DE69717974T2 - Verfahren zur herstellung von ganciclovirderivaten - Google Patents

Verfahren zur herstellung von ganciclovirderivaten

Info

Publication number
DE69717974T2
DE69717974T2 DE69717974T DE69717974T DE69717974T2 DE 69717974 T2 DE69717974 T2 DE 69717974T2 DE 69717974 T DE69717974 T DE 69717974T DE 69717974 T DE69717974 T DE 69717974T DE 69717974 T2 DE69717974 T2 DE 69717974T2
Authority
DE
Germany
Prior art keywords
group
formula
acid
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69717974T
Other languages
German (de)
English (en)
Other versions
DE69717974D1 (de
Inventor
B. Arzeno
R. Humphreys
R. Roberts
Jim-Wah Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE69717974D1 publication Critical patent/DE69717974D1/de
Application granted granted Critical
Publication of DE69717974T2 publication Critical patent/DE69717974T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69717974T 1996-01-26 1997-01-20 Verfahren zur herstellung von ganciclovirderivaten Expired - Lifetime DE69717974T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59228296A 1996-01-26 1996-01-26
PCT/EP1997/000238 WO1997027197A1 (en) 1996-01-26 1997-01-20 Process for preparing ganciclovir derivatives

Publications (2)

Publication Number Publication Date
DE69717974D1 DE69717974D1 (de) 2003-01-30
DE69717974T2 true DE69717974T2 (de) 2003-10-02

Family

ID=24370063

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69717974T Expired - Lifetime DE69717974T2 (de) 1996-01-26 1997-01-20 Verfahren zur herstellung von ganciclovirderivaten

Country Status (7)

Country Link
US (2) US5840890A (enExample)
EP (1) EP0885224B1 (enExample)
JP (1) JP4094666B2 (enExample)
AU (1) AU1593197A (enExample)
DE (1) DE69717974T2 (enExample)
ES (1) ES2187752T3 (enExample)
WO (1) WO1997027197A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040446A (en) * 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US6703394B2 (en) 1996-02-16 2004-03-09 Medivir Ab Acyclic nucleoside derivatives
US5869493A (en) * 1996-02-16 1999-02-09 Medivir Ab Acyclic nucleoside derivatives
JP2001503767A (ja) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ ヌクレオシド
CN1551880A (zh) * 2001-09-07 2004-12-01 ������ҩ��ҵ���޹�˾ 阿昔洛韦缬氨酸酯盐酸盐的晶型
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
CA2537132A1 (en) * 2003-08-28 2005-03-10 Ranbaxy Laboratories Limited Amorphous valganciclovir hydrochloride
US7629461B2 (en) 2004-09-04 2009-12-08 Teva Pharmaceutical Industries Ltd Isolated valacyclovir impurity, process for the preparation of valacyclovir impurity and use as a reference standard
BRPI0607301A2 (pt) * 2005-01-25 2017-05-30 Sigma Coatings Bv composição aglutinante, método de preparação de um composto oligomérico ou polimérico, composição de tinta, e, composição polimérica de siloxano
ZA200702234B (en) * 2006-03-21 2008-07-30 Cipla Ltd Preparation of ester of purine derivatives
EP1870411B1 (en) * 2006-06-21 2016-03-16 Fidia Farmaceutici S.p.A. Process for the preparation and purification of valgancyclovir
SI2101733T1 (sl) 2006-12-13 2012-12-31 F. Hoffmann-La Roche Ag Prašnata formulacija za valganciklovir
US20090076040A1 (en) * 2007-09-15 2009-03-19 Protia, Llc Deuterium-enriched valganciclovir
WO2010036904A2 (en) * 2008-09-26 2010-04-01 Dr. Reddy's Laboratories Ltd. Preparation of valganciclovir and its salts
IT1397233B1 (it) * 2010-01-08 2013-01-04 Fidia Farmaceutici Procedimento migliorativo per la sintesi del mono-acetil ganciclovir, intermedio chiave per la sintesi del valganciclovir.
CN101955481B (zh) * 2010-10-09 2016-04-20 广东肇庆星湖生物科技股份有限公司 一种盐酸缬更昔洛韦的制备方法
CN103562207B (zh) * 2011-05-31 2016-08-17 法尔玛赞公司 用于制备缬更昔洛韦的2-氨基-9-((2-苯基-1，3-二噁烷-5-基氧基)甲基)-1h-嘌呤-6(9h)-酮化合物的制备方法
CN105693722B (zh) * 2016-04-20 2018-07-20 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105732630B (zh) * 2016-04-20 2018-11-30 安徽海康药业有限责任公司 一种cbz-缬更昔洛韦的制备方法
CN105693724B (zh) * 2016-04-20 2017-08-11 安徽海康药业有限责任公司 一种cbz‑缬更昔洛韦的制备方法
CN112409359A (zh) * 2020-11-30 2021-02-26 沃德药业(安徽)股份有限公司 一种盐酸缬更昔洛韦制备方法
CN113880838B (zh) * 2021-11-15 2024-03-19 仁合益康集团有限公司 一种微通道反应器合成盐酸缬更昔洛韦的方法
CN115286632B (zh) * 2022-09-16 2023-05-09 河北医科大学 一种盐酸缬更昔洛韦的制备工艺

