ES2187958T3 - Antagonistas de gnrh. - Google Patents
Antagonistas de gnrh.Info
- Publication number
- ES2187958T3 ES2187958T3 ES98918206T ES98918206T ES2187958T3 ES 2187958 T3 ES2187958 T3 ES 2187958T3 ES 98918206 T ES98918206 T ES 98918206T ES 98918206 T ES98918206 T ES 98918206T ES 2187958 T3 ES2187958 T3 ES 2187958T3
- Authority
- ES
- Spain
- Prior art keywords
- 4aph
- acetyl
- 4cpa
- 2nal
- xaa3
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940121381 gonadotrophin releasing hormone (gnrh) antagonists Drugs 0.000 title abstract 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- ZDXPYRJPNDTMRX-GSVOUGTGSA-N D-glutamine Chemical compound OC(=O)[C@H](N)CCC(N)=O ZDXPYRJPNDTMRX-GSVOUGTGSA-N 0.000 abstract 1
- NMJREATYWWNIKX-UHFFFAOYSA-N GnRH Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CC(C)C)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 NMJREATYWWNIKX-UHFFFAOYSA-N 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 abstract 1
- 108010070822 acyline Proteins 0.000 abstract 1
- ZWNUQDJANZGVFO-YHSALVGYSA-N acyline Chemical compound C([C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CC=1C=CC(NC(C)=O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(NC(C)=O)C=C1 ZWNUQDJANZGVFO-YHSALVGYSA-N 0.000 abstract 1
- 230000003042 antagnostic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 239000002474 gonadorelin antagonist Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 238000011866 long-term treatment Methods 0.000 abstract 1
- -1 methylcarbamoyl Chemical group 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/837,041 US5821230A (en) | 1997-04-11 | 1997-04-11 | GnRH antagonist decapeptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2187958T3 true ES2187958T3 (es) | 2003-06-16 |
Family
ID=25273348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98918206T Expired - Lifetime ES2187958T3 (es) | 1997-04-11 | 1998-04-13 | Antagonistas de gnrh. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5821230A (OSRAM) |
| EP (1) | EP0973801B1 (OSRAM) |
| JP (1) | JP4191259B2 (OSRAM) |
| AT (1) | ATE229976T1 (OSRAM) |
| AU (1) | AU7117498A (OSRAM) |
| DE (1) | DE69810283T2 (OSRAM) |
| DK (1) | DK0973801T3 (OSRAM) |
| ES (1) | ES2187958T3 (OSRAM) |
| PT (1) | PT973801E (OSRAM) |
| WO (1) | WO1998046635A1 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| DE19712718C2 (de) * | 1997-03-26 | 1999-09-23 | Asta Medica Ag | Immobilisierte und aktivitätsstabilisierte Komplexe von LHRH-Antagonisten und Verfahren zu deren Herstellung |
| US5977302A (en) * | 1997-11-20 | 1999-11-02 | Ortho-Mcneil Pharmaceutical, Inc. | Liquid phase process for the preparation of GnRH peptides |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| US7658938B2 (en) | 1999-02-22 | 2010-02-09 | Merrion Reasearch III Limited | Solid oral dosage form containing an enhancer |
| US8119159B2 (en) * | 1999-02-22 | 2012-02-21 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| JP4524823B2 (ja) * | 1999-04-14 | 2010-08-18 | 住友化学株式会社 | タンパク質のアミノ末端のアミノ酸配列決定方法 |
| US7109171B2 (en) * | 2000-02-28 | 2006-09-19 | Praecis Pharmaceuticals Inc. | Methods for treating FSH related conditions with GnRH antagonists |
| GB0117057D0 (en) * | 2001-07-12 | 2001-09-05 | Ferring Bv | Pharmaceutical composition |
| WO2007117706A2 (en) * | 2006-04-07 | 2007-10-18 | Merrion Research Iii Limited | Solid oral dosage form containing an enhancer |
| TWI442932B (zh) | 2008-02-11 | 2014-07-01 | Ferring Int Ct Sa | 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法 |
| CN102046192B (zh) * | 2008-05-07 | 2014-11-19 | 默里昂研究Ⅲ有限公司 | GnRH相关化合物的组合物及制备方法 |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| SI2712622T1 (sl) | 2008-05-21 | 2016-10-28 | Ferring B.V. | Orodisperzibilni dezmopresin za povečanje začetnega obdobja spanja nemotenega z nokturijo |
| WO2010099255A1 (en) * | 2009-02-25 | 2010-09-02 | Merrion Research Iii Limited | Composition and drug delivery of bisphosphonates |
| TWI508734B (zh) | 2009-05-01 | 2015-11-21 | Ferring Int Ct Sa | 用於前列腺癌之治療的組成物 |
| TW201043221A (en) * | 2009-05-06 | 2010-12-16 | Ferring Int Ct Sa | Kit and method for preparation of a Degarelix solution |
