ES2189434T3 - Isoquinolinas como inhibidores de uroquinasa. - Google Patents
Isoquinolinas como inhibidores de uroquinasa.Info
- Publication number
- ES2189434T3 ES2189434T3 ES99928177T ES99928177T ES2189434T3 ES 2189434 T3 ES2189434 T3 ES 2189434T3 ES 99928177 T ES99928177 T ES 99928177T ES 99928177 T ES99928177 T ES 99928177T ES 2189434 T3 ES2189434 T3 ES 2189434T3
- Authority
- ES
- Spain
- Prior art keywords
- optionally substituted
- alkyl
- alkoxy
- co2r7
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Un compuesto de fórmula (I): **(Fórmula)** y sus sales farmacéuticamente aceptables, en la que: G es N=C(NH2)2 o NHC(=NH)NH2; R1 es H o halógeno; X es CO, CH2 o SO2; R2 es H, arilo, heteroarilo, cicloalquilo C3 - 7 o alquilo C1 - 6, cada uno de los cicloalquilo C3 - 7 y alquilo C1 - 6 está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de halógeno, arilo, het, cicloalquilo C3 - 7, cicloalquenilo C5 - 7, OH, alcoxi C1 - 6, O - het1, alquilo C1 - 3, CO2R7 y NR4R5; X1 es arileno, alquileno C1 - 6 opcionalmente sustituido con uno o más grupos R6, o cicloalquileno C4 - 7 opcionalmente sustituido con R6, cuyo anillo de cicloalquileno C4 - 7 puede contener opcionalmente un resto hetero seleccionado de O, S(O)p o NR7; o R2 y X1 se pueden considerar junto con el átomo de N al que están unidos para formar un anillo de azetidina, pirrolidina, piperidina u homopiperidina; R3 es CO2R7, CH2OH, CONR8R9 o CH2NR8R9; o cuando X1 se considera independientemente de R2, yes metileno opcionalmente sustituido con uno o más grupos R6, o es un 1, 1 - cicloalquileno C4 - 7 que contiene opcionalmente un resto hetero seleccionado de O, S(O)p o NR7 y opcionalmente sustituido con R6, entonces R2 y R3 se pueden considerar junto con los grupos N y X1 a los que están unidos, como un grupo de fórmula (IA) o (IB): **(Fórmula)** en la que X2 es etileno, n - propileno o n - butileno; R4 y R5 son cada uno independientemente H, arilo o alquilo C1 - 6 opcionalmente sustituido con arilo; R6 es halógeno, OH, alcoxi C1 - 6, alquiltio C1 - 6, cicloalquilo C3 - 7, SH, arilo, CO2R7, CONHR8, o alquilo C1- 6 opcionalmente sustituido con arilo, alcoxi C1 - 6, CO2H, OH, CONR8R9o con NR8R9; R7 es H o alquilo C1 - 6; R8 y R9 son cada uno independientemente H, o alquilo C1 - 6 opcionalmente sustituido con OH, CO2R7, alcoxi C1 - 6 o con NR4R5; o R8 y R9 se pueden considerar junto con el átomo de N al que están unidos, para formar un anillo de 4 a 7 miembros que opcionalmente incorpora un grupo hetero adicional seleccionado de O, S y NR7; p es 0, 1 ó 2; ¿arilo¿ es fenilo opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de alquilo C1 - 6, alcoxi C1 - 6, o halógeno; ¿het¿ es un heterociclo de 5 a 7 miembros saturado o parcialmente o completamente insaturado que contiene hasta 3 heteroátomos independientemente seleccionados de O, N y S, y que opcionalmente está sustituido con uno o más sustituyentes independientemente seleccionados de alquilo C1 - 6, alcoxi C1 - 6, CO2R7 o halógeno; ¿heteroarilo¿ es un heterociclo de 5 a 7 miembros completamente insaturado que contiene hasta 3 heteroátomos independientemente seleccionado de O, N y S, y que está opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de alquilo C1 - 6, alcoxi C1 - 6, CO2R7 o halógeno; ¿het¿ es tetrahidropiran - 2 - ilo (2 - THP); y ¿arileno¿ es fenileno opcionalmente sustituido con uno o más sustituyentes independientemente seleccionados de alquilo C1 - 6, alcoxi C1 - 6, CO2R7 o halógeno.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816228.2A GB9816228D0 (en) | 1998-07-24 | 1998-07-24 | Isoquinolines |
| GBGB9908829.6A GB9908829D0 (en) | 1998-07-24 | 1999-04-16 | Isoquinolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2189434T3 true ES2189434T3 (es) | 2003-07-01 |
Family
ID=10836172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99928177T Expired - Lifetime ES2189434T3 (es) | 1998-07-24 | 1999-07-15 | Isoquinolinas como inhibidores de uroquinasa. |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP1077945B1 (es) |
| JP (1) | JP2002521367A (es) |
| KR (1) | KR20010083137A (es) |
| CN (1) | CN1318059A (es) |
| AR (1) | AR018960A1 (es) |
| AT (1) | ATE230730T1 (es) |
| AU (1) | AU745545B2 (es) |
| BG (1) | BG105252A (es) |
| BR (1) | BR9912374A (es) |
| CA (1) | CA2337247A1 (es) |
| CO (1) | CO5080787A1 (es) |
| DE (1) | DE69904814T2 (es) |
| DK (1) | DK1077945T3 (es) |
| DZ (1) | DZ2852A1 (es) |
| EA (1) | EA200100073A1 (es) |
| EE (1) | EE200100049A (es) |
| ES (1) | ES2189434T3 (es) |
| GB (2) | GB9816228D0 (es) |
| GT (1) | GT199900116A (es) |
| HK (1) | HK1040996A1 (es) |
| HN (1) | HN1999000116A (es) |
| HR (1) | HRP20010059A2 (es) |
| HU (1) | HUP0103665A3 (es) |
| ID (1) | ID26993A (es) |
| IS (1) | IS5789A (es) |
| MA (1) | MA26664A1 (es) |
| NO (1) | NO20010400L (es) |
| OA (1) | OA11578A (es) |
| PA (1) | PA8478901A1 (es) |
| PE (1) | PE20000937A1 (es) |
| PL (1) | PL346022A1 (es) |
| PT (1) | PT1077945E (es) |
| SI (1) | SI1077945T1 (es) |
| SK (1) | SK1062001A3 (es) |
| TN (1) | TNSN99149A1 (es) |
| TR (1) | TR200100222T2 (es) |
| TW (1) | TW530049B (es) |
| UY (1) | UY25663A1 (es) |
| ZA (1) | ZA200100230B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003219039A1 (en) * | 2002-03-11 | 2003-09-22 | Curacyte Ag | Urokinase inhibitors, production and use thereof |
| DE602004020657D1 (de) | 2003-12-02 | 2009-05-28 | Sanol Arznei Schwarz Gmbh | Neue verwendung von peptidverbindungen zur behandlung ovn zentralen neuropathischen schmerzen |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| ES2450070T5 (es) | 2006-06-15 | 2018-05-08 | Ucb Pharma Gmbh | Composición farmacéutica que comprende lacosamida y levetiracetam con efecto anticonvulsionante sinérgico |
-
1998
- 1998-07-24 GB GBGB9816228.2A patent/GB9816228D0/en not_active Ceased
-
1999
- 1999-04-16 GB GBGB9908829.6A patent/GB9908829D0/en not_active Ceased
- 1999-07-15 SK SK106-2001A patent/SK1062001A3/sk unknown
- 1999-07-15 HU HU0103665A patent/HUP0103665A3/hu unknown
- 1999-07-15 CN CN99809025A patent/CN1318059A/zh active Pending
- 1999-07-15 TR TR2001/00222T patent/TR200100222T2/xx unknown
- 1999-07-15 CA CA002337247A patent/CA2337247A1/en not_active Abandoned
- 1999-07-15 AU AU45289/99A patent/AU745545B2/en not_active Ceased
- 1999-07-15 EA EA200100073A patent/EA200100073A1/ru unknown
- 1999-07-15 KR KR1020017000956A patent/KR20010083137A/ko not_active Application Discontinuation
- 1999-07-15 PL PL99346022A patent/PL346022A1/xx not_active Application Discontinuation
- 1999-07-15 JP JP2000561170A patent/JP2002521367A/ja active Pending
- 1999-07-15 ES ES99928177T patent/ES2189434T3/es not_active Expired - Lifetime
- 1999-07-15 PT PT99928177T patent/PT1077945E/pt unknown
- 1999-07-15 OA OA1200100002A patent/OA11578A/en unknown
- 1999-07-15 DK DK99928177T patent/DK1077945T3/da active
- 1999-07-15 ID IDW20010169D patent/ID26993A/id unknown
- 1999-07-15 SI SI9930178T patent/SI1077945T1/xx unknown
- 1999-07-15 BR BR9912374-6A patent/BR9912374A/pt not_active IP Right Cessation
- 1999-07-15 AT AT99928177T patent/ATE230730T1/de not_active IP Right Cessation
- 1999-07-15 EP EP99928177A patent/EP1077945B1/en not_active Expired - Lifetime
- 1999-07-15 EE EEP200100049A patent/EE200100049A/xx unknown
- 1999-07-15 DE DE69904814T patent/DE69904814T2/de not_active Expired - Fee Related
- 1999-07-16 HN HN1999000116A patent/HN1999000116A/es unknown
- 1999-07-21 TN TNTNSN99149A patent/TNSN99149A1/fr unknown
- 1999-07-21 DZ DZ990152A patent/DZ2852A1/xx active
- 1999-07-21 MA MA25695A patent/MA26664A1/fr unknown
- 1999-07-21 PE PE1999000733A patent/PE20000937A1/es not_active Application Discontinuation
- 1999-07-22 AR ARP990103614A patent/AR018960A1/es not_active Application Discontinuation
- 1999-07-23 GT GT199900116A patent/GT199900116A/es unknown
- 1999-07-23 TW TW088112548A patent/TW530049B/zh active
- 1999-07-23 PA PA19998478901A patent/PA8478901A1/es unknown
- 1999-07-26 CO CO99047012A patent/CO5080787A1/es unknown
- 1999-08-16 UY UY25663A patent/UY25663A1/es unknown
-
2000
- 2000-12-22 IS IS5789A patent/IS5789A/is unknown
-
2001
- 2001-01-09 ZA ZA200100230A patent/ZA200100230B/en unknown
- 2001-01-23 NO NO20010400A patent/NO20010400L/no not_active Application Discontinuation
- 2001-01-23 HR HR20010059A patent/HRP20010059A2/hr not_active Application Discontinuation
- 2001-02-14 BG BG105252A patent/BG105252A/xx unknown
-
2002
- 2002-04-10 HK HK02102712.1A patent/HK1040996A1/zh unknown
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