ES2187044T3 - Procedimiento para la obtencion de enantiomeros de cizolirtina. - Google Patents
Procedimiento para la obtencion de enantiomeros de cizolirtina.Info
- Publication number
- ES2187044T3 ES2187044T3 ES98935042T ES98935042T ES2187044T3 ES 2187044 T3 ES2187044 T3 ES 2187044T3 ES 98935042 T ES98935042 T ES 98935042T ES 98935042 T ES98935042 T ES 98935042T ES 2187044 T3 ES2187044 T3 ES 2187044T3
- Authority
- ES
- Spain
- Prior art keywords
- cizolirtine
- enantiomers
- procedure
- obtaining
- enantiomer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un procedimiento para la obtención de los enantiómeros de cizolirtina, -2-[fenil(1-metil-1H-pirazol-5-il)metoxi]-N,N-dimetiletanamina, de fórmula I, **fórmula** que comprende la reducción nantioselectiva de la cetona proquiral de fórmula III, **fórmula** utilizando un agente reductor de borano y un catalizador quiral derivado de boro seleccionado de una oxazaborolidina quiral, en un disolvente anhidro o una mezcla de disolventes anhidros a temperaturas comprendidas entre 78ºC y 55ºC, para formar un enantiómero del alcohol de fórmula II, **fórmula** y la alquilación, en condiciones de transferencia de fase, de este compuesto ópticamente activo, previo aislamiento y purificación o sin aislamiento con 2-cloro-N,N-dimetiletilamina.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701728A ES2130083B1 (es) | 1997-08-04 | 1997-08-04 | Procedimiento para la obtencion de los enantiomeros de cizolirtina. |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2187044T3 true ES2187044T3 (es) | 2003-05-16 |
Family
ID=8300306
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009701728A Expired - Fee Related ES2130083B1 (es) | 1997-08-04 | 1997-08-04 | Procedimiento para la obtencion de los enantiomeros de cizolirtina. |
ES98935042T Expired - Lifetime ES2187044T3 (es) | 1997-08-04 | 1998-07-31 | Procedimiento para la obtencion de enantiomeros de cizolirtina. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009701728A Expired - Fee Related ES2130083B1 (es) | 1997-08-04 | 1997-08-04 | Procedimiento para la obtencion de los enantiomeros de cizolirtina. |
Country Status (12)
Country | Link |
---|---|
US (1) | US6118009A (es) |
EP (1) | EP1029852B1 (es) |
JP (1) | JP2001512718A (es) |
AT (1) | ATE227272T1 (es) |
AU (1) | AU8442698A (es) |
CA (1) | CA2299447C (es) |
DE (1) | DE69809282T2 (es) |
DK (1) | DK1029852T3 (es) |
ES (2) | ES2130083B1 (es) |
NO (1) | NO314499B1 (es) |
PT (1) | PT1029852E (es) |
WO (1) | WO1999007684A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040142929A1 (en) * | 2001-07-06 | 2004-07-22 | Ramon Merce-Vidal | Derivatives of aryl (or heteroaryl) azolylcarbinoles for the treatment of urinary incontinence |
TW200533657A (en) * | 2004-02-17 | 2005-10-16 | Esteve Labor Dr | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1584335A3 (en) * | 2004-04-05 | 2006-02-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising a carbinol composition and an opioid |
ES2244326B1 (es) * | 2004-04-05 | 2007-02-16 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de substancias activas. |
JP2007531785A (ja) * | 2004-04-05 | 2007-11-08 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | 活性物質組合せ物 |
US20060040924A1 (en) * | 2004-06-22 | 2006-02-23 | Laboratorios Dr. Esteve S.A. | Derivatives of aryl (or heteroaryl) azolylcarbinols for the treatment of renal colic |
WO2006063861A1 (en) * | 2004-12-17 | 2006-06-22 | Laboratorios Del Dr. Esteve, S.A. | Process for obtaining cizolirtine and its enantiomers |
EP1671953A1 (en) | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Process for obtaining cizolirtine and its enantiomers |
EP1671968A1 (en) * | 2004-12-17 | 2006-06-21 | Laboratorios Del Dr. Esteve, S.A. | Process for obtaining enantiomers of thienylazolylalcoxyethanamines |
US7897589B2 (en) * | 2005-07-15 | 2011-03-01 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1743890A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | 4,5-Dihydro-1H-pyrazole derivatives, their preparation and use as medicaments |
EP1743892A1 (en) * | 2005-07-15 | 2007-01-17 | Laboratorios del Dr. Esteve S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1757587A1 (en) * | 2005-07-15 | 2007-02-28 | Laboratorios Del Dr. Esteve, S.A. | Substituted pyrazoline compounds, their preparation and use as medicaments |
EP1820502A1 (en) | 2006-02-10 | 2007-08-22 | Laboratorios Del Dr. Esteve, S.A. | Active substance combination comprising azolylcarbinol compounds |
EP2151234A1 (en) * | 2008-07-28 | 2010-02-10 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical formulation comprising a CB1-receptor compound in a solid solution and/or solid dispersion |
US20100291151A1 (en) * | 2009-04-21 | 2010-11-18 | Auspex Pharmaceuticals, Inc. | 1-methylpyrazole modulators of substance p, calcitonin gene-related peptide, adrenergic receptor, and/or 5-ht receptor |