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4355032B2 (en) * 1981-05-21 1990-10-30 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent
HU189609B (en) * 1981-08-11 1986-07-28 The Wellcome Foundation Ltd,Us Process for production of new purin derivatives with antivirus effect and medical preparatives containing thereof as reagent
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
US4816447A (en) * 1981-08-26 1989-03-28 Merck & Co., Inc. Anti-viral guanine compounds
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
NL8202626A (nl) * 1982-06-29 1984-01-16 Stichting Rega V Z W Derivaten van 9-(2-hydroxyethoxymethyl)guanine.
DE3376326D1 (en) * 1982-10-14 1988-05-26 Wellcome Found Antiviral purine derivatives
AP160A (en) * 1987-08-15 1991-11-18 The Wellcome Foundation Ltd Therapeutic acyclic nucleosides.
US5043339A (en) * 1988-12-19 1991-08-27 Burroughs Wellcome Co. Antiviral compounds
GB8829571D0 (en) 1988-12-19 1989-02-08 Wellcome Found Antiviral compounds
EP0702682B1 (en) * 1993-06-10 2001-03-14 Rolabo Sl Process for the preparation of amino acid esters of nucleoside analogues
PE32296A1 (es) * 1994-07-28 1996-08-07 Hoffmann La Roche Ester de l-monovalina derivado de 2-(2-amino-1,6-dihidro-6-oxo-purin-9-il) metoxi-1,3-propandiol y sus sales farmaceuticamente aceptables
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives

Also Published As

Publication number Publication date
DE69717974D1 (de) 2003-01-30
JP4094666B2 (ja) 2008-06-04
WO1997027197A1 (en) 1997-07-31
JP2000505080A (ja) 2000-04-25
ES2187752T3 (es) 2003-06-16
EP0885224A1 (en) 1998-12-23
US6103901A (en) 2000-08-15
AU1593197A (en) 1997-08-20
EP0885224B1 (en) 2002-12-18
US5840890A (en) 1998-11-24

Similar Documents

Publication Publication Date Title
DE69737636T2 (de) Verfahren zur herstellung von purinderivaten
DE69509173T2 (de) 2-(2-Amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propandiol-Derivate
DE69516847T2 (de) Chlorpyrimidine als zwischenprodukte
JP4094666B2 (ja) ガンシクロビル誘導体の製造方法
DE69718626T2 (de) Azyklische nukleosidderivate
US5543414A (en) Achiral amino acid acyl esters of ganciclovir and its derivatives
DE69706828T2 (de) Verfahren zur herstellung von purinderivaten
US6040446A (en) Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
WO1997027195A9 (en) Process for preparing purine derivatives
CN112272665A (zh) 制备立他司特的方法
DE69714971T2 (de) Verfahren zur herstellung von purin-derivaten
DE69513313T2 (de) Verfahren zur Herstellung von Nukleinsäurebasenderivaten
WO1997027194A1 (en) Process for preparing purine derivatives
JP4531250B2 (ja) クロロプリン中間体の合成法
WO1990003386A1 (de) Verfahren zur herstellung von dipeptiden mit c-terminalen nicht-proteinogenen aminosäuren
CN111808040B (zh) 多构型2-氧代噁唑烷-4-羧酸类化合物的合成方法
DE69809205T2 (de) Verfahren zur herstellung von azyklischen nukleosiden
DE69614030T2 (de) Herstellung und Verwendung von 7-((2-Carbo-alkoxy-1-methylethenyl)amino)-3-hydroxymethyl-3-cephem-4-carbonsäuren
CA2243972C (en) Process for preparing purine derivatives
CA2246164C (en) Process for preparing ganciclovir derivatives
JPH08311049A (ja) Ｌ−スレオ−βーヒドロキシアスパラギン酸誘導体および製造法
JPH04108768A (ja) アミノ酸エステルの製造法
CA2547307A1 (en) Process for preparing ganciclovir derivatives
MXPA00003379A (en) Process for the synthesis of chloropurine intermediates

Legal Events

Date Code Title Description
8364 No opposition during term of opposition