ES2187752T3 - Procedimiento para la preparacion de derivados de ganciclovir. - Google Patents

Procedimiento para la preparacion de derivados de ganciclovir.

Info

Publication number
ES2187752T3
ES2187752T3 ES97902187T ES97902187T ES2187752T3 ES 2187752 T3 ES2187752 T3 ES 2187752T3 ES 97902187 T ES97902187 T ES 97902187T ES 97902187 T ES97902187 T ES 97902187T ES 2187752 T3 ES2187752 T3 ES 2187752T3
Authority
ES
Spain
Prior art keywords
procedure
ganciclovir
preparation
ester
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97902187T
Other languages
English (en)
Spanish (es)
Inventor
Humberto B Arzeno
Eric R Humphreys
Jim-Wah Wong
Christopher R Roberts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2187752T3 publication Critical patent/ES2187752T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
ES97902187T 1996-01-26 1997-01-20 Procedimiento para la preparacion de derivados de ganciclovir. Expired - Lifetime ES2187752T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26

Publications (1)

Publication Number Publication Date
ES2187752T3 true ES2187752T3 (es) 2003-06-16

Family

ID=24370063

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97902187T Expired - Lifetime ES2187752T3 (es) 1996-01-26 1997-01-20 Procedimiento para la preparacion de derivados de ganciclovir.

Country Status (7)

Country Link
US (2) US5840890A (enExample)
EP (1) EP0885224B1 (enExample)
JP (1) JP4094666B2 (enExample)
AU (1) AU1593197A (enExample)
DE (1) DE69717974T2 (enExample)
ES (1) ES2187752T3 (enExample)
WO (1) WO1997027197A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
CN1551880A (zh) * 2001-09-07 2004-12-01 ������ҩ��ҵ���޹�˾ 阿昔洛韦缬氨酸酯盐酸盐的晶型
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CA2537132A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Amorphous valganciclovir hydrochloride
US7629461B2 (en) 2004-09-04 2009-12-08 Teva Pharmaceutical Industries Ltd Isolated valacyclovir impurity, process for the preparation of valacyclovir impurity and use as a reference standard
BRPI0607301A2 (pt) * 2005-01-25 2017-05-30 Sigma Coatings Bv composição aglutinante, método de preparação de um composto oligomérico ou polimérico, composição de tinta, e, composição polimérica de siloxano
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (en) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
SI2101733T1 (sl) 2006-12-13 2012-12-31 F. Hoffmann-La Roche Ag Prašnata formulacija za valganciklovir
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
IT1397233B1 (it) * 2010-01-08 2013-01-04 Fidia Farmaceutici Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.
CN101955481B (zh) * 2010-10-09 2016-04-20 广东肇庆星湖生物科技股份有限公司 一种盐酸缬更昔洛韦的制备方法
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
CN105693722B (zh) * 2016-04-20 2018-07-20 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105732630B (zh) * 2016-04-20 2018-11-30 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105693724B (zh) * 2016-04-20 2017-08-11 安徽海康药业有限责任公司 一种cbz‑缬更昔洛韦的制备方法
CN112409359A (zh) * 2020-11-30 2021-02-26 沃德药业(安徽)股份有限公司 一种盐酸缬更昔洛韦制备方法
CN113880838B (zh) * 2021-11-15 2024-03-19 仁合益康集团有限公司 一种微通道反应器合成盐酸缬更昔洛韦的方法
CN115286632B (zh) * 2022-09-16 2023-05-09 河北医科大学 一种盐酸缬更昔洛韦的制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
HU189609B (en) * 1981-08-11 1986-07-28 The Wellcome Foundation Ltd,Us Process for production of new purin derivatives with antivirus effect and medical preparatives containing thereof as reagent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3376326D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
GB8829571D0 (en) 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives

Also Published As

Publication number Publication date
DE69717974D1 (de) 2003-01-30
JP4094666B2 (ja) 2008-06-04
WO1997027197A1 (en) 1997-07-31
JP2000505080A (ja) 2000-04-25
DE69717974T2 (de) 2003-10-02
EP0885224A1 (en) 1998-12-23
US6103901A (en) 2000-08-15
AU1593197A (en) 1997-08-20
EP0885224B1 (en) 2002-12-18
US5840890A (en) 1998-11-24

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