DE69717974T2 - Verfahren zur herstellung von ganciclovirderivaten - Google Patents

Verfahren zur herstellung von ganciclovirderivaten

Info

Publication number
DE69717974T2
DE69717974T2 DE69717974T DE69717974T DE69717974T2 DE 69717974 T2 DE69717974 T2 DE 69717974T2 DE 69717974 T DE69717974 T DE 69717974T DE 69717974 T DE69717974 T DE 69717974T DE 69717974 T2 DE69717974 T2 DE 69717974T2
Authority
DE
Germany
Prior art keywords
group
formula
acid
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69717974T
Other languages
German (de)
English (en)
Other versions
DE69717974D1 (de
Inventor
B. Arzeno
R. Humphreys
R. Roberts
Jim-Wah Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of DE69717974D1 publication Critical patent/DE69717974D1/de
Publication of DE69717974T2 publication Critical patent/DE69717974T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69717974T 1996-01-26 1997-01-20 Verfahren zur herstellung von ganciclovirderivaten Expired - Lifetime DE69717974T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26
PCT/EP1997/000238 WO1997027197A1 (en) 1996-01-26 1997-01-20 Process for preparing ganciclovir derivatives

Publications (2)

Publication Number Publication Date
DE69717974D1 DE69717974D1 (de) 2003-01-30
DE69717974T2 true DE69717974T2 (de) 2003-10-02

Family

ID=24370063

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717974T Expired - Lifetime DE69717974T2 (de) 1996-01-26 1997-01-20 Verfahren zur herstellung von ganciclovirderivaten

Country Status (7)

Country Link
US (2) US5840890A (enExample)
EP (1) EP0885224B1 (enExample)
JP (1) JP4094666B2 (enExample)
AU (1) AU1593197A (enExample)
DE (1) DE69717974T2 (enExample)
ES (1) ES2187752T3 (enExample)
WO (1) WO1997027197A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
AU735438B2 (en) * 1996-11-12 2001-07-05 Medivir Ab Nucleosides
EP1436295A4 (en) * 2001-09-07 2007-07-11 Teva Pharma CRISTALLINE FORMS OF VALACYCLOVIR HYDROCHLORIDE
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CN1860120A (zh) * 2003-08-28 2006-11-08 兰贝克赛实验室有限公司 无定形盐酸缬更昔洛韦
CN101068814A (zh) 2004-09-04 2007-11-07 特瓦制药工业有限公司 分离的伐昔洛韦杂质，制备伐昔洛韦杂质的方法及其作为参比标准物的应用
CA2594688A1 (en) * 2005-01-25 2006-08-03 Sigma Coatings B.V. A binder composition
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (en) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
NZ577179A (en) 2006-12-13 2011-12-22 Hoffmann La Roche Powder formulation for valganciclovir
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
IT1397233B1 (it) * 2010-01-08 2013-01-04 Fidia Farmaceutici Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.
CN101955481B (zh) * 2010-10-09 2016-04-20 广东肇庆星湖生物科技股份有限公司 一种盐酸缬更昔洛韦的制备方法
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
CN105693722B (zh) * 2016-04-20 2018-07-20 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105693724B (zh) * 2016-04-20 2017-08-11 安徽海康药业有限责任公司 一种cbz‑缬更昔洛韦的制备方法
CN105732630B (zh) * 2016-04-20 2018-11-30 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN112409359A (zh) * 2020-11-30 2021-02-26 沃德药业(安徽)股份有限公司 一种盐酸缬更昔洛韦制备方法
CN113880838B (zh) * 2021-11-15 2024-03-19 仁合益康集团有限公司 一种微通道反应器合成盐酸缬更昔洛韦的方法
CN115286632B (zh) * 2022-09-16 2023-05-09 河北医科大学 一种盐酸缬更昔洛韦的制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
FI76086C (fi) * 1981-08-11 1988-09-09 Wellcome Found Foerfarande foer framstaellning av antivirala purinderivat.
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
KR890001487B1 (ko) * 1982-10-14 1989-05-04 더 웰컴 파운데이숀 리미티드 푸린 유도체의 제조방법
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
GB8829571D0 (en) 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
CA2005815C (en) * 1988-12-19 1999-08-03 Wellcome Foundation Limited (The) Antiviral acyclic nucleoside derivatives
ES2157259T3 (es) * 1993-06-10 2001-08-16 Rolabo Sl Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables

Also Published As

Publication number Publication date
WO1997027197A1 (en) 1997-07-31
JP2000505080A (ja) 2000-04-25
US5840890A (en) 1998-11-24
JP4094666B2 (ja) 2008-06-04
EP0885224B1 (en) 2002-12-18
EP0885224A1 (en) 1998-12-23
US6103901A (en) 2000-08-15
AU1593197A (en) 1997-08-20
DE69717974D1 (de) 2003-01-30
ES2187752T3 (es) 2003-06-16

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