DE102010056283A1 (de) | 2010-12-24 | 2012-06-28 | Volkswagen Ag | Wärmeübertragungssystem |
CN108558695A (zh) * | 2018-05-15 | 2018-09-21 | 浙江华贝药业有限责任公司 | 2,2,2-三氟-n-[(1s,4s)-4-羟基四氢萘-1-基]-乙酰胺制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4943635A (en) * | 1987-08-27 | 1990-07-24 | President & Fellows Of Harvard College | Enantioselective reduction of ketones |
NZ249302A (en) * | 1992-05-14 | 1996-11-26 | Pfizer | 4,5-diphenyl-1,3,2-oxazaborolidine derivatives and their use as catalysts in reduction of ketones to chiral alcohols |
US5442118A (en) * | 1994-04-22 | 1995-08-15 | Sepracor, Inc. | Asymmetric synthesis of (R)- and (S)-arylethanolamines from iminoketones |
-
1997
- 1997-08-04 ES ES009701728A patent/ES2130083B1/es not_active Expired - Fee Related
-
1998
- 1998-07-31 US US09/485,023 patent/US6118009A/en not_active Expired - Fee Related
- 1998-07-31 DK DK98935042T patent/DK1029852T3/da active
- 1998-07-31 AT AT98935042T patent/ATE227272T1/de not_active IP Right Cessation
- 1998-07-31 JP JP2000506188A patent/JP2001512718A/ja active Pending
- 1998-07-31 CA CA002299447A patent/CA2299447C/en not_active Expired - Fee Related
- 1998-07-31 ES ES98935042T patent/ES2187044T3/es not_active Expired - Lifetime
- 1998-07-31 AU AU84426/98A patent/AU8442698A/en not_active Abandoned
- 1998-07-31 WO PCT/ES1998/000223 patent/WO1999007684A1/es active IP Right Grant
- 1998-07-31 EP EP98935042A patent/EP1029852B1/en not_active Expired - Lifetime
- 1998-07-31 PT PT98935042T patent/PT1029852E/pt unknown
- 1998-07-31 DE DE69809282T patent/DE69809282T2/de not_active Expired - Fee Related
-
2000
- 2000-02-03 NO NO20000560A patent/NO314499B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
CA2299447A1 (en) | 1999-02-18 |
WO1999007684A1 (es) | 1999-02-18 |
CA2299447C (en) | 2007-05-29 |
US6118009A (en) | 2000-09-12 |
DE69809282D1 (de) | 2002-12-12 |
JP2001512718A (ja) | 2001-08-28 |
ATE227272T1 (de) | 2002-11-15 |
DK1029852T3 (da) | 2003-02-24 |
DE69809282T2 (de) | 2003-09-11 |
NO20000560L (no) | 2000-03-29 |
NO20000560D0 (no) | 2000-02-03 |
ES2130083A1 (es) | 1999-06-16 |
AU8442698A (en) | 1999-03-01 |
EP1029852A1 (en) | 2000-08-23 |
ES2130083B1 (es) | 2000-01-16 |
EP1029852B1 (en) | 2002-11-06 |
NO314499B1 (no) | 2003-03-31 |
PT1029852E (pt) | 2003-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2187044T3 (es) | Procedimiento para la obtencion de enantiomeros de cizolirtina. | |
Garlets et al. | Asymmetric Palladium‐Catalyzed Alkene Carboamination Reactions for the Synthesis of Cyclic Sulfamides | |
BR0012434A (pt) | Composto, processo para a preparação do mesmo, uso de um composto, composição farmacêutica. | |
DE59705550D1 (de) | Verfahren zur herstellung von nitrobiphenylen | |
Yu et al. | Enantioselective Synthesis of 2‐Bromomethyl Indolines via BINAP (S)‐Catalyzed Bromoaminocyclization of Allyl Aniline | |
DE69805926D1 (de) | Verfahren zur Herstellung von Sevoflurane | |
WO1996000729A3 (en) | Process for the preparation of azanoradamantane benzamides | |
Ishitani et al. | Enantioselective sequential‐flow synthesis of baclofen precursor via asymmetric 1, 4‐Addition and chemoselective hydrogenation on platinum/carbon/calcium phosphate composites | |
KR960702468A (ko) | 거울상선택적 옥사자보로리딘 촉매(Enantioselective oxazaborolidine catalysts) | |
BR9903573A (pt) | Processo para preparação de haloformiminas, e, compostos de haloforminina | |
BR9915868A (pt) | Processo para a decomposição de tramadol | |
Rulev et al. | Direct Access to Cumbersome Aminated Quaternary Centers by Hyperbaric Aza‐Michael Additions | |
Kim et al. | Concise Asymmetric Total Synthesis of ent‐Ancistrocladinium A | |
AR043825A1 (es) | Procesos de preparacion de 5-(haloacetil)-8-(oxisustituidos)-(1h)-quinolin-2-onas | |
McSweeney et al. | The asymmetric alkylation of dimethylhydrazones; intermolecular chirality transfer using sparteine as chiral ligand | |
BR0314966A (pt) | Processo para preparar um composto, e, composto | |
PT1349828E (pt) | Processo para a preparacao de isomeros de salutamol | |
PT909751E (pt) | Um processo para a preparacao de esteres do acido cinamico | |
BR0111317A (pt) | Processo para preparar compostos, composto, sistema de catalisador, e, usos de um composto e de um sistema de catalisador | |
Yoshida et al. | Chemoselective Catalytic Asymmetric Synthesis of Functionalized Aminals Through the Umpolung Organocascade Reaction of α‐Imino Amides | |
BR9909151A (pt) | processos para preparação de intermediários | |
ES485645A1 (es) | Un procedimiento mejorado para preparar n-fenil-n'-alcohil- fenilendiamina | |
DE50211314D1 (de) | Verfahren zur katalytischen Hydrierung | |
BR9902525A (pt) | Processo para compostos de ácido pirrolidinil-hidroxâmico | |
Xu et al. | Chiral oxazaborolidine‐catalyzed asymmetric borane reduction of alkyl 4‐dialkylaminophenyl ketones |