CO5080787A1 - Isoquinolinas - Google Patents
IsoquinolinasInfo
- Publication number
- CO5080787A1 CO5080787A1 CO99047012A CO99047012A CO5080787A1 CO 5080787 A1 CO5080787 A1 CO 5080787A1 CO 99047012 A CO99047012 A CO 99047012A CO 99047012 A CO99047012 A CO 99047012A CO 5080787 A1 CO5080787 A1 CO 5080787A1
- Authority
- CO
- Colombia
- Prior art keywords
- optionally substituted
- aryl
- alkylene
- cyclo
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/48—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Un compuesto de fórmula (I)<EMI FILE="99047012_1" ID="1" IMF=JPEG >y sales farmacéuticamente aceptables del mismo, en la que:G es N=C(NH)2 o NHC(=NH)NH2 ;R1 es H o halo;X es CO, CH2 o SO2 ;R2 es H, arilo, heteroarilo, cicloalquilo C3-7 o alquilo C1-6, estando cada uno de cicloalquilo C3-7 y alquilo C1-6 opcionalmente sustituido con uno o más sustituyentes seleccionados independientemente entre halo, arilo, het, cicloalquilo C3-7, cicloalquenilo C5-7 , OH, alcoxi C1-6, O-het1, alquiol C1-3, CO2 R7 y NR4 R5 ;X1 es arileno, alquileno C1-6 opcionalmente sustituido con uno más grupos R6, o ciclo-alquileno (C4-7) opcionalmente sustituido con R6, anillo de ciclo-alquileno (C4-7 ) que puede contener opcionalmente un radical hetero seleccionado entre O, S(O)n o NR7 ;o R2 y X1 pueden tomarse conjuntamente con el átomo de N al que están unidos para formar un anillo de azetidina, pirrolidina, piperidina u homopiperidina;R3 es CO2R7, CH2OH, CONR8 R9 o CH2 NR8 R9 ;o cuando X1 se toma independientemente de R2 y es metileno opcionalmente sustituido con uno o más grupos R6, o es un 1,1-ciclo-alquileno (C4-7) que contiene opcionalmente un radical hetero seleccionado entre O, S(O)p o NR7 y opcionalmente sustituido con R6,entonces R2 y R3 pueden tomarse conjuntamente con los grupos N y X1 a los que están unidos, como un grupo de fórmula (IA) o (IB):<EMI FILE="99047012_2" ID="2" IMF=JPEG >en la que X2 es etileno n-propileno o n-butileno;cada uno de R4 y R5 es independientemente H, arilo o alquilo C1-6 opcionalmente sustituido con arilo; ...
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9816228.2A GB9816228D0 (en) | 1998-07-24 | 1998-07-24 | Isoquinolines |
| GBGB9908829.6A GB9908829D0 (en) | 1998-07-24 | 1999-04-16 | Isoquinolines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5080787A1 true CO5080787A1 (es) | 2001-09-25 |
Family
ID=10836172
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99047012A CO5080787A1 (es) | 1998-07-24 | 1999-07-26 | Isoquinolinas |
Country Status (39)
| Country | Link |
|---|---|
| EP (1) | EP1077945B1 (es) |
| JP (1) | JP2002521367A (es) |
| KR (1) | KR20010083137A (es) |
| CN (1) | CN1318059A (es) |
| AR (1) | AR018960A1 (es) |
| AT (1) | ATE230730T1 (es) |
| AU (1) | AU745545B2 (es) |
| BG (1) | BG105252A (es) |
| BR (1) | BR9912374A (es) |
| CA (1) | CA2337247A1 (es) |
| CO (1) | CO5080787A1 (es) |
| DE (1) | DE69904814T2 (es) |
| DK (1) | DK1077945T3 (es) |
| DZ (1) | DZ2852A1 (es) |
| EA (1) | EA200100073A1 (es) |
| EE (1) | EE200100049A (es) |
| ES (1) | ES2189434T3 (es) |
| GB (2) | GB9816228D0 (es) |
| GT (1) | GT199900116A (es) |
| HK (1) | HK1040996A1 (es) |
| HN (1) | HN1999000116A (es) |
| HR (1) | HRP20010059A2 (es) |
| HU (1) | HUP0103665A3 (es) |
| ID (1) | ID26993A (es) |
| IS (1) | IS5789A (es) |
| MA (1) | MA26664A1 (es) |
| NO (1) | NO20010400L (es) |
| OA (1) | OA11578A (es) |
| PA (1) | PA8478901A1 (es) |
| PE (1) | PE20000937A1 (es) |
| PL (1) | PL346022A1 (es) |
| PT (1) | PT1077945E (es) |
| SI (1) | SI1077945T1 (es) |
| SK (1) | SK1062001A3 (es) |
| TN (1) | TNSN99149A1 (es) |
| TR (1) | TR200100222T2 (es) |
| TW (1) | TW530049B (es) |
| UY (1) | UY25663A1 (es) |
| ZA (1) | ZA200100230B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE50310038D1 (de) * | 2002-03-11 | 2008-08-07 | Curacyte Ag | Hemmstoffe der urokinase, ihre herstellung und verwendung |
| EP1689378B1 (en) | 2003-12-02 | 2009-04-15 | Schwarz Pharma Ag | Novel use of peptide compounds for treating central neuropathic pain |
| EP1604656A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating amyotrophic lateral sclerosis (ALS) |
| EP1604655A1 (en) | 2004-06-09 | 2005-12-14 | Schwarz Pharma Ag | Novel use of peptide compounds for treating pain in trigeminal neuralgia |
| EA019757B1 (ru) | 2006-06-15 | 2014-06-30 | ЮСиБи ФАРМА ГМБХ | Фармацевтическая композиция с синергетическим противосудорожным эффектом |
-
1998
- 1998-07-24 GB GBGB9816228.2A patent/GB9816228D0/en not_active Ceased
-
1999
- 1999-04-16 GB GBGB9908829.6A patent/GB9908829D0/en not_active Ceased
- 1999-07-15 ES ES99928177T patent/ES2189434T3/es not_active Expired - Lifetime
- 1999-07-15 OA OA1200100002A patent/OA11578A/en unknown
- 1999-07-15 PL PL99346022A patent/PL346022A1/xx not_active Application Discontinuation
- 1999-07-15 SI SI9930178T patent/SI1077945T1/xx unknown
- 1999-07-15 CA CA002337247A patent/CA2337247A1/en not_active Abandoned
- 1999-07-15 EA EA200100073A patent/EA200100073A1/ru unknown
- 1999-07-15 BR BR9912374-6A patent/BR9912374A/pt not_active IP Right Cessation
- 1999-07-15 TR TR2001/00222T patent/TR200100222T2/xx unknown
- 1999-07-15 EP EP99928177A patent/EP1077945B1/en not_active Expired - Lifetime
- 1999-07-15 EE EEP200100049A patent/EE200100049A/xx unknown
- 1999-07-15 HU HU0103665A patent/HUP0103665A3/hu unknown
- 1999-07-15 SK SK106-2001A patent/SK1062001A3/sk unknown
- 1999-07-15 KR KR1020017000956A patent/KR20010083137A/ko not_active Application Discontinuation
- 1999-07-15 ID IDW20010169D patent/ID26993A/id unknown
- 1999-07-15 JP JP2000561170A patent/JP2002521367A/ja active Pending
- 1999-07-15 DE DE69904814T patent/DE69904814T2/de not_active Expired - Fee Related
- 1999-07-15 CN CN99809025A patent/CN1318059A/zh active Pending
- 1999-07-15 PT PT99928177T patent/PT1077945E/pt unknown
- 1999-07-15 DK DK99928177T patent/DK1077945T3/da active
- 1999-07-15 AU AU45289/99A patent/AU745545B2/en not_active Ceased
- 1999-07-15 AT AT99928177T patent/ATE230730T1/de not_active IP Right Cessation
- 1999-07-16 HN HN1999000116A patent/HN1999000116A/es unknown
- 1999-07-21 TN TNTNSN99149A patent/TNSN99149A1/fr unknown
- 1999-07-21 DZ DZ990152A patent/DZ2852A1/xx active
- 1999-07-21 MA MA25695A patent/MA26664A1/fr unknown
- 1999-07-21 PE PE1999000733A patent/PE20000937A1/es not_active Application Discontinuation
- 1999-07-22 AR ARP990103614A patent/AR018960A1/es not_active Application Discontinuation
- 1999-07-23 GT GT199900116A patent/GT199900116A/es unknown
- 1999-07-23 PA PA19998478901A patent/PA8478901A1/es unknown
- 1999-07-23 TW TW088112548A patent/TW530049B/zh active
- 1999-07-26 CO CO99047012A patent/CO5080787A1/es unknown
- 1999-08-16 UY UY25663A patent/UY25663A1/es unknown
-
2000
- 2000-12-22 IS IS5789A patent/IS5789A/is unknown
-
2001
- 2001-01-09 ZA ZA200100230A patent/ZA200100230B/en unknown
- 2001-01-23 HR HR20010059A patent/HRP20010059A2/hr not_active Application Discontinuation
- 2001-01-23 NO NO20010400A patent/NO20010400L/no not_active Application Discontinuation
- 2001-02-14 BG BG105252A patent/BG105252A/xx unknown
-
2002
- 2002-04-10 HK HK02102712.1A patent/HK1040996A1/zh unknown
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| TW197421B (es) | ||
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