ZA (1) ZA9710262B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001009116A2 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
AU2002230409A1 (en) * 2000-11-27 2002-06-03 Eli Lilly And Company Process for preparing 3-aryl-benzo(b)thiophenes
US20050069962A1 (en) 2001-10-12 2005-03-31 Archer Robert M Antibody complexes and methods for immunolabeling
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
CA2492631C (en) * 2002-05-31 2013-03-12 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
ATE541840T1 (de) 2002-09-30 2012-02-15 Gea Farmaceutisk Fabrik As Raloxifene-l-lactat oder ein hemihydrat davon, deren verwendungen, pharmazeutischen zusammensetzungen und herstellungsverfahren
US8394582B2 (en) * 2003-03-05 2013-03-12 Genetic Technologies, Inc Identification of fetal DNA and fetal cell markers in maternal plasma or serum
WO2008047105A1 (en) 2006-10-17 2008-04-24 Cipla Limited Crystalline form of benzothiophene compound and process for preparation thereof
AU2010239131A1 (en) 2009-04-21 2011-11-17 Genetic Technologies Limited Methods for obtaining fetal genetic material

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509682B2 (en) * 1975-10-28 1980-05-22 Eli Lilly And Company 2-Aroyl-3-Phenylbenzothiophene Derivatives
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AT364852B (de) * 1977-11-05 1981-11-25 Thomae Gmbh Dr K Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
US4544746A (en) * 1982-05-17 1985-10-01 Ciba-Geigy Corporation Process for preparing 2-anilinoacridone
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US5466810A (en) * 1994-06-10 1995-11-14 Eli Lilly And Company 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes
DE4423893C2 (de) * 1994-07-07 1996-09-05 Freudenberg Carl Fa Flachdichtung mit flexibler Leiterplatte
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes
US5552401A (en) * 1995-02-28 1996-09-03 Eli Lilly And Company 2-benzyl-3-arylbenzothiophenes
US5614639A (en) * 1995-03-31 1997-03-25 Eli Lilly And Company Process for preparing 2-substituted benzo[b]thiophene compounds and intermediates thereof
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes

Also Published As

Publication number Publication date
KR20000053333A (ko) 2000-08-25
JP2001504497A (ja) 2001-04-03
EP0842930A1 (en) 1998-05-20
PT842930E (pt) 2002-08-30
ZA9710262B (en) 1999-05-13
ATE217620T1 (de) 2002-06-15
BR9712773A (pt) 1999-10-26
IL129868A0 (en) 2000-02-29
WO1998022456A1 (en) 1998-05-28
DE69712590T2 (de) 2002-10-31
EP0842930B1 (en) 2002-05-15
CO4920247A1 (es) 2000-05-29
ES2173399T3 (es) 2002-10-16
DK0842930T3 (da) 2002-07-15
DE69712590D1 (de) 2002-06-20
AU726401B2 (en) 2000-11-09
CA2271922A1 (en) 1998-05-28
PE16799A1 (es) 1999-02-19
SI0842930T1 (en) 2002-10-31
TW461888B (en) 2001-11-01
HUP9904510A2 (hu) 2000-05-28
CN1237968A (zh) 1999-12-08
HUP9904510A3 (en) 2000-08-28
ID18917A (id) 1998-05-20
US5969157A (en) 1999-10-19
AU5462298A (en) 1998-06-10
IL129868A (en) 2002-09-12
CN1130357C (zh) 2003-12-10

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