| US20110039787A1 (en) * | 2009-07-06 | 2011-02-17 | Ferring International Center S.A. | Compositions, kits and methods for treating benign prostate hyperplasia |
| US20110182985A1 (en) * | 2010-01-28 | 2011-07-28 | Coughlan David C | Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof |
| WO2011120033A1 (en) * | 2010-03-26 | 2011-09-29 | Merrion Research Iii Limited | Pharmaceutical compositions of selective factor xa inhibitors for oral administration |
| EP2447276A1 (en) | 2010-10-27 | 2012-05-02 | Ferring B.V. | Process for the manufacture of Degarelix and its intermediates |
| ES2617336T3 (es) | 2010-10-27 | 2017-06-16 | Ferring B.V. | Procedimiento para la fabricación de degarelix y sus productos intermedios |
| WO2012094598A2 (en) | 2011-01-07 | 2012-07-12 | Merrion Research Iii Limited | Pharmaceutical compositions of iron for oral administration |
| JO3755B1 (ar) | 2011-01-26 | 2021-01-31 | Ferring Bv | تركيبات تستوستيرون |
| JP6226966B2 (ja) | 2012-06-01 | 2017-11-08 | フェリング ベスローテン フェンノートシャップ | デガレリクスの製造 |
| US10265384B2 (en) | 2015-01-29 | 2019-04-23 | Novo Nordisk A/S | Tablets comprising GLP-1 agonist and enteric coating |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5073624A (en) * | 1985-04-09 | 1991-12-17 | Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US4866160A (en) * | 1985-04-09 | 1989-09-12 | The Administrators Of The Tulane Educational Fund | Therapeutic decapeptides |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| US4935491A (en) * | 1987-08-24 | 1990-06-19 | Board Of Regents, The University Of Texas System | Effective antagonists of the luteinizing hormone releasing hormone which release negligible histamine |
| US5110904A (en) * | 1989-08-07 | 1992-05-05 | Abbott Laboratories | Lhrh analogs |
| US5171835A (en) * | 1988-10-21 | 1992-12-15 | The Administrators Of The Tulane Educational Fund | LHRH antagonists |
| US5296468A (en) * | 1989-10-30 | 1994-03-22 | The Salk Institute For Biological Studies | GnRH analogs |
| US5169932A (en) * | 1989-10-30 | 1992-12-08 | The Salk Institute For Biological Studies | Gnrh analogs |
| US5064939A (en) * | 1990-02-06 | 1991-11-12 | The Salk Institute For Biological Studies | Cyclic gnrh antagonists |
| IL101074A (en) * | 1991-03-14 | 1997-09-30 | Salk Inst For Biological Studi | GnRH ANALOGS AND THEIR PREPARATION |
| AU1371892A (en) * | 1991-04-25 | 1992-12-21 | Romano Deghenghi | Luteinizing hormone releasing hormone antagonist peptides |
| US5508383A (en) * | 1994-03-09 | 1996-04-16 | Tap Holdings Inc. | Cyclic peptide LHRH antagonists |
| US5506207A (en) * | 1994-03-18 | 1996-04-09 | The Salk Institute For Biological Studies | GNRH antagonists XIII |
| US5681928A (en) * | 1994-12-16 | 1997-10-28 | The Salk Institute For Biological Studies | Betides and methods for screening peptides using same |
| AU4974596A (en) * | 1995-12-15 | 1997-07-14 | Salk Institute For Biological Studies, The | Betide-substituted gnrh antagonists |
-
1997
- 1997-04-11 US US08/837,041 patent/US5821230A/en not_active Expired - Lifetime
-
1998
- 1998-04-13 PT PT98918206T patent/PT973801E/pt unknown
- 1998-04-13 DK DK98918206T patent/DK0973801T3/da active
- 1998-04-13 EP EP98918206A patent/EP0973801B1/en not_active Expired - Lifetime
- 1998-04-13 AU AU71174/98A patent/AU7117498A/en not_active Abandoned
- 1998-04-13 JP JP54422598A patent/JP4191259B2/ja not_active Expired - Lifetime
- 1998-04-13 WO PCT/US1998/007519 patent/WO1998046635A1/en not_active Ceased
- 1998-04-13 AT AT98918206T patent/ATE229976T1/de active
- 1998-04-13 DE DE69810283T patent/DE69810283T2/de not_active Expired - Lifetime
- 1998-04-13 ES ES98918206T patent/ES2187958T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4191259B2 (ja) | 2008-12-03 |
| WO1998046635A1 (en) | 1998-10-22 |
| DE69810283D1 (de) | 2003-01-30 |
| US5821230A (en) | 1998-10-13 |
| ATE229976T1 (de) | 2003-01-15 |
| PT973801E (pt) | 2003-04-30 |
| JP2001523232A (ja) | 2001-11-20 |
| EP0973801A1 (en) | 2000-01-26 |
| EP0973801B1 (en) | 2002-12-18 |
| DE69810283T2 (de) | 2003-07-24 |
| DK0973801T3 (da) | 2003-04-07 |
| AU7117498A (en) | 1998-11-11 |